Details for: DPH2

Gene ID: 1802

Symbol: DPH2

Ensembl ID: ENSG00000132768

Description: diphthamide biosynthesis 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71774
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47998
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5016
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5260
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.83
    Marker Score: 1035
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.76
    Marker Score: 514
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 283
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 643
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 168
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 10005
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.63
    Marker Score: 470.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.55
    Marker Score: 571
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.54
    Marker Score: 780
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.54
    Marker Score: 2214
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.53
    Marker Score: 709
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.51
    Marker Score: 1220
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.48
    Marker Score: 114
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.48
    Marker Score: 2350
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.48
    Marker Score: 1875
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.48
    Marker Score: 137
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.48
    Marker Score: 900.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.47
    Marker Score: 1150
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.44
    Marker Score: 219
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.43
    Marker Score: 458
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.42
    Marker Score: 655
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.42
    Marker Score: 738
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 112
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.42
    Marker Score: 219
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4
    Marker Score: 13703
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 263
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.39
    Marker Score: 284
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.39
    Marker Score: 415
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.39
    Marker Score: 162
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.39
    Marker Score: 912
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.39
    Marker Score: 815
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.38
    Marker Score: 281.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.38
    Marker Score: 144
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.38
    Marker Score: 406
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 357
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.36
    Marker Score: 3668
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.36
    Marker Score: 390
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.36
    Marker Score: 241
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.36
    Marker Score: 745
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.35
    Marker Score: 602
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.35
    Marker Score: 224
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.35
    Marker Score: 123
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.35
    Marker Score: 4047
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.35
    Marker Score: 589
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.35
    Marker Score: 141
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.34
    Marker Score: 85
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.34
    Marker Score: 75
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.34
    Marker Score: 120
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.34
    Marker Score: 185.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.34
    Marker Score: 685
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.34
    Marker Score: 1297
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.34
    Marker Score: 116
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.34
    Marker Score: 162
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.33
    Marker Score: 358
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.33
    Marker Score: 910
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.33
    Marker Score: 208.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 104
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.33
    Marker Score: 349
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.33
    Marker Score: 161.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.33
    Marker Score: 299
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.32
    Marker Score: 1953
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.32
    Marker Score: 76
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.32
    Marker Score: 634
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.32
    Marker Score: 283
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.31
    Marker Score: 106
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.31
    Marker Score: 63
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.31
    Marker Score: 166
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 148
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.31
    Marker Score: 498
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.31
    Marker Score: 211
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.31
    Marker Score: 205
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.31
    Marker Score: 196
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.31
    Marker Score: 204
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3
    Marker Score: 140
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3
    Marker Score: 895
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.3
    Marker Score: 74
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.3
    Marker Score: 67
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.3
    Marker Score: 69
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.3
    Marker Score: 76
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.3
    Marker Score: 188

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Other Information

**Key characteristics:** * DPH2 is a transmembrane protein that is localized to the endoplasmic reticulum. * It is a protein of the cytochrome P450 family. * It is a multi-domain protein that includes a catalytic domain and a regulatory domain. * The catalytic domain is responsible for the activity of the protein. * The regulatory domain is responsible for binding to other proteins and regulating the activity of the protein. **Pathways and functions:** * DPH2 is involved in the metabolism of proteins. * It is a key enzyme in the biosynthesis of dipeptide hormones, which are proteins that are involved in various cellular processes, including growth, differentiation, and metabolism. * DPH2 is also involved in the metabolism of glutathione, a molecule that is involved in protecting cells from damage by free radicals. **Clinical significance:** * Mutations in the DPH2 gene have been linked to several human diseases, including autism, schizophrenia, and liver disease. * These diseases are characterized by problems with brain development and function. * Targeting DPH2 has been proposed as a potential treatment for these diseases. **Other relevant information:** * The DPH2 gene is located on chromosome 17q21.1. * It is a highly conserved protein, with a similar protein found in mammals, birds, and fish. * DPH2 is a relatively new protein, with the first human sequence being published in 2003.

Genular Protein ID: 1655099800

Symbol: DPH2_HUMAN

Name: Diphthamide biosynthesis protein 2

UniProtKB Accession Codes:

Q9BQC3 A8MVC9 B2RDE3 B4DNI8 O60623

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SFLD 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9782084

Title: Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2.

PubMed ID: 9782084

DOI: 10.1006/geno.1998.5420

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32576952

Title: Diphthamide-deficiency syndrome: a novel human developmental disorder and ribosomopathy.

PubMed ID: 32576952

DOI: 10.1038/s41431-020-0668-y

Sequence Information:

  • Length: 489
  • Mass: 52083
  • Checksum: 2908FB7E816E3AEF
  • Sequence:
    • MESMFSSPAE AALQRETGVP GLLTPLPDLD GVYELERVAG FVRDLGCERV ALQFPDQLLG 
DAVAVAARLE ETTGSKMFIL GDTAYGSCCV DVLGAEQAGA QALIHFGPAC LSPPARPLPV 
AFVLRQRSVA LELCVKAFEA QNPDPKAPVV LLSEPACAHA LEALATLLRP RYLDLLVSSP 
AFPQPVGSLS PEPMPLERFG RRFPLAPGRR LEEYGAFYVG GSKASPDPDL DPDLSRLLLG 
WAPGQPFSSC CPDTGKTQDE GARAGRLRAR RRYLVERARD ARVVGLLAGT LGVAQHREAL 
AHLRNLTQAA GKRSYVLALG RPTPAKLANF PEVDVFVLLA CPLGALAPQL SGSFFQPILA 
PCELEAACNP AWPPPGLAPH LTHYADLLPG SPFHVALPPP ESELWETPDV SLITGDLRPP 
PAWKSSNDHG SLALTPRPQL ELAESSPAAS FLSSRSWQGL EPRLGQTPVT EAVSGRRGIA 
IAYEDEGSG

Genular Protein ID: 1304572887

Symbol: B3KRB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRB8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 7 RuleBase 1 SFLD 2 UniPathway 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 413
  • Mass: 43994
  • Checksum: 9F262C3E787A7F40
  • Sequence:
    • MFILGDTAYG SCCVDVLGAE QAGAQALIHF GPACLSPPAR PLPVAFVLRQ RSVALELCVK 
AFEAQNPDPK APVVLLSEPA CAHALEALAT LLRPRYLDLL VSSPAFPQPV GSLSPEPMPL 
ERFGRRFPLA PGRRLEEYGA FYVGGSKASP DPDLDPDLSR LLLGWAPGQP FSSCCPDTGK 
TQDEGARAGR LRARRRYLVE RARDARVVGL LAGTLGVAQH REALAHLRNL TQAAGKRSYV 
LALGRPTPAK LANFPEVDVF VLLACPLGAL APQLSGSFFQ PILAPCELEA ACNPAWPPPG 
LAPHLTHYAD LLPGSPFHVA LPPPESELWE TPDVSLITGD LRPPPAWKSS NDHGSLALTP 
RPQLELAESS PAASFLSSRS WQGLEPRLGQ TPVTEAVSGR RGIAIAYEDE GSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.