Details for: DLX6

Gene ID: 1750

Symbol: DLX6

Ensembl ID: ENSG00000006377

Description: distal-less homeobox 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.9719
    Cell Significance Index: 45.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3545
    Cell Significance Index: 173.6400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.9487
    Cell Significance Index: 8.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5710
    Cell Significance Index: 13.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4269
    Cell Significance Index: 26.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3769
    Cell Significance Index: 205.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2303
    Cell Significance Index: 6.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2123
    Cell Significance Index: 11.0300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1658
    Cell Significance Index: 1.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1605
    Cell Significance Index: 7.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1421
    Cell Significance Index: 50.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1360
    Cell Significance Index: 26.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1239
    Cell Significance Index: 4.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0680
    Cell Significance Index: 47.0300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0631
    Cell Significance Index: 0.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0313
    Cell Significance Index: 5.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0214
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0091
    Cell Significance Index: -4.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0096
    Cell Significance Index: -5.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0128
    Cell Significance Index: -5.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0162
    Cell Significance Index: -0.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0196
    Cell Significance Index: -0.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0208
    Cell Significance Index: -5.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0251
    Cell Significance Index: -3.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0258
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0273
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0310
    Cell Significance Index: -6.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0311
    Cell Significance Index: -3.8300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0386
    Cell Significance Index: -0.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0400
    Cell Significance Index: -5.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0532
    Cell Significance Index: -6.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0538
    Cell Significance Index: -1.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0538
    Cell Significance Index: -6.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0549
    Cell Significance Index: -6.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0562
    Cell Significance Index: -5.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0603
    Cell Significance Index: -1.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0643
    Cell Significance Index: -1.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0882
    Cell Significance Index: -4.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0885
    Cell Significance Index: -1.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0900
    Cell Significance Index: -6.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0998
    Cell Significance Index: -5.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1092
    Cell Significance Index: -2.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1366
    Cell Significance Index: -6.4200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1371
    Cell Significance Index: -1.7300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1542
    Cell Significance Index: -2.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1582
    Cell Significance Index: -1.5000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1615
    Cell Significance Index: -2.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1633
    Cell Significance Index: -5.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1639
    Cell Significance Index: -3.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1652
    Cell Significance Index: -6.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1654
    Cell Significance Index: -4.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1656
    Cell Significance Index: -7.2000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1702
    Cell Significance Index: -1.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1735
    Cell Significance Index: -5.6800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1748
    Cell Significance Index: -2.0900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1814
    Cell Significance Index: -3.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1850
    Cell Significance Index: -5.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1868
    Cell Significance Index: -5.9500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1876
    Cell Significance Index: -3.7400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1910
    Cell Significance Index: -1.5200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1958
    Cell Significance Index: -1.8600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2093
    Cell Significance Index: -3.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2127
    Cell Significance Index: -6.0700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2225
    Cell Significance Index: -3.5300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2232
    Cell Significance Index: -1.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2274
    Cell Significance Index: -5.9800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2352
    Cell Significance Index: -7.4400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2364
    Cell Significance Index: -4.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2389
    Cell Significance Index: -5.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2397
    Cell Significance Index: -6.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2470
    Cell Significance Index: -5.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2485
    Cell Significance Index: -6.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2493
    Cell Significance Index: -7.1500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2504
    Cell Significance Index: -6.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2666
    Cell Significance Index: -6.1600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.2679
    Cell Significance Index: -2.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2868
    Cell Significance Index: -6.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2917
    Cell Significance Index: -4.4300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2937
    Cell Significance Index: -5.0200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3095
    Cell Significance Index: -3.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3105
    Cell Significance Index: -6.0700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.3211
    Cell Significance Index: -3.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3282
    Cell Significance Index: -5.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3430
    Cell Significance Index: -5.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3514
    Cell Significance Index: -5.9200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.3542
    Cell Significance Index: -3.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3566
    Cell Significance Index: -6.9600
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.3664
    Cell Significance Index: -4.2800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3738
    Cell Significance Index: -4.8300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3740
    Cell Significance Index: -6.2900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3787
    Cell Significance Index: -6.1100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3803
    Cell Significance Index: -5.6900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3811
    Cell Significance Index: -6.2800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3833
    Cell Significance Index: -5.0200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.3876
    Cell Significance Index: -3.1300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.3890
    Cell Significance Index: -3.6100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3945
    Cell Significance Index: -6.3900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3981
    Cell Significance Index: -4.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DLX6 is a transcription factor that belongs to the homeobox gene family, which plays a pivotal role in the regulation of gene expression during development. The DLX6 protein is a transcriptional regulator that interacts with specific DNA sequences to modulate the expression of target genes involved in embryonic development, tissue homeostasis, and cell differentiation. DLX6 is specifically expressed in various cell types, including blood vessel endothelial cells, goblet cells, T cells, and neural progenitor cells. **Pathways and Functions** DLX6 is involved in multiple signaling pathways that regulate embryonic development, tissue homeostasis, and cell differentiation. Some of the key pathways and functions of DLX6 include: 1. **Morphogenesis**: DLX6 is involved in the regulation of embryonic morphogenesis, including the development of the inner ear, nervous system, and skeletal system. 2. **Cell differentiation**: DLX6 regulates the differentiation of various cell types, including blood vessel endothelial cells, goblet cells, and neural progenitor cells. 3. **Transcriptional regulation**: DLX6 acts as a transcriptional regulator by interacting with specific DNA sequences to modulate the expression of target genes involved in embryonic development and tissue homeostasis. 4. **Epithelial cell proliferation**: DLX6 is involved in the regulation of epithelial cell proliferation, including the regulation of Runx2 expression and activity. **Clinical Significance** Dysregulation of DLX6 expression has been implicated in various developmental disorders and diseases, including: 1. **Embryonic development disorders**: Alterations in DLX6 expression have been linked to embryonic development disorders, such as limb abnormalities and neural tube defects. 2. **Cancer**: DLX6 has been implicated in the development and progression of various cancers, including leukemia, lymphoma, and solid tumors. 3. **Neurological disorders**: DLX6 has been linked to neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. 4. **Immunological disorders**: DLX6 has been implicated in immunological disorders, including T cell dysfunction and autoimmune diseases. In conclusion, DLX6 is a critical regulator of embryonic development, tissue homeostasis, and cell differentiation. Its dysregulation has been implicated in various developmental disorders and diseases, highlighting the importance of DLX6 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which DLX6 regulates embryonic development and tissue homeostasis, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2067203485

Symbol: DLX6_HUMAN

Name: Homeobox protein DLX-6

UniProtKB Accession Codes:

P56179 A4D1I2 B3KSQ0 J3KR92 Q3ZAR6 Q9UPL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 7907794

Title: Cloning and characterization of two members of the vertebrate Dlx gene family.

PubMed ID: 7907794

DOI: 10.1073/pnas.91.6.2250

Sequence Information:

  • Length: 175
  • Mass: 19708
  • Checksum: F5552738D7E0CB84
  • Sequence:
    • MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR KPRTIYSSLQ 
LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK RSKFKKLLKQ GSNPHESDPL 
QGSAALSPRS PALPPVWDVS ASAKGVSMPP NSYMPGYSHW YSSPHQDTMQ RPQMM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.