Details for: ARID3A

Gene ID: 1820

Symbol: ARID3A

Ensembl ID: ENSG00000116017

Description: AT-rich interaction domain 3A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.71
    Marker Score: 8878
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.58
    Marker Score: 2116.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.46
    Marker Score: 2973
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.02
    Marker Score: 7926
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.72
    Marker Score: 946
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.67
    Marker Score: 862
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.62
    Marker Score: 946
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168329
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.28
    Marker Score: 3179
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.27
    Marker Score: 1099.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.24
    Marker Score: 5149
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.15
    Marker Score: 469
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.13
    Marker Score: 561
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.12
    Marker Score: 405
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.11
    Marker Score: 2619
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.11
    Marker Score: 459
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.08
    Marker Score: 60179
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.03
    Marker Score: 729
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2049
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1
    Marker Score: 322
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71742.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47967
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15521
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.97
    Marker Score: 1859
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.96
    Marker Score: 226
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.96
    Marker Score: 642
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.95
    Marker Score: 1097.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.94
    Marker Score: 888
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.94
    Marker Score: 344
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.94
    Marker Score: 947
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.94
    Marker Score: 593.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1506
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.92
    Marker Score: 3415
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.91
    Marker Score: 381
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.9
    Marker Score: 177
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.9
    Marker Score: 1872
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.89
    Marker Score: 3733
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.89
    Marker Score: 537
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.88
    Marker Score: 598.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.87
    Marker Score: 8174
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.87
    Marker Score: 971
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4924
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.84
    Marker Score: 1981
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.84
    Marker Score: 220
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.84
    Marker Score: 51376
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.83
    Marker Score: 412
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.82
    Marker Score: 547
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.82
    Marker Score: 1091
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.81
    Marker Score: 206
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.8
    Marker Score: 7604
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 734
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.79
    Marker Score: 634
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.79
    Marker Score: 954
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.78
    Marker Score: 169
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.77
    Marker Score: 377
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.76
    Marker Score: 268
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3106
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 470
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.73
    Marker Score: 337
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.73
    Marker Score: 1245
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1129
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.72
    Marker Score: 557
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.72
    Marker Score: 351
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.7
    Marker Score: 757.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.7
    Marker Score: 6017
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.69
    Marker Score: 839
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.69
    Marker Score: 9125.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.69
    Marker Score: 378
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.68
    Marker Score: 6941
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.68
    Marker Score: 1245
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.68
    Marker Score: 728
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.68
    Marker Score: 4075
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.67
    Marker Score: 602
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.67
    Marker Score: 327
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.67
    Marker Score: 439
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.66
    Marker Score: 298
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.66
    Marker Score: 6838
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.66
    Marker Score: 1785
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.65
    Marker Score: 438
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.64
    Marker Score: 343
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.64
    Marker Score: 336
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.64
    Marker Score: 2590
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.63
    Marker Score: 234
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.62
    Marker Score: 1504
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.62
    Marker Score: 388
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.62
    Marker Score: 293
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.62
    Marker Score: 336

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Other Information

**Key characteristics:** * ARID3A is a protein of approximately 400 amino acids. * It is found in the nucleus and cytoplasm of eukaryotic cells. * It is a member of the ARID family of proteins, which are involved in chromatin remodeling and gene regulation. * ARID3A is a key regulator of cell cycle genes. **Pathways and functions:** * ARID3A is involved in the regulation of cell cycle genes through a variety of mechanisms. * It is a key regulator of the G1/S transition, which is the phase of the cell cycle in which cells decide whether to divide or stop dividing. * ARID3A also regulates the expression of genes involved in apoptosis, cell cycle arrest, and DNA repair. **Clinical significance:** * Mutations in ARID3A have been linked to a number of human diseases, including liver cancer, pancreatic cancer, and kidney cancer. * Targeting ARID3A has been shown to be a promising strategy for treating these diseases. **Additional information:** * ARID3A is a highly conserved protein, with a similar protein found in other mammals. * It is a member of the WD repeat family of proteins, which are involved in protein-protein interactions. * ARID3A is a relatively new protein, with no known paralogs in humans.

Genular Protein ID: 466829677

Symbol: ARI3A_HUMAN

Name: AT-rich interactive domain-containing protein 3A

UniProtKB Accession Codes:

Q99856 Q5I858 Q6P9C6 Q8IZA7 Q8N4Z3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9722953

Title: The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome.

PubMed ID: 9722953

DOI: 10.1006/geno.1998.5259

PubMed ID: 9780002

Title: A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer.

PubMed ID: 9780002

DOI: 10.1038/sj.onc.1202163

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11812999

Title: A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

PubMed ID: 11812999

DOI: 10.1038/ncb742

PubMed ID: 12692263

Title: E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53.

PubMed ID: 12692263

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16738337

Title: Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.

PubMed ID: 16738337

DOI: 10.1128/mcb.02009-05

PubMed ID: 17400556

Title: REKLES is an ARID3-restricted multifunctional domain.

PubMed ID: 17400556

DOI: 10.1074/jbc.m700397200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20455271

Title: Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target.

PubMed ID: 20455271

DOI: 10.1002/prot.22718

Sequence Information:

  • Length: 593
  • Mass: 62889
  • Checksum: 4D09131E168A2880
  • Sequence:
    • MKLQAVMETL LQRQQRARQE LEARQQLPPD PPAAPPGRAR AAPDEDREPE SARMQRAQMA 
ALAAMRAAAA GLGHPASPGG SEDGPPGSEE EDAAREGTPG SPGRGREGPG EEHFEDMASD 
EDMKPKWEEE EMEEDLGEDE EEEEEDYEDE EEEEDEEGLG PPGPASLGTT ALFPRKAQPP 
QAFRGDGVPR VLGGQERPGP GPAHPGGAAH VAPQLQPPDH GDWTYEEQFK QLYELDGDPK 
RKEFLDDLFS FMQKRGTPVN RIPIMAKQVL DLFMLYVLVT EKGGLVEVIN KKLWREITKG 
LNLPTSITSA AFTLRTQYMK YLYPYECEKR GLSNPNELQA AIDSNRREGR RQSFGGSLFA 
YSPGGAHGML SSPKLPVSSL GLAASTNGSS ITPAPKIKKE EDSAIPITVP GRLPVSLAGH 
PVVAAQAAAV QAAAAQAAVA AQAAALEQLR EKLESAEPPE KKMALVADEQ QRLMQRALQQ 
NFLAMAAQLP MSIRINSQAS ESRQDSAVNL TGTNGSNSIS MSVEINGIMY TGVLFAQPPA 
PTPTSAPNKG GGGGGGSSSN AGGRGGNTGT SGGQAGPAGL STPSTSTSNN SLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.