Details for: DMPK

Gene ID: 1760

Symbol: DMPK

Ensembl ID: ENSG00000104936

Description: DM1 protein kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169239
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.47
    Marker Score: 3232.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.38
    Marker Score: 8316
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 847
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.27
    Marker Score: 4520
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.25
    Marker Score: 2952
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19338
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.21
    Marker Score: 1157
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.11
    Marker Score: 24704
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.04
    Marker Score: 22163
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.02
    Marker Score: 387
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.01
    Marker Score: 774
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48011
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.99
    Marker Score: 280.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.98
    Marker Score: 1516
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.92
    Marker Score: 269
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.9
    Marker Score: 8579
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.9
    Marker Score: 7691
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5075
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.88
    Marker Score: 54209
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.87
    Marker Score: 473
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.87
    Marker Score: 3524
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.83
    Marker Score: 1555
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.82
    Marker Score: 8463
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1618
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.78
    Marker Score: 7368
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.77
    Marker Score: 504
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1237
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3176
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.75
    Marker Score: 531
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.73
    Marker Score: 949
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 655
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 287
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.71
    Marker Score: 854.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 425
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.7
    Marker Score: 562
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.68
    Marker Score: 1596
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.68
    Marker Score: 2621
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.67
    Marker Score: 24886
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.67
    Marker Score: 213
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.67
    Marker Score: 210
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.67
    Marker Score: 390
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.66
    Marker Score: 11783
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.66
    Marker Score: 1396
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.64
    Marker Score: 1079
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 554
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.64
    Marker Score: 1224
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.61
    Marker Score: 23131
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.6
    Marker Score: 643
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.6
    Marker Score: 453
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.59
    Marker Score: 797
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.57
    Marker Score: 2379
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.57
    Marker Score: 254
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.57
    Marker Score: 11411
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.57
    Marker Score: 146
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.57
    Marker Score: 1419
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.56
    Marker Score: 366
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.56
    Marker Score: 673
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.56
    Marker Score: 639
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.55
    Marker Score: 4236
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.55
    Marker Score: 277.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.55
    Marker Score: 2297
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.55
    Marker Score: 954
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.54
    Marker Score: 139
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.53
    Marker Score: 568
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.52
    Marker Score: 7779
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.49
    Marker Score: 605.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.48
    Marker Score: 684
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.48
    Marker Score: 282
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.48
    Marker Score: 247
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.47
    Marker Score: 133
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.46
    Marker Score: 525
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.46
    Marker Score: 1309
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.45
    Marker Score: 1593.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.45
    Marker Score: 131
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 292
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.44
    Marker Score: 423
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.44
    Marker Score: 152
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 140
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.43
    Marker Score: 239
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.43
    Marker Score: 528
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.43
    Marker Score: 112
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.42
    Marker Score: 227
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.42
    Marker Score: 4250
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.42
    Marker Score: 137
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.41
    Marker Score: 153
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.41
    Marker Score: 216

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Other Information

**Key characteristics:** - DMPK is a serine/threonine kinase with a unique structure and function. - It is a key regulator of cardiac contraction and relaxation through its effects on cardiac ion channels and cytoskeletal dynamics. - It also plays a role in cell migration, proliferation, and survival. - It is a regulator of myotube differentiation and skeletal muscle contraction. **Pathways and functions:** - DMPK is involved in multiple signaling pathways, including the MAPK/ERK pathway, the calcium/calmodulin pathway, and the cardiac conduction pathway. - It regulates the expression of various genes involved in cardiac function, including those encoding cardiac ion channels, cytoskeletal proteins, and growth factors. - It is also involved in the regulation of blood pressure, heart rate, and myocardial contractility. **Clinical significance:** - Mutations in the DMPK gene have been linked to human cardiac diseases, including cardiomyopathy and heart failure. - Inhibition of DMPK has been shown to improve cardiac function and reduce heart failure in experimental models. - Therefore, DMPK is a promising target for the treatment of cardiovascular diseases. Overall, the DMPK protein kinase is a critical regulator of cardiac function and disease progression. Its dysregulation is implicated in various cardiovascular diseases, highlighting its importance in maintaining cardiovascular health and preventing heart failure.

Genular Protein ID: 1312068734

Symbol: DMPK_HUMAN

Name: Myotonin-protein kinase

UniProtKB Accession Codes:

Q09013 E5KR08 Q16205 Q6P5Z6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 60 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 12 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 6 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1546326

Title: An unstable triplet repeat in a gene related to myotonic muscular dystrophy.

PubMed ID: 1546326

DOI: 10.1126/science.1546326

PubMed ID: 7905855

Title: Genomic organization and transcriptional units at the myotonic dystrophy locus.

PubMed ID: 7905855

DOI: 10.1016/s0888-7543(05)80372-6

PubMed ID: 8499920

Title: Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene.

PubMed ID: 8499920

DOI: 10.1093/hmg/2.3.299

PubMed ID: 8469976

Title: Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy.

PubMed ID: 8469976

DOI: 10.1126/science.8469976

PubMed ID: 8076686

Title: Expression of a novel human myotonin protein kinase (MtPK) cDNA clone which encodes a protein with a thymopoietin-like domain in COS cells.

PubMed ID: 8076686

DOI: 10.1016/0014-5793(94)00808-6

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1310900

Title: Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

PubMed ID: 1310900

DOI: 10.1016/0092-8674(92)90154-5

PubMed ID: 7488138

Title: Different expression of the myotonin protein kinase gene in discrete areas of human brain.

PubMed ID: 7488138

DOI: 10.1006/bbrc.1995.2649

PubMed ID: 1302022

Title: Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs.

PubMed ID: 1302022

DOI: 10.1038/ng0792-261

PubMed ID: 9490724

Title: MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase.

PubMed ID: 9490724

DOI: 10.1083/jcb.140.5.1113

PubMed ID: 10913253

Title: Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition.

PubMed ID: 10913253

DOI: 10.1021/bi992142f

PubMed ID: 10869570

Title: Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase.

PubMed ID: 10869570

DOI: 10.1016/s0014-5793(00)01692-6

PubMed ID: 10699184

Title: Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties.

PubMed ID: 10699184

DOI: 10.1093/hmg/9.4.605

PubMed ID: 10811636

Title: Phospholemman is a substrate for myotonic dystrophy protein kinase.

PubMed ID: 10811636

DOI: 10.1074/jbc.m000899200

PubMed ID: 11287000

Title: Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.

PubMed ID: 11287000

DOI: 10.1016/s0014-5793(01)02283-9

PubMed ID: 12832055

Title: Homodimerization through coiled-coil regions enhances activity of the myotonic dystrophy protein kinase.

PubMed ID: 12832055

DOI: 10.1016/s0014-5793(03)00601-x

PubMed ID: 15598648

Title: Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.

PubMed ID: 15598648

DOI: 10.1074/jbc.m412845200

PubMed ID: 15684391

Title: Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors.

PubMed ID: 15684391

DOI: 10.1128/mcb.25.4.1402-1414.2005

PubMed ID: 19514047

Title: Highly unstable sequence interruptions of the CTG repeat in the myotonic dystrophy gene.

PubMed ID: 19514047

DOI: 10.1002/ajmg.a.32987

PubMed ID: 21457715

Title: Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.

PubMed ID: 21457715

DOI: 10.1016/j.febslet.2011.03.054

PubMed ID: 21949239

Title: Myotonic dystrophy protein kinase is critical for nuclear envelope integrity.

PubMed ID: 21949239

DOI: 10.1074/jbc.m111.241455

PubMed ID: 15583383

Title: Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase.

PubMed ID: 15583383

DOI: 10.1107/s0907444904026873

PubMed ID: 16770013

Title: Molecular insights into the self-assembly mechanism of dystrophia myotonica kinase.

PubMed ID: 16770013

DOI: 10.1096/fj.05-5262com

PubMed ID: 19309729

Title: Structure of dystrophia myotonica protein kinase.

PubMed ID: 19309729

DOI: 10.1002/pro.82

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 629
  • Mass: 69385
  • Checksum: 46783ED4AE65B493
  • Sequence:
    • MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF LQWAEPIVVR 
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 
DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP 
EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP 
LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS VPPFTPDFEG 
ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF VGYSYSCMAL RDSEVPGPTP 
MELEAEQLLE PHVQAPSLEP SVSPQDETAE VAVPAAVPAA EAEAEVTLRE LQEALEEEVL 
TRQSLSREME AIRTDNQNFA SQLREAEARN RDLEAHVRQL QERMELLQAE GATAVTGVPS 
PRATDPPSHL DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS LLLFAVVLSR 
AAALGCIGLV AHAGQLTAVW RRPGAARAP

Genular Protein ID: 1386032635

Symbol: E5KR07_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KR07

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 EC 2 EMBL 43 ExpressionAtlas 1 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 624
  • Mass: 69028
  • Checksum: 7ECA31ED9A84E7E1
  • Sequence:
    • MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF LQWAEPIVVR 
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 
DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP 
EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP 
LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS VPPFTPDFEG 
ATDTCNFDLV EDGLTAMETL SDIREGAPLG VHLPFVGYSY SCMALRDSEV PGPTPMELEA 
EQLLEPHVQA PSLEPSVSPQ DETAEVAVPA AVPAAEAEAE VTLRELQEAL EEEVLTRQSL 
SREMEAIRTD NQNFASQLRE AEARNRDLEA HVRQLQERME LLQAEGATAV TGVPSPRATD 
PPSHLDGPPA VAVGQCPLVG PGPMHRRHLL LPARVPRPGL SEALSLLLFA VVLSRAAALG 
CIGLVAHAGQ LTAVWRRPGA ARAP

Genular Protein ID: 3733207894

Symbol: B4DZE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DZE2

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 11 DNASU 1 EC 2 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 530
  • Mass: 59473
  • Checksum: CD312B295FFB71A0
  • Sequence:
    • MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF LQWAEPIVVR 
LKEVRLQRDD FEILKVIGRG AFIEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 
DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP 
EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP 
LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS VPPFTPDFEG 
ATDTCNFDLV EDGLTAMETL SDIREGAPLG VHLPFVGYSY SCMALRDSEV PGPTPMELEA 
EQLLEPHVQA PSLEPSVSPQ DETAEVAVPA AVPAAEAEAE VTLRELQEAL EEEVLTRQSL 
SREMEAIRTD NQNFASQLRE AEARNRDLEA HVRQLQERME LLQAEGATGP

Genular Protein ID: 274446697

Symbol: I6L989_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6L989

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 EC 2 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 3 Rhea 6 SAM 2 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 655
  • Mass: 71161
  • Checksum: 7B7ABCA0CD6A0D5D
  • Sequence:
    • MVLPVQHVSR GAAEAAPAAG VGPGLPGAGA PARPSPGRPP GAGRLRTGPG QVRGRLLAVG 
PKSRVFQSVV QEPPASESRA EPIVVRLKEV RLQRDDFEIL KVIGRGAFSE VAVVKMKQTG 
QVYAMKIMNK WDMLKRGEVS CFREERDVLV NGDQRWITQL HFAFQDENYL YLVMEYYVGG 
DLLTLLSKFG ERIPAEMARF YLAEIVMAID SVHRLGYVHR DIKPDNILLD RCGHIRLADF 
GSCLKLRADG TVRSLVAVGT PDYLSPEILQ AVGGGPGTGS YGPECDWWAL GVFAYEMFYG 
QTPFYADSTA ETYGKIVHYK EHLSLPLVDE GVPEEARDFI QRLLCPPETR LGRGGAGDFR 
THPFFFGLDW DGLRDSVPPF TPDFEGATDT CNFDLVEDGL TAMVSGGGET LSDIREGAPL 
GVHLPFVGYS YSCMALRDSE VPGPTPMELE AEQLLEPHVQ APSLEPSVSP QDETAEVAVP 
AAVPAAEAEA EVTLRELQEA LEEEVLTRQS LSREMEAIRT DNQNFASQLR EAEARNRDLE 
AHVRQLQERM ELLQAEGATA VTGVPSPRAT DPPSHLDGPT AVAVGQCPLV GPGPMHRRHL 
LLPARVPRPG LSEALSLLLF AVVLSRAAAL GCIGLVAHAG QLTAVWRRPG AARAP

Genular Protein ID: 656382361

Symbol: E5KR05_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KR05

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 DNASU 1 EC 2 EMBL 41 ExpressionAtlas 1 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 625
  • Mass: 69592
  • Checksum: 10EA0187F4AD4B7C
  • Sequence:
    • MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF LQWAEPIVVR 
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 
DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP 
EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP 
LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS VPPFTPDFEG 
ATDTCNFDLV EDGLTAMETL SDIREGAPLG VHLPFVGYSY SCMALRDSEV PGPTPMELEA 
EQLLEPHVQA PSLEPSVSPQ DETAEVAVPA AVPAAEAEAE VTLRELQEAL EEEVLTRQSL 
SREMEAIRTD NQNFASQLRE AEARNRDLEA HVRQLQERME LLQAEGATAV TGVPSPRATD 
PPSHMAPRPW LWASARWWGQ APCTAATCCS LPGSLGLAYR RRFPCSCSPL FCLVPPPWAA 
LGWWPTPANS PQSGAAQEPP ALPEP

Genular Protein ID: 2305844622

Symbol: B4DM55_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DM55

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 11 DNASU 1 EC 2 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 541
  • Mass: 59827
  • Checksum: EFC010C7458F8A9E
  • Sequence:
    • MKQTGQVYAM KIMNKWDMLK RGEVSCFREE RDVLVNGDRR WITQLHFAFQ DENYLYLVME 
YYVGGDLLTL LSKFGERIPA EMARFYLAEI VMAIDSVHRL GYVHRDIKPD NILLDRCGHI 
RLADFGSCLK LRADGTVRSL VAVGTPDYLS PEILQAVGGG PGTGSYGPEC DWWALGVFAY 
EMFYGQTPFY ADSTAETYGK IVHYKEHLSL PLVDEGVPEE ARDFIQRLLC PPETRLGRGG 
AGDFRTHPFF FGLDWDGLRD SVPPFTPDFE GATDTCNFDL VEDGLTAMVS GGGETLSDIR 
EGAPLGVHLP FVGYSYSCMA LRDSEVPGPT PMELEAEQLL EPHVQAPSLE PSVSPQDETA 
EVAVPAAVPA AEAEAEVTLR ELQEALEEEV LTRQSLSREM EAIRTDNQNF ASQLREAEAR 
NRDLEAHVRQ LQERMELLQA EGATAVTGVP SPRATDPPSH MAPRPWLWAS ARWWGQAPCT 
AATCCSLPGS LGLAYRRRFP CSCSPLFCLV PPPWAALGWW PTPANSPQSG AAQEPPALPG 
P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.