Details for: DNAH5

Gene ID: 1767

Symbol: DNAH5

Ensembl ID: ENSG00000039139

Description: dynein axonemal heavy chain 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.0920
    Cell Significance Index: -10.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.5110
    Cell Significance Index: -10.9900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.3464
    Cell Significance Index: 14.4400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.5532
    Cell Significance Index: 1.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4258
    Cell Significance Index: 30.8900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.4157
    Cell Significance Index: 13.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3059
    Cell Significance Index: 41.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1066
    Cell Significance Index: 67.8500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.0647
    Cell Significance Index: 4.0100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.7796
    Cell Significance Index: 7.7200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4642
    Cell Significance Index: 7.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4535
    Cell Significance Index: 20.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4409
    Cell Significance Index: 83.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4276
    Cell Significance Index: 9.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4215
    Cell Significance Index: 7.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4000
    Cell Significance Index: 20.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3509
    Cell Significance Index: 70.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3427
    Cell Significance Index: 187.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3086
    Cell Significance Index: 213.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3005
    Cell Significance Index: 187.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2689
    Cell Significance Index: 18.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2674
    Cell Significance Index: 19.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2096
    Cell Significance Index: 20.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1840
    Cell Significance Index: 4.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1739
    Cell Significance Index: 157.0100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.1459
    Cell Significance Index: 1.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1424
    Cell Significance Index: 8.5500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.1361
    Cell Significance Index: 1.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1324
    Cell Significance Index: 14.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1182
    Cell Significance Index: 160.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1068
    Cell Significance Index: 17.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0878
    Cell Significance Index: 31.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0335
    Cell Significance Index: 6.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0287
    Cell Significance Index: 18.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0283
    Cell Significance Index: 5.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0249
    Cell Significance Index: 0.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0236
    Cell Significance Index: 36.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0070
    Cell Significance Index: 0.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0048
    Cell Significance Index: 0.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0044
    Cell Significance Index: 3.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0067
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0077
    Cell Significance Index: -4.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0126
    Cell Significance Index: -9.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0130
    Cell Significance Index: -0.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0151
    Cell Significance Index: -0.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0197
    Cell Significance Index: -8.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0229
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0262
    Cell Significance Index: -5.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0276
    Cell Significance Index: -0.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0327
    Cell Significance Index: -9.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0346
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0599
    Cell Significance Index: -6.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0638
    Cell Significance Index: -2.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0642
    Cell Significance Index: -8.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0647
    Cell Significance Index: -8.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0662
    Cell Significance Index: -7.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0679
    Cell Significance Index: -9.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0702
    Cell Significance Index: -1.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0736
    Cell Significance Index: -1.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0816
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0866
    Cell Significance Index: -9.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1028
    Cell Significance Index: -10.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1060
    Cell Significance Index: -11.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1194
    Cell Significance Index: -7.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1241
    Cell Significance Index: -14.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1244
    Cell Significance Index: -2.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1312
    Cell Significance Index: -10.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1345
    Cell Significance Index: -9.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1430
    Cell Significance Index: -2.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1468
    Cell Significance Index: -6.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1498
    Cell Significance Index: -6.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1630
    Cell Significance Index: -12.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1736
    Cell Significance Index: -5.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1816
    Cell Significance Index: -3.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1848
    Cell Significance Index: -10.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2013
    Cell Significance Index: -6.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2098
    Cell Significance Index: -7.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2225
    Cell Significance Index: -11.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2338
    Cell Significance Index: -12.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2403
    Cell Significance Index: -5.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2522
    Cell Significance Index: -6.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2626
    Cell Significance Index: -6.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2900
    Cell Significance Index: -10.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3156
    Cell Significance Index: -6.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3170
    Cell Significance Index: -3.2800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3293
    Cell Significance Index: -2.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3299
    Cell Significance Index: -7.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3432
    Cell Significance Index: -8.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3446
    Cell Significance Index: -10.9000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3656
    Cell Significance Index: -7.6300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3683
    Cell Significance Index: -16.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3707
    Cell Significance Index: -8.8900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.3844
    Cell Significance Index: -4.5300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3924
    Cell Significance Index: -7.9900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3964
    Cell Significance Index: -5.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3977
    Cell Significance Index: -13.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** DNAH5 is primarily found in ciliated cells, including those of the tracheobronchial tree, lung, colon, and secondary lens fiber. Its expression is also observed in cardiac endothelial cells, mural cells, and granulocyte monocyte progenitor cells. 2. **Structural Role:** DNAH5 is a heavy chain of the dynein arm, a microtubule-based motor that propels motile cilia forward. Its unique structure allows it to interact with other dynein arms and microtubules, enabling coordinated movement and maintaining ciliary beat frequency. 3. **Function:** DNAH5 is involved in the assembly and disassembly of motile cilia, regulating their movement and function. It also plays a role in the determination of left/right symmetry and the establishment of localization in cells. **Pathways and Functions:** 1. **Motile Cilium Pathway:** DNAH5 is integral to the motile cilium pathway, which involves the coordinated movement of cilia to propagate signals, clear mucus, and maintain epithelial function. 2. **Cilia Movement Pathway:** DNAH5 regulates the movement of cilia, enabling cells to respond to their environment and maintain tissue homeostasis. 3. **Cell Motility Pathway:** DNAH5 contributes to cell motility, facilitating the movement of cells and tissues in response to various stimuli. 4. **Determination of Left/Right Symmetry:** DNAH5 is involved in the determination of left/right symmetry, a critical process in embryonic development. 5. **Establishment of Localization:** DNAH5 plays a role in the establishment of localization in cells, ensuring that specific proteins and organelles are directed to their correct locations. **Clinical Significance:** 1. **Primary Ciliary Dyskinesia (PCD):** Mutations in DNAH5 can lead to PCD, a rare genetic disorder characterized by recurrent respiratory infections, sinusitis, and infertility. PCD is often associated with immotile or dysfunctional cilia, resulting in impaired respiratory function and other symptoms. 2. **Cilia-Related Disorders:** Abnormalities in DNAH5 have been linked to other cilia-related disorders, including respiratory and gastrointestinal diseases. 3. **Cancer and Metastasis:** Dysregulation of DNAH5 has been implicated in cancer progression and metastasis, highlighting its potential as a therapeutic target. 4. **Neurological Disorders:** DNAH5 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, underscoring its role in maintaining cellular homeostasis. In conclusion, DNAH5 is a critical component of the motile cilium, playing a pivotal role in maintaining the structural integrity and function of these cilia. Its dysregulation has been implicated in various diseases, emphasizing the need for further research into the mechanisms underlying DNAH5 function and its clinical significance.

Genular Protein ID: 2201839026

Symbol: DYH5_HUMAN

Name: Dynein axonemal heavy chain 5

UniProtKB Accession Codes:

Q8TE73 Q92860 Q96L74 Q9H5S7 Q9HCG9

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 Ensembl 1 GO 23 Gene3D 14 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 12 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11788826

Title: Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry.

PubMed ID: 11788826

DOI: 10.1038/ng817

PubMed ID: 11062149

Title: Homozygosity mapping of a gene locus for primary ciliary dyskinesia on chromosome 5p and identification of the heavy dynein chain DNAH5 as a candidate gene.

PubMed ID: 11062149

DOI: 10.1165/ajrcmb.23.5.4257

PubMed ID: 8812413

Title: Multiple mouse chromosomal loci for dynein-based motility.

PubMed ID: 8812413

DOI: 10.1006/geno.1996.0422

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21496787

Title: Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1.

PubMed ID: 21496787

DOI: 10.1016/j.ajhg.2011.03.018

PubMed ID: 16627867

Title: DNAH5 mutations are a common cause of primary ciliary dyskinesia with outer dynein arm defects.

PubMed ID: 16627867

DOI: 10.1164/rccm.200601-084oc

PubMed ID: 25186273

Title: Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia.

PubMed ID: 25186273

DOI: 10.1183/09031936.00052014

PubMed ID: 31178125

Title: Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

PubMed ID: 31178125

DOI: 10.1016/j.ajhg.2019.04.015

Sequence Information:

  • Length: 4624
  • Mass: 529021
  • Checksum: B9BC9F20A4C581BE
  • Sequence:
    • MFRIGRRQLW KHSVTRVLTQ RLKGEKEAKR ALLDARHNYL FAIVASCLDL NKTEVEDAIL 
EGNQIERIDQ LFAVGGLRHL MFYYQDVEEA ETGQLGSLGG VNLVSGKIKK PKVFVTEGND 
VALTGVCVFF IRTDPSKAIT PDNIHQEVSF NMLDAADGGL LNSVRRLLSD IFIPALRATS 
HGWGELEGLQ DAANIRQEFL SSLEGFVNVL SGAQESLKEK VNLRKCDILE LKTLKEPTDY 
LTLANNPETL GKIEDCMKVW IKQTEQVLAE NNQLLKEADD VGPRAELEHW KKRLSKFNYL 
LEQLKSPDVK AVLAVLAAAK SKLLKTWREM DIRITDATNE AKDNVKYLYT LEKCCDPLYS 
SDPLSMMDAI PTLINAIKMI YSISHYYNTS EKITSLFVKV TNQIISACKA YITNNGTASI 
WNQPQDVVEE KILSAIKLKQ EYQLCFHKTK QKLKQNPNAK QFDFSEMYIF GKFETFHRRL 
AKIIDIFTTL KTYSVLQDST IEGLEDMATK YQGIVATIKK KEYNFLDQRK MDFDQDYEEF 
CKQTNDLHNE LRKFMDVTFA KIQNTNQALR MLKKFERLNI PNLGIDDKYQ LILENYGADI 
DMISKLYTKQ KYDPPLARNQ PPIAGKILWA RQLFHRIQQP MQLFQQHPAV LSTAEAKPII 
RSYNRMAKVL LEFEVLFHRA WLRQIEEIHV GLEASLLVKA PGTGELFVNF DPQILILFRE 
TECMAQMGLE VSPLATSLFQ KRDRYKRNFS NMKMMLAEYQ RVKSKIPAAI EQLIVPHLAK 
VDEALQPGLA ALTWTSLNIE AYLENTFAKI KDLELLLDRV NDLIEFRIDA ILEEMSSTPL 
CQLPQEEPLT CEEFLQMTKD LCVNGAQILH FKSSLVEEAV NELVNMLLDV EVLSEEESEK 
ISNENSVNYK NESSAKREEG NFDTLTSSIN ARANALLLTT VTRKKKETEM LGEEARELLS 
HFNHQNMDAL LKVTRNTLEA IRKRIHSSHT INFRDSNSAS NMKQNSLPIF RASVTLAIPN 
IVMAPALEDV QQTLNKAVEC IISVPKGVRQ WSSELLSKKK IQERKMAALQ SNEDSDSDVE 
MGENELQDTL EIASVNLPIP VQTKNYYKNV SENKEIVKLV SVLSTIINST KKEVITSMDC 
FKRYNHIWQK GKEEAIKTFI TQSPLLSEFE SQILYFQNLE QEINAEPEYV CVGSIALYTA 
DLKFALTAET KAWMVVIGRH CNKKYRSEME NIFMLIEEFN KKLNRPIKDL DDIRIAMAAL 
KEIREEQISI DFQVGPIEES YALLNRYGLL IAREEIDKVD TLHYAWEKLL ARAGEVQNKL 
VSLQPSFKKE LISAVEVFLQ DCHQFYLDYD LNGPMASGLK PQEASDRLIM FQNQFDNIYR 
KYITYTGGEE LFGLPATQYP QLLEIKKQLN LLQKIYTLYN SVIETVNSYY DILWSEVNIE 
KINNELLEFQ NRCRKLPRAL KDWQAFLDLK KIIDDFSECC PLLEYMASKA MMERHWERIT 
TLTGHSLDVG NESFKLRNIM EAPLLKYKEE IEDICISAVK ERDIEQKLKQ VINEWDNKTF 
TFGSFKTRGE LLLRGDSTSE IIANMEDSLM LLGSLLSNRY NMPFKAQIQK WVQYLSNSTD 
IIESWMTVQN LWIYLEAVFV GGDIAKQLPK EAKRFSNIDK SWVKIMTRAH EVPSVVQCCV 
GDETLGQLLP HLLDQLEICQ KSLTGYLEKK RLCFPRFFFV SDPALLEILG QASDSHTIQA 
HLLNVFDNIK SVKFHEKIYD RILSISSQEG ETIELDKPVM AEGNVEVWLN SLLEESQSSL 
HLVIRQAAAN IQETGFQLTE FLSSFPAQVG LLGIQMIWTR DSEEALRNAK FDKKIMQKTN 
QAFLELLNTL IDVTTRDLSS TERVKYETLI TIHVHQRDIF DDLCHMHIKS PMDFEWLKQC 
RFYFNEDSDK MMIHITDVAF IYQNEFLGCT DRLVITPLTD RCYITLAQAL GMSMGGAPAG 
PAGTGKTETT KDMGRCLGKY VVVFNCSDQM DFRGLGRIFK GLAQSGSWGC FDEFNRIDLP 
VLSVAAQQIS IILTCKKEHK KSFIFTDGDN VTMNPEFGLF LTMNPGYAGR QELPENLKIN 
FRSVAMMVPD RQIIIRVKLA SCGFIDNVVL ARKFFTLYKL CEEQLSKQVH YDFGLRNILS 
VLRTLGAAKR ANPMDTESTI VMRVLRDMNL SKLIDEDEPL FLSLIEDLFP NILLDKAGYP 
ELEAAISRQV EEAGLINHPP WKLKVIQLFE TQRVRHGMMT LGPSGAGKTT CIHTLMRAMT 
DCGKPHREMR MNPKAITAPQ MFGRLDVATN DWTDGIFSTL WRKTLRAKKG EHIWIILDGP 
VDAIWIENLN SVLDDNKTLT LANGDRIPMA PNCKIIFEPH NIDNASPATV SRNGMVFMSS 
SILDWSPILE GFLKKRSPQE AEILRQLYTE SFPDLYRFCI QNLEYKMEVL EAFVITQSIN 
MLQGLIPLKE QGGEVSQAHL GRLFVFALLW SAGAALELDG RRRLELWLRS RPTGTLELPP 
PAGPGDTAFD YYVAPDGTWT HWNTRTQEYL YPSDTTPEYG SILVPNVDNV RTDFLIQTIA 
KQGKAVLLIG EQGTAKTVII KGFMSKYDPE CHMIKSLNFS SATTPLMFQR TIESYVDKRM 
GTTYGPPAGK KMTVFIDDVN MPIINEWGDQ VTNEIVRQLM EQNGFYNLEK PGEFTSIVDI 
QFLAAMIHPG GGRNDIPQRL KRQFSIFNCT LPSEASVDKI FGVIGVGHYC TQRGFSEEVR 
DSVTKLVPLT RRLWQMTKIK MLPTPAKFHY VFNLRDLSRV WQGMLNTTSE VIKEPNDLLK 
LWKHECKRVI ADRFTVSSDV TWFDKALVSL VEEEFGEEKK LLVDCGIDTY FVDFLRDAPE 
AAGETSEEAD AETPKIYEPI ESFSHLKERL NMFLQLYNES IRGAGMDMVF FADAMVHLVK 
ISRVIRTPQG NALLVGVGGS GKQSLTRLAS FIAGYVSFQI TLTRSYNTSN LMEDLKVLYR 
TAGQQGKGIT FIFTDNEIKD ESFLEYMNNV LSSGEVSNLF ARDEIDEINS DLASVMKKEF 
PRCLPTNENL HDYFMSRVRQ NLHIVLCFSP VGEKFRNRAL KFPALISGCT IDWFSRWPKD 
ALVAVSEHFL TSYDIDCSLE IKKEVVQCMG SFQDGVAEKC VDYFQRFRRS THVTPKSYLS 
FIQGYKFIYG EKHVEVRTLA NRMNTGLEKL KEASESVAAL SKELEAKEKE LQVANDKADM 
VLKEVTMKAQ AAEKVKAEVQ KVKDRAQAIV DSISKDKAIA EEKLEAAKPA LEEAEAALQT 
IRPSDIATVR TLGRPPHLIM RIMDCVLLLF QRKVSAVKID LEKSCTMPSW QESLKLMTAG 
NFLQNLQQFP KDTINEEVIE FLSPYFEMPD YNIETAKRVC GNVAGLCSWT KAMASFFSIN 
KEVLPLKANL VVQENRHLLA MQDLQKAQAE LDDKQAELDV VQAEYEQAMT EKQTLLEDAE 
RCRHKMQTAS TLISGLAGEK ERWTEQSQEF AAQTKRLVGD VLLATAFLSY SGPFNQEFRD 
LLLNDWRKEM KARKIPFGKN LNLSEMLIDA PTISEWNLQG LPNDDLSIQN GIIVTKASRY 
PLLIDPQTQG KIWIKNKESR NELQITSLNH KYFRNHLEDS LSLGRPLLIE DVGEELDPAL 
DNVLERNFIK TGSTFKVKVG DKEVDVLDGF RLYITTKLPN PAYTPEISAR TSIIDFTVTM 
KGLEDQLLGR VILTEKQELE KERTHLMEDV TANKRRMKEL EDNLLYRLTS TQGSLVEDES 
LIVVLSNTKR TAEEVTQKLE ISAETEVQIN SAREEYRPVA TRGSILYFLI TEMRLVNEMY 
QTSLRQFLGL FDLSLARSVK SPITSKRIAN IIEHMTYEVY KYAARGLYEE HKFLFTLLLT 
LKIDIQRNRV KHEEFLTLIK GGASLDLKAC PPKPSKWILD ITWLNLVELS KLRQFSDVLD 
QISRNEKMWK IWFDKENPEE EPLPNAYDKS LDCFRRLLLI RSWCPDRTIA QARKYIVDSM 
GEKYAEGVIL DLEKTWEESD PRTPLICLLS MGSDPTDSII ALGKRLKIET RYVSMGQGQE 
VHARKLLQQT MANGGWALLQ NCHLGLDFMD ELMDIIIETE LVHDAFRLWM TTEAHKQFPI 
TLLQMSIKFA NDPPQGLRAG LKRTYSGVSQ DLLDVSSGSQ WKPMLYAVAF LHSTVQERRK 
FGALGWNIPY EFNQADFNAT VQFIQNHLDD MDVKKGVSWT TIRYMIGEIQ YGGRVTDDYD 
KRLLNTFAKV WFSENMFGPD FSFYQGYNIP KCSTVDNYLQ YIQSLPAYDS PEVFGLHPNA 
DITYQSKLAK DVLDTILGIQ PKDTSGGGDE TREAVVARLA DDMLEKLPPD YVPFEVKERL 
QKMGPFQPMN IFLRQEIDRM QRVLSLVRST LTELKLAIDG TIIMSENLRD ALDCMFDARI 
PAWWKKASWI SSTLGFWFTE LIERNSQFTS WVFNGRPHCF WMTGFFNPQG FLTAMRQEIT 
RANKGWALDN MVLCNEVTKW MKDDISAPPT EGVYVYGLYL EGAGWDKRNM KLIESKPKVL 
FELMPVIRIY AENNTLRDPR FYSCPIYKKP VRTDLNYIAA VDLRTAQTPE HWVLRGVALL 
CDVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.