CTNNA1 | ENSG00000044115 | NCBI 1495

Details for: CTNNA1

Gene ID: 1495

Symbol: CTNNA1

Ensembl ID: ENSG00000044115

Description: catenin alpha 1

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cdh11 homotypic and heterotypic interactions
(R-HSA-9833576)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Developmental biology
(R-HSA-1266738)
Myogenesis
(R-HSA-525793)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 function
(R-HSA-9762292)
Regulation of cdh19 expression and function
(R-HSA-9764302)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Acrosomal vesicle
(GO:0001669)
Actin cytoskeleton
(GO:0015629)
Actin filament binding
(GO:0051015)
Adherens junction
(GO:0005912)
Apical junction assembly
(GO:0043297)
Axon regeneration
(GO:0031103)
Beta-catenin binding
(GO:0008013)
Cadherin binding
(GO:0045296)
Catenin complex
(GO:0016342)
Cell-cell adhesion
(GO:0098609)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell junction
(GO:0030054)
Cell migration
(GO:0016477)
Cellular response to indole-3-methanol
(GO:0071681)
Cytosol
(GO:0005829)
Epithelial cell-cell adhesion
(GO:0090136)
Establishment or maintenance of cell polarity
(GO:0007163)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Flotillin complex
(GO:0016600)
Focal adhesion
(GO:0005925)
Gamma-catenin binding
(GO:0045295)
Gap junction assembly
(GO:0016264)
Identical protein binding
(GO:0042802)
Integrin-mediated signaling pathway
(GO:0007229)
Intercalated disc
(GO:0014704)
Intracellular membrane-bounded organelle
(GO:0043231)
Lamellipodium
(GO:0030027)
Male gonad development
(GO:0008584)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of integrin-mediated signaling pathway
(GO:2001045)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of protein localization to nucleus
(GO:1900181)
Neuroblast proliferation
(GO:0007405)
Nucleus
(GO:0005634)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Ovarian follicle development
(GO:0001541)
Plasma membrane
(GO:0005886)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001241)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Response to estrogen
(GO:0043627)
Rna binding
(GO:0003723)
Smoothened signaling pathway
(GO:0007224)
Structural molecule activity
(GO:0005198)
Vinculin binding
(GO:0017166)
Zonula adherens
(GO:0005915)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.46
Cell Significance Index: 2
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.17
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.12
Cell Significance Index: 1
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: melanocyte of skin (CL1000458)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: peridermal cell (CL0000078)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: articular chondrocyte (CL1001607)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: microglial cell (CL0000129)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.98
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Cell-Cell Adhesion:** CTNNA1 is a key component of adherens junctions, which are critical for maintaining cell-cell adhesion and tissue integrity. 2. **Regulation of Cell Migration:** CTNNA1 regulates cell migration by modulating the dynamics of adherens junctions and the activity of the cytoskeleton. 3. **Signaling Pathways:** CTNNA1 interacts with various signaling molecules, including cadherins, integrins, and Rho GTPases, to regulate cell-cell adhesion, cell migration, and signaling pathways. 4. **Developmental Biology:** CTNNA1 is involved in various developmental processes, including embryonic development, organogenesis, and tissue patterning. 5. **Tissue Homeostasis:** CTNNA1 maintains tissue homeostasis by regulating cell-cell adhesion, cell migration, and the dynamics of the cytoskeleton. **Pathways and Functions:** 1. **Adherens Junction Assembly:** CTNNA1 interacts with cadherins and catenins to form adherens junctions, which are critical for maintaining cell-cell adhesion. 2. **Cytoskeleton Dynamics:** CTNNA1 regulates the dynamics of the cytoskeleton, including actin filaments and microtubules, to control cell migration and shape. 3. **Signaling by Rho GTPases:** CTNNA1 interacts with Rho GTPases to regulate cell migration, cell adhesion, and signaling pathways. 4. **Smoothened Signaling Pathway:** CTNNA1 is involved in the Smoothened signaling pathway, which regulates cell proliferation and differentiation. 5. **Regulation of Cell Polarity:** CTNNA1 maintains cell polarity by regulating the dynamics of adherens junctions and the activity of the cytoskeleton. **Clinical Significance:** 1. **Cancer:** Alterations in CTNNA1 expression have been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** CTNNA1 is involved in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cardiovascular Disease:** CTNNA1 is involved in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 4. **Developmental Disorders:** CTNNA1 is involved in developmental disorders, including congenital heart defects and neural tube defects. 5. **Regenerative Medicine:** CTNNA1 is a potential target for regenerative medicine, as it plays a critical role in tissue homeostasis and repair. In conclusion, CTNNA1 is a critical gene involved in various biological processes, including cell-cell adhesion, cell migration, signaling pathways, and tissue homeostasis. Alterations in CTNNA1 expression have been implicated in various diseases, including cancer, neurological disorders, cardiovascular disease, and developmental disorders, making it a potential target for therapeutic interventions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.