Details for: CTNNA1

Gene ID: 1495

Symbol: CTNNA1

Ensembl ID: ENSG00000044115

Description: catenin alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.46
    Cell Significance Index: 2
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.17
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.12
    Cell Significance Index: 1
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.98
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-Cell Adhesion:** CTNNA1 is a key component of adherens junctions, which are critical for maintaining cell-cell adhesion and tissue integrity. 2. **Regulation of Cell Migration:** CTNNA1 regulates cell migration by modulating the dynamics of adherens junctions and the activity of the cytoskeleton. 3. **Signaling Pathways:** CTNNA1 interacts with various signaling molecules, including cadherins, integrins, and Rho GTPases, to regulate cell-cell adhesion, cell migration, and signaling pathways. 4. **Developmental Biology:** CTNNA1 is involved in various developmental processes, including embryonic development, organogenesis, and tissue patterning. 5. **Tissue Homeostasis:** CTNNA1 maintains tissue homeostasis by regulating cell-cell adhesion, cell migration, and the dynamics of the cytoskeleton. **Pathways and Functions:** 1. **Adherens Junction Assembly:** CTNNA1 interacts with cadherins and catenins to form adherens junctions, which are critical for maintaining cell-cell adhesion. 2. **Cytoskeleton Dynamics:** CTNNA1 regulates the dynamics of the cytoskeleton, including actin filaments and microtubules, to control cell migration and shape. 3. **Signaling by Rho GTPases:** CTNNA1 interacts with Rho GTPases to regulate cell migration, cell adhesion, and signaling pathways. 4. **Smoothened Signaling Pathway:** CTNNA1 is involved in the Smoothened signaling pathway, which regulates cell proliferation and differentiation. 5. **Regulation of Cell Polarity:** CTNNA1 maintains cell polarity by regulating the dynamics of adherens junctions and the activity of the cytoskeleton. **Clinical Significance:** 1. **Cancer:** Alterations in CTNNA1 expression have been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** CTNNA1 is involved in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cardiovascular Disease:** CTNNA1 is involved in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 4. **Developmental Disorders:** CTNNA1 is involved in developmental disorders, including congenital heart defects and neural tube defects. 5. **Regenerative Medicine:** CTNNA1 is a potential target for regenerative medicine, as it plays a critical role in tissue homeostasis and repair. In conclusion, CTNNA1 is a critical gene involved in various biological processes, including cell-cell adhesion, cell migration, signaling pathways, and tissue homeostasis. Alterations in CTNNA1 expression have been implicated in various diseases, including cancer, neurological disorders, cardiovascular disease, and developmental disorders, making it a potential target for therapeutic interventions.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.