Details for: DDX11

Gene ID: 1663

Symbol: DDX11

Ensembl ID: ENSG00000013573

Description: DEAD/H-box helicase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 51.1748
    Cell Significance Index: -7.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.5437
    Cell Significance Index: -10.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.8057
    Cell Significance Index: -10.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.6289
    Cell Significance Index: -12.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8040
    Cell Significance Index: -10.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3638
    Cell Significance Index: -11.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8864
    Cell Significance Index: -11.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.7349
    Cell Significance Index: -8.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3988
    Cell Significance Index: -5.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8082
    Cell Significance Index: 178.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3020
    Cell Significance Index: 247.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9801
    Cell Significance Index: 27.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9472
    Cell Significance Index: 187.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7366
    Cell Significance Index: 80.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7093
    Cell Significance Index: 115.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6982
    Cell Significance Index: 41.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6277
    Cell Significance Index: 16.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6107
    Cell Significance Index: 17.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5995
    Cell Significance Index: 541.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4859
    Cell Significance Index: 57.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4602
    Cell Significance Index: 11.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4205
    Cell Significance Index: 19.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3853
    Cell Significance Index: 20.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3541
    Cell Significance Index: 41.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3484
    Cell Significance Index: 9.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3131
    Cell Significance Index: 17.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2953
    Cell Significance Index: 20.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2880
    Cell Significance Index: 6.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2820
    Cell Significance Index: 50.8300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2772
    Cell Significance Index: 1.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2705
    Cell Significance Index: 9.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2635
    Cell Significance Index: 16.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2408
    Cell Significance Index: 4.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2360
    Cell Significance Index: 6.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1627
    Cell Significance Index: 32.6300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1603
    Cell Significance Index: 1.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1378
    Cell Significance Index: 1.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1309
    Cell Significance Index: 46.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1287
    Cell Significance Index: 15.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1242
    Cell Significance Index: 1.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1208
    Cell Significance Index: 3.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1185
    Cell Significance Index: 64.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0859
    Cell Significance Index: 3.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0811
    Cell Significance Index: 5.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0755
    Cell Significance Index: 0.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0695
    Cell Significance Index: 3.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0524
    Cell Significance Index: 7.1900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0480
    Cell Significance Index: 0.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0461
    Cell Significance Index: 3.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0427
    Cell Significance Index: 0.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0413
    Cell Significance Index: 18.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0329
    Cell Significance Index: 5.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0197
    Cell Significance Index: 1.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0153
    Cell Significance Index: 10.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0114
    Cell Significance Index: 21.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0089
    Cell Significance Index: 0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0062
    Cell Significance Index: 9.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0053
    Cell Significance Index: 9.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0008
    Cell Significance Index: 0.1000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0092
    Cell Significance Index: -5.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0121
    Cell Significance Index: -5.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0125
    Cell Significance Index: -9.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0133
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0179
    Cell Significance Index: -10.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0199
    Cell Significance Index: -12.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0217
    Cell Significance Index: -6.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0219
    Cell Significance Index: -0.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0220
    Cell Significance Index: -2.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0241
    Cell Significance Index: -3.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0279
    Cell Significance Index: -0.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0318
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0385
    Cell Significance Index: -4.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0573
    Cell Significance Index: -8.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0573
    Cell Significance Index: -12.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0589
    Cell Significance Index: -4.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0635
    Cell Significance Index: -4.7300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0647
    Cell Significance Index: -0.8300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0852
    Cell Significance Index: -2.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0961
    Cell Significance Index: -10.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1279
    Cell Significance Index: -7.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1288
    Cell Significance Index: -2.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1293
    Cell Significance Index: -8.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1382
    Cell Significance Index: -2.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1410
    Cell Significance Index: -1.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1435
    Cell Significance Index: -11.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1561
    Cell Significance Index: -6.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1649
    Cell Significance Index: -3.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1751
    Cell Significance Index: -3.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1786
    Cell Significance Index: -4.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1810
    Cell Significance Index: -9.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1839
    Cell Significance Index: -3.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1844
    Cell Significance Index: -4.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1944
    Cell Significance Index: -7.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2100
    Cell Significance Index: -6.0200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2130
    Cell Significance Index: -3.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2318
    Cell Significance Index: -5.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DDX11 shares several key characteristics with other DEAD/H-box helicases, including: 1. **Helicase activity**: DDX11 possesses 5'-3' DNA helicase activity, which enables it to unwind and separate DNA strands. 2. **ATP-dependent activity**: DDX11 exhibits ATP-dependent activity on both DNA and RNA, indicating its role in RNA metabolism and transcriptional regulation. 3. **DNA binding**: DDX11 binds to single-stranded and double-stranded DNA, suggesting its involvement in DNA replication, repair, and transcription. 4. **Regulation of chromatin binding**: DDX11 positively regulates chromatin binding, which may contribute to its role in transcriptional regulation and chromatin remodeling. **Pathways and Functions** DDX11 is involved in several key cellular pathways, including: 1. **DNA replication and repair**: DDX11 participates in the unwinding and separation of DNA strands during replication and repair, ensuring accurate DNA replication and preventing genome instability. 2. **Transcriptional regulation**: DDX11 regulates transcription by unwinding chromatin and facilitating the access of transcription factors to specific DNA sequences. 3. **Stress response and damage response**: DDX11 is activated in response to cellular stress and damage, suggesting its role in maintaining genomic stability and cellular homeostasis. 4. **Cellular responses to stimuli**: DDX11 is involved in various cellular responses to stimuli, including the activation of chaperones and the regulation of protein binding. **Clinical Significance** DDX11 has been implicated in various diseases and disorders, including: 1. **Cancer**: DDX11 has been found to be overexpressed in several types of cancer, suggesting its role in tumorigenesis and cancer progression. 2. **Neurological disorders**: DDX11 has been implicated in neurological disorders, such as autism and schizophrenia, suggesting its role in neuronal development and function. 3. **Genetic disorders**: DDX11 mutations have been associated with genetic disorders, such as Fanconi anemia and Bloom syndrome, highlighting its importance in genome stability and repair. In conclusion, DDX11 is a multifunctional gene that plays a critical role in various cellular processes, including DNA replication, repair, and transcription. Its involvement in disease and disorder suggests its clinical significance and potential as a therapeutic target. Further research is needed to fully elucidate the functions and implications of DDX11 in human disease.

Genular Protein ID: 970077289

Symbol: DDX11_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96FC9 Q13333 Q86VQ4 Q86W62 Q92498 Q92770 Q92998 Q92999

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CPTC 1 CTD 1 ChEBI 12 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 5 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 1 SMART 2 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8798685

Title: The human homologue of the yeast CHL1 gene is a novel keratinocyte growth factor regulated gene.

PubMed ID: 8798685

DOI: 10.1074/jbc.271.40.24337

PubMed ID: 9013641

Title: Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.

PubMed ID: 9013641

DOI: 10.1074/jbc.272.6.3823

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10648783

Title: Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase.

PubMed ID: 10648783

DOI: 10.1093/nar/28.4.917

PubMed ID: 17105772

Title: The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.

PubMed ID: 17105772

DOI: 10.1242/jcs.03262

PubMed ID: 17189189

Title: ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance.

PubMed ID: 17189189

DOI: 10.1016/j.molcel.2006.11.005

PubMed ID: 18499658

Title: Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.

PubMed ID: 18499658

DOI: 10.1074/jbc.m802696200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20137776

Title: Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1.

PubMed ID: 20137776

DOI: 10.1016/j.ajhg.2010.01.008

PubMed ID: 20124417

Title: Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion.

PubMed ID: 20124417

DOI: 10.1242/jcs.057984

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21854770

Title: Mammalian ChlR1 has a role in heterochromatin organization.

PubMed ID: 21854770

DOI: 10.1016/j.yexcr.2011.08.006

PubMed ID: 22102414

Title: Biochemical characterization of Warsaw breakage syndrome helicase.

PubMed ID: 22102414

DOI: 10.1074/jbc.m111.276022

PubMed ID: 23116066

Title: The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas.

PubMed ID: 23116066

DOI: 10.1186/1476-4598-11-82

PubMed ID: 23797032

Title: Roles of ChlR1 DNA helicase in replication recovery from DNA damage.

PubMed ID: 23797032

DOI: 10.1016/j.yexcr.2013.06.005

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26089203

Title: The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development.

PubMed ID: 26089203

DOI: 10.1093/hmg/ddv213

PubMed ID: 27477908

Title: A Long Noncoding RNA Regulates Sister Chromatid Cohesion.

PubMed ID: 27477908

DOI: 10.1016/j.molcel.2016.06.031

PubMed ID: 26503245

Title: Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway.

PubMed ID: 26503245

DOI: 10.1093/nar/gkv1112

PubMed ID: 32705708

Title: Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.

PubMed ID: 32705708

DOI: 10.15252/embj.2019104185

PubMed ID: 23033317

Title: Identification and biochemical characterization of a novel mutation in DDX11 causing warsaw breakage syndrome.

PubMed ID: 23033317

DOI: 10.1002/humu.22226

Sequence Information:

  • Length: 970
  • Mass: 108313
  • Checksum: 5BF49FE74E912B48
  • Sequence:
    • MANETQKVGA IHFPFPFTPY SIQEDFMAEL YRVLEAGKIG IFESPTGTGK SLSLICGALS 
WLRDFEQKKR EEEARLLETG TGPLHDEKDE SLCLSSSCEG AAGTPRPAGE PAWVTQFVQK 
KEERDLVDRL KAEQARRKQR EERLQQLQHR VQLKYAAKRL RQEEEERENL LRLSREMLET 
GPEAERLEQL ESGEEELVLA EYESDEEKKV ASRVDEDEDD LEEEHITKIY YCSRTHSQLA 
QFVHEVKKSP FGKDVRLVSL GSRQNLCVNE DVKSLGSVQL INDRCVDMQR SRHEKKKGAE 
EEKPKRRRQE KQAACPFYNH EQMGLLRDEA LAEVKDMEQL LALGKEARAC PYYGSRLAIP 
AAQLVVLPYQ MLLHAATRQA AGIRLQDQVV IIDEAHNLID TITGMHSVEV SGSQLCQAHS 
QLLQYVERYG KRLKAKNLMY LKQILYLLEK FVAVLGGNIK QNPNTQSLSQ TGTELKTIND 
FLFQSQIDNI NLFKVQRYCE KSMISRKLFG FTERYGAVFS SREQPKLAGF QQFLQSLQPR 
TTEALAAPAD ESQASTLRPA SPLMHIQGFL AALTTANQDG RVILSRQGSL SQSTLKFLLL 
NPAVHFAQVV KECRAVVIAG GTMQPVSDFR QQLLACAGVE AERVVEFSCG HVIPPDNILP 
LVICSGISNQ PLEFTFQKRE LPQMMDEVGR ILCNLCGVVP GGVVCFFPSY EYLRQVHAHW 
EKGGLLGRLA ARKKIFQEPK SAHQVEQVLL AYSRCIQACG QERGQVTGAL LLSVVGGKMS 
EGINFSDNLG RCVVMVGMPF PNIRSAELQE KMAYLDQTLS PRPGTPREGS GGEPVHEGRQ 
PVHRQGHQAP EGFCQRSAPG PAICPAPCPG QAAGLDPSPC GGQSYLWPRH CCCAEVSPGE 
VGLFLMGNHT TAWRRALPLS CPLETVFVVG VVCGDPVTKV KPRRRVWSPE CCQDPGTGVS 
SRRRKWGNPE

Genular Protein ID: 3463577510

Symbol: Q2NKM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2NKM7

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 InterPro 7 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 3 SAM 2 SMART 2 SUPFAM 1 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 906
  • Mass: 101622
  • Checksum: 2C4916339682C62B
  • Sequence:
    • MANETQKVGA IHFPFPFTPY SIQEDFMAEL YRVLEAGKIG IFESPTGTGK SLSLICGALS 
WLRDFEQKKR EEEARLLETG TGPLHDEKDE SLCLSSSCEG AAGTPRPAGE PAWVTQFVQK 
KEERDLVDRL KAEQARRKQR EERLQQLQHR VQLKYAAKRL RQEEEERENL LRLSREMLET 
GPEAERLEQL ESGEEELVLA EYESDEEKKV ASRVDEDEDD LEEEHITKIY YCSRTHSQLA 
QFVHEVKKSP FGKDVRLVSL GSRQNLCVNE DVKSLGSVQL INDRCVDMQR SRHEKKKGAE 
EEKPKRRRQE KQAACPFYNH EQMGLLRDEA LAEVKDMEQL LALGKEARAC PYYGSRLAIP 
AAQLVVLPYQ MLLHAATRQA AGIRLQDQVV IIDEAHNLID TITGMHSVEV SGSQLCQAHS 
QLLQYVERYG KRLKAKNLMY LKQILYLLEK FVAVLGGNIK QNPNTQSLSQ TGTELKTIND 
FLFQSQIDNI NLFKVQRYCE KSMISRKLFG FTERYGAVFS SREQPKLAGF QQFLQSLQPR 
TTEALAAPAD ESQASVPQPA SPLMHIEGFL AALTTANQDG RVILSRQGSL SQSTLKFLLL 
NPAVHFAQVV KECRAVVIAG GTMQPVSDFR QQLLACAGVE AERVVEFSCG HVIPPDNILP 
LVICIGVSNQ PLEFTFQKRD LPQMMDEVGR ILCNLCSVVS GGVVCFFPSY EYLRQVHAHW 
EKGGLLGHLA ARKKIFQEPK SAHQVEQVLL AYSRCIQACG QERGPVTGAL LLSVVGGKMS 
EGINFSDNLG RCVVMVGMPF PNIRSAELQE KMAYLDQTLP RAPGQAPPGK ALVENLCMKA 
VNQSIGRAIR HQKDFASIVL LDQRYARPPV LAKLPAWIRA RVEVKATFGP AIAAVQKFHR 
EKSASS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.