CD55 | ENSG00000196352 | NCBI 1604

Details for: CD55

Gene ID: 1604

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CD55

Ensembl ID: ENSG00000196352

Description: CD55 molecule (Cromer blood group)

Cell Significance Landscape

Display Count:

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Complement cascade
(R-HSA-166658)
Copi-mediated anterograde transport
(R-HSA-6807878)
Er to golgi anterograde transport
(R-HSA-199977)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Post-translational protein modification
(R-HSA-597592)
Regulation of complement cascade
(R-HSA-977606)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Cell surface
(GO:0009986)
Complement activation, classical pathway
(GO:0006958)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule membrane
(GO:0101003)
Golgi membrane
(GO:0000139)
Innate immune response
(GO:0045087)
Lipid binding
(GO:0008289)
Membrane raft
(GO:0045121)
Negative regulation of complement activation
(GO:0045916)
Plasma membrane
(GO:0005886)
Positive regulation of cd4-positive, alpha-beta t cell activation
(GO:2000516)
Positive regulation of cd4-positive, alpha-beta t cell proliferation
(GO:2000563)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of t cell cytokine production
(GO:0002726)
Protein binding
(GO:0005515)
Regulation of complement-dependent cytotoxicity
(GO:1903659)
Regulation of complement activation
(GO:0030449)
Regulation of lipopolysaccharide-mediated signaling pathway
(GO:0031664)
Respiratory burst
(GO:0045730)
Secretory granule membrane
(GO:0030667)
Side of membrane
(GO:0098552)
Symbiont entry into host cell
(GO:0046718)
Transport vesicle
(GO:0030133)
Virus receptor activity
(GO:0001618)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

epithelial cell of lower respiratory tract CL0002632

CSI 98.96

rCSI 76.72%

PRS 10.7
nasal mucosa goblet cell CL0002480

CSI 68.03

rCSI 78.9%

PRS 16.6
CD14-low, CD16-positive monocyte CL0002396

CSI 61.44

rCSI 47.34%

PRS 10.14
conjunctival epithelial cell CL1000432

CSI 55.04

rCSI 84.06%

PRS 11.24
extravillous trophoblast CL0008036

CSI 54.88

rCSI 67.89%

PRS 9.84
respiratory suprabasal cell CL4033048

CSI 52.59

rCSI 67.45%

PRS 12.94
club cell CL0000158

CSI 50.34

rCSI 73.74%

PRS 13.1
placental villous trophoblast CL2000060

CSI 37.71

rCSI 58.26%

PRS 10.52
respiratory basal cell CL0002633

CSI 37.68

rCSI 39.03%

PRS 13.18
tracheal goblet cell CL1000329

CSI 36.67

rCSI 80.06%

PRS 22.69
intermediate monocyte CL0002393

CSI 36

rCSI 54.31%

PRS 11.04
lung ciliated cell CL1000271

CSI 33.21

rCSI 38.4%

PRS 8.21
corneal epithelial cell CL0000575

CSI 31.32

rCSI 89.59%

PRS 20.3
immature B cell CL0000816

CSI 30.48

rCSI 22.64%

PRS 16.6
duct epithelial cell CL0000068

CSI 30.23

rCSI 44.23%

PRS 11.87
secretory cell CL0000151

CSI 26.72

rCSI 27.88%

PRS 11.51
BEST4+ enteroycte CL4030026

CSI 26.09

rCSI 32.45%

PRS 11.86
colon epithelial cell CL0011108

CSI 25.72

rCSI 26.94%

PRS 10.44
naive B cell CL0000788

CSI 25.33

rCSI 21.73%

PRS 20.53
pulmonary alveolar type 2 cell CL0002063

CSI 25.24

rCSI 39.15%

PRS 17.2
CD14-positive, CD16-positive monocyte CL0002397

CSI 24.89

rCSI 32.61%

PRS 15.67
syncytiotrophoblast cell CL0000525

CSI 24.3

rCSI 70%

PRS 21.99
activated CD4-positive, alpha-beta T cell CL0000896

CSI 22.74

rCSI 21.02%

PRS 20.4
mucous neck cell CL0000651

CSI 21.71

rCSI 31.28%

PRS 18.08
bronchial goblet cell CL1000312

CSI 19.94

rCSI 79.68%

PRS 24.75
pulmonary alveolar type 1 cell CL0002062

CSI 19.33

rCSI 100%

PRS 15.1
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 19.32

rCSI 13.57%

PRS 29.66
epithelial cell CL0000066

CSI 19.1

rCSI 29.35%

PRS 16.04
myeloid dendritic cell CL0000782

CSI 18.77

rCSI 27.2%

PRS 16.49
enterocyte CL0000584

CSI 18.67

rCSI 30.1%

PRS 17.96
epithelial cell of lung CL0000082

CSI 18.53

rCSI 15.36%

PRS 10.58
elicited macrophage CL0000861

CSI 18.24

rCSI 16.75%

PRS 12.82
non-classical monocyte CL0000875

CSI 17.66

rCSI 28.31%

PRS 34.56
activated type II NK T cell CL0000931

CSI 17.48

rCSI 19.67%

PRS 17.94
fallopian tube secretory epithelial cell CL4030006

CSI 17.05

rCSI 16.41%

PRS 11.59
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 17.04

rCSI 11.48%

PRS 13.41
intestinal crypt stem cell of small intestine CL0009017

CSI 16.78

rCSI 45.25%

PRS 14.47
multi-ciliated epithelial cell CL0005012

CSI 15.9

rCSI 15.87%

PRS 9.61
glandular epithelial cell CL0000150

CSI 15.63

rCSI 41.14%

PRS 21.97
monocyte CL0000576

CSI 15.58

rCSI 28.16%

PRS 30.29
goblet cell CL0000160

CSI 15.32

rCSI 14.47%

PRS 11.71
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 14.75

rCSI 9.83%

PRS 29.38
memory B cell CL0000787

CSI 13.76

rCSI 13.59%

PRS 43.01
skin fibroblast CL0002620

CSI 13.74

rCSI 11.84%

PRS 18.27
mature B cell CL0000785

CSI 13.42

rCSI 11.67%

PRS 13.8
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 12.26

rCSI 27.95%

PRS 11.75
transit amplifying cell CL0009010

CSI 12.18

rCSI 18.63%

PRS 18.24
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 12.18

rCSI 15.3%

PRS 49.45
B cell CL0000236

CSI 12.06

rCSI 16.14%

PRS 47.09
paneth cell of epithelium of small intestine CL1000343

CSI 11.99

rCSI 33.6%

PRS 17.35
stem cell CL0000034

CSI 11.82

rCSI 11.39%

PRS 7.57
keratocyte CL0002363

CSI 11.61

rCSI 27.91%

PRS 16.95
natural T-regulatory cell CL0000903

CSI 11.47

rCSI 21.73%

PRS 30.74
cardiac muscle cell CL0000746

CSI 11.07

rCSI 15.89%

PRS 8.81
follicular B cell CL0000843

CSI 10.96

rCSI 39.84%

PRS 43.86
mature NK T cell CL0000814

CSI 10.92

rCSI 13.97%

PRS 45.06
mature T cell CL0002419

CSI 10.89

rCSI 8.47%

PRS 16.16
neutrophil CL0000775

CSI 10.56

rCSI 59.07%

PRS 24.37
retinal blood vessel endothelial cell CL0002585

CSI 10.04

rCSI 16.04%

PRS 12.23
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 9.79

rCSI 7.34%

PRS 32.15
mammary gland epithelial cell CL0002327

CSI 9.78

rCSI 34.33%

PRS 20.32
granulocyte CL0000094

CSI 9.77

rCSI 14.92%

PRS 14.14
stromal cell of ovary CL0002132

CSI 9.22

rCSI 25.32%

PRS 18.62
lung endothelial cell CL1001567

CSI 9.11

rCSI 21.24%

PRS 27.25
acinar cell CL0000622

CSI 9.11

rCSI 13.35%

PRS 14.74
CD1c-positive myeloid dendritic cell CL0002399

CSI 9.1

rCSI 10.99%

PRS 13.15
myofibroblast cell CL0000186

CSI 9.06

rCSI 12.54%

PRS 16.17
unswitched memory B cell CL0000970

CSI 9.05

rCSI 7.62%

PRS 18.06
pulmonary capillary endothelial cell CL4028001

CSI 9.02

rCSI 17.2%

PRS 17.97
tracheobronchial serous cell CL0019001

CSI 9

rCSI 38.9%

PRS 21.59
class switched memory B cell CL0000972

CSI 8.84

rCSI 6.6%

PRS 18.79
plasmacytoid dendritic cell, human CL0001058

CSI 8.78

rCSI 6.13%

PRS 11.75
squamous epithelial cell CL0000076

CSI 8.33

rCSI 19.78%

PRS 14.24
deuterosomal cell CL4033044

CSI 8.27

rCSI 27.95%

PRS 18.99
lung goblet cell CL1000143

CSI 8.18

rCSI 91.39%

PRS 37
naive T cell CL0000898

CSI 7.94

rCSI 5.52%

PRS 15.9
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 7.81

rCSI 47.23%

PRS 25.13
effector CD8-positive, alpha-beta T cell CL0001050

CSI 7.72

rCSI 5.87%

PRS 14.64
CD14-positive monocyte CL0001054

CSI 7.67

rCSI 9.56%

PRS 15.87
dendritic cell CL0000451

CSI 7.54

rCSI 9.29%

PRS 35.81
tissue-resident macrophage CL0000864

CSI 7.54

rCSI 35.28%

PRS 24.3
inflammatory macrophage CL0000863

CSI 7.54

rCSI 12.88%

PRS 22.59
respiratory goblet cell CL0002370

CSI 7.52

rCSI 81.78%

PRS 21.75
conventional dendritic cell CL0000990

CSI 7.27

rCSI 6.07%

PRS 33.11
melanocyte CL0000148

CSI 7.01

rCSI 5.19%

PRS 10.01
bronchus fibroblast of lung CL2000093

CSI 6.92

rCSI 5.62%

PRS 11.87
M cell of gut CL0000682

CSI 6.9

rCSI 7.33%

PRS 19.99
small pre-B-II cell CL0000954

CSI 6.64

rCSI 6.39%

PRS 23.31
group 3 innate lymphoid cell CL0001071

CSI 6.55

rCSI 4.92%

PRS 11.6
intestine goblet cell CL0019031

CSI 6.4

rCSI 5.68%

PRS 11.22
basal cell CL0000646

CSI 6.25

rCSI 8.36%

PRS 12.27
early lymphoid progenitor CL0000936

CSI 6.21

rCSI 5.46%

PRS 12.58
basal cell of prostate epithelium CL0002341

CSI 6.14

rCSI 17.76%

PRS 25.09
plasma cell CL0000786

CSI 6.12

rCSI 8.03%

PRS 49.19
alternatively activated macrophage CL0000890

CSI 6.12

rCSI 7.69%

PRS 17.14
basophil CL0000767

CSI 6.08

rCSI 12.86%

PRS 23.08
mononuclear phagocyte CL0000113

CSI 6.01

rCSI 13.24%

PRS 12.34
Langerhans cell CL0000453

CSI 5.91

rCSI 9.03%

PRS 19.57
double negative thymocyte CL0002489

CSI 5.86

rCSI 4.08%

PRS 13.08
fibroblast of lung CL0002553

CSI 5.84

rCSI 5.43%

PRS 11.26

CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI -17.2

rCSI -16.8%

PRS 17.6%
CD4-positive, alpha-beta memory T cell CL0000897

CSI -3.8

rCSI -2.7%

PRS 15.2%
kidney connecting tubule epithelial cell CL1000768

CSI -1.9

rCSI -4.8%

PRS 8.6%
platelet CL0000233

CSI -1.8

rCSI -7.4%

PRS 24.8%
renal principal cell CL0005009

CSI -1.3

rCSI -3.4%

PRS 15.2%
double negative T regulatory cell CL0011024

CSI -0.5

rCSI -9.3%

PRS 60.7%
central nervous system neuron CL2000029

CSI -0.3

rCSI -2.5%

PRS 5.5%
regular ventricular cardiac myocyte CL0002131

CSI -0.1

rCSI -0.5%

PRS 8.9%
erythroid progenitor cell CL0000038

CSI 0.1

rCSI 0.6%

PRS 17.4%
megakaryocyte progenitor cell CL0000553

CSI 0.2

rCSI 2.8%

PRS 32.2%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.2

rCSI 0.9%

PRS 18.4%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.3

rCSI 3.2%

PRS 42.8%
mesenchymal cell CL0008019

CSI 0.3

rCSI 0.9%

PRS 11.4%
myelocyte CL0002193

CSI 0.4

rCSI 2.3%

PRS 36.1%
microcirculation associated smooth muscle cell CL0008035

CSI 0.4

rCSI 1.0%

PRS 12.7%
mesenchymal stem cell CL0000134

CSI 0.4

rCSI 4.0%

PRS 20.4%
amacrine cell CL0000561

CSI 0.4

rCSI 1.1%

PRS 8.9%
transit amplifying cell of colon CL0009011

CSI 0.4

rCSI 0.4%

PRS 13.3%
lung microvascular endothelial cell CL2000016

CSI 0.4

rCSI 7.3%

PRS 36.3%
intestinal crypt stem cell of colon CL0009043

CSI 0.4

rCSI 2.8%

PRS 20.7%
cytotoxic T cell CL0000910

CSI 0.4

rCSI 2.4%

PRS 16.4%
paneth cell of colon CL0009009

CSI 0.4

rCSI 4.3%

PRS 32.2%
collagen secreting cell CL0000667

CSI 0.5

rCSI 2.6%

PRS 41.9%
enteroglial cell CL4040002

CSI 0.5

rCSI 2.5%

PRS 21.3%
IgM plasma cell CL0000986

CSI 0.5

rCSI 2.2%

PRS 51.5%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 2.8%

PRS 16.8%
intestinal tuft cell CL0019032

CSI 0.5

rCSI 0.8%

PRS 12.9%
enterocyte of epithelium of large intestine CL0002071

CSI 0.5

rCSI 2.7%

PRS 20.4%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.5

rCSI 2.6%

PRS 14.6%
erythroblast CL0000765

CSI 0.5

rCSI 1.4%

PRS 18.7%
vasa recta descending limb cell CL1001285

CSI 0.6

rCSI 4.4%

PRS 45.6%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.6

rCSI 0.7%

PRS 15.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.6

rCSI 2.4%

PRS 6.7%
pancreatic PP cell CL0002275

CSI 0.7

rCSI 2.6%

PRS 19.7%
L6b glutamatergic cortical neuron CL4023038

CSI 0.7

rCSI 2.1%

PRS 7.0%
regular atrial cardiac myocyte CL0002129

CSI 0.7

rCSI 2.3%

PRS 12.4%
endothelial cell of venule CL1000414

CSI 0.8

rCSI 6.7%

PRS 46.5%
helper T cell CL0000912

CSI 0.8

rCSI 1.1%

PRS 15.8%
small intestine goblet cell CL1000495

CSI 0.8

rCSI 1.7%

PRS 15.1%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 0.8

rCSI 1.2%

PRS 27.2%
endothelial cell of arteriole CL1000412

CSI 0.8

rCSI 4.4%

PRS 35.3%
late pro-B cell CL0002048

CSI 0.8

rCSI 2.0%

PRS 33.4%
retinal ganglion cell CL0000740

CSI 0.8

rCSI 1.8%

PRS 8.0%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.8

rCSI 2.5%

PRS 7.6%
type B pancreatic cell CL0000169

CSI 0.8

rCSI 1.8%

PRS 10.4%
mesenchymal stem cell of adipose tissue CL0002570

CSI 0.9

rCSI 4.8%

PRS 33.7%
fibroblast of breast CL4006000

CSI 0.9

rCSI 3.7%

PRS 29.3%
pancreatic ductal cell CL0002079

CSI 0.9

rCSI 1.7%

PRS 11.4%
luminal cell of prostate epithelium CL0002340

CSI 0.9

rCSI 4.8%

PRS 20.3%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.9

rCSI 3.3%

PRS 6.1%
lung resident memory CD4-positive, alpha-beta T cell CL4033038

CSI 0.9

rCSI 9.2%

PRS 62.9%
mature alpha-beta T cell CL0000791

CSI 1.0

rCSI 3.5%

PRS 19.1%
enterocyte of epithelium of small intestine CL1000334

CSI 1.0

rCSI 15.2%

PRS 27.8%
large pre-B-II cell CL0000957

CSI 1.0

rCSI 2.8%

PRS 19.4%
colonocyte CL1000347

CSI 1.1

rCSI 1.5%

PRS 15.4%
respiratory hillock cell CL4030023

CSI 1.1

rCSI 1.9%

PRS 19.1%
common lymphoid progenitor CL0000051

CSI 1.1

rCSI 1.5%

PRS 21.4%
vasa recta ascending limb cell CL1001131

CSI 1.1

rCSI 5.0%

PRS 41.9%
podocyte CL0000653

CSI 1.2

rCSI 5.2%

PRS 11.1%
B-1 B cell CL0000819

CSI 1.2

rCSI 31.1%

PRS 52.5%
pancreatic D cell CL0000173

CSI 1.2

rCSI 1.2%

PRS 12.2%
erythroid lineage cell CL0000764

CSI 1.2

rCSI 7.9%

PRS 26.8%
paneth cell CL0000510

CSI 1.3

rCSI 1.9%

PRS 17.6%
megakaryocyte CL0000556

CSI 1.3

rCSI 5.5%

PRS 20.2%
basophil mast progenitor cell CL0002028

CSI 1.3

rCSI 6.9%

PRS 40.7%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.3

rCSI 2.2%

PRS 6.6%
type EC enteroendocrine cell CL0000577

CSI 1.4

rCSI 4.9%

PRS 18.4%
renal interstitial pericyte CL1001318

CSI 1.4

rCSI 3.8%

PRS 10.7%
brush cell CL0002204

CSI 1.4

rCSI 2.8%

PRS 30.2%
metallothionein-positive alveolar macrophage CL4033042

CSI 1.4

rCSI 15.7%

PRS 43.9%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.5

rCSI 4.5%

PRS 18.0%
follicular dendritic cell CL0000442

CSI 1.5

rCSI 24.2%

PRS 55.6%
common myeloid progenitor CL0000049

CSI 1.5

rCSI 1.2%

PRS 11.1%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.5

rCSI 3.1%

PRS 18.7%
Hofbauer cell CL3000001

CSI 1.6

rCSI 2.9%

PRS 13.9%
luminal epithelial cell of mammary gland CL0002326

CSI 1.6

rCSI 2.9%

PRS 17.1%
endocardial cell CL0002350

CSI 1.7

rCSI 8.3%

PRS 14.8%
cerebral cortex endothelial cell CL1001602

CSI 1.8

rCSI 3.0%

PRS 8.5%
memory T cell CL0000813

CSI 1.9

rCSI 3.6%

PRS 25.1%
pulmonary ionocyte CL0017000

CSI 1.9

rCSI 2.3%

PRS 14.1%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.9

rCSI 4.9%

PRS 10.4%
colon macrophage CL0009038

CSI 1.9

rCSI 8.8%

PRS 23.5%
vascular leptomeningeal cell CL4023051

CSI 1.9

rCSI 3.4%

PRS 8.1%
retinal pigment epithelial cell CL0002586

CSI 1.9

rCSI 3.8%

PRS 12.0%
basal cell of epithelium of trachea CL1000348

CSI 1.9

rCSI 13.6%

PRS 34.7%
eosinophil CL0000771

CSI 1.9

rCSI 12.7%

PRS 29.1%
hepatocyte CL0000182

CSI 2.0

rCSI 3.7%

PRS 10.5%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 2.1

rCSI 2.5%

PRS 19.4%
perivascular cell CL4033054

CSI 2.1

rCSI 2.8%

PRS 12.7%
brush cell of tracheobronchial tree CL0002075

CSI 2.1

rCSI 6.4%

PRS 17.0%
pvalb GABAergic cortical interneuron CL4023018

CSI 2.2

rCSI 2.7%

PRS 6.1%
hematopoietic multipotent progenitor cell CL0000837

CSI 2.2

rCSI 5.2%

PRS 17.8%
B-2 B cell CL0000822

CSI 2.2

rCSI 47.3%

PRS 56.1%
airway submucosal gland duct basal cell CL4033024

CSI 2.3

rCSI 14.6%

PRS 35.8%
fraction A pre-pro B cell CL0002045

CSI 2.3

rCSI 2.6%

PRS 23.0%
lung macrophage CL1001603

CSI 2.3

rCSI 5.2%

PRS 12.7%
endothelial cell of uterus CL0009095

CSI 2.4

rCSI 17.9%

PRS 30.9%
granulocyte monocyte progenitor cell CL0000557

CSI 2.4

rCSI 2.1%

PRS 12.5%
innate lymphoid cell CL0001065

CSI 2.6

rCSI 5.3%

PRS 17.2%
chondrocyte CL0000138

CSI 2.6

rCSI 4.1%

PRS 9.6%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CD55](/details-gene/1604), also known as Decay-Accelerating Factor (DAF), is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein that plays a critical role in the regulation of the innate immune system. Its primary function is to protect host cells from autologous complement-mediated damage by inhibiting the assembly of the C3 and C5 convertases of both the classical and alternative complement pathways ([Link](https://pubmed.ncbi.nlm.nih.gov/2436222/)). **Overall**, expression data reveals that [CD55](/details-gene/1604) is most significantly expressed in mucosal and barrier tissues, particularly in cell types such as [epithelial cell of lower respiratory tract](/details-cell/CL0002632) and [nasal mucosa goblet cell](/details-cell/CL0002480), as well as in specific myeloid lineages like [CD14-low, CD16-positive monocyte](/details-cell/CL0002396). This expression pattern underscores its role as a frontline defense molecule at host-environment interfaces. Clinically, variations in [CD55](/details-gene/1604) are associated with the Cromer blood group system and have been linked to conditions involving complement dysregulation ([125240](https://omim.org/entry/125240), [226300](https://omim.org/entry/226300)). ## Cellular Roles and Expression Landscape The expression profile of [CD55](/details-gene/1604) highlights its specialized function in protecting tissues exposed to external environments and in regulating immune cell interactions. **Overall**, the gene shows the highest significance in various epithelial lineages, suggesting a primary role in maintaining tissue integrity at mucosal surfaces. Top-ranking cell types include [epithelial cell of lower respiratory tract](/details-cell/CL0002632) (CSI: 98.96), [nasal mucosa goblet cell](/details-cell/CL0002480) (CSI: 68.03), [conjunctival epithelial cell](/details-cell/CL1000432) (CSI: 55.04), and [club cell](/details-cell/CL0000158) (CSI: 50.34). Its high significance in placental cells, such as [extravillous trophoblast](/details-cell/CL0008036) and [placental villous trophoblast](/details-cell/CL2000060), is consistent with its function in preventing maternal complement attack at the fetal-maternal interface. Beyond epithelial barriers, [CD55](/details-gene/1604) is also a significant marker for specific myeloid populations, including [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) and [intermediate monocyte](/details-cell/CL0002393), indicating a role in regulating complement activity on the surface of these phagocytic cells. Conversely, the gene's expression is notably low or absent in several key cell types, which helps to define its functional specificity. It is a significant anti-marker for [CD4-positive, CD25-positive, alpha-beta regulatory T cell](/details-cell/CL0000792) (CSI: -17.15), suggesting its direct role on these cells is minimal. Furthermore, its low significance in [platelet](/details-cell/CL0000233) and [central nervous system neuron](/details-cell/CL2000029) indicates a highly specialized role outside of hemostasis and neuronal function. ## Pathways and Molecular Function The functional annotations for [CD55](/details-gene/1604) confirm its central role in the immune system, particularly as a negative regulator of the complement cascade. Gene Ontology (GO) terms prominently feature [Negative regulation of complement activation](/details-term/GO:0045916) and [Regulation of complement-dependent cytotoxicity](/details-term/GO:1903659). This is further supported by its involvement in the Reactome pathways [Regulation of complement cascade](/details-pathway/R-HSA-977606) and the broader [Innate immune system](/details-pathway/R-HSA-168249). As a cell-surface protein located in the [plasma membrane](/details-term/GO:0005886) and [membrane raft](/details-term/GO:0045121), it is perfectly positioned to perform this protective function. In addition to its role in complement regulation, [CD55](/details-gene/1604) is also annotated with [Virus receptor activity](/details-term/GO:0001618). Research has demonstrated that it serves as a cellular receptor for several enteroviruses, including echoviruses, coxsackieviruses B, and enterovirus 70 ([Link](https://doi.org/10.1002/j.1460-2075.1994.tb06836.x), [Link](https://doi.org/10.1128/jvi.69.6.3873-3877.1995)). This function aligns with its high expression on mucosal epithelial cells, which are common portals of entry for such pathogens. Interestingly, despite its low expression in T cells, GO terms suggest a role in the [Positive regulation of cd4-positive, alpha-beta t cell activation](/details-term/GO:2000516), which may indicate an indirect regulatory mechanism, possibly mediated by its expression on antigen-presenting cells. ## Research Directions The expression profile and functional annotations of [CD55](/details-gene/1604) suggest several avenues for future research, particularly concerning its roles in host defense, autoimmunity, and cancer biology. **Testable Hypotheses:** 1. **Role in T cell co-stimulation:** Despite its low expression on T cells, the high expression of [CD55](/details-gene/1604) on monocytes and its annotated role in T cell activation suggest an indirect regulatory function. We hypothesize that [CD55](/details-gene/1604) on antigen-presenting cells (APCs) fine-tunes T cell responses by controlling local complement deposition at the immunological synapse, thereby acting as a contextual co-stimulatory or co-inhibitory signal. 2. **Mechanism in Placental Immunity:** The high significance of [CD55](/details-gene/1604) in trophoblasts suggests it is critical for maternal-fetal tolerance. We hypothesize that reduced expression or functional impairment of [CD55](/details-gene/1604) on trophoblasts leads to excessive complement activation at the placental interface, contributing to the pathogenesis of pregnancy complications such as pre-eclampsia and recurrent miscarriage. 3. **Involvement in Respiratory Viral Pathogenesis:** Given its role as a viral receptor and its high expression in respiratory epithelium, we hypothesize that the expression level of [CD55](/details-gene/1604) dictates cellular susceptibility to certain respiratory viruses and that viral binding may also modulate its complement regulatory function, exacerbating local inflammation. **Proposed Experimental Approach:** To test the hypothesis that APC-expressed [CD55](/details-gene/1604) modulates T cell activation (Hypothesis 1), a human monocyte-T cell co-culture system could be employed. Primary human [monocytes](/details-cell/CL0000576) would be isolated and treated with siRNA or a CRISPR-Cas9 system to specifically knock down [CD55](/details-gene/1604) expression. These [CD55](/details-gene/1604)-deficient monocytes, along with control monocytes, would then be pulsed with a specific antigen and co-cultured with autologous [CD4-positive, alpha-beta T cells](/details-cell/CL0000492). The impact on T cell function would be assessed by measuring proliferation (e.g., via CFSE dilution using flow cytometry), cytokine production (e.g., IL-2, IFN-gamma, and IL-10 via ELISA or Luminex), and the expression of T cell activation markers (e.g., CD69, CD25). This experiment would directly elucidate the role of APC-derived [CD55](/details-gene/1604) in regulating adaptive immune responses. **Therapeutic Potential:** [CD55](/details-gene/1604) presents a dual-faceted therapeutic potential. As a protective molecule, its upregulation or supplementation via soluble recombinant forms could be beneficial in diseases characterized by excessive complement activation, such as atypical hemolytic uremic syndrome or ischemia-reperfusion injury. Conversely, many cancer cells overexpress [CD55](/details-gene/1604) to evade complement-dependent cytotoxicity, a key mechanism for monoclonal antibody therapies. In this context, [CD55](/details-gene/1604) represents a compelling target for **inhibition**. The development of blocking antibodies or small molecules against [CD55](/details-gene/1604) could serve as a valuable adjuvant to enhance the efficacy of complement-fixing anti-cancer antibodies like rituximab or trastuzumab.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Complement decay-accelerating factor
B1AP13_HUMAN

Genular Protein ID: 2793829098

Symbol: DAF_HUMAN

Name: Complement decay-accelerating factor

UniProtKB Accession Codes:

P08174 B1AP14 D3DT83 D3DT84 E7ER69 P09679 P78361 Q14UF2 Q14UF3 Q14UF4 Q14UF5 Q14UF6

Database IDs:

Citations:

PubMed ID: 2433596

Title: Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins.

PubMed ID: 2433596

DOI: 10.1038/325545a0

PubMed ID: 16503113

Title: Molecular cloning and characterization of novel splicing variants of human decay-accelerating factor.

PubMed ID: 16503113

DOI: 10.1016/j.ygeno.2006.01.006

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1711208

Title: Characterization of the decay-accelerating factor gene promoter region.

PubMed ID: 1711208

DOI: 10.1073/pnas.88.11.4675

PubMed ID: 2436222

Title: Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.

PubMed ID: 2436222

DOI: 10.1073/pnas.84.7.2007

PubMed ID: 2428813

Title: Improved method for the isolation and preliminary characterization of human DAF (decay-accelerating factor).

PubMed ID: 2428813

DOI: 10.1093/oxfordjournals.jbchem.a121686

PubMed ID: 1712233

Title: Isolation of two forms of decay-accelerating factor (DAF) from human urine.

PubMed ID: 1712233

DOI: 10.1016/0304-4165(91)90171-c

PubMed ID: 1824699

Title: Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site.

PubMed ID: 1824699

DOI: 10.1016/s0021-9258(17)35308-5

PubMed ID: 1377029

Title: Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen).

PubMed ID: 1377029

DOI: 10.1016/0304-4165(92)90016-n

PubMed ID: 7525274

Title: Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method.

PubMed ID: 7525274

DOI: 10.1002/j.1460-2075.1994.tb06836.x

PubMed ID: 7517044

Title: Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses.

PubMed ID: 7517044

DOI: 10.1073/pnas.91.13.6245

PubMed ID: 7538177

Title: Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment.

PubMed ID: 7538177

DOI: 10.1128/jvi.69.6.3873-3877.1995

PubMed ID: 8764022

Title: The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55).

PubMed ID: 8764022

DOI: 10.1128/jvi.70.8.5143-5152.1996

PubMed ID: 9151867

Title: Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry.

PubMed ID: 9151867

DOI: 10.1128/jvi.71.6.4736-4743.1997

PubMed ID: 11297558

Title: Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.

PubMed ID: 11297558

DOI: 10.1074/jbc.m101770200

PubMed ID: 12409401

Title: Human rhinovirus 87 and enterovirus 68 represent a unique serotype with rhinovirus and enterovirus features.

PubMed ID: 12409401

DOI: 10.1128/jcm.40.11.4218-4223.2002

PubMed ID: 17804498

Title: Interaction of decay-accelerating factor with coxsackievirus B3.

PubMed ID: 17804498

DOI: 10.1128/jvi.00931-07

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26207632

Title: Obif, a transmembrane protein, is required for bone mineralization and spermatogenesis in mice.

PubMed ID: 26207632

DOI: 10.1371/journal.pone.0133704

PubMed ID: 28657861

Title: Loss of CD55 in eculizumab-responsive protein-losing enteropathy.

PubMed ID: 28657861

DOI: 10.1056/nejmc1707173

PubMed ID: 7519480

Title: Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes.

PubMed ID: 7519480

PubMed ID: 12675719

Title: GUTI: a new antigen in the Cromer blood group system.

PubMed ID: 12675719

DOI: 10.1046/j.1537-2995.2003.00319.x

PubMed ID: 1720702

Title: Biochemical studies on red blood cells from a patient with the Inab phenotype (decay-accelerating factor deficiency).

PubMed ID: 1720702

PubMed ID: 12499389

Title: Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A.

PubMed ID: 12499389

DOI: 10.1074/jbc.m212561200

PubMed ID: 14734808

Title: Complement regulation at the molecular level: the structure of decay-accelerating factor.

PubMed ID: 14734808

DOI: 10.1073/pnas.0307200101

PubMed ID: 12672958

Title: Solution structure of a functionally active fragment of decay-accelerating factor.

PubMed ID: 12672958

DOI: 10.1073/pnas.0730844100

PubMed ID: 28657829

Title: CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis.

PubMed ID: 28657829

DOI: 10.1056/nejmoa1615887

Sequence Information:

Length: 381
Mass: 41400
Checksum: C1CBE5300F60C176
Sequence:

MTVARPSVPA ALPLLGELPR LLLLVLLCLP AVWGDCGLPP DVPNAQPALE GRTSFPEDTV 
ITYKCEESFV KIPGEKDSVI CLKGSQWSDI EEFCNRSCEV PTRLNSASLK QPYITQNYFP 
VGTVVEYECR PGYRREPSLS PKLTCLQNLK WSTAVEFCKK KSCPNPGEIR NGQIDVPGGI 
LFGATISFSC NTGYKLFGST SSFCLISGSS VQWSDPLPEC REIYCPAPPQ IDNGIIQGER 
DHYGYRQSVT YACNKGFTMI GEHSIYCTVN NDEGEWSGPP PECRGKSLTS KVPPTVQKPT 
TVNVPTTEVS PTSQKTTTKT TTPNAQATRS TPVSRTTKHF HETTPNKGSG TTSGTTRLLS 
GHTCFTLTGL LGTLVTMGLL T

Genular Protein ID: 943026165

Symbol: B1AP13_HUMAN

Name: N/A

UniProtKB Accession Codes:

B1AP13

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 444
Mass: 49338
Checksum: 38B7D12413F52A23
Sequence:

MTVARPSVPA ALPLLGELPR LLLLVLLCLP AVWGDCGLPP DVPNAQPALE GRTSFPEDTV 
ITYKCEESFV KIPGEKDSVI CLKGSQWSDI EEFCNRSCEV PTRLNSASLK QPYITQNYFP 
VGTVVEYECR PGYRREPSLS PKLTCLQNLK WSTAVEFCKK KSCPNPGEIR NGQIDVPGGI 
LFGATISFSC NTGYKLFGST SSFCLISGSS VQWSDPLPEC REIYCPAPPQ IDNGIIQGER 
DHYGYRQSVT YACNKGFTMI GEHSIYCTVN NDEGEWSGPP PECRGKSLTS KVPPTVQKPT 
TVNVPTTEVS PTSQKTTTKT TTPNAQATRS TPVSRTTKHF HETTPNKGSG TTSGTTRLLS 
GSRPVTQAGM RWCDRSSLQS RTPGFKRSFH FSLPSSWYYR CVPRHPAKFL KFIFCRDRIF 
LCCPGWFQTP GRKRFFRPPK TLRL

Details for: CD55

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. PubMed ID: 2433596

Molecular cloning and characterization of novel splicing variants of human decay-accelerating factor. PubMed ID: 16503113

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the decay-accelerating factor gene promoter region. PubMed ID: 1711208

Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement. PubMed ID: 2436222

Improved method for the isolation and preliminary characterization of human DAF (decay-accelerating factor). PubMed ID: 2428813

Isolation of two forms of decay-accelerating factor (DAF) from human urine. PubMed ID: 1712233

Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site. PubMed ID: 1824699

Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen). PubMed ID: 1377029

Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method. PubMed ID: 7525274

Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses. PubMed ID: 7517044

Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment. PubMed ID: 7538177

The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55). PubMed ID: 8764022

Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry. PubMed ID: 9151867

Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. PubMed ID: 11297558

Human rhinovirus 87 and enterovirus 68 represent a unique serotype with rhinovirus and enterovirus features. PubMed ID: 12409401

Interaction of decay-accelerating factor with coxsackievirus B3. PubMed ID: 17804498

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

Obif, a transmembrane protein, is required for bone mineralization and spermatogenesis in mice. PubMed ID: 26207632

Loss of CD55 in eculizumab-responsive protein-losing enteropathy. PubMed ID: 28657861

Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. PubMed ID: 7519480

GUTI: a new antigen in the Cromer blood group system. PubMed ID: 12675719

Biochemical studies on red blood cells from a patient with the Inab phenotype (decay-accelerating factor deficiency). PubMed ID: 1720702

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A. PubMed ID: 12499389

Complement regulation at the molecular level: the structure of decay-accelerating factor. PubMed ID: 14734808

Solution structure of a functionally active fragment of decay-accelerating factor. PubMed ID: 12672958

CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis. PubMed ID: 28657829

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Initial characterization of the human central proteome. PubMed ID: 21269460

PubMed ID: 2433596

PubMed ID: 16503113

PubMed ID: 16710414

PubMed ID: 15489334

PubMed ID: 1711208

PubMed ID: 2436222

PubMed ID: 2428813

PubMed ID: 1712233

PubMed ID: 1824699

PubMed ID: 1377029

PubMed ID: 7525274

PubMed ID: 7517044

PubMed ID: 7538177

PubMed ID: 8764022

PubMed ID: 9151867

PubMed ID: 11297558

PubMed ID: 12409401

PubMed ID: 17804498

PubMed ID: 19159218

PubMed ID: 21269460

PubMed ID: 26207632

PubMed ID: 28657861

PubMed ID: 7519480

PubMed ID: 12675719

PubMed ID: 1720702

PubMed ID: 12499389

PubMed ID: 14734808

PubMed ID: 12672958

PubMed ID: 28657829

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 21269460