Details for: ZBTB46

Gene ID: 140685

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZBTB46

Ensembl ID: ENSG00000130584

Description: zinc finger and BTB domain containing 46

Cell Significance Landscape

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Granulocyte differentiation
    (GO:0030851)
  • Macrophage differentiation
    (GO:0030225)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of dendritic cell differentiation
    (GO:2001199)
  • Negative regulation of granulocyte differentiation
    (GO:0030853)
  • Negative regulation of leukocyte activation
    (GO:0002695)
  • Negative regulation of macrophage differentiation
    (GO:0045650)
  • Negative regulation of monocyte differentiation
    (GO:0045656)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Plasmacytoid dendritic cell differentiation
    (GO:0002273)
  • Positive regulation of dendritic cell differentiation
    (GO:2001200)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • mononuclear phagocyte CL0000113
    CSI 8.39
    rCSI 18.46%
    PRS 89.86
  • blood vessel endothelial cell CL0000071
    CSI 7.64
    rCSI 15.85%
    PRS 84.84
  • astrocyte of the cerebral cortex CL0002605
    CSI 7.32
    rCSI 16.41%
    PRS 72.89
  • neural crest cell CL0011012
    CSI 6.4
    rCSI 5.06%
    PRS 78.62
  • chondrocyte CL0000138
    CSI 5.72
    rCSI 9.1%
    PRS 81.67
  • adipocyte CL0000136
    CSI 4.78
    rCSI 6.13%
    PRS 78.08
  • inhibitory interneuron CL0000498
    CSI 4.74
    rCSI 10.93%
    PRS 76.94
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 4.69
    rCSI 6.01%
    PRS 83.64
  • vascular leptomeningeal cell CL4023051
    CSI 4.22
    rCSI 7.39%
    PRS 82.55
  • ependymal cell CL0000065
    CSI 4.21
    rCSI 8.55%
    PRS 68.08
  • mesangial cell CL0000650
    CSI 4.02
    rCSI 16.38%
    PRS 93.16
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 3.74
    rCSI 11.52%
    PRS 89.8
  • hepatic stellate cell CL0000632
    CSI 3.69
    rCSI 13.83%
    PRS 81.41
  • mural cell CL0008034
    CSI 3.65
    rCSI 12.37%
    PRS 81.98
  • renal interstitial pericyte CL1001318
    CSI 3.56
    rCSI 9.82%
    PRS 83.53
  • cerebellar granule cell CL0001031
    CSI 3.51
    rCSI 5.16%
    PRS 81.24
  • fibroblast of cardiac tissue CL0002548
    CSI 3.48
    rCSI 16.69%
    PRS 87.65
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 3.36
    rCSI 8.77%
    PRS 88.39
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.28
    rCSI 7.96%
    PRS 69.93
  • endothelial cell of vascular tree CL0002139
    CSI 3.14
    rCSI 17.15%
    PRS 83.69
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.95
    rCSI 4.18%
    PRS 84.53
  • retinal bipolar neuron CL0000748
    CSI 2.93
    rCSI 5.48%
    PRS 77.56
  • choroid plexus epithelial cell CL0000706
    CSI 2.64
    rCSI 4.32%
    PRS 78.76
  • blood vessel smooth muscle cell CL0019018
    CSI 2.61
    rCSI 21.25%
    PRS 83.2
  • interneuron CL0000099
    CSI 2.61
    rCSI 5.23%
    PRS 79.88
  • dopaminergic neuron CL0000700
    CSI 2.57
    rCSI 14.53%
    PRS 75.3
  • cardiac muscle cell CL0000746
    CSI 2.51
    rCSI 3.6%
    PRS 78.44
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.46
    rCSI 2.94%
    PRS 72.32
  • cerebral cortex endothelial cell CL1001602
    CSI 2.45
    rCSI 4.23%
    PRS 80.68
  • retinal ganglion cell CL0000740
    CSI 2.38
    rCSI 5.25%
    PRS 75.11
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.31
    rCSI 3.68%
    PRS 90.13
  • epithelial cell of proximal tubule CL0002306
    CSI 2.26
    rCSI 5.52%
    PRS 80.09
  • kidney interstitial fibroblast CL1000692
    CSI 2.22
    rCSI 11.82%
    PRS 79.12
  • Langerhans cell CL0000453
    CSI 2.2
    rCSI 3.37%
    PRS 94.66
  • L6b glutamatergic cortical neuron CL4023038
    CSI 2.17
    rCSI 6.77%
    PRS 73.5
  • Schwann cell CL0002573
    CSI 2.07
    rCSI 5.89%
    PRS 83.24
  • renal beta-intercalated cell CL0002201
    CSI 2
    rCSI 4.76%
    PRS 87.11
  • lung pericyte CL0009089
    CSI 1.93
    rCSI 5.1%
    PRS 91.86
  • pulmonary artery endothelial cell CL1001568
    CSI 1.92
    rCSI 2.62%
    PRS 92.57
  • stromal cell CL0000499
    CSI 1.91
    rCSI 5.36%
    PRS 82.72
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.89
    rCSI 4.81%
    PRS 79.59
  • parietal epithelial cell CL1000452
    CSI 1.85
    rCSI 4.95%
    PRS 80.59
  • retinal pigment epithelial cell CL0002586
    CSI 1.85
    rCSI 3.67%
    PRS 83.35
  • endocardial cell CL0002350
    CSI 1.79
    rCSI 8.59%
    PRS 83.26
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.76
    rCSI 2.12%
    PRS 92.85
  • contractile cell CL0000183
    CSI 1.72
    rCSI 5.09%
    PRS 86.15
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.71
    rCSI 3.02%
    PRS 71.62
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.67
    rCSI 6.31%
    PRS 72.45
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.6
    rCSI 4.14%
    PRS 83.73
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.57
    rCSI 9.27%
    PRS 72.6
  • cardiac endothelial cell CL0010008
    CSI 1.52
    rCSI 6.11%
    PRS 87.64
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 1.45
    rCSI 4.76%
    PRS 74.52
  • retinal cone cell CL0000573
    CSI 1.41
    rCSI 2.26%
    PRS 78.67
  • macroglial cell CL0000126
    CSI 1.4
    rCSI 3.6%
    PRS 83.29
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.38
    rCSI 2.23%
    PRS 73.34
  • direct pathway medium spiny neuron CL4023026
    CSI 1.33
    rCSI 31.83%
    PRS 69.75
  • podocyte CL0000653
    CSI 1.29
    rCSI 5.74%
    PRS 87.86
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.24
    rCSI 2.97%
    PRS 75.62
  • regular atrial cardiac myocyte CL0002129
    CSI 1.12
    rCSI 3.62%
    PRS 83.97
  • cardiac blood vessel endothelial cell CL0010006
    CSI 1.1
    rCSI 7.76%
    PRS 80.58
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.08
    rCSI 1.82%
    PRS 72.17
  • serotonergic neuron CL0000850
    CSI 1.03
    rCSI 4.59%
    PRS 72.29
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.92
    rCSI 22.25%
    PRS 70.19
  • endothelial cell of placenta CL0009092
    CSI 0.71
    rCSI 3.51%
    PRS 92.22
  • cerebellar neuron CL1001611
    CSI 0.71
    rCSI 6.22%
    PRS 75.46
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.62
    rCSI 2.25%
    PRS 70.13
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.56
    rCSI 1.74%
    PRS 75.59
  • central nervous system neuron CL2000029
    CSI 0.55
    rCSI 4.06%
    PRS 76.95
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.45
    rCSI 2.83%
    PRS 80.23
  • medium spiny neuron CL1001474
    CSI 0.34
    rCSI 2.92%
    PRS 77.57

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZBTB46](/details-gene/140685) is a protein-coding gene located on chromosome 20 that encodes the Zinc finger and BTB domain-containing protein 46. This protein functions as a nuclear DNA-binding transcription factor, specifically acting as a transcriptional repressor. Functional annotations strongly implicate [ZBTB46](/details-gene/140685) as a key regulator of myeloid cell lineage commitment, with established roles in the differentiation of granulocytes, macrophages, and dendritic cells. Consistent with this, expression data reveals its highest significance in [mononuclear phagocyte](/details-cell/CL0000113) populations. However, its significant expression in a wide range of non-hematopoietic cells, including [blood vessel endothelial cell](/details-cell/CL0000071) and various neural cell types like [astrocyte of the cerebral cortex](/details-cell/CL0002605), suggests broader roles in cellular differentiation and identity maintenance beyond the immune system. ## Cellular Roles and Expression Landscape The expression profile of [ZBTB46](/details-gene/140685) highlights its multifaceted role across diverse cellular lineages. **Overall**, its most significant expression is observed in [mononuclear phagocyte](/details-cell/CL0000113) (CSI: 8.39), which aligns perfectly with its established function in regulating myeloid cell differentiation. However, the gene's significance extends well beyond the immune system, indicating a more fundamental role in various tissues: * **Vascular and Endothelial System:** [ZBTB46](/details-gene/140685) shows high significance in [blood vessel endothelial cell](/details-cell/CL0000071) (CSI: 7.64), as well as more specialized endothelial populations like [endothelial cell of pericentral hepatic sinusoid](/details-cell/CL0019022) (CSI: 3.74). Its expression in associated cell types such as [mural cell](/details-cell/CL0008034) and [renal interstitial pericyte](/details-cell/CL1001318) further suggests a role in vascular homeostasis and development. * **Central Nervous System:** The gene is a significant marker for several neural and glial cell types, including [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 7.32), [inhibitory interneuron](/details-cell/CL0000498) (CSI: 4.74), [neuroblast (sensu Vertebrata)](/details-cell/CL0000031) (CSI: 4.69), and [ependymal cell](/details-cell/CL0000065) (CSI: 4.21). This pattern suggests a potential function in neural development or the maintenance of mature glial and neuronal identity. * **Mesenchymal and Connective Tissues:** Significant expression is also noted in cells of mesenchymal origin, such as [chondrocyte](/details-cell/CL0000138) (CSI: 5.72) and [adipocyte](/details-cell/CL0000136) (CSI: 4.78), implying a role in the biology of these structural tissues. This broad yet specific expression pattern suggests that while [ZBTB46](/details-gene/140685) is a key regulator in the myeloid compartment, it may also function as a more general lineage-defining or maintenance factor in a variety of other terminally differentiated cell types. ## Pathways and Molecular Function Functionally, [ZBTB46](/details-gene/140685) is annotated as a nuclear protein that binds to chromatin ([GO:0000785](https://www.ebi.ac.uk/QuickGO/term/GO:0000785)) and exhibits [dna-binding transcription repressor activity, rna polymerase ii-specific](/details-go/GO0001227) ([GO:0001227](https://www.ebi.ac.uk/QuickGO/term/GO:0001227)). Its primary biological role involves the regulation of cell fate decisions, particularly within the hematopoietic system. The gene is deeply involved in multiple aspects of myeloid cell development: * **Dendritic Cell Differentiation:** It plays a dual role, participating in both [negative regulation of dendritic cell differentiation](/details-go/GO2001199) ([GO:2001199](https://www.ebi.ac.uk/QuickGO/term/GO:2001199)) and [positive regulation of dendritic cell differentiation](/details-go/GO2001200) ([GO:2001200](https://www.ebi.ac.uk/QuickGO/term/GO:2001200)), as well as being specifically involved in [plasmacytoid dendritic cell differentiation](/details-go/GO0002273) ([GO:0002273](https://www.ebi.ac.uk/QuickGO/term/GO:0002273)). This suggests it acts as a fine-tuning switch, directing progenitor cells toward or away from specific DC lineages depending on the cellular context. * **Macrophage and Granulocyte Regulation:** [ZBTB46](/details-gene/140685) is also implicated in the differentiation of other myeloid cells, including [macrophage differentiation](/details-go/GO0030225) ([GO:0030225](https://www.ebi.ac.uk/QuickGO/term/GO:0030225)) and [granulocyte differentiation](/details-go/GO0030851) ([GO:0030851](https://www.ebi.ac.uk/QuickGO/term/GO:0030851)). Its repressive function likely contributes to the negative regulation of these processes, preventing inappropriate or premature differentiation. * **Leukocyte Activation:** Beyond differentiation, it is involved in the [negative regulation of leukocyte activation](/details-go/GO0002695) ([GO:0002695](https://www.ebi.ac.uk/QuickGO/term/GO:0002695)), pointing to a role in maintaining immune quiescence. The combination of its repressor function and its specific roles in myeloid development supports a model where [ZBTB46](/details-gene/140685) acts as a crucial gatekeeper, controlling lineage commitment and maintaining the identity of progenitor and mature cells. ## Research Directions The widespread significance of [ZBTB46](/details-gene/140685) across diverse cell types, extending beyond its well-characterized role in the myeloid lineage, opens several avenues for future investigation. The provided data represents a baseline **Overall** context, and future studies should explore how its expression and significance change in disease states like cancer or inflammation. ### Proposed Hypotheses: 1. **Hypothesis on Immune Regulation:** Given its involvement in both positive and negative regulation of dendritic cell (DC) differentiation, [ZBTB46](/details-gene/140685) functions as a master regulator that dictates the balance between conventional DC (cDC) and plasmacytoid DC (pDC) lineages. Its expression level in common myeloid progenitors may determine the ultimate fate of these cells in response to specific cytokine cues. 2. **Hypothesis on Non-Hematopoietic Lineage Maintenance:** The high expression of [ZBTB46](/details-gene/140685) in terminally differentiated cells such as [astrocyte of the cerebral cortex](/details-cell/CL0002605) and [blood vessel endothelial cell](/details-cell/CL0000071) suggests it actively suppresses alternative transcriptional programs to maintain cellular identity. Loss of [ZBTB46](/details-gene/140685) in these cells may lead to de-differentiation or trans-differentiation, particularly under conditions of cellular stress or injury. ### Key Experimental Approach: To test the hypothesis regarding lineage maintenance (Hypothesis 2), a powerful approach would be to use a conditional knockout mouse model. For instance, crossing a *Zbtb46-floxed* mouse with a *Tie2-Cre* mouse would allow for specific deletion of the gene in endothelial cells. The resulting phenotype could be assessed using single-cell RNA sequencing (scRNA-seq) on endothelial populations isolated from various organs. This experiment would reveal whether the loss of [ZBTB46](/details-gene/140685) leads to the aberrant expression of mesenchymal or hematopoietic genes, which would support its role as a guardian of endothelial identity. ### Therapeutic Potential: As an intracellular transcription factor, [ZBTB46](/details-gene/140685) presents a challenging direct target for small molecule inhibitors. Furthermore, its broad expression across multiple critical cell types, including vascular and neural cells, raises significant safety concerns for systemic therapies. However, its crucial role in controlling dendritic cell differentiation makes it an attractive target for *ex vivo* cell-based immunotherapies. Modulating [ZBTB46](/details-gene/140685) expression (e.g., via siRNA knockdown or CRISPR-based modulation) in hematopoietic stem cells could be used to generate specific DC subsets with enhanced anti-tumor or tolerogenic properties for adoptive cell transfer. Therefore, targeting would likely focus on manipulating cellular products rather than direct in-vivo administration.

Genular Protein ID: 84655772

Symbol: ZBT46_HUMAN

Name: Zinc finger and BTB domain-containing protein 46

UniProtKB Accession Codes:

Q86UZ6 E1P5K9 Q5JWJ3 Q6GMV4 Q9BQK3 Q9H3Z8 Q9H3Z9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 7 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 589
  • Mass: 64083
  • Checksum: F03FC7D7BF9B9E09
  • Sequence:
    • MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL GSSRYFKTLY 
CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA 
CHDFIKAALD ISIKSDASDE LAEFEIGASS SSSTEALISA VMAGRSISPW LARRTSPANS 
SGDSAIASCH DGGSSYGKED QEPKADGPDD VSSQPLWPGD VGYGPLRIKE EQVSPSQYGG 
SELPSAKDGA VQNSFSEQSA GDAWQPTGRR KNRKNKETVR HITQQVEDDS RASSPVPSFL 
PTSGWPFSSR DSNADLSVTE ASSSDSRGER AELYAQVEEG LLGGEASYLG PPLTPEKDDA 
LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP RGAHSLSLNE FTVIRKKFKC 
PYCSFSAMHQ CILKRHMRSH TGERPYPCEI CGKKFTRREH MKRHTLVHSK DKKYVCKVCS 
RVFMSAASVG IRHGSRRHGV CTDCAGRGMA GPLDHGGGGG EGSPEALFPG DGPYLEDPED 
PRGEAEELGE DDEGLAPEDA LLADDKDEED SPRPRSPPGG PDKDFAWLS

Genular Protein ID: 1748079771

Symbol: Q6ZMU8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZMU8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 589
  • Mass: 64084
  • Checksum: F8F769D35EECB661
  • Sequence:
    • MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL GSSRYFKTLY 
CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA 
CHDFIKAALD ISIKSDASDE LAEFEIGASS SSSTEALISA VMAGRSISPW LARRTSPADS 
SGDSAIASCH DGGSSYGKED QEPKADGPDD VSSQPLWPGD VGYGPLRIKE EQVSPSQYGG 
SELPSAKDGA VQNSFSEQSA GDAWQPTGRR KNRKNKETVR HITQQVEDDS RASSPVPSFL 
PTSGWPFSSR DSNADLSVTE ASSSDSRGER AELYAQVEEG LLGGEASYLG PPLTPEKDDA 
LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP RGAHSLSLNE FTVIRKKFKC 
PYCSFSAMHQ CILKRHMRSH TGERPYPCEI CGKKFTRREH MKRHTLVHSK DKKYVCKVCS 
RVFMSAASVG IRHGSRRHGV CTDCAGRGMA GPLDHGGGGG EGSPEALFPG DGPYLEDPED 
PRGEAEELGE DDEGLAPEDA LLADDKDEED SPRPRSPPGG PDKDFAWLS

Genular Protein ID: 1172716164

Symbol: A0A494BZW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494BZW5

Database IDs:

AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 432
  • Mass: 46518
  • Checksum: 3DCA9D3DFBEE76AD
  • Sequence:
    • MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL GSSRYFKTLY 
CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA 
CHDFIKAALD ISIKSDASDE LAEFEIGASS SSSTEALISA VMAGRSISPW LARRTSPANS 
SGDSAIASCH DGGSSYGKED QEPKADGPDD VSSQPLWPGD VGYGPLRIKE EQVSPSQYGG 
SELPSAKDGA VQNSFSEQSA GDAWQPTGRR KNRKNKETVR HITQQVEDDS RASSPVPSFL 
PTSGWPFSSR DSNADLSVTE ASSSDSRGER AELYAQVEEG LLGGEASYLG PPLTPEKDDA 
LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP RGAHSLSRPG SLVRVADGRT 
EAPPPSTLRA TG