Details for: DAG1

Gene ID: 1605

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DAG1

Ensembl ID: ENSG00000173402

Description: dystroglycan 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • placental villous trophoblast CL2000060
    CSI 14.24
    rCSI 22%
    PRS 70.16
  • bronchus fibroblast of lung CL2000093
    CSI 13.28
    rCSI 10.79%
    PRS 71.41
  • enteroendocrine cell CL0000164
    CSI 11.34
    rCSI 15.5%
    PRS 72.16
  • extravillous trophoblast CL0008036
    CSI 8.75
    rCSI 10.82%
    PRS 68.4
  • parietal epithelial cell CL1000452
    CSI 7.51
    rCSI 20.06%
    PRS 62.25
  • regular atrial cardiac myocyte CL0002129
    CSI 7.33
    rCSI 23.58%
    PRS 68.85
  • skeletal muscle satellite cell CL0000594
    CSI 6.72
    rCSI 19.66%
    PRS 87.6
  • colonocyte CL1000347
    CSI 6.2
    rCSI 8.89%
    PRS 73.37
  • enteroglial cell CL4040002
    CSI 4.61
    rCSI 24.21%
    PRS 74.58
  • cerebral cortex endothelial cell CL1001602
    CSI 3.78
    rCSI 6.54%
    PRS 61.78
  • intestinal tuft cell CL0019032
    CSI 3.46
    rCSI 5.28%
    PRS 75.7
  • ciliated cell CL0000064
    CSI 3.43
    rCSI 5.56%
    PRS 66.85
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.23
    rCSI 9.59%
    PRS 80.89
  • epithelial cell of proximal tubule CL0002306
    CSI 3.14
    rCSI 7.68%
    PRS 64.37
  • fibroblast of lung CL0002553
    CSI 3.11
    rCSI 2.9%
    PRS 72.13
  • glioblast CL0000030
    CSI 3.1
    rCSI 4.95%
    PRS 62.94
  • goblet cell CL0000160
    CSI 3.09
    rCSI 2.92%
    PRS 70.49
  • midzonal region hepatocyte CL0019028
    CSI 3.07
    rCSI 7.21%
    PRS 73.68
  • ependymal cell CL0000065
    CSI 2.86
    rCSI 5.8%
    PRS 49.41
  • podocyte CL0000653
    CSI 2.85
    rCSI 12.66%
    PRS 71.61
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 2.84
    rCSI 10.74%
    PRS 53
  • pancreatic D cell CL0000173
    CSI 2.8
    rCSI 2.76%
    PRS 73.96
  • small intestine goblet cell CL1000495
    CSI 2.8
    rCSI 6.13%
    PRS 78.04
  • renal alpha-intercalated cell CL0005011
    CSI 2.77
    rCSI 3.7%
    PRS 79.2
  • epithelial cell of lung CL0000082
    CSI 2.75
    rCSI 2.28%
    PRS 71.46
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.73
    rCSI 2.63%
    PRS 70.91
  • secretory cell CL0000151
    CSI 2.53
    rCSI 2.64%
    PRS 71.2
  • hepatic stellate cell CL0000632
    CSI 2.51
    rCSI 9.39%
    PRS 63.19
  • neural crest cell CL0011012
    CSI 2.49
    rCSI 1.97%
    PRS 58.61
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.46
    rCSI 1.91%
    PRS 74.61
  • colon epithelial cell CL0011108
    CSI 2.39
    rCSI 2.51%
    PRS 68.26
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 2.39
    rCSI 10.97%
    PRS 78.39
  • multi-ciliated epithelial cell CL0005012
    CSI 2.35
    rCSI 2.34%
    PRS 64.78
  • ionocyte CL0005006
    CSI 2.31
    rCSI 2.47%
    PRS 71.8
  • ciliated epithelial cell CL0000067
    CSI 2.3
    rCSI 2.02%
    PRS 59.4
  • Kupffer cell CL0000091
    CSI 2.29
    rCSI 5.25%
    PRS 72.01
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.23
    rCSI 3.56%
    PRS 75.41
  • intestine goblet cell CL0019031
    CSI 2.22
    rCSI 1.97%
    PRS 69.12
  • periportal region hepatocyte CL0019026
    CSI 2.22
    rCSI 8.62%
    PRS 73.43
  • hepatocyte CL0000182
    CSI 2.15
    rCSI 3.85%
    PRS 70.78
  • pancreatic A cell CL0000171
    CSI 2.12
    rCSI 2.22%
    PRS 74.76
  • stem cell CL0000034
    CSI 2.11
    rCSI 2.04%
    PRS 63.12
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.01
    rCSI 2.85%
    PRS 67.45
  • myoepithelial cell CL0000185
    CSI 1.98
    rCSI 5%
    PRS 77.98
  • pancreatic acinar cell CL0002064
    CSI 1.96
    rCSI 2.61%
    PRS 77.61
  • cerebellar granule cell CL0001031
    CSI 1.93
    rCSI 2.84%
    PRS 64.3
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.92
    rCSI 4.31%
    PRS 53.06
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.9
    rCSI 2.36%
    PRS 50.52
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.89
    rCSI 11.15%
    PRS 53.58
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.89
    rCSI 3.17%
    PRS 52.43
  • basal cell CL0000646
    CSI 1.84
    rCSI 2.47%
    PRS 70.95
  • foveolar cell of stomach CL0002179
    CSI 1.82
    rCSI 3.88%
    PRS 79.96
  • lung neuroendocrine cell CL1000223
    CSI 1.8
    rCSI 2.66%
    PRS 76.02
  • blood vessel endothelial cell CL0000071
    CSI 1.78
    rCSI 3.7%
    PRS 68.26
  • respiratory suprabasal cell CL4033048
    CSI 1.78
    rCSI 2.28%
    PRS 75.54
  • duct epithelial cell CL0000068
    CSI 1.76
    rCSI 2.57%
    PRS 76.18
  • lung secretory cell CL1000272
    CSI 1.76
    rCSI 4.35%
    PRS 70.16
  • tuft cell of colon CL0009041
    CSI 1.74
    rCSI 4.05%
    PRS 80.01
  • vascular leptomeningeal cell CL4023051
    CSI 1.73
    rCSI 3.04%
    PRS 63.8
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.72
    rCSI 2.06%
    PRS 52.33
  • Bergmann glial cell CL0000644
    CSI 1.7
    rCSI 2.32%
    PRS 63.45
  • transit amplifying cell of colon CL0009011
    CSI 1.69
    rCSI 1.98%
    PRS 73.42
  • peripheral nervous system neuron CL2000032
    CSI 1.68
    rCSI 2.28%
    PRS 62.59
  • renal interstitial pericyte CL1001318
    CSI 1.62
    rCSI 4.46%
    PRS 66.16
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.61
    rCSI 2.08%
    PRS 53.82
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.61
    rCSI 4.08%
    PRS 60.91
  • nasal mucosa goblet cell CL0002480
    CSI 1.6
    rCSI 1.86%
    PRS 77.22
  • Schwann cell CL0002573
    CSI 1.54
    rCSI 4.39%
    PRS 68.07
  • mucous neck cell CL0000651
    CSI 1.54
    rCSI 2.21%
    PRS 80.11
  • M cell of gut CL0000682
    CSI 1.52
    rCSI 1.62%
    PRS 78.77
  • type B pancreatic cell CL0000169
    CSI 1.5
    rCSI 3.32%
    PRS 70.05
  • regular ventricular cardiac myocyte CL0002131
    CSI 1.49
    rCSI 9.3%
    PRS 62.6
  • club cell CL0000158
    CSI 1.47
    rCSI 2.16%
    PRS 66.12
  • cardiac neuron CL0010022
    CSI 1.46
    rCSI 4.67%
    PRS 68.37
  • centrilobular region hepatocyte CL0019029
    CSI 1.46
    rCSI 3.8%
    PRS 72.25
  • acinar cell CL0000622
    CSI 1.39
    rCSI 2.04%
    PRS 82.21
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.38
    rCSI 2.44%
    PRS 51.54
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.36
    rCSI 3.52%
    PRS 66.16
  • lung pericyte CL0009089
    CSI 1.35
    rCSI 3.55%
    PRS 79.68
  • choroid plexus epithelial cell CL0000706
    CSI 1.28
    rCSI 2.1%
    PRS 60.24
  • enteric smooth muscle cell CL0002504
    CSI 1.26
    rCSI 1.8%
    PRS 72.97
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.24
    rCSI 1.99%
    PRS 54.31
  • cardiac muscle cell CL0000746
    CSI 1.18
    rCSI 1.69%
    PRS 60.67
  • syncytiotrophoblast cell CL0000525
    CSI 1.16
    rCSI 3.35%
    PRS 81.41
  • lung ciliated cell CL1000271
    CSI 1.02
    rCSI 1.18%
    PRS 62.36
  • paneth cell CL0000510
    CSI 1.01
    rCSI 1.5%
    PRS 84.36
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.95
    rCSI 2.76%
    PRS 71.76
  • neural progenitor cell CL0011020
    CSI 0.92
    rCSI 4.04%
    PRS 60.28
  • pancreatic ductal cell CL0002079
    CSI 0.87
    rCSI 1.69%
    PRS 74.69
  • forebrain radial glial cell CL0013000
    CSI 0.85
    rCSI 2.72%
    PRS 74.72
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.75
    rCSI 1.83%
    PRS 50.84
  • cell of skeletal muscle CL0000188
    CSI 0.58
    rCSI 6.28%
    PRS 84.2
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.48
    rCSI 1.49%
    PRS 56.72
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.46
    rCSI 1.05%
    PRS 66.25
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.4
    rCSI 1.25%
    PRS 54.26
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.38
    rCSI 1.37%
    PRS 50.61
  • blood vessel smooth muscle cell CL0019018
    CSI 0.35
    rCSI 2.86%
    PRS 64.78
  • mesenchymal stem cell CL0000134
    CSI 0.33
    rCSI 3.66%
    PRS 80.23
  • medium spiny neuron CL1001474
    CSI 0.25
    rCSI 2.15%
    PRS 58.42
  • central nervous system neuron CL2000029
    CSI 0.18
    rCSI 1.29%
    PRS 57.95

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DAG1](/details-gene/1605) encodes dystroglycan, a highly conserved transmembrane protein that is cleaved into two subunits, alpha-dystroglycan and beta-dystroglycan. This complex forms the central component of the dystrophin-associated glycoprotein complex (DGC), which acts as a critical structural link between the intracellular cytoskeleton and the extracellular matrix (ECM). Functionally, [DAG1](/details-gene/1605) is integral to basement membrane organization, cell-matrix adhesion, and signal transduction. Its expression is particularly significant in a wide range of cell types requiring strong adhesion and structural integrity, including [placental villous trophoblast](/details-cell/CL2000060), [bronchus fibroblast of lung](/details-cell/CL2000093), and various muscle cells. Mutations and defects in the post-translational glycosylation of [DAG1](/details-gene/1605) are associated with several forms of congenital muscular dystrophy, collectively known as dystroglycanopathies (OMIM: [153245](https://omim.org/entry/153245)). ## Cellular Roles and Expression Landscape The expression profile of [DAG1](/details-gene/1605) highlights its fundamental role in maintaining tissue architecture across diverse physiological systems. **Overall**, the gene shows the highest significance in cells that form critical barriers or provide structural support. It is a top marker in [placental villous trophoblast](/details-cell/CL2000060) (CSI: 14.24) and [extravillous trophoblast](/details-cell/CL0008036) (CSI: 8.75), suggesting a crucial function in maternal-fetal interface integrity. The gene's importance extends to other barrier and secretory tissues, with high significance scores in gut epithelial cell types such as [enteroendocrine cell](/details-cell/CL0000164) (CSI: 11.34) and [colonocyte](/details-cell/CL1000347) (CSI: 6.20), as well as in [ciliated cell](/details-cell/CL0000064) of the respiratory tract. Furthermore, its high significance in mesenchymal-derived cells, such as [bronchus fibroblast of lung](/details-cell/CL2000093) (CSI: 13.28), underscores its contribution to connective tissue organization and wound healing. Consistent with its classical role, [DAG1](/details-gene/1605) is also significantly expressed in muscle lineages, including [regular atrial cardiac myocyte](/details-cell/CL0002129) (CSI: 7.33) and [skeletal muscle satellite cell](/details-cell/CL0000594) (CSI: 6.72), where it is essential for sarcolemma stability and muscle regeneration. ## Pathways and Molecular Function The molecular functions of [DAG1](/details-gene/1605) are centered on its role as a versatile adhesion molecule. Gene Ontology annotations confirm its ability to bind directly to key ECM components, such as in `laminin binding` ([GO:0043236](https://www.ebi.ac.uk/QuickGO/term/GO:0043236)), and to cytoskeletal elements via `actin binding` ([GO:0003779](https://www.ebi.ac.uk/QuickGO/term/GO:0003779)) and `dystroglycan binding` ([GO:0002162](https://www.ebi.ac.uk/QuickGO/term/GO:0002162)) ([Link](https://pubmed.ncbi.nlm.nih.gov/7592992/)). This dual interaction is the basis for its function as a `structural constituent of muscle` ([GO:0008307](https://www.ebi.ac.uk/QuickGO/term/GO:0008307)). Biologically, [DAG1](/details-gene/1605) is involved in a broad spectrum of processes related to tissue development and maintenance. Its participation in `Extracellular matrix organization` ([R-HSA-1474244](https://reactome.org/content/detail/R-HSA-1474244)) and `Basement membrane organization` ([GO:0071711](https://www.ebi.ac.uk/QuickGO/term/GO:0071711)) aligns with its high expression in fibroblasts and epithelial cells. The gene also plays a critical role in `Nervous system development` ([R-HSA-9675108](https://reactome.org/content/detail/R-HSA-9675108)), including `axon guidance` ([GO:0007411](https://www.ebi.ac.uk/QuickGO/term/GO:0007411)) and `myelination in peripheral nervous system` ([GO:0022011](https://www.ebi.ac.uk/QuickGO/term/GO:0022011)). Its function as a receptor for certain pathogens is noted under `virus receptor activity` ([GO:0001618](https://www.ebi.ac.uk/QuickGO/term/GO:0001618)) and its interaction with Mycobacterium leprae has also been described ([Link](https://doi.org/10.1126/science.282.5396.2076)). Reactome pathways further connect [DAG1](/details-gene/1605) to `Diseases of glycosylation` ([R-HSA-3781865](https://reactome.org/content/detail/R-HSA-3781865)), highlighting that its proper post-translational modification is essential for function ([Link](https://doi.org/10.1038/nature00837)). ## Research Directions Based on its expression profile and known functions, [DAG1](/details-gene/1605) presents several avenues for future investigation, particularly regarding its role outside of muscle tissue. **Proposed Hypotheses:** 1. Given its exceptionally high significance in [placental villous trophoblast](/details-cell/CL2000060) and its role in cell-matrix adhesion, we hypothesize that impaired [DAG1](/details-gene/1605) function or glycosylation in trophoblasts disrupts proper placental implantation and vascularization, potentially contributing to pathologies such as pre-eclampsia and intrauterine growth restriction. 2. The high significance of [DAG1](/details-gene/1605) in [bronchus fibroblast of lung](/details-cell/CL2000093), coupled with its role in ECM organization, suggests that dysregulation of [DAG1](/details-gene/1605) expression or signaling in these fibroblasts may be a key factor in the pathogenesis of fibrotic lung diseases, promoting excessive ECM deposition and tissue stiffening. **Experimental Approach:** To test the hypothesis regarding lung fibrosis (Hypothesis 2), a robust experimental plan could be implemented. Primary lung fibroblasts would be isolated from both healthy donors and patients with idiopathic pulmonary fibrosis (IPF). Using a CRISPR-Cas9 system, [DAG1](/details-gene/1605) would be knocked down in these primary cell lines. The functional consequences would be assessed by measuring key fibrotic indicators, including the differentiation of fibroblasts into myofibroblasts (via alpha-smooth muscle actin staining), the production and deposition of collagen I and fibronectin (via western blot and immunofluorescence), and changes in cell contractility using a collagen gel contraction assay. This would directly probe the cell-autonomous role of [DAG1](/details-gene/1605) in driving the fibrotic phenotype. **Therapeutic Potential:** As a cell surface protein, dystroglycan is a tractable drug target. For loss-of-function diseases like muscular dystrophies, therapeutic strategies are focused on **restoration of function**. This includes gene therapies designed to reintroduce a functional copy of [DAG1](/details-gene/1605) or other DGC components, as well as small molecule approaches aimed at improving the defective glycosylation that underlies many dystroglycanopathies. Conversely, in the context of fibrosis, where [DAG1](/details-gene/1605)-mediated cell adhesion might be pathologically enhanced, a strategy of **inhibition** could be more appropriate. A monoclonal antibody or small molecule designed to block the interaction of dystroglycan with specific pro-fibrotic ECM ligands could potentially mitigate tissue remodeling and disease progression.

Genular Protein ID: 1478942946

Symbol: DAG1_HUMAN

Name: Alpha-dystroglycan

UniProtKB Accession Codes:

Q14118 A8K6M7 Q969J9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 14 EvolutionaryTrace 1 ExpressionAtlas 1 GO 83 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 13 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8268918

Title: Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization.

PubMed ID: 8268918

DOI: 10.1093/hmg/2.10.1651

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7592992

Title: Identification and characterization of the dystrophin anchoring site on beta-dystroglycan.

PubMed ID: 7592992

DOI: 10.1074/jbc.270.45.27305

PubMed ID: 9851927

Title: Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae.

PubMed ID: 9851927

DOI: 10.1126/science.282.5396.2076

PubMed ID: 10767429

Title: Contribution of the different modules in the utrophin carboxy-terminal region to the formation and regulation of the DAP complex.

PubMed ID: 10767429

DOI: 10.1016/s0014-5793(00)01400-9

PubMed ID: 10988290

Title: Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members.

PubMed ID: 10988290

DOI: 10.1074/jbc.m005321200

PubMed ID: 10769203

Title: Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin.

PubMed ID: 10769203

DOI: 10.1242/jcs.113.10.1717

PubMed ID: 11724572

Title: Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.

PubMed ID: 11724572

DOI: 10.1021/bi011247r

PubMed ID: 11495720

Title: The interaction of dystrophin with beta-dystroglycan is regulated by tyrosine phosphorylation.

PubMed ID: 11495720

DOI: 10.1016/s0898-6568(01)00188-7

PubMed ID: 12140558

Title: Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies.

PubMed ID: 12140558

DOI: 10.1038/nature00837

PubMed ID: 12795607

Title: Localization of phospho-beta-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo.

PubMed ID: 12795607

DOI: 10.1021/bi0271289

PubMed ID: 12592373

Title: hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.

PubMed ID: 12592373

DOI: 10.1038/sj.bjc.6600740

PubMed ID: 15175026

Title: Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface.

PubMed ID: 15175026

DOI: 10.1111/j.0022-202x.2004.22605.x

PubMed ID: 16254364

Title: O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function.

PubMed ID: 16254364

DOI: 10.1128/jvi.79.22.14297-14308.2005

PubMed ID: 17212656

Title: Cys669-Cys713 disulfide bridge formation is a key to dystroglycan cleavage and subunit association.

PubMed ID: 17212656

DOI: 10.1111/j.1365-2443.2006.01033.x

PubMed ID: 17360738

Title: Old World and clade C New World arenaviruses mimic the molecular mechanism of receptor recognition used by alpha-dystroglycan's host-derived ligands.

PubMed ID: 17360738

DOI: 10.1128/jvi.02574-06

PubMed ID: 17905726

Title: SEA domain proteolysis determines the functional composition of dystroglycan.

PubMed ID: 17905726

DOI: 10.1096/fj.07-8354com

PubMed ID: 18764929

Title: Nuclear translocation of beta-dystroglycan reveals a distinctive trafficking pattern of autoproteolyzed mucins.

PubMed ID: 18764929

DOI: 10.1111/j.1600-0854.2008.00822.x

PubMed ID: 19946898

Title: Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site.

PubMed ID: 19946898

DOI: 10.1002/iub.273

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 19324387

Title: Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction.

PubMed ID: 19324387

DOI: 10.1016/j.virol.2009.02.042

PubMed ID: 20507882

Title: Characterization of site-specific O-glycan structures within the mucin-like domain of {alpha}-dystroglycan from human skeletal muscle.

PubMed ID: 20507882

DOI: 10.1093/glycob/cwq082

PubMed ID: 20512930

Title: Characterization of an Importin alpha/beta-recognized nuclear localization signal in beta-dystroglycan.

PubMed ID: 20512930

DOI: 10.1002/jcb.22581

PubMed ID: 20044576

Title: O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding.

PubMed ID: 20044576

DOI: 10.1126/science.1180512

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21987822

Title: Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.

PubMed ID: 21987822

DOI: 10.1073/pnas.1114836108

PubMed ID: 23723439

Title: HNK-1 sulfotransferase-dependent sulfation regulating laminin-binding glycans occurs in the post-phosphoryl moiety on alpha-dystroglycan.

PubMed ID: 23723439

DOI: 10.1093/glycob/cwt043

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24256719

Title: AGO61-dependent GlcNAc modification primes the formation of functional glycans on alpha-dystroglycan.

PubMed ID: 24256719

DOI: 10.1038/srep03288

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21388311

Title: A dystroglycan mutation associated with limb-girdle muscular dystrophy.

PubMed ID: 21388311

DOI: 10.1056/nejmoa1006939

PubMed ID: 24052401

Title: Homozygous dystroglycan mutation associated with a novel muscle-eye-brain disease-like phenotype with multicystic leucodystrophy.

PubMed ID: 24052401

DOI: 10.1007/s10048-013-0374-9

PubMed ID: 25503980

Title: DAG1 mutations associated with asymptomatic hyperCKemia and hypoglycosylation of alpha-dystroglycan.

PubMed ID: 25503980

DOI: 10.1212/wnl.0000000000001162

PubMed ID: 25934851

Title: Absence of alpha- and beta-dystroglycan is associated with Walker-Warburg syndrome.

PubMed ID: 25934851

DOI: 10.1212/wnl.0000000000001615

PubMed ID: 26848865

Title: CD93 and dystroglycan cooperation in human endothelial cell adhesion and migration adhesion and migration.

PubMed ID: 26848865

DOI: 10.18632/oncotarget.7136

PubMed ID: 10932245

Title: Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.

PubMed ID: 10932245

DOI: 10.1038/77923

PubMed ID: 27493216

Title: Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of alpha-dystroglycan.

PubMed ID: 27493216

DOI: 10.1073/pnas.1525545113

PubMed ID: 28781947

Title: Structural flexibility of human alpha-dystroglycan.

PubMed ID: 28781947

DOI: 10.1002/2211-5463.12259

Sequence Information:

  • Length: 895
  • Mass: 97441
  • Checksum: 3AF6CBB0DCF91962
  • Sequence:
    • MRMSVGLSLL LPLSGRTFLL LLSVVMAQSH WPSEPSEAVR DWENQLEASM HSVLSDLHEA 
VPTVVGIPDG TAVVGRSFRV TIPTDLIASS GDIIKVSAAG KEALPSWLHW DSQSHTLEGL 
PLDTDKGVHY ISVSATRLGA NGSHIPQTSS VFSIEVYPED HSELQSVRTA SPDPGEVVSS 
ACAADEPVTV LTVILDADLT KMTPKQRIDL LHRMRSFSEV ELHNMKLVPV VNNRLFDMSA 
FMAGPGNAKK VVENGALLSW KLGCSLNQNS VPDIHGVEAP AREGAMSAQL GYPVVGWHIA 
NKKPPLPKRV RRQIHATPTP VTAIGPPTTA IQEPPSRIVP TPTSPAIAPP TETMAPPVRD 
PVPGKPTVTI RTRGAIIQTP TLGPIQPTRV SEAGTTVPGQ IRPTMTIPGY VEPTAVATPP 
TTTTKKPRVS TPKPATPSTD STTTTTRRPT KKPRTPRPVP RVTTKVSITR LETASPPTRI 
RTTTSGVPRG GEPNQRPELK NHIDRVDAWV GTYFEVKIPS DTFYDHEDTT TDKLKLTLKL 
REQQLVGEKS WVQFNSNSQL MYGLPDSSHV GKHEYFMHAT DKGGLSAVDA FEIHVHRRPQ 
GDRAPARFKA KFVGDPALVL NDIHKKIALV KKLAFAFGDR NCSTITLQNI TRGSIVVEWT 
NNTLPLEPCP KEQIAGLSRR IAEDDGKPRP AFSNALEPDF KATSITVTGS GSCRHLQFIP 
VVPPRRVPSE APPTEVPDRD PEKSSEDDVY LHTVIPAVVV AAILLIAGII AMICYRKKRK 
GKLTLEDQAT FIKKGVPIIF ADELDDSKPP PSSSMPLILQ EEKAPLPPPE YPNQSVPETT 
PLNQDTMGEY TPLRDEDPNA PPYQPPPPFT APMEGKGSRP KNMTPYRSPP PYVPP