Details for: DNASE1

Gene ID: 1773

Symbol: DNASE1

Ensembl ID: ENSG00000213918

Description: deoxyribonuclease 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.44
    Marker Score: 6541
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.39
    Marker Score: 3688
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.34
    Marker Score: 2480
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.89
    Marker Score: 2545
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.5
    Marker Score: 7218
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.47
    Marker Score: 1773
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.44
    Marker Score: 415
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.41
    Marker Score: 29993
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.36
    Marker Score: 797
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.33
    Marker Score: 12514
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.32
    Marker Score: 5389
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2036
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12132
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.26
    Marker Score: 46651
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.26
    Marker Score: 10834
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 77116
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.25
    Marker Score: 1106
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.22
    Marker Score: 12588
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.2
    Marker Score: 17929
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.15
    Marker Score: 43739
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.14
    Marker Score: 1297
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.11
    Marker Score: 8545
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.11
    Marker Score: 772
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.09
    Marker Score: 575
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.07
    Marker Score: 1177
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.06
    Marker Score: 4435
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.05
    Marker Score: 2630
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.04
    Marker Score: 2004.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.04
    Marker Score: 4004
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71737
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1
    Marker Score: 1741
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47962
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.98
    Marker Score: 238
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.97
    Marker Score: 2137.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.97
    Marker Score: 19208
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.96
    Marker Score: 562
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.96
    Marker Score: 3997
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.95
    Marker Score: 1088
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.93
    Marker Score: 1538
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1502
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2716
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.9
    Marker Score: 442
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.9
    Marker Score: 967
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.89
    Marker Score: 4130
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.89
    Marker Score: 334
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.88
    Marker Score: 329
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13809
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.88
    Marker Score: 657
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4951
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.86
    Marker Score: 876
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.84
    Marker Score: 594
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.84
    Marker Score: 551
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.83
    Marker Score: 1743
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.81
    Marker Score: 3005
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.81
    Marker Score: 190
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1892
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.79
    Marker Score: 2347
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.79
    Marker Score: 227
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.78
    Marker Score: 969
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.77
    Marker Score: 321
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.77
    Marker Score: 764
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.77
    Marker Score: 663
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.75
    Marker Score: 902
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.74
    Marker Score: 374
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.74
    Marker Score: 430
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.73
    Marker Score: 1036
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.73
    Marker Score: 408
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3042
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.72
    Marker Score: 184
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.72
    Marker Score: 292
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.71
    Marker Score: 208
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.71
    Marker Score: 225
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.71
    Marker Score: 676
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.7
    Marker Score: 2204
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.7
    Marker Score: 251.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.69
    Marker Score: 139
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.68
    Marker Score: 15281
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.68
    Marker Score: 1636
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.68
    Marker Score: 353
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.68
    Marker Score: 215
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.68
    Marker Score: 1940
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 620
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.68
    Marker Score: 11998
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.67
    Marker Score: 1125
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 401
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.66
    Marker Score: 532
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.66
    Marker Score: 322
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.66
    Marker Score: 403
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.66
    Marker Score: 395

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Other Information

**Key characteristics**: * DNAS1 is a large protein that is composed of 1300 amino acids. * It is a member of the RNase superfamily of enzymes. * DNAS1 is expressed in high levels in cells that are involved in inflammation, such as epithelial cells and immune cells. * It is a key regulator of the inflammatory response. * It is involved in the regulation of the development of autoimmune diseases. **Pathways and functions**: * DNAS1 is involved in the regulation of acute inflammatory response by proteasomal degradation of the protein. * It is also involved in the development of autoimmune diseases by promoting the production of inflammatory cytokines and chemokines. * It is involved in the regulation of the development of autoimmune diseases by promoting the production of inflammatory cytokines and chemokines. * It is involved in the development of autoimmune diseases by promoting the migration of immune cells to sites of inflammation. **Clinical significance**: DNASE1 is a potential therapeutic target for inflammatory diseases. Inhibition of DNAS1 has been shown to be effective in reducing inflammation and promoting the resolution of inflammation. This suggests that DNAS1 is a potential target for the treatment of inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and asthma.

Genular Protein ID: 2400991122

Symbol: DNAS1_HUMAN

Name: Deoxyribonuclease-1

UniProtKB Accession Codes:

P24855 B4DV35 Q14UU9 Q14UV0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2251263

Title: Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.

PubMed ID: 2251263

DOI: 10.1073/pnas.87.23.9188

PubMed ID: 7762978

Title: Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism.

PubMed ID: 7762978

DOI: 10.1111/j.1469-1809.1995.tb01601.x

PubMed ID: 11241278

Title: DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis.

PubMed ID: 11241278

DOI: 10.1002/1521-4141(200103)31:3<743::aid-immu743>3.0.co;2-9

PubMed ID: 16771825

Title: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation.

PubMed ID: 16771825

DOI: 10.1111/j.1742-4658.2006.05320.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3263467

Title: A human urine-derived interleukin 1 inhibitor. Homology with deoxyribonuclease I.

PubMed ID: 3263467

DOI: 10.1084/jem.168.5.1767

PubMed ID: 2277032

Title: Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I.

PubMed ID: 2277032

DOI: 10.1093/oxfordjournals.jbchem.a123212

PubMed ID: 11479590

Title: Mutation of DNASE1 in people with systemic lupus erythematosus.

PubMed ID: 11479590

DOI: 10.1038/91070

PubMed ID: 20439745

Title: Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.

PubMed ID: 20439745

DOI: 10.1073/pnas.0909927107

PubMed ID: 7625762

Title: Molecular analysis of the third allele of human deoxyribonuclease I polymorphism.

PubMed ID: 7625762

DOI: 10.1111/j.1469-1809.1995.tb00737.x

PubMed ID: 7867802

Title: The molecular basis for genetic polymorphism of human deoxyribonuclease I: identification of the nucleotide substitution that generates the fourth allele.

PubMed ID: 7867802

DOI: 10.1016/0014-5793(95)00037-a

PubMed ID: 9420147

Title: The fifth allele of the human deoxyribonuclease I (DNase I) polymorphism.

PubMed ID: 9420147

DOI: 10.1002/elps.1150181108

PubMed ID: 10381379

Title: A new allele, DNASE1*6, of human deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability.

PubMed ID: 10381379

DOI: 10.1006/bbrc.1999.0900

Sequence Information:

  • Length: 282
  • Mass: 31434
  • Checksum: 040042E2D23555B6
  • Sequence:
    • MRGMKLLGAL LALAALLQGA VSLKIAAFNI QTFGETKMSN ATLVSYIVQI LSRYDIALVQ 
EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE RYLFVYRPDQ VSAVDSYYYD 
DGCEPCGNDT FNREPAIVRF FSRFTEVREF AIVPLHAAPG DAVAEIDALY DVYLDVQEKW 
GLEDVMLMGD FNAGCSYVRP SQWSSIRLWT SPTFQWLIPD SADTTATPTH CAYDRIVVAG 
MLLRGAVVPD SALPFNFQAA YGLSDQLAQA ISDHYPVEVM LK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.