Details for: CTNNA1

Gene ID: 1495

Symbol: CTNNA1

Ensembl ID: ENSG00000044115

Description: catenin alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 617.4410
    Cell Significance Index: -96.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 403.2039
    Cell Significance Index: -102.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 249.8376
    Cell Significance Index: -102.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 224.3485
    Cell Significance Index: -105.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 218.8515
    Cell Significance Index: -88.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 194.2513
    Cell Significance Index: -99.9200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 158.1915
    Cell Significance Index: -106.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 93.0931
    Cell Significance Index: -88.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 83.3607
    Cell Significance Index: -102.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.5458
    Cell Significance Index: -100.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.5329
    Cell Significance Index: -104.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.2772
    Cell Significance Index: -57.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.1547
    Cell Significance Index: -74.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.5095
    Cell Significance Index: 120.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.2344
    Cell Significance Index: 90.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.1708
    Cell Significance Index: 165.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9346
    Cell Significance Index: 225.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.8284
    Cell Significance Index: 40.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4076
    Cell Significance Index: 477.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0310
    Cell Significance Index: 366.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8925
    Cell Significance Index: 1033.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8576
    Cell Significance Index: 228.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6321
    Cell Significance Index: 35.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6233
    Cell Significance Index: 91.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5950
    Cell Significance Index: 45.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3770
    Cell Significance Index: 84.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2677
    Cell Significance Index: 254.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1115
    Cell Significance Index: 52.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9440
    Cell Significance Index: 25.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9223
    Cell Significance Index: 18.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9012
    Cell Significance Index: 42.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8769
    Cell Significance Index: 1651.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8540
    Cell Significance Index: 59.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8319
    Cell Significance Index: 367.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8137
    Cell Significance Index: 111.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8071
    Cell Significance Index: 36.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7034
    Cell Significance Index: 36.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6718
    Cell Significance Index: 86.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6218
    Cell Significance Index: 394.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6024
    Cell Significance Index: 44.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6014
    Cell Significance Index: 16.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5711
    Cell Significance Index: 73.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5266
    Cell Significance Index: 188.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4517
    Cell Significance Index: 312.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4264
    Cell Significance Index: 6.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3844
    Cell Significance Index: 3.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3654
    Cell Significance Index: 562.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3530
    Cell Significance Index: 21.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3407
    Cell Significance Index: 33.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3343
    Cell Significance Index: 616.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2952
    Cell Significance Index: 56.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2793
    Cell Significance Index: 7.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2635
    Cell Significance Index: 9.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2406
    Cell Significance Index: 109.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1620
    Cell Significance Index: 27.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1514
    Cell Significance Index: 205.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -2.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0135
    Cell Significance Index: -12.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0182
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0296
    Cell Significance Index: -18.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0365
    Cell Significance Index: -27.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0450
    Cell Significance Index: -1.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0683
    Cell Significance Index: -4.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1065
    Cell Significance Index: -60.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1170
    Cell Significance Index: -11.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2647
    Cell Significance Index: -38.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3133
    Cell Significance Index: -90.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3237
    Cell Significance Index: -68.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3379
    Cell Significance Index: -36.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3961
    Cell Significance Index: -5.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3974
    Cell Significance Index: -6.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4145
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4483
    Cell Significance Index: -51.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4731
    Cell Significance Index: -55.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4947
    Cell Significance Index: -6.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5258
    Cell Significance Index: -60.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5689
    Cell Significance Index: -14.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5829
    Cell Significance Index: -60.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6417
    Cell Significance Index: -16.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6837
    Cell Significance Index: -14.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6942
    Cell Significance Index: -14.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7085
    Cell Significance Index: -31.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7266
    Cell Significance Index: -85.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8854
    Cell Significance Index: -21.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8870
    Cell Significance Index: -33.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8995
    Cell Significance Index: -60.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9232
    Cell Significance Index: -59.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9254
    Cell Significance Index: -29.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9698
    Cell Significance Index: -76.8100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9731
    Cell Significance Index: -14.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0288
    Cell Significance Index: -17.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0384
    Cell Significance Index: -23.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1230
    Cell Significance Index: -58.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4084
    Cell Significance Index: -14.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4315
    Cell Significance Index: -90.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.4868
    Cell Significance Index: -42.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5642
    Cell Significance Index: -95.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.6030
    Cell Significance Index: -23.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.6654
    Cell Significance Index: -28.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-Cell Adhesion:** CTNNA1 is a key component of adherens junctions, which are critical for maintaining cell-cell adhesion and tissue integrity. 2. **Regulation of Cell Migration:** CTNNA1 regulates cell migration by modulating the dynamics of adherens junctions and the activity of the cytoskeleton. 3. **Signaling Pathways:** CTNNA1 interacts with various signaling molecules, including cadherins, integrins, and Rho GTPases, to regulate cell-cell adhesion, cell migration, and signaling pathways. 4. **Developmental Biology:** CTNNA1 is involved in various developmental processes, including embryonic development, organogenesis, and tissue patterning. 5. **Tissue Homeostasis:** CTNNA1 maintains tissue homeostasis by regulating cell-cell adhesion, cell migration, and the dynamics of the cytoskeleton. **Pathways and Functions:** 1. **Adherens Junction Assembly:** CTNNA1 interacts with cadherins and catenins to form adherens junctions, which are critical for maintaining cell-cell adhesion. 2. **Cytoskeleton Dynamics:** CTNNA1 regulates the dynamics of the cytoskeleton, including actin filaments and microtubules, to control cell migration and shape. 3. **Signaling by Rho GTPases:** CTNNA1 interacts with Rho GTPases to regulate cell migration, cell adhesion, and signaling pathways. 4. **Smoothened Signaling Pathway:** CTNNA1 is involved in the Smoothened signaling pathway, which regulates cell proliferation and differentiation. 5. **Regulation of Cell Polarity:** CTNNA1 maintains cell polarity by regulating the dynamics of adherens junctions and the activity of the cytoskeleton. **Clinical Significance:** 1. **Cancer:** Alterations in CTNNA1 expression have been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** CTNNA1 is involved in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cardiovascular Disease:** CTNNA1 is involved in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 4. **Developmental Disorders:** CTNNA1 is involved in developmental disorders, including congenital heart defects and neural tube defects. 5. **Regenerative Medicine:** CTNNA1 is a potential target for regenerative medicine, as it plays a critical role in tissue homeostasis and repair. In conclusion, CTNNA1 is a critical gene involved in various biological processes, including cell-cell adhesion, cell migration, signaling pathways, and tissue homeostasis. Alterations in CTNNA1 expression have been implicated in various diseases, including cancer, neurological disorders, cardiovascular disease, and developmental disorders, making it a potential target for therapeutic interventions.

Genular Protein ID: 1247861161

Symbol: CTNA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P35221 Q12795 Q8N1C0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 31 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 48 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 22 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8404069

Title: Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1).

PubMed ID: 8404069

DOI: 10.1159/000133603

PubMed ID: 8323564

Title: Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line.

PubMed ID: 8323564

DOI: 10.1006/bbrc.1993.1710

PubMed ID: 7945318

Title: Molecular cloning reveals alternative splice forms of human alpha(E)-catenin.

PubMed ID: 7945318

DOI: 10.1006/bbrc.1994.2381

PubMed ID: 21708131

Title: Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms.

PubMed ID: 21708131

DOI: 10.1016/j.bbrc.2011.06.085

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8188230

Title: Assignment of the human alpha-catenin gene (CTNNA1) to chromosome 5q21-q22.

PubMed ID: 8188230

DOI: 10.1006/geno.1994.1042

PubMed ID: 7982500

Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.

PubMed ID: 7982500

DOI: 10.1016/0014-5793(94)01205-9

PubMed ID: 9341178

Title: Alpha-catenin can form asymmetric homodimeric complexes and/or heterodimeric complexes with beta-catenin.

PubMed ID: 9341178

DOI: 10.1074/jbc.272.43.27301

PubMed ID: 9152027

Title: Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.

PubMed ID: 9152027

DOI: 10.1242/jcs.110.8.1013

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 12417594

Title: The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin.

PubMed ID: 12417594

DOI: 10.1074/jbc.m205391200

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 16184169

Title: ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion.

PubMed ID: 16184169

DOI: 10.1038/ncb1308

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18093941

Title: EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.

PubMed ID: 18093941

DOI: 10.1073/pnas.0710504105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26182300

Title: Hereditary diffuse gastric cancer syndrome: CDH1 mutations and beyond.

PubMed ID: 26182300

DOI: 10.1001/jamaoncol.2014.168

PubMed ID: 25653389

Title: alpha-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

PubMed ID: 25653389

DOI: 10.1242/jcs.163824

PubMed ID: 28051089

Title: Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.

PubMed ID: 28051089

DOI: 10.1038/mi.2016.120

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11447106

Title: Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion.

PubMed ID: 11447106

DOI: 10.1093/emboj/20.14.3645

PubMed ID: 26691986

Title: Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity.

PubMed ID: 26691986

DOI: 10.1038/ng.3474

PubMed ID: 23208944

Title: An alpha-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.

PubMed ID: 23208944

DOI: 10.1002/path.4152

Sequence Information:

  • Length: 906
  • Mass: 100071
  • Checksum: 7AAE6F5DDBAF5099
  • Sequence:
    • MTAVHAGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK KRGRSKKAHV 
LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVEDVRKQ GDLMKAAAGE FADDPCSSVK 
RGNMVRAARA LLSAVTRLLI LADMADVYKL LVQLKVVEDG ILKLRNAGNE QDLGIQYKAL 
KPEVDKLNIM AAKRQQELKD VGHRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN 
RDLIYKQLQQ AVTGISNAAQ ATASDDASQH QGGGGGELAY ALNNFDKQII VDPLSFSEER 
FRPSLEERLE SIISGAALMA DSSCTRDDRR ERIVAECNAV RQALQDLLSE YMGNAGRKER 
SDALNSAIDK MTKKTRDLRR QLRKAVMDHV SDSFLETNVP LLVLIEAAKN GNEKEVKEYA 
QVFREHANKL IEVANLACSI SNNEEGVKLV RMSASQLEAL CPQVINAALA LAAKPQSKLA 
QENMDLFKEQ WEKQVRVLTD AVDDITSIDD FLAVSENHIL EDVNKCVIAL QEKDVDGLDR 
TAGAIRGRAA RVIHVVTSEM DNYEPGVYTE KVLEATKLLS NTVMPRFTEQ VEAAVEALSS 
DPAQPMDENE FIDASRLVYD GIRDIRKAVL MIRTPEELDD SDFETEDFDV RSRTSVQTED 
DQLIAGQSAR AIMAQLPQEQ KAKIAEQVAS FQEEKSKLDA EVSKWDDSGN DIIVLAKQMC 
MIMMEMTDFT RGKGPLKNTS DVISAAKKIA EAGSRMDKLG RTIADHCPDS ACKQDLLAYL 
QRIALYCHQL NICSKVKAEV QNLGGELVVS GVDSAMSLIQ AAKNLMNAVV QTVKASYVAS 
TKYQKSQGMA SLNLPAVSWK MKAPEKKPLV KREKQDETQT KIKRASQKKH VNPVQALSEF 
KAMDSI

Genular Protein ID: 3829527559

Symbol: B4DU00_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DU00

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 3 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 803
  • Mass: 88703
  • Checksum: CE18BC8266F19BA6
  • Sequence:
    • MKAAAGEFAD DPCSSVKRGN MVRAARALLS AVTRLLILAD MADVYKLLVQ LKVVEDGILK 
LRNAGNEQDL GIQYKALKPE VDKLNIMAAK RQQELKDVGH RDQMAAARGI LQKNVPILYT 
ASQACLQHPD VAAYKANRDL IYKQLQQAVT GISNAAQATA SDDASQHQGG GGGELAYALN 
NFDKQIIVDP LSFSEERFRP SLEERLESII SGAALMADSS CTRDDRRERI VAECNAVRQA 
LQDLLSEYMG NAGRKERSDA LNSAIDKMTK KTRDLRRQLR KAVMDHVSDS FLETNVPLLV 
LIEAAKNGNE KEVKEYAQVF REHANKLIEV ANLACSISNN EEGVKLVRMS ASQLEALCPQ 
VINAALALPA KPQSKLAQEN MDLFKEQWEK QVRVLTDAVD DITSIDDFLA VSENHILEDV 
NKCVIALQEK DVDGLDRTAG AIRGRAARVI HVVTSEMDNY EPGVYTEKVL EATKLLSNTV 
MPRFTEQVEA AVEALSSDPA QPMDENEFID ASRLVYDGIR DIRKAVLMIR TPEELDDSDF 
ETEDFDVRSR TSVQTEDDQL IAGQSARAIM AQLPQEQKAK IAEQVASFQE EKSKLDAEVS 
KWDDSGNDII VLAKQMCMIM MEMTDFTRGK GPLKNTSDVI SAAKKIAEAG SRMDKLGRTI 
ADHCPDSACK QDLLAYLQRI ALYCHQLNIC SKVKAEVQNL GGELVVSGVD SAMSLIQAAK 
NLMNAVVQTV KASYVASTKY QKSQGMASLN LPAVSWKMKA PEKKPLVKRE KQDETQTKIK 
RASQKKHVNP VQALSEFKAM DSI

Genular Protein ID: 3095132755

Symbol: G3XAM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3XAM7

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 GO 10 Gene3D 2 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 841
  • Mass: 92722
  • Checksum: C5168109B1E7B113
  • Sequence:
    • MTAVHAGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK KRGRSKKAHV 
LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVEDVRKQ GDLMKAAAGE FADDPCSSVK 
RGNMVRAARA LLSAVTRLLI LADMADVYKL LVQLKVVEDG ILKLRNAGNE QDLGIQYKAL 
KPEVDKLNIM AAKRQQELKD VGHRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN 
RDLIYKQLQQ AVTGISNAAQ ATASDDASQH QGGGGGELAY ALNNFDKQII VDPLSFSEER 
FRPSLEERLE SIISGAALMA DSSCTRDDRR ERIVAECNAV RQALQDLLSE YMGNAGRKER 
SDALNSAIDK MTKKTRDLRR QLRKAVMDHV SDSFLETNVP LLVLIEAAKN GNEKEVKEYA 
QVFREHANKL IEVANLACSI SNNEEGVKLV RMSASQLEAL CPQVINAALA LAAKPQSKLA 
QENMDLFKEQ WEKQVRVLTD AVDDITSIDD FLAVSENHIL EDVNKCVIAL QEKDVDGLDR 
TAGAIRGRAA RVIHVVTSEM DNYEPGVYTE KVLEATKLLS NTVMPRFTEQ VEAAVEALSS 
DPAQPMDENE FIDASRLVYD GIRDIRKAVL MIRTPEELDD SDFETEDFDV RSRTSVQTED 
DQLIAGQSAR AIMAQLPQEQ KAKIAEQVAS FQEEKSKLDA EVSKWDDSGN DIIVLAKQMC 
MIMMEMTDFT RGKGPLKNTS DVISAAKKIA EAGSRMDKLG RTIADHCPDS ACKQDLLAYL 
QRIALYCHQL NICSKVKAEV QNLGGELVVS GNCDTCGALQ GLKGWPPPLC WPLTGWTAPC 
P

Genular Protein ID: 1116203026

Symbol: B4DKT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DKT9

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 3 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 783
  • Mass: 86641
  • Checksum: EFFA7E1FFD60FFC0
  • Sequence:
    • MVRAARALLS AVTRLLILAD MADVYKLLVQ LKVVEDGILK LRNAGNEQDL GIQYKALKPE 
VDKLNIMAAK RQQELKDVGH RDQMAAARGI LQKNVPILYT ASQACLQHPD VAAYKANRDL 
IYKQLQQAVT GISNAAQATA SDDASQHQGG GGGELAYALN NFDKQIIVDP LSFSEERFRP 
SLEERLESII SGAALMADSS CTRDDRRERI VAECNAVRQA LQDLLSEYMG NAGRKERSDA 
LNSAIDKMTK KTRDLRRQLR KAVMDHVSDS FLETNVPLLV LIEAAKNGNE KEVKEYAQVF 
REHANKLIEV ANLACSISNN EEGVKLVRMS ASQLEALCPQ VINAALALAA KPQSKLAQEN 
MDLFKEQWEK QVRVLTDAVD DITSIDDFLA VSENHILEDV NKCVIALQEK DVDGLDRTAG 
AIRGRAARVI HVVTSEMDNY EPGVYTEKVL EATKLLSNTV MPRFTEQVEA AVEALSSDPA 
QPMDENEFID ASRLVYDGIR DIRKAVLMIR TPEELDDSDF ETEDFDVRSR TSVQTEDDQL 
IAGQSARAIM AQLPQEQKAK IAEQVASFQE EKSKLDAEVS KWDDSGNDII VLAKQMCMIM 
MEMTDFTRGK GPLKNTSDVI SAAKKIAEAG SRMDKLGRTI ADHCPDSACK QDLLAYLQRI 
ALYCHQLNIC SKVKAEVQNL GGELVVSGVD SAMSLIQAAK NLMNAVVQTV KASYVASTKY 
QKSQGMASLN LPAVSWKMKA PEKKPLVKRE KQDETQTKIK RASQKKHVNP VQALSEFKAM 
DSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.