Details for: TRDMT1

Gene ID: 1787

Symbol: TRDMT1

Ensembl ID: ENSG00000107614

Description: tRNA aspartic acid methyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.57
    Marker Score: 6078
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.38
    Marker Score: 3021
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.37
    Marker Score: 2114
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.25
    Marker Score: 11797
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.23
    Marker Score: 721
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.17
    Marker Score: 24868
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.15
    Marker Score: 8817
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.14
    Marker Score: 43196
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.11
    Marker Score: 4501
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.04
    Marker Score: 434
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.03
    Marker Score: 2419
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71773
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1
    Marker Score: 1341
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47997
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.96
    Marker Score: 1166
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.95
    Marker Score: 1656.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.94
    Marker Score: 749
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.93
    Marker Score: 3909
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.92
    Marker Score: 13682
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1831
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 358
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5047
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.87
    Marker Score: 591.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.85
    Marker Score: 8109
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.85
    Marker Score: 7275
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.84
    Marker Score: 51430
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.8
    Marker Score: 3316
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.79
    Marker Score: 15715
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.78
    Marker Score: 229
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.78
    Marker Score: 213
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.77
    Marker Score: 7986
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1233
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3003.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.71
    Marker Score: 26301
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 619
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.64
    Marker Score: 801
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.63
    Marker Score: 199
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.61
    Marker Score: 353
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9418
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.59
    Marker Score: 202
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.58
    Marker Score: 3498
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.58
    Marker Score: 264
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.56
    Marker Score: 487
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.56
    Marker Score: 799
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 329
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 169
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 324
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.5
    Marker Score: 243
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.5
    Marker Score: 184
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.49
    Marker Score: 238
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.49
    Marker Score: 10911
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.48
    Marker Score: 230
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.48
    Marker Score: 151.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 228
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.48
    Marker Score: 344
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.47
    Marker Score: 141
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.46
    Marker Score: 253
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.45
    Marker Score: 164
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 198
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.45
    Marker Score: 482
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 292
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.44
    Marker Score: 244
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.43
    Marker Score: 3740
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.43
    Marker Score: 312
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.42
    Marker Score: 489
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.42
    Marker Score: 1450
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.42
    Marker Score: 22238
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 402
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.41
    Marker Score: 168
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.41
    Marker Score: 232
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.41
    Marker Score: 1169
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.4
    Marker Score: 104
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.4
    Marker Score: 368
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.4
    Marker Score: 493
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4
    Marker Score: 232
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.4
    Marker Score: 182
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 224
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.39
    Marker Score: 4578
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.39
    Marker Score: 523.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 121.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.38
    Marker Score: 134
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.38
    Marker Score: 147
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.37
    Marker Score: 288
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.37
    Marker Score: 732
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.37
    Marker Score: 625
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.37
    Marker Score: 106

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * TRDMT1 is a transmembrane protein that is localized to the cytoplasm. * It is a member of the tRNA methyltransferase family of proteins. * TRDMT1 is responsible for the methylation of specific tRNA molecules, including those that are involved in the production of neurotransmitters. **Pathways and functions:** * TRDMT1 is involved in the processing of tRNA molecules in the cytoplasm. * It is responsible for the methylation of specific tRNA molecules that are targeted to the nucleus or cytosol. * These modifications are necessary for the proper translation of mRNA molecules. **Clinical significance:** * Mutations in TRDMT1 have been linked to a number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), schizophrenia, and autism. * These mutations can lead to the accumulation of abnormal tRNA molecules in the brain, which can disrupt protein synthesis and lead to cell death. **Additional information:** * TRDMT1 is a relatively conserved protein, with similar sequences found in organisms from yeast to humans. * It is a ubiquitin-dependent protein, which means that it is targeted for degradation by the proteasome. * TRDMT1 is a promising target for the treatment of neurodegenerative diseases.

Genular Protein ID: 1469379413

Symbol: TRDMT_HUMAN

Name: tRNA (cytosine(38)-C(5))-methyltransferase

UniProtKB Accession Codes:

O14717 B0YJ02 B0YJ03 B0YJ07 B0YJ08 O43669 Q86WW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 17 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9425235

Title: A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast.

PubMed ID: 9425235

DOI: 10.1093/hmg/7.2.279

PubMed ID: 9599025

Title: Cloning and analysis of a novel human putative DNA methyltransferase.

PubMed ID: 9599025

DOI: 10.1016/s0014-5793(98)00362-7

PubMed ID: 9592134

Title: Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells.

PubMed ID: 9592134

DOI: 10.1093/nar/26.11.2536

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551826

Title: Five novel alternatively spliced transcripts of DNA (cytosine-5) methyltransferase 2 in human peripheral blood leukocytes.

PubMed ID: 11551826

DOI: 10.1016/s1357-2725(01)00074-7

PubMed ID: 16424344

Title: Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.

PubMed ID: 16424344

DOI: 10.1126/science.1120976

PubMed ID: 11139614

Title: Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.

PubMed ID: 11139614

DOI: 10.1093/nar/29.2.439

Sequence Information:

  • Length: 391
  • Mass: 44597
  • Checksum: BCA549E4EB2E6950
  • Sequence:
    • MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT QLLAKTIEGI 
TLEEFDRLSF DMILMSPPCQ PFTRIGRQGD MTDSRTNSFL HILDILPRLQ KLPKYILLEN 
VKGFEVSSTR DLLIQTIENC GFQYQEFLLS PTSLGIPNSR LRYFLIAKLQ SEPLPFQAPG 
QVLMEFPKIE SVHPQKYAMD VENKIQEKNV EPNISFDGSI QCSGKDAILF KLETAEEIHR 
KNQQDSDLSV KMLKDFLEDD TDVNQYLLPP KSLLRYALLL DIVQPTCRRS VCFTKGYGSY 
IEGTGSVLQT AEDVQVENIY KSLTNLSQEE QITKLLILKL RYFTPKEIAN LLGFPPEFGF 
PEKITVKQRY RLLGNSLNVH VVAKLIKILY E

Genular Protein ID: 114871253

Symbol: Q7Z3E4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z3E4

Database IDs:

ARBA 3 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 69
  • Mass: 7631
  • Checksum: 5F397FE36E924467
  • Sequence:
    • MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT QLLAKTIEKR 
SNTAQFSAT

Genular Protein ID: 3625030200

Symbol: B4DQZ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQZ2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 2 SUPFAM 1

Sequence Information:

  • Length: 310
  • Mass: 35573
  • Checksum: 98FCA74DDAB88E7C
  • Sequence:
    • MSTLSLMKYT SIIFLTHSYL PRRLKIGRQG DMTDSRTNSF LHILDILPRD LLIQTIENCG 
FQYQEFLLSP TSLGIPNSRL RYFLIAKLQS EPLPFQAPGQ VLMEFPKIES VHPQKYAMDV 
ENKIQEKNVE PNISFDGSIQ CSGKDAILFK LETAEEIHRK NQQDSDLSVK MLKDFLEDDT 
DVNQYLLPPK SLLRYALLLD IVQPTCRRSV CFTKGYGSYI EGTGSVLQTA EDVQVENIYK 
SLTNLSQEEQ ITKLLVLKLR YFTPKEIANL LGFPPEFGFP EKITVKQRYR LLGNSLNVHV 
VAKLIKILYE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.