Details for: DUSP5

Gene ID: 1847

Symbol: DUSP5

Ensembl ID: ENSG00000138166

Description: dual specificity phosphatase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.9137
    Cell Significance Index: -23.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.1085
    Cell Significance Index: -23.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 61.9739
    Cell Significance Index: -25.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.6795
    Cell Significance Index: -25.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.3073
    Cell Significance Index: -23.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1102
    Cell Significance Index: -24.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0161
    Cell Significance Index: -23.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5251
    Cell Significance Index: -16.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.4436
    Cell Significance Index: 282.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.8139
    Cell Significance Index: 131.0300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.0313
    Cell Significance Index: 18.6600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.8705
    Cell Significance Index: 50.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7574
    Cell Significance Index: 205.5100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.2791
    Cell Significance Index: 14.1100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.9368
    Cell Significance Index: 13.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6602
    Cell Significance Index: 47.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5622
    Cell Significance Index: 41.8600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.0885
    Cell Significance Index: 18.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7972
    Cell Significance Index: 22.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7608
    Cell Significance Index: 10.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6659
    Cell Significance Index: 17.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5751
    Cell Significance Index: 314.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4708
    Cell Significance Index: 4.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4591
    Cell Significance Index: 56.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4370
    Cell Significance Index: 20.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4264
    Cell Significance Index: 69.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4008
    Cell Significance Index: 51.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3592
    Cell Significance Index: 46.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3119
    Cell Significance Index: 33.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2774
    Cell Significance Index: 6.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2459
    Cell Significance Index: 17.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2145
    Cell Significance Index: 94.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1977
    Cell Significance Index: 8.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1594
    Cell Significance Index: 15.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1410
    Cell Significance Index: 25.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1374
    Cell Significance Index: 9.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1038
    Cell Significance Index: 11.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0837
    Cell Significance Index: 2.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0733
    Cell Significance Index: 14.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0578
    Cell Significance Index: 3.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0568
    Cell Significance Index: 10.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0245
    Cell Significance Index: 1.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0237
    Cell Significance Index: 4.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0229
    Cell Significance Index: 0.2600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.0069
    Cell Significance Index: 0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0024
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0114
    Cell Significance Index: -21.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0145
    Cell Significance Index: -26.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0174
    Cell Significance Index: -26.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0190
    Cell Significance Index: -10.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0201
    Cell Significance Index: -27.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0204
    Cell Significance Index: -15.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0222
    Cell Significance Index: -15.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0264
    Cell Significance Index: -0.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0272
    Cell Significance Index: -19.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0281
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0298
    Cell Significance Index: -18.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0308
    Cell Significance Index: -0.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0473
    Cell Significance Index: -13.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0483
    Cell Significance Index: -21.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0489
    Cell Significance Index: -10.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0504
    Cell Significance Index: -18.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0597
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0787
    Cell Significance Index: -9.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0810
    Cell Significance Index: -9.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0828
    Cell Significance Index: -12.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0861
    Cell Significance Index: -17.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1044
    Cell Significance Index: -5.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1101
    Cell Significance Index: -4.5100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1184
    Cell Significance Index: -1.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1353
    Cell Significance Index: -4.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1453
    Cell Significance Index: -14.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1473
    Cell Significance Index: -9.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1682
    Cell Significance Index: -10.6000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1741
    Cell Significance Index: -1.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1796
    Cell Significance Index: -5.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1877
    Cell Significance Index: -8.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1953
    Cell Significance Index: -5.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2198
    Cell Significance Index: -3.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2284
    Cell Significance Index: -5.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2288
    Cell Significance Index: -23.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2965
    Cell Significance Index: -23.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2989
    Cell Significance Index: -7.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3257
    Cell Significance Index: -19.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3288
    Cell Significance Index: -22.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3416
    Cell Significance Index: -7.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3625
    Cell Significance Index: -7.7200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3679
    Cell Significance Index: -3.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3680
    Cell Significance Index: -20.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3711
    Cell Significance Index: -6.3600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3991
    Cell Significance Index: -2.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4085
    Cell Significance Index: -25.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4110
    Cell Significance Index: -18.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4125
    Cell Significance Index: -9.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4218
    Cell Significance Index: -13.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4313
    Cell Significance Index: -22.6500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4338
    Cell Significance Index: -4.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4432
    Cell Significance Index: -16.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DUSP5 is a dual specificity phosphatase, meaning it possesses the ability to dephosphorylate both tyrosine and threonine/serine residues on MAPKs. This unique property allows it to regulate the activity of multiple MAPKs, including ERK1/2, JNK, and p38, which are involved in various cellular processes. DUSP5 is also known to interact with other proteins, such as Raf, to regulate the activation of MAPKs. The gene is highly expressed in epithelial cells, suggesting its importance in tissue homeostasis and repair. **Pathways and Functions** DUSP5 plays a crucial role in regulating the MAPK signaling cascade, which is involved in various cellular processes, including: 1. **Cell growth and differentiation**: DUSP5 regulates the activity of ERK1/2, which is involved in cell proliferation, differentiation, and survival. 2. **Apoptosis**: DUSP5 can regulate the activity of p38, which is involved in apoptosis and cell death. 3. **Inflammation**: DUSP5 can regulate the activity of JNK, which is involved in inflammation and immune responses. 4. **Immune responses**: DUSP5 is highly expressed in immune cells like IgA plasma cells, suggesting its importance in regulating immune responses. **Clinical Significance** DUSP5 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of DUSP5 has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential as a therapeutic target. 2. **Inflammatory diseases**: DUSP5 has been implicated in inflammatory diseases, such as rheumatoid arthritis and asthma, suggesting its potential as a therapeutic target. 3. **Neurological disorders**: DUSP5 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential as a therapeutic target. In conclusion, DUSP5 is a critical regulator of the MAPK signaling cascade, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functions of DUSP5 and its potential as a therapeutic target.

Genular Protein ID: 3032859118

Symbol: DUS5_HUMAN

Name: Dual specificity protein phosphatase 5

UniProtKB Accession Codes:

Q16690 Q12997 Q5T603

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 9 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7961985

Title: A novel dual specificity phosphatase induced by serum stimulation and heat shock.

PubMed ID: 7961985

DOI: 10.1016/s0021-9258(18)43965-8

PubMed ID: 7836374

Title: Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines.

PubMed ID: 7836374

DOI: 10.1074/jbc.270.3.1156

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17078075

Title: Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase.

PubMed ID: 17078075

DOI: 10.1002/prot.21224

Sequence Information:

  • Length: 384
  • Mass: 42047
  • Checksum: 2E4B2938F886CB4E
  • Sequence:
    • MKVTSLDGRQ LRKMLRKEAA ARCVVLDCRP YLAFAASNVR GSLNVNLNSV VLRRARGGAV 
SARYVLPDEA ARARLLQEGG GGVAAVVVLD QGSRHWQKLR EESAARVVLT SLLACLPAGP 
RVYFLKGGYE TFYSEYPECC VDVKPISQEK IESERALISQ CGKPVVNVSY RPAYDQGGPV 
EILPFLYLGS AYHASKCEFL ANLHITALLN VSRRTSEACA THLHYKWIPV EDSHTADISS 
HFQEAIDFID CVREKGGKVL VHCEAGISRS PTICMAYLMK TKQFRLKEAF DYIKQRRSMV 
SPNFGFMGQL LQYESEILPS TPNPQPPSCQ GEAAGSSLIG HLQTLSPDMQ GAYCTFPASV 
LAPVPTHSTV SELSRSPVAT ATSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.