Details for: TRDMT1

Gene ID: 1787

Symbol: TRDMT1

Ensembl ID: ENSG00000107614

Description: tRNA aspartic acid methyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.5858
    Cell Significance Index: -16.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.9337
    Cell Significance Index: -16.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.1854
    Cell Significance Index: -17.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1705
    Cell Significance Index: -16.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4728
    Cell Significance Index: -17.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2879
    Cell Significance Index: -13.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1515
    Cell Significance Index: 120.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5371
    Cell Significance Index: 25.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1791
    Cell Significance Index: 422.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1670
    Cell Significance Index: 222.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8590
    Cell Significance Index: 32.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6861
    Cell Significance Index: 67.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6691
    Cell Significance Index: 29.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6257
    Cell Significance Index: 13.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6155
    Cell Significance Index: 123.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5899
    Cell Significance Index: 37.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5561
    Cell Significance Index: 502.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4848
    Cell Significance Index: 11.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4190
    Cell Significance Index: 10.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4086
    Cell Significance Index: 24.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4073
    Cell Significance Index: 44.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3740
    Cell Significance Index: 60.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3525
    Cell Significance Index: 23.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2158
    Cell Significance Index: 13.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2080
    Cell Significance Index: 4.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1836
    Cell Significance Index: 12.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1564
    Cell Significance Index: 3.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1470
    Cell Significance Index: 101.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1470
    Cell Significance Index: 11.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1237
    Cell Significance Index: 56.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1229
    Cell Significance Index: 3.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1040
    Cell Significance Index: 20.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0860
    Cell Significance Index: 46.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0839
    Cell Significance Index: 1.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0830
    Cell Significance Index: 1.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0783
    Cell Significance Index: 147.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0751
    Cell Significance Index: 9.6300
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0733
    Cell Significance Index: 0.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0729
    Cell Significance Index: 8.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0701
    Cell Significance Index: 12.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0649
    Cell Significance Index: 41.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0633
    Cell Significance Index: 97.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0610
    Cell Significance Index: 112.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0566
    Cell Significance Index: 7.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0475
    Cell Significance Index: 64.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0448
    Cell Significance Index: 0.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0429
    Cell Significance Index: 18.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0419
    Cell Significance Index: 1.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0350
    Cell Significance Index: 0.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0273
    Cell Significance Index: 3.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0012
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0074
    Cell Significance Index: -1.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0170
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0199
    Cell Significance Index: -14.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0203
    Cell Significance Index: -15.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0208
    Cell Significance Index: -0.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0245
    Cell Significance Index: -1.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0294
    Cell Significance Index: -16.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0312
    Cell Significance Index: -19.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0482
    Cell Significance Index: -13.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0578
    Cell Significance Index: -9.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0886
    Cell Significance Index: -18.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0931
    Cell Significance Index: -10.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0943
    Cell Significance Index: -9.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1029
    Cell Significance Index: -13.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1041
    Cell Significance Index: -10.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1082
    Cell Significance Index: -3.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1140
    Cell Significance Index: -8.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1245
    Cell Significance Index: -5.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1353
    Cell Significance Index: -2.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1605
    Cell Significance Index: -5.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1828
    Cell Significance Index: -5.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1836
    Cell Significance Index: -2.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1913
    Cell Significance Index: -3.8400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1921
    Cell Significance Index: -1.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1927
    Cell Significance Index: -2.3900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1952
    Cell Significance Index: -2.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1971
    Cell Significance Index: -15.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1982
    Cell Significance Index: -14.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2046
    Cell Significance Index: -10.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2117
    Cell Significance Index: -12.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2146
    Cell Significance Index: -6.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2187
    Cell Significance Index: -4.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2317
    Cell Significance Index: -3.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2421
    Cell Significance Index: -12.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2575
    Cell Significance Index: -6.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2621
    Cell Significance Index: -8.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2657
    Cell Significance Index: -5.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2662
    Cell Significance Index: -6.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2674
    Cell Significance Index: -8.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2847
    Cell Significance Index: -5.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2848
    Cell Significance Index: -7.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2932
    Cell Significance Index: -3.7000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2967
    Cell Significance Index: -5.1300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3049
    Cell Significance Index: -2.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3071
    Cell Significance Index: -10.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3271
    Cell Significance Index: -5.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3292
    Cell Significance Index: -6.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3533
    Cell Significance Index: -6.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRDMT1 is a single-copy gene located on chromosome 1q21.3. It is expressed in a wide range of cell types, including neurons, astrocytes, and ciliary muscle cells. The TRDMT1 protein is a cytidine-5'-methyltransferase that specifically methylates the C38 position of tRNA molecules. This methylation event is essential for the proper folding, stability, and function of tRNAs. **Pathways and Functions** TRDMT1 is involved in several key pathways that regulate protein synthesis, including: 1. **Metabolism of RNA**: TRDMT1 plays a critical role in the regulation of tRNA metabolism, which is essential for the proper functioning of protein synthesis. 2. **Response to Amphetamine**: Research has shown that TRDMT1 is involved in the regulation of dopamine release in response to amphetamine, a key neurotransmitter involved in motivation and reward. 3. **RNA Binding**: TRDMT1 interacts with RNA-binding proteins, which are essential for the regulation of mRNA translation and stability. 4. **Trna Modification**: TRDMT1 is involved in the methylation of tRNAs, which regulates their stability, accuracy, and efficiency in protein synthesis. 5. **Trna Processing**: TRDMT1 plays a critical role in the processing of tRNAs, which is essential for their proper folding and function. **Clinical Significance** Dysregulation of TRDMT1 has been implicated in various neurological disorders, including: 1. **Neurodegenerative Diseases**: TRDMT1 has been linked to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Psychiatric Conditions**: TRDMT1 has been implicated in psychiatric conditions such as schizophrenia and bipolar disorder. 3. **Neurodevelopmental Disorders**: TRDMT1 has been linked to neurodevelopmental disorders such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD). In conclusion, TRDMT1 is a critical gene that plays a pivotal role in the regulation of tRNA methylation and protein synthesis. Dysregulation of TRDMT1 has been implicated in various neurological disorders, highlighting the importance of this gene in maintaining proper brain function. Further research is needed to elucidate the mechanisms by which TRDMT1 regulates protein synthesis and to identify potential therapeutic targets for the treatment of neurodegenerative and psychiatric disorders.

Genular Protein ID: 1469379413

Symbol: TRDMT_HUMAN

Name: tRNA (cytosine(38)-C(5))-methyltransferase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9425235

Title: A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast.

PubMed ID: 9425235

DOI: 10.1093/hmg/7.2.279

PubMed ID: 9599025

Title: Cloning and analysis of a novel human putative DNA methyltransferase.

PubMed ID: 9599025

DOI: 10.1016/s0014-5793(98)00362-7

PubMed ID: 9592134

Title: Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells.

PubMed ID: 9592134

DOI: 10.1093/nar/26.11.2536

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551826

Title: Five novel alternatively spliced transcripts of DNA (cytosine-5) methyltransferase 2 in human peripheral blood leukocytes.

PubMed ID: 11551826

DOI: 10.1016/s1357-2725(01)00074-7

PubMed ID: 16424344

Title: Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.

PubMed ID: 16424344

DOI: 10.1126/science.1120976

PubMed ID: 30093495

Title: Queuosine-modified tRNAs confer nutritional control of protein translation.

PubMed ID: 30093495

DOI: 10.15252/embj.201899777

PubMed ID: 11139614

Title: Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.

PubMed ID: 11139614

DOI: 10.1093/nar/29.2.439

Sequence Information:

  • Length: 391
  • Mass: 44597
  • Checksum: BCA549E4EB2E6950
  • Sequence:
  • MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT QLLAKTIEGI 
    TLEEFDRLSF DMILMSPPCQ PFTRIGRQGD MTDSRTNSFL HILDILPRLQ KLPKYILLEN 
    VKGFEVSSTR DLLIQTIENC GFQYQEFLLS PTSLGIPNSR LRYFLIAKLQ SEPLPFQAPG 
    QVLMEFPKIE SVHPQKYAMD VENKIQEKNV EPNISFDGSI QCSGKDAILF KLETAEEIHR 
    KNQQDSDLSV KMLKDFLEDD TDVNQYLLPP KSLLRYALLL DIVQPTCRRS VCFTKGYGSY 
    IEGTGSVLQT AEDVQVENIY KSLTNLSQEE QITKLLILKL RYFTPKEIAN LLGFPPEFGF 
    PEKITVKQRY RLLGNSLNVH VVAKLIKILY E

Genular Protein ID: 3625030200

Symbol: B4DQZ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 310
  • Mass: 35573
  • Checksum: 98FCA74DDAB88E7C
  • Sequence:
  • MSTLSLMKYT SIIFLTHSYL PRRLKIGRQG DMTDSRTNSF LHILDILPRD LLIQTIENCG 
    FQYQEFLLSP TSLGIPNSRL RYFLIAKLQS EPLPFQAPGQ VLMEFPKIES VHPQKYAMDV 
    ENKIQEKNVE PNISFDGSIQ CSGKDAILFK LETAEEIHRK NQQDSDLSVK MLKDFLEDDT 
    DVNQYLLPPK SLLRYALLLD IVQPTCRRSV CFTKGYGSYI EGTGSVLQTA EDVQVENIYK 
    SLTNLSQEEQ ITKLLVLKLR YFTPKEIANL LGFPPEFGFP EKITVKQRYR LLGNSLNVHV 
    VAKLIKILYE

Genular Protein ID: 114871253

Symbol: Q7Z3E4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 69
  • Mass: 7631
  • Checksum: 5F397FE36E924467
  • Sequence:
  • MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT QLLAKTIEKR 
    SNTAQFSAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.