Details for: DLX6

Gene ID: 1750

Symbol: DLX6

Ensembl ID: ENSG00000006377

Description: distal-less homeobox 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.37
    Marker Score: 2382
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.16
    Marker Score: 1994
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.95
    Marker Score: 2339
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.89
    Marker Score: 843
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1540
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3295
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.8
    Marker Score: 3331
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.75
    Marker Score: 212
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.68
    Marker Score: 983
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 514
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.64
    Marker Score: 346
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.63
    Marker Score: 21704
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.59
    Marker Score: 659
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.58
    Marker Score: 168
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.56
    Marker Score: 594.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.45
    Marker Score: 1846
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.44
    Marker Score: 16576
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.43
    Marker Score: 107
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.42
    Marker Score: 549
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.37
    Marker Score: 13487
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.36
    Marker Score: 5436
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.36
    Marker Score: 1398
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.34
    Marker Score: 176
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.34
    Marker Score: 707
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.33
    Marker Score: 372
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.32
    Marker Score: 2464
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.31
    Marker Score: 142
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.31
    Marker Score: 6097
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.27
    Marker Score: 66
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.26
    Marker Score: 1203
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.26
    Marker Score: 59
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 471
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.24
    Marker Score: 117
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.23
    Marker Score: 3594
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 367
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.22
    Marker Score: 589
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 94
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 396
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 102.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.19
    Marker Score: 166
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.18
    Marker Score: 2392
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 159
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.17
    Marker Score: 281
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.17
    Marker Score: 1008
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.14
    Marker Score: 178
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 81
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.12
    Marker Score: 99
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 118
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 85
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1
    Marker Score: 5703
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.09
    Marker Score: 185
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.09
    Marker Score: 349
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.08
    Marker Score: 102
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.07
    Marker Score: 108
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.07
    Marker Score: 109
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 145
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.06
    Marker Score: 15.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 242
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 17

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Other Information

**Key characteristics:** * The DLX6 gene is a member of the DLX homeobox family of transcription factors. * It is expressed in a variety of cell types during embryonic development. * It is involved in the regulation of epithelial cell proliferation, migration, and differentiation. * It is also involved in the development of the inner ear, nervous system, and skeletal system. **Pathways and functions:** * The DLX6 gene is involved in the regulation of epithelial cell proliferation and differentiation. * It is a key regulator of the development of blood vessel endothelial cells, goblet cells, and T cells. * It is also involved in the development of the inner ear, nervous system, and skeletal system. * DLX6 is a key regulator of epithelial cell proliferation in the developing embryo. * It is also involved in the regulation of the differentiation of other cell types, such as goblet cells and T cells. **Clinical significance:** * Mutations in the DLX6 gene have been linked to a number of human diseases, including autism, intellectual disability, and cardiovascular disease. * Studies of DLX6 mutations have also been used to understand the development of cancer. * DLX6 is a promising target for the treatment of cancer and other diseases that are caused by mutations in genes involved in epithelial cell proliferation and differentiation.

Genular Protein ID: 2067203485

Symbol: DLX6_HUMAN

Name: Homeobox protein DLX-6

UniProtKB Accession Codes:

P56179 A4D1I2 B3KSQ0 J3KR92 Q3ZAR6 Q9UPL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 7907794

Title: Cloning and characterization of two members of the vertebrate Dlx gene family.

PubMed ID: 7907794

DOI: 10.1073/pnas.91.6.2250

Sequence Information:

  • Length: 175
  • Mass: 19708
  • Checksum: F5552738D7E0CB84
  • Sequence:
    • MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR KPRTIYSSLQ 
LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK RSKFKKLLKQ GSNPHESDPL 
QGSAALSPRS PALPPVWDVS ASAKGVSMPP NSYMPGYSHW YSSPHQDTMQ RPQMM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.