Details for: CD55

Gene ID: 1604

Symbol: CD55

Ensembl ID: ENSG00000196352

Description: CD55 molecule (Cromer blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.33
    Marker Score: 5210
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.17
    Marker Score: 16655
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.91
    Marker Score: 5315
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.81
    Marker Score: 1385
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.8
    Marker Score: 2203
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.79
    Marker Score: 6733
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.77
    Marker Score: 2731
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.75
    Marker Score: 6269
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.71
    Marker Score: 1811
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.7
    Marker Score: 778
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.69
    Marker Score: 5631
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6
    Marker Score: 2738
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.6
    Marker Score: 879
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.49
    Marker Score: 16258
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.49
    Marker Score: 84818
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.44
    Marker Score: 10512
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.43
    Marker Score: 2842.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.41
    Marker Score: 3544
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4
    Marker Score: 38608
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.38
    Marker Score: 869
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.37
    Marker Score: 27545
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.35
    Marker Score: 1099
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.35
    Marker Score: 131553
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.34
    Marker Score: 81032
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.21
    Marker Score: 859
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.2
    Marker Score: 10802.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.18
    Marker Score: 977
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.18
    Marker Score: 3794
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.16
    Marker Score: 624
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.15
    Marker Score: 590
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.15
    Marker Score: 5248.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.15
    Marker Score: 5343.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.12
    Marker Score: 950
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.11
    Marker Score: 2328
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.11
    Marker Score: 1395
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.08
    Marker Score: 1957
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.06
    Marker Score: 2477
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.06
    Marker Score: 1403
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2
    Marker Score: 1790
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2
    Marker Score: 7859
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.99
    Marker Score: 2282
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.99
    Marker Score: 1952
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.98
    Marker Score: 491
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.97
    Marker Score: 1189
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.96
    Marker Score: 1674
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.95
    Marker Score: 49954
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.92
    Marker Score: 3085
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.9
    Marker Score: 1363
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.89
    Marker Score: 4289
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.88
    Marker Score: 12018
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.87
    Marker Score: 7777
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.87
    Marker Score: 932
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.84
    Marker Score: 1121
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.84
    Marker Score: 1048
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.84
    Marker Score: 3577
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.82
    Marker Score: 2897
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.82
    Marker Score: 418
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.81
    Marker Score: 639
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.8
    Marker Score: 777
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.8
    Marker Score: 2321
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.79
    Marker Score: 94752
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.79
    Marker Score: 8600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.78
    Marker Score: 552
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.77
    Marker Score: 1215
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.77
    Marker Score: 1451
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.77
    Marker Score: 736
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.75
    Marker Score: 435
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.75
    Marker Score: 10613
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.74
    Marker Score: 1317
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.74
    Marker Score: 443
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.73
    Marker Score: 435
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.73
    Marker Score: 496
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.7
    Marker Score: 370
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.69
    Marker Score: 508
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.68
    Marker Score: 867
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.68
    Marker Score: 1675
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.67
    Marker Score: 1820
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.67
    Marker Score: 1425
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.65
    Marker Score: 2922
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.62
    Marker Score: 12661
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.62
    Marker Score: 362
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.62
    Marker Score: 491
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.6
    Marker Score: 13911.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.59
    Marker Score: 2066
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.59
    Marker Score: 1486
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.58
    Marker Score: 567
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.56
    Marker Score: 1140
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.56
    Marker Score: 709
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.55
    Marker Score: 3099
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.54
    Marker Score: 367
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.54
    Marker Score: 2232
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.53
    Marker Score: 379
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.53
    Marker Score: 1630
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.53
    Marker Score: 894
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.52
    Marker Score: 379
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.52
    Marker Score: 658
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.52
    Marker Score: 369
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.52
    Marker Score: 1637
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.52
    Marker Score: 4427
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.51
    Marker Score: 3914

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Other Information

**Key characteristics:** - CD55 is a glycoprotein that is present on the surface of cells. - It is a member of the C1r family of cell surface receptors. - CD55 is expressed on a variety of cell types, including epithelial cells, immune cells, and cancer cells. **Pathways and functions:** - CD55 is involved in the regulation of the complement cascade. It is a regulator of the alternative pathway of the complement cascade, which is responsible for the formation of the membrane attack complex (MAC). - CD55 also plays a role in cell trafficking. It is expressed on the surface of epithelial cells of the lung, and it is involved in the uptake of antigens from the air. - In addition, CD55 is also expressed on the surface of immune cells, where it plays a role in the initiation of the immune response. - CD55 is a key regulator of the immune response. Its expression is regulated by a variety of factors, including cytokines, growth factors, and hormones. - Dysregulation of CD55 has been linked to a number of diseases, including cancer and autoimmune disorders. **Clinical significance:** - CD55 is a potential therapeutic target for a variety of diseases. For example, CD55 is expressed on the surface of cancer cells, and it is a target for antibodies in cancer immunotherapy. - Inhibition of CD55 has been shown to inhibit the growth of cancer cells and to induce apoptosis. - Therefore, CD55 is a promising target for the treatment of cancer.

Genular Protein ID: 2793829098

Symbol: DAF_HUMAN

Name: Complement decay-accelerating factor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2433596

Title: Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins.

PubMed ID: 2433596

DOI: 10.1038/325545a0

PubMed ID: 16503113

Title: Molecular cloning and characterization of novel splicing variants of human decay-accelerating factor.

PubMed ID: 16503113

DOI: 10.1016/j.ygeno.2006.01.006

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1711208

Title: Characterization of the decay-accelerating factor gene promoter region.

PubMed ID: 1711208

DOI: 10.1073/pnas.88.11.4675

PubMed ID: 2436222

Title: Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.

PubMed ID: 2436222

DOI: 10.1073/pnas.84.7.2007

PubMed ID: 2428813

Title: Improved method for the isolation and preliminary characterization of human DAF (decay-accelerating factor).

PubMed ID: 2428813

DOI: 10.1093/oxfordjournals.jbchem.a121686

PubMed ID: 1712233

Title: Isolation of two forms of decay-accelerating factor (DAF) from human urine.

PubMed ID: 1712233

DOI: 10.1016/0304-4165(91)90171-c

PubMed ID: 1824699

Title: Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site.

PubMed ID: 1824699

DOI: 10.1016/s0021-9258(17)35308-5

PubMed ID: 1377029

Title: Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen).

PubMed ID: 1377029

DOI: 10.1016/0304-4165(92)90016-n

PubMed ID: 7525274

Title: Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method.

PubMed ID: 7525274

DOI: 10.1002/j.1460-2075.1994.tb06836.x

PubMed ID: 7517044

Title: Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses.

PubMed ID: 7517044

DOI: 10.1073/pnas.91.13.6245

PubMed ID: 7538177

Title: Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment.

PubMed ID: 7538177

DOI: 10.1128/jvi.69.6.3873-3877.1995

PubMed ID: 8764022

Title: The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55).

PubMed ID: 8764022

DOI: 10.1128/jvi.70.8.5143-5152.1996

PubMed ID: 9151867

Title: Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry.

PubMed ID: 9151867

DOI: 10.1128/jvi.71.6.4736-4743.1997

PubMed ID: 11297558

Title: Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.

PubMed ID: 11297558

DOI: 10.1074/jbc.m101770200

PubMed ID: 12409401

Title: Human rhinovirus 87 and enterovirus 68 represent a unique serotype with rhinovirus and enterovirus features.

PubMed ID: 12409401

DOI: 10.1128/jcm.40.11.4218-4223.2002

PubMed ID: 17804498

Title: Interaction of decay-accelerating factor with coxsackievirus B3.

PubMed ID: 17804498

DOI: 10.1128/jvi.00931-07

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26207632

Title: Obif, a transmembrane protein, is required for bone mineralization and spermatogenesis in mice.

PubMed ID: 26207632

DOI: 10.1371/journal.pone.0133704

PubMed ID: 28657861

Title: Loss of CD55 in eculizumab-responsive protein-losing enteropathy.

PubMed ID: 28657861

DOI: 10.1056/nejmc1707173

PubMed ID: 7519480

Title: Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes.

PubMed ID: 7519480

PubMed ID: 12675719

Title: GUTI: a new antigen in the Cromer blood group system.

PubMed ID: 12675719

DOI: 10.1046/j.1537-2995.2003.00319.x

PubMed ID: 1720702

Title: Biochemical studies on red blood cells from a patient with the Inab phenotype (decay-accelerating factor deficiency).

PubMed ID: 1720702

PubMed ID: 12499389

Title: Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A.

PubMed ID: 12499389

DOI: 10.1074/jbc.m212561200

PubMed ID: 14734808

Title: Complement regulation at the molecular level: the structure of decay-accelerating factor.

PubMed ID: 14734808

DOI: 10.1073/pnas.0307200101

PubMed ID: 12672958

Title: Solution structure of a functionally active fragment of decay-accelerating factor.

PubMed ID: 12672958

DOI: 10.1073/pnas.0730844100

PubMed ID: 28657829

Title: CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis.

PubMed ID: 28657829

DOI: 10.1056/nejmoa1615887

Sequence Information:

  • Length: 381
  • Mass: 41400
  • Checksum: C1CBE5300F60C176
  • Sequence:
  • MTVARPSVPA ALPLLGELPR LLLLVLLCLP AVWGDCGLPP DVPNAQPALE GRTSFPEDTV 
    ITYKCEESFV KIPGEKDSVI CLKGSQWSDI EEFCNRSCEV PTRLNSASLK QPYITQNYFP 
    VGTVVEYECR PGYRREPSLS PKLTCLQNLK WSTAVEFCKK KSCPNPGEIR NGQIDVPGGI 
    LFGATISFSC NTGYKLFGST SSFCLISGSS VQWSDPLPEC REIYCPAPPQ IDNGIIQGER 
    DHYGYRQSVT YACNKGFTMI GEHSIYCTVN NDEGEWSGPP PECRGKSLTS KVPPTVQKPT 
    TVNVPTTEVS PTSQKTTTKT TTPNAQATRS TPVSRTTKHF HETTPNKGSG TTSGTTRLLS 
    GHTCFTLTGL LGTLVTMGLL T

Genular Protein ID: 943026165

Symbol: B1AP13_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 444
  • Mass: 49338
  • Checksum: 38B7D12413F52A23
  • Sequence:
  • MTVARPSVPA ALPLLGELPR LLLLVLLCLP AVWGDCGLPP DVPNAQPALE GRTSFPEDTV 
    ITYKCEESFV KIPGEKDSVI CLKGSQWSDI EEFCNRSCEV PTRLNSASLK QPYITQNYFP 
    VGTVVEYECR PGYRREPSLS PKLTCLQNLK WSTAVEFCKK KSCPNPGEIR NGQIDVPGGI 
    LFGATISFSC NTGYKLFGST SSFCLISGSS VQWSDPLPEC REIYCPAPPQ IDNGIIQGER 
    DHYGYRQSVT YACNKGFTMI GEHSIYCTVN NDEGEWSGPP PECRGKSLTS KVPPTVQKPT 
    TVNVPTTEVS PTSQKTTTKT TTPNAQATRS TPVSRTTKHF HETTPNKGSG TTSGTTRLLS 
    GSRPVTQAGM RWCDRSSLQS RTPGFKRSFH FSLPSSWYYR CVPRHPAKFL KFIFCRDRIF 
    LCCPGWFQTP GRKRFFRPPK TLRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.