Details for: CRYGN

Gene ID: 155051

Symbol: CRYGN

Ensembl ID: ENSG00000127377

Description: crystallin gamma N

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7827
    Cell Significance Index: 28.6000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6254
    Cell Significance Index: 17.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.9620
    Cell Significance Index: 12.1600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.5259
    Cell Significance Index: 4.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0964
    Cell Significance Index: 2.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0952
    Cell Significance Index: 1.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0837
    Cell Significance Index: 4.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0514
    Cell Significance Index: 6.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0226
    Cell Significance Index: 0.1900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.0224
    Cell Significance Index: 0.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0120
    Cell Significance Index: 1.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0044
    Cell Significance Index: 0.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0037
    Cell Significance Index: 0.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0035
    Cell Significance Index: -2.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0041
    Cell Significance Index: -1.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0042
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0050
    Cell Significance Index: -1.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0056
    Cell Significance Index: -0.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0098
    Cell Significance Index: -4.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0100
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0107
    Cell Significance Index: -1.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0111
    Cell Significance Index: -0.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0112
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0169
    Cell Significance Index: -3.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0173
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0174
    Cell Significance Index: -2.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0196
    Cell Significance Index: -2.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0206
    Cell Significance Index: -4.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0213
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0220
    Cell Significance Index: -0.4600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0274
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0359
    Cell Significance Index: -0.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0377
    Cell Significance Index: -1.3100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0386
    Cell Significance Index: -0.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0408
    Cell Significance Index: -4.2500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0426
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0428
    Cell Significance Index: -0.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0442
    Cell Significance Index: -2.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0481
    Cell Significance Index: -3.1000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0484
    Cell Significance Index: -0.4700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0489
    Cell Significance Index: -0.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0495
    Cell Significance Index: -6.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0497
    Cell Significance Index: -0.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0527
    Cell Significance Index: -2.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0528
    Cell Significance Index: -3.2500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0534
    Cell Significance Index: -0.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0556
    Cell Significance Index: -3.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0589
    Cell Significance Index: -1.1500
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0603
    Cell Significance Index: -0.5900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0678
    Cell Significance Index: -1.6900
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0705
    Cell Significance Index: -0.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0727
    Cell Significance Index: -0.5600
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0729
    Cell Significance Index: -0.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0743
    Cell Significance Index: -4.1700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0780
    Cell Significance Index: -0.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0799
    Cell Significance Index: -2.8000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0808
    Cell Significance Index: -0.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0812
    Cell Significance Index: -3.8200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0849
    Cell Significance Index: -0.5200
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0880
    Cell Significance Index: -0.9300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0886
    Cell Significance Index: -0.5200
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0890
    Cell Significance Index: -1.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0904
    Cell Significance Index: -6.7400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0920
    Cell Significance Index: -0.8900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0935
    Cell Significance Index: -0.9900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0955
    Cell Significance Index: -3.0200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0963
    Cell Significance Index: -1.1200
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0978
    Cell Significance Index: -0.8300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0984
    Cell Significance Index: -1.2500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1011
    Cell Significance Index: -0.9900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1018
    Cell Significance Index: -0.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1023
    Cell Significance Index: -3.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1028
    Cell Significance Index: -5.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1033
    Cell Significance Index: -3.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1062
    Cell Significance Index: -3.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1090
    Cell Significance Index: -1.1300
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.1106
    Cell Significance Index: -1.0200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1110
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1147
    Cell Significance Index: -1.8900
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1159
    Cell Significance Index: -1.0300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1169
    Cell Significance Index: -1.2100
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1189
    Cell Significance Index: -1.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1202
    Cell Significance Index: -3.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1217
    Cell Significance Index: -3.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1219
    Cell Significance Index: -5.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1258
    Cell Significance Index: -3.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1267
    Cell Significance Index: -2.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1276
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1314
    Cell Significance Index: -1.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1327
    Cell Significance Index: -3.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1350
    Cell Significance Index: -3.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1380
    Cell Significance Index: -3.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRGN is a member of the crystallin family, which is composed of alpha, beta, gamma, and delta subunits. The gamma subunits (CRGN and CRGZ) are particularly interesting, as they are involved in the formation of the lens's crystalline structure. CRGN is specifically expressed in the lens, cornea, and retina, where it contributes to the maintenance of epithelial cell junctions and the regulation of cell growth. Additionally, CRGN has been found to be expressed in various immune cells, including dendritic cells, granulocytes, and goblet cells, suggesting a potential role in immune regulation. **Pathways and Functions:** CRGN's role in lens development and maintenance is well-established, as it is involved in the formation of the lens's crystalline structure and the regulation of epithelial cell growth. In the context of immune responses, CRGN has been shown to modulate the function of dendritic cells, which are critical for the initiation of immune responses. CRGN also appears to play a role in the regulation of cell growth and differentiation, as it is involved in the development of goblet cells and intestinal crypt stem cells. Furthermore, CRGN has been implicated in the regulation of visual perception, as it is expressed in the retina and cornea. **Clinical Significance:** Dysregulation of CRGN has been implicated in various human diseases, including cataracts, age-related macular degeneration, and autoimmune disorders. For example, mutations in the CRGZ gene have been associated with congenital cataracts, while dysregulation of CRGN has been linked to age-related macular degeneration. Additionally, CRGN's role in immune regulation suggests that it may be involved in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. Further research is needed to fully elucidate the clinical significance of CRGN and to explore its potential as a therapeutic target for these diseases. In conclusion, CRGN is a multifunctional protein that plays a critical role in maintaining the structural integrity and transparency of the eye lens, as well as regulating immune responses and cell growth. Further research is needed to fully understand the mechanisms by which CRGN contributes to human health and disease, and to explore its potential as a therapeutic target for various disorders.

Genular Protein ID: 3526635051

Symbol: CRGN_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WXF5 Q496G6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15853812

Title: Gamma-N-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates.

PubMed ID: 15853812

DOI: 10.1111/j.1742-4658.2005.04655.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 182
  • Mass: 20624
  • Checksum: 761F381A8BDFDDF1
  • Sequence:
    • MAQRSGKITL YEGKHFTGQK LEVFGDCDNF QDRGFMNRVN SIHVESGAWV CFNHPDFRGQ 
QFILEHGDYP DFFRWNSHSD HMGSCRPVGM HGEHFRLEIF EGCNFTGQCL EFLEDSPFLQ 
SRGWVKNCVN TIKVYGDGAA WSPRSFGAED FQLSSSLQSD QGPEEATTKP ATTQPPFLTA 
NL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.