Details for: DNAH9

Gene ID: 1770

Symbol: DNAH9

Ensembl ID: ENSG00000007174

Description: dynein axonemal heavy chain 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.5003
    Cell Significance Index: -13.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.6117
    Cell Significance Index: -13.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.4172
    Cell Significance Index: -12.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2128
    Cell Significance Index: -9.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.1468
    Cell Significance Index: 144.3500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.4653
    Cell Significance Index: 14.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4060
    Cell Significance Index: 40.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2294
    Cell Significance Index: 246.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1729
    Cell Significance Index: 51.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0833
    Cell Significance Index: 41.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7313
    Cell Significance Index: 505.7800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.4998
    Cell Significance Index: 4.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4714
    Cell Significance Index: 29.7100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4634
    Cell Significance Index: 3.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4579
    Cell Significance Index: 14.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4325
    Cell Significance Index: 155.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3260
    Cell Significance Index: 9.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3153
    Cell Significance Index: 172.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2503
    Cell Significance Index: 4.2900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2436
    Cell Significance Index: 3.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2085
    Cell Significance Index: 4.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1988
    Cell Significance Index: 12.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1978
    Cell Significance Index: 4.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1758
    Cell Significance Index: 3.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1178
    Cell Significance Index: 22.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1003
    Cell Significance Index: 19.9000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0997
    Cell Significance Index: 1.0800
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.0508
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0266
    Cell Significance Index: 50.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0204
    Cell Significance Index: 27.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0193
    Cell Significance Index: 35.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0181
    Cell Significance Index: 27.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0106
    Cell Significance Index: 0.6000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0101
    Cell Significance Index: 0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0044
    Cell Significance Index: 2.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0020
    Cell Significance Index: 0.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0032
    Cell Significance Index: -2.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0104
    Cell Significance Index: -0.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0150
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0201
    Cell Significance Index: -14.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0205
    Cell Significance Index: -1.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0207
    Cell Significance Index: -9.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0208
    Cell Significance Index: -15.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0263
    Cell Significance Index: -16.4400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0283
    Cell Significance Index: -0.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0289
    Cell Significance Index: -3.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0305
    Cell Significance Index: -4.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0398
    Cell Significance Index: -11.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0531
    Cell Significance Index: -9.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0553
    Cell Significance Index: -7.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0574
    Cell Significance Index: -1.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0609
    Cell Significance Index: -2.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0688
    Cell Significance Index: -6.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0698
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0734
    Cell Significance Index: -15.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0794
    Cell Significance Index: -10.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0831
    Cell Significance Index: -10.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0867
    Cell Significance Index: -6.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0932
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0992
    Cell Significance Index: -11.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1106
    Cell Significance Index: -12.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1154
    Cell Significance Index: -14.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1184
    Cell Significance Index: -12.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1227
    Cell Significance Index: -8.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1292
    Cell Significance Index: -13.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1379
    Cell Significance Index: -2.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1530
    Cell Significance Index: -9.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1586
    Cell Significance Index: -3.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1676
    Cell Significance Index: -4.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1689
    Cell Significance Index: -8.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1805
    Cell Significance Index: -3.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1865
    Cell Significance Index: -5.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1865
    Cell Significance Index: -4.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1902
    Cell Significance Index: -13.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1910
    Cell Significance Index: -15.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1933
    Cell Significance Index: -3.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1955
    Cell Significance Index: -14.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1969
    Cell Significance Index: -4.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2040
    Cell Significance Index: -6.6800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2064
    Cell Significance Index: -3.1100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2365
    Cell Significance Index: -2.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2495
    Cell Significance Index: -8.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2532
    Cell Significance Index: -5.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2609
    Cell Significance Index: -13.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2693
    Cell Significance Index: -13.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2819
    Cell Significance Index: -10.3500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2859
    Cell Significance Index: -3.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2864
    Cell Significance Index: -4.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2889
    Cell Significance Index: -13.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2902
    Cell Significance Index: -7.2400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2929
    Cell Significance Index: -6.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2975
    Cell Significance Index: -6.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2988
    Cell Significance Index: -13.9300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3184
    Cell Significance Index: -3.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3323
    Cell Significance Index: -3.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3517
    Cell Significance Index: -8.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3545
    Cell Significance Index: -6.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNAH9 is a heavy chain of the dynein complex, a group of motor proteins responsible for the movement of cilia and flagella in eukaryotic cells. The protein consists of a conserved N-terminal domain, a middle domain, and a C-terminal domain, which interact with other dynein subunits to form the axonemal dynein complex. DNAH9 is specifically expressed in epithelial cells of the alveolus, tracheobronchial tree, and other tissues, where it plays a crucial role in maintaining ciliary function and motility. **Pathways and Functions:** The DNAH9 gene is involved in several signaling pathways, including: 1. **Motile Cilium Signaling:** DNAH9 is a critical component of the dynein complex, which regulates the movement of cilia. The protein interacts with other dynein subunits to generate a force that propels the cilium forward, allowing for the clearance of mucus and debris from the respiratory tract and other epithelial surfaces. 2. **Cell Motility Signaling:** DNAH9 is also involved in regulating cell motility, particularly in the context of cilia-mediated cell migration. The protein helps to maintain the integrity of the cilium and facilitate the movement of cells, such as epithelial cells and neurons. 3. **Microtubule Signaling:** DNAH9 interacts with microtubules to regulate the movement of cilia and other cellular structures. The protein helps to maintain the stability and organization of microtubules, which is essential for maintaining cellular homeostasis. **Clinical Significance:** Dysregulation of DNAH9 has been implicated in various human diseases, including: 1. **Primary Ciliary Dyskinesia (PCD):** A genetic disorder characterized by defective ciliary function, leading to respiratory and other complications. 2. **Mucociliary Clearance Disorders:** Conditions such as bronchiectasis and chronic obstructive pulmonary disease (COPD), where impaired ciliary function leads to persistent mucus accumulation and respiratory complications. 3. **Neurological Disorders:** DNAH9 has been implicated in the pathogenesis of certain neurological disorders, such as cerebral palsy and autism spectrum disorder, where impaired ciliary function and cell motility contribute to disease progression. In conclusion, DNAH9 is a critical protein involved in the structure and function of motile cilia and dynein complexes. Its dysregulation has significant implications for human health, highlighting the importance of maintaining ciliary function and cell motility in various physiological processes.

Genular Protein ID: 198315399

Symbol: DYH9_HUMAN

Name: Axonemal beta dynein heavy chain 9

UniProtKB Accession Codes:

Q9NYC9 A2VCQ8 O15064 O95494 Q9NQ28

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 14 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 12 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11247663

Title: Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia.

PubMed ID: 11247663

DOI: 10.1006/geno.2000.6462

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 11104725

Title: Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis.

PubMed ID: 11104725

DOI: 10.1165/ajrcmb.23.6.4045

PubMed ID: 30471717

Title: Mutations in outer dynein arm heavy chain DNAH9 cause motile cilia defects and situs inversus.

PubMed ID: 30471717

DOI: 10.1016/j.ajhg.2018.10.016

PubMed ID: 30471718

Title: Recessive DNAH9 loss-of-function mutations cause laterality defects and subtle respiratory ciliary-beating defects.

PubMed ID: 30471718

DOI: 10.1016/j.ajhg.2018.10.020

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 31178125

Title: Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

PubMed ID: 31178125

DOI: 10.1016/j.ajhg.2019.04.015

Sequence Information:

  • Length: 4486
  • Mass: 511877
  • Checksum: 27EB53C39FA3A293
  • Sequence:
    • MRLAEERAAL AAENADGEPG ADRRLRLLGT YVAMSLRPAA GAWERCAGSA EAEQLLQAFL 
GRDAAEGPRP LLVVRPGPRG LAIRPGLEVG PESGLAGAKA LFFLRTGPEP PGPDSFRGAV 
VCGDLPAAPL EHLAALFSEV VLPVLANEKN RLNWPHMICE DVRRHAHSLQ CDLSVILEQV 
KGKTLLPLPA GSEKMEFADS KSETVLDSID KSVIYAIESA VIKWSYQVQV VLKRESSQPL 
LQGENPTPKV ELEFWKSRYE DLKYIYNQLR TITVRGMAKL LDKLQSSYFP AFKAMYRDVV 
AALAEAQDIH VHLIPLQRHL EALENAEFPE VKPQLRPLLH VVCLIWATCK SYRSPGRLTV 
LLQEICNLLI QQASNYLSPE DLLRSEVEES QRKLQVVSDT LSFFKQEFQD RRENLHTYFK 
ENQEVKEWDF QSSLVFVRLD GFLGQLHVVE GLLKTALDFH KLGKVEFSGV RGNALSQQVQ 
QMHEEFQEMY RLLSGSSSDC LYLQSTDFEN DVSEFNQKVE DLDRRLGTIF IQAFDDAPGL 
EHAFKLLDIA GNLLERPLVA RDTSDKYLVL IQMFNKDLDA VRMIYSQHVQ EEAELGFSPV 
HKNMPTVAGG LRWAQELRQR IQGPFSNFGR ITHPCMESAE GKRMQQKYED MLSLLEKYET 
RLYEDWCRTV SEKSQYNLSQ PLLKRDPETK EITINFNPQL ISVLKEMSYL EPREMKHMPE 
TAAAMFSSRD FYRQLVANLE LMANWYNKVM KTLLEVEFPL VEEELQNIDL RLRAAEETLN 
WKTEGICDYV TEITSSIHDL EQRIQKTKDN VEEIQNIMKT WVTPIFKTKD GKRESLLSLD 
DRHDRMEKYY NLIKESGLKI HALVQENLGL FSADPTSNIW KTYVNSIDNL LLNGFFLAIE 
CSLKYLLENT ECKAGLTPIF EAQLSLAIPE LVFYPSLESG VKGGFCDIVE GLITSIFRIP 
SLVPRLSPQN GSPHYQVDLD GIPDLANMRR TLMERVQRMM GLCCGYQSTF SQYSYLYVED 
RKEVLGQFLL YGHILTPEEI EDHVEDGIPE NPPLLSQFKV QIDSYETLYE EVCRLEPIKV 
FDGWMKIDIR PFKASLLNII KRWSLLFKQH LVDHVTHSLA NLDAFIKKSE SGLLKKVEKG 
DFQGLVEIMG HLMAVKERQS NTDEMFEPLK QTIELLKTYE QELPETVFKQ LEELPEKWNN 
IKKVAITVKQ QVAPLQANEV TLLRQRCTAF DAEQQQFWEQ FHKEAPFRFD SIHPHQMLDA 
RHIEIQQMES TMASISESAS LFEVNVPDYK QLRQCRKEVC QLKELWDTIG MVTSSIHAWE 
TTPWRNINVE AMELECKQFA RHIRNLDKEV RAWDAFTGLE STVWNTLSSL RAVAELQNPA 
IRERHWRQLM QATGVSFTMD QDTTLAHLLQ LQLHHYEDEV RGIVDKAAKE MGMEKTLKEL 
QTTWAGMEFQ YEPHPRTNVP LLCSDEDLIE VLEDNQVQLQ NLVMSKYVAF FLEEVSGWQK 
KLSTVDAVIS IWFEVQRTWT HLESIFTGSE DIRAQLPQDS KRFEGIDIDF KELAYDAQKI 
PNVVQTTNKP GLYEKLEDIQ GRLCLCEKAL AEYLDTKRLA FPRFYFLSSS DLLDILSNGT 
APQQVQRHLS KLFDNMAKMR FQLDASGEPT KTSLGMYSKE EEYVAFSEPC DCSGQVEIWL 
NHVLGHMKAT VRHEMTEGVT AYEEKPREQW LFDHPAQVAL TCTQIWWTTE VGMAFARLEE 
GYESAMKDYY KKQVAQLKTL ITMLIGQLSK GDRQKIMTIC TIDVHARDVV AKMIAQKVDN 
AQAFLWLSQL RHRWDDEVKH CFANICDAQF LYSYEYLGNT PRLVITPLTD RCYITLTQSL 
HLTMSGAPAG PAGTGKTETT KDLGRALGIL VYVFNCSEQM DYKSCGNIYK GLAQTGAWGC 
FDEFNRISVE VLSVVAVQVK SIQDAIRDKK QWFSFLGEEI SLNPSVGIFI TMNPGYAGRT 
ELPENLKSLF RPCAMVVPDF ELICEIMLVA EGFIEAQSLA RKFITLYQLC KELLSKQDHY 
DWGLRAIKSV LVVAGSLKRG DPDRPEDQVL MRSLRDFNIP KIVTDDMPIF MGLIGDLFPA 
LDVPRRRDPN FEALVRKAIV DLKLQAEDNF VLKVVQLEEL LAVRHSVFVV GGAGTGKSQV 
LRSLHKTYQI MKRRPVWTDL NPKAVTNDEL FGIINPATGE WKDGLFSSIM RELANITHDG 
PKWILLDGDI DPMWIESLNT VMDDNKVLTL ASNERIPLNP TMKLLFEISH LRTATPATVS 
RAGILYINPA DLGWNPPVSS WIEKREIQTE RANLTILFDK YLPTCLDTLR TRFKKIIPIP 
EQSMVQMVCH LLECLLTTED IPADCPKEIY EHYFVFAAIW AFGGAMVQDQ LVDYRAEFSK 
WWLTEFKTVK FPSQGTIFDY YIDPETKKFE PWSKLVPQFE FDPEMPLQAC LVHTSETIRV 
CYFMERLMAR QRPVMLVGTA GTGKSVLVGA KLASLDPEAY LVKNVPFNYY TTSAMLQAVL 
EKPLEKKAGR NYGPPGNKKL IYFIDDMNMP EVDAYGTVQP HTIIRQHLDY GHWYDRSKLS 
LKEITNVQYV SCMNPTAGSF TINPRLQRHF SVFVLSFPGA DALSSIYSII LTQHLKLGNF 
PASLQKSIPP LIDLALAFHQ KIATTFLPTG IKFHYIFNLR DFANIFQGIL FSSVECVKST 
WDLIRLYLHE SNRVYRDKMV EEKDFDLFDK IQTEVLKKTF DDIEDPVEQT QSPNLYCHFA 
NGIGEPKYMP VQSWELLTQT LVEALENHNE VNTVMDLVLF EDAMRHVCHI NRILESPRGN 
ALLVGVGGSG KQSLTRLAAF ISSMDVFQIT LRKGYQIQDF KMDLASLCLK AGVKNLNTVF 
LMTDAQVADE RFLVLINDLL ASGEIPDLYS DDEVENIISN VRNEVKSQGL VDNRENCWKF 
FIDRIRRQLK VTLCFSPVGN KLRVRSRKFP AIVNCTAIHW FHEWPQQALE SVSLRFLQNT 
EGIEPTVKQS ISKFMAFVHT SVNQTSQSYL SNEQRYNYTT PKSFLEFIRL YQSLLHRHRK 
ELKCKTERLE NGLLKLHSTS AQVDDLKAKL AAQEVELKQK NEDADKLIQV VGVETDKVSR 
EKAMADEEEQ KVAVIMLEVK QKQKDCEEDL AKAEPALTAA QAALNTLNKT NLTELKSFGS 
PPLAVSNVSA AVMVLMAPRG RVPKDRSWKA AKVTMAKVDG FLDSLINFNK ENIHENCLKA 
IRPYLQDPEF NPEFVATKSY AAAGLCSWVI NIVRFYEVFC DVEPKRQALN KATADLTAAQ 
EKLAAIKAKI AHLNENLAKL TARFEKATAD KLKCQQEAEV TAVTISLANR LVGGLASENV 
RWADAVQNFK QQERTLCGDI LLITAFISYL GFFTKKYRQS LLDRTWRPYL SQLKTPIPVT 
PALDPLRMLM DDADVAAWQN EGLPADRMSV ENATILINCE RWPLMVDPQL QGIKWIKNKY 
GEDLRVTQIG QKGYLQIIEQ ALEAGAVVLI ENLEESIDPV LGPLLGREVI KKGRFIKIGD 
KECEYNPKFR LILHTKLANP HYQPELQAQA TLINFTVTRD GLEDQLLAAV VSMERPDLEQ 
LKSDLTKQQN GFKITLKTLE DSLLSRLSSA SGNFLGETVL VENLEITKQT AAEVEKKVQE 
AKVTEVKINE AREHYRPAAA RASLLYFIMN DLSKIHPMYQ FSLKAFSIVF QKAVERAAPD 
ESLRERVANL IDSITFSVYQ YTIRGLFECD KLTYLAQLTF QILLMNREVN AVELDFLLRS 
PVQTGTASPV EFLSHQAWGA VKVLSSMEEF SNLDRDIEGS AKSWKKFVES ECPEKEKLPQ 
EWKNKTALQR LCMLRAMRPD RMTYALRDFV EEKLGSKYVV GRALDFATSF EESGPATPMF 
FILSPGVDPL KDVESQGRKL GYTFNNQNFH NVSLGQGQEV VAEAALDLAA KKGHWVILQN 
IHLVAKWLST LEKKLEEHSE NSHPEFRVFM SAEPAPSPEG HIIPQGILEN SIKITNEPPT 
GMHANLHKAL DNFTQDTLEM CSRETEFKSI LFALCYFHAV VAERRKFGPQ GWNRSYPFNT 
GDLTISVNVL YNFLEANAKV PYDDLRYLFG EIMYGGHITD DWDRRLCRTY LGEFIRPEML 
EGELSLAPGF PLPGNMDYNG YHQYIDAELP PESPYLYGLH PNAEIGFLTQ TSEKLFRTVL 
ELQPRDSQAR DGAGATREEK VKALLEEILE RVTDEFNIPE LMAKVEERTP YIVVAFQECG 
RMNILTREIQ RSLRELELGL KGELTMTSHM ENLQNALYFD MVPESWARRA YPSTAGLAAW 
FPDLLNRIKE LEAWTGDFTM PSTVWLTGFF NPQSFLTAIM QSTARKNEWP LDQMALQCDM 
TKKNREEFRS PPREGAYIHG LFMEGACWDT QAGIITEAKL KDLTPPMPVM FIKAIPADKQ 
DCRSVYSCPV YKTSQRGPTY VWTFNLKTKE NPSKWVLAGV ALLLQI

Genular Protein ID: 3178761815

Symbol: Q99499_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99499

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 5 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 1

Citations:

PubMed ID: 8703119

Title: Characterization of a novel human dynein-related gene that is specifically expressed in testis.

PubMed ID: 8703119

DOI: 10.1007/s003359900202

Sequence Information:

  • Length: 798
  • Mass: 91087
  • Checksum: FD0FD7E3C0AFC7CB
  • Sequence:
    • MNDLSKIHPM YQFSLKAFSI VFQKAVERAA PDESLRERVA NLIDSITFSV YQYTIRGLFE 
CDKLTYLAQL TFQILLMNRE VNAVELDFLL RSPVQTGTAS PVEFLSHQAW GAVKVLSSME 
EFSNLDRDIE GSAKSWKKFV ESECPEKEKL PQEWKNKTAL QRLCMLRAMR PDRMTYALRD 
FVEEKLGSKY VVGRALDFAT SFEESGPATP MFFILSPGVD PLKDVESQGR KLGYTFNNQN 
FHNVSLGQGQ EVVAEAALDL AAKKGHWVIL QNIHLVAKWL STLEKKLEEH SENSHPEFRV 
FMSAEPAPSP EGHIIPQGIL ENSIKITNEP PTGMHANLHK ALDNFTQDTL EMCSRETEFK 
SILFALCYFH AVVAERRKFG PQGWNRSYPF NTGDLTISVN VLYNFLEANA KVPYDDLRYL 
FGEIMYGGHI TDDWDRRLCR TYLGEFIRPE MLEGELSLAP GFPLPGNMDY NGYHQYIDAE 
LPPESPYLYG LHPNAEIGFL TQTSEKLFRT VLELQPRDSQ ARDGAGATRE EKVKALLEEI 
LERVTDEFNI PELMAKVEER TPYIVVAFQE CGRMNILTRE IQRSLRELEL GLKGELTMTS 
HMENLQNALY FDMVPESWAR RAYPSTAGLA ARFPDLLNRI KELEAWTGDF TIPSTVWLTG 
FFNPQSFLTA IMQSTARKNE WPLDQMALQC DMTKKNREEF RSPPREGAYI HGLFMEGACW 
DTQAGIITEA KLKDLTPPMP VMFIKAIPAD KQDCRSVYSC PVYKTSQRGP TYVWTFNLKT 
KENPSKWVLA GVALLLQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.