Gene DUSP5 - ENSG00000138166 | NCBI Gene ID: 1847

Details for: DUSP5

Gene ID: 1847

Symbol: DUSP5

Ensembl ID: ENSG00000138166

Description: dual specificity phosphatase 5

Associated with

Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of mapk pathway
(R-HSA-5675221)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Signal transduction
(R-HSA-162582)
Cytoplasm
(GO:0005737)
Dephosphorylation
(GO:0016311)
Endoderm formation
(GO:0001706)
Erk1 and erk2 cascade
(GO:0070371)
Mapk cascade
(GO:0000165)
Map kinase tyrosine/serine/threonine phosphatase activity
(GO:0017017)
Map kinase tyrosine phosphatase activity
(GO:0033550)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of mapk cascade
(GO:0043409)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-threonine dephosphorylation
(GO:0035970)
Peptidyl-tyrosine dephosphorylation
(GO:0035335)
Phosphatase activity
(GO:0016791)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein tyrosine/serine/threonine phosphatase activity
(GO:0008138)
Protein tyrosine/threonine phosphatase activity
(GO:0008330)
Protein tyrosine phosphatase activity
(GO:0004725)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.94
Marker Score: 2313
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.28
Marker Score: 1550.5
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.2
Marker Score: 3242.5
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.18
Marker Score: 5352
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.13
Marker Score: 8227
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.88
Marker Score: 1599
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.83
Marker Score: 1921
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.72
Marker Score: 1081
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.61
Marker Score: 54745
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.55
Marker Score: 3796
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.51
Marker Score: 629.5
Cell Name: male germ cell (CL0000015)
Fold Change: 1.46
Marker Score: 422
Cell Name: germ cell (CL0000586)
Fold Change: 1.42
Marker Score: 2473
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.41
Marker Score: 5231
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.4
Marker Score: 348
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.39
Marker Score: 348
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.36
Marker Score: 2770
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.33
Marker Score: 418
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.31
Marker Score: 407.5
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.3
Marker Score: 2208.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.27
Marker Score: 3549
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.26
Marker Score: 19642
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.2
Marker Score: 2390
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.19
Marker Score: 422
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.17
Marker Score: 456
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.16
Marker Score: 695
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.14
Marker Score: 961
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.14
Marker Score: 585
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.14
Marker Score: 1907
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.07
Marker Score: 272
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.06
Marker Score: 323
Cell Name: club cell (CL0000158)
Fold Change: 1.05
Marker Score: 1231
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.03
Marker Score: 592
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.02
Marker Score: 353
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1
Marker Score: 379
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1
Marker Score: 494
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71695.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47920
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30396
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.97
Marker Score: 281
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.97
Marker Score: 614
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2395
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.94
Marker Score: 206
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 478
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 432
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.91
Marker Score: 763
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2697
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9
Marker Score: 3533
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 0.88
Marker Score: 234
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.87
Marker Score: 1271
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.87
Marker Score: 210
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.87
Marker Score: 351
Cell Name: secretory cell (CL0000151)
Fold Change: 0.87
Marker Score: 1589
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.87
Marker Score: 280
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.87
Marker Score: 228
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5232
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.85
Marker Score: 29435
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.84
Marker Score: 4782
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.83
Marker Score: 748
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.83
Marker Score: 1044
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.82
Marker Score: 236
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.8
Marker Score: 203
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.8
Marker Score: 745
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.79
Marker Score: 2036
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.78
Marker Score: 666
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.78
Marker Score: 859
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1260
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.77
Marker Score: 309.5
Cell Name: leukocyte (CL0000738)
Fold Change: 0.77
Marker Score: 441
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.77
Marker Score: 821
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 583
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.76
Marker Score: 594
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.75
Marker Score: 774
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.74
Marker Score: 322
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.73
Marker Score: 502
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.73
Marker Score: 246
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 374
Cell Name: mature T cell (CL0002419)
Fold Change: 0.72
Marker Score: 7095
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.69
Marker Score: 747
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.68
Marker Score: 166
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.68
Marker Score: 341
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.68
Marker Score: 5837.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.68
Marker Score: 323
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.68
Marker Score: 843
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.68
Marker Score: 432
Cell Name: fibroblast (CL0000057)
Fold Change: 0.67
Marker Score: 648
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.67
Marker Score: 445
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.66
Marker Score: 5192
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.66
Marker Score: 150
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.66
Marker Score: 247
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.66
Marker Score: 395
Cell Name: brush cell (CL0002204)
Fold Change: 0.66
Marker Score: 603
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.66
Marker Score: 714
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.65
Marker Score: 350
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.64
Marker Score: 400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.64
Marker Score: 2689
Cell Name: plasma cell (CL0000786)
Fold Change: 0.63
Marker Score: 709
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.63
Marker Score: 261

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**Key characteristics:** - DUSP5 is a cytoplasmic protein with a molecular weight of approximately 120 kDa. - It is a serine/threonine phosphatase with dual specificities for tyrosine and serine/threonine residues. - It is a key regulator of the MAPK pathway, which is involved in cell growth, differentiation, and migration. - It also regulates the endoderm formation pathway, which is essential for the development of the gastrointestinal tract. - It is involved in the regulation of cell migration and adhesion. **Pathways and functions:** - DUSP5 is a key regulator of the MAPK pathway. It is a negative regulator of the pathway, meaning that it inhibits the activation of the MAPK pathway. - MAPK pathway is involved in various cellular processes, including cell growth, differentiation, and migration. - DUSP5 inhibits the activation of the MAPK pathway by dephosphorylating MAPK substrates, such as MAPKAPK and MAPKAPK2. - This prevents the phosphorylation of MAPK substrates and inhibits their activity. - DUSP5 also regulates the endoderm formation pathway. It is expressed in epithelial cells of the gastrointestinal tract and is required for the formation of the endoderm. - It is involved in the regulation of cell migration and adhesion. **Clinical significance:** - Mutations in DUSP5 have been linked to several human diseases, including cancer and cardiovascular disease. - Overexpression of DUSP5 has been observed in many human cancers, where it promotes cell growth and migration. - Inhibition of DUSP5 has been shown to inhibit cancer cell growth and migration, suggesting that it could be a potential therapeutic target for cancer treatment. **Additional notes:** - DUSP5 is a highly conserved protein with homologs in other species. - It is a member of the dual-specificity phosphatase family of proteins, which also includes DUSP1, DUSP2, and DUSP3. - DUSP5 is a relatively new protein that is still being extensively studied.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dual specificity protein phosphatase 5

Genular Protein ID: 3032859118

Symbol: DUS5_HUMAN

Name: Dual specificity protein phosphatase 5

UniProtKB Accession Codes:

Q16690 Q12997 Q5T603

Database IDs:

Citations:

PubMed ID: 7961985

Title: A novel dual specificity phosphatase induced by serum stimulation and heat shock.

PubMed ID: 7961985

DOI: 10.1016/s0021-9258(18)43965-8

PubMed ID: 7836374

Title: Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines.

PubMed ID: 7836374

DOI: 10.1074/jbc.270.3.1156

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17078075

Title: Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase.

PubMed ID: 17078075

DOI: 10.1002/prot.21224

Sequence Information:

Length: 384
Mass: 42047
Checksum: 2E4B2938F886CB4E
Sequence:

MKVTSLDGRQ LRKMLRKEAA ARCVVLDCRP YLAFAASNVR GSLNVNLNSV VLRRARGGAV 
SARYVLPDEA ARARLLQEGG GGVAAVVVLD QGSRHWQKLR EESAARVVLT SLLACLPAGP 
RVYFLKGGYE TFYSEYPECC VDVKPISQEK IESERALISQ CGKPVVNVSY RPAYDQGGPV 
EILPFLYLGS AYHASKCEFL ANLHITALLN VSRRTSEACA THLHYKWIPV EDSHTADISS 
HFQEAIDFID CVREKGGKVL VHCEAGISRS PTICMAYLMK TKQFRLKEAF DYIKQRRSMV 
SPNFGFMGQL LQYESEILPS TPNPQPPSCQ GEAAGSSLIG HLQTLSPDMQ GAYCTFPASV 
LAPVPTHSTV SELSRSPVAT ATSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DUSP5

Associated with

Cells (max top 100)

Other Information

A novel dual specificity phosphatase induced by serum stimulation and heat shock. PubMed ID: 7961985

Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. PubMed ID: 7836374

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054