Gene E2F2 - ENSG00000007968 | NCBI Gene ID: 1870

Details for: E2F2

Gene ID: 1870

Symbol: E2F2

Ensembl ID: ENSG00000007968

Description: E2F transcription factor 2

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin d associated events in g1
(R-HSA-69231)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
G1 phase
(R-HSA-69236)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Cell cycle
(GO:0007049)
Chromatin
(GO:0000785)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Lens fiber cell apoptotic process
(GO:1990086)
Negative regulation of sprouting angiogenesis
(GO:1903671)
Nucleoplasm
(GO:0005654)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Rb-e2f complex
(GO:0035189)
Regulation of cell cycle
(GO:0051726)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 2.4
Marker Score: 1572
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.85
Marker Score: 2650
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.24
Marker Score: 3362
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.01
Marker Score: 2092
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71822
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48047
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5226
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5285
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 695
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 391
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 565
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.71
Marker Score: 195
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.69
Marker Score: 276.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.66
Marker Score: 2754
Cell Name: plasmablast (CL0000980)
Fold Change: 0.61
Marker Score: 815
Cell Name: Unknown (CL0000548)
Fold Change: 0.58
Marker Score: 424
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.53
Marker Score: 396
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.51
Marker Score: 326.5
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.48
Marker Score: 156
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.47
Marker Score: 123
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 274
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.45
Marker Score: 1322
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.41
Marker Score: 215
Cell Name: thymocyte (CL0000893)
Fold Change: 0.4
Marker Score: 423
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 375
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.37
Marker Score: 326
Cell Name: germ cell (CL0000586)
Fold Change: 0.34
Marker Score: 594
Cell Name: mature B cell (CL0000785)
Fold Change: 0.34
Marker Score: 247
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.33
Marker Score: 376
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.32
Marker Score: 313
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.32
Marker Score: 102
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.31
Marker Score: 131
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.31
Marker Score: 174
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.3
Marker Score: 96
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.3
Marker Score: 146
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.28
Marker Score: 669
Cell Name: stem cell (CL0000034)
Fold Change: 0.28
Marker Score: 671
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.28
Marker Score: 312
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.26
Marker Score: 316
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.26
Marker Score: 128
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.26
Marker Score: 93
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.26
Marker Score: 126
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.26
Marker Score: 726
Cell Name: erythroblast (CL0000765)
Fold Change: 0.25
Marker Score: 158
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.25
Marker Score: 249
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.24
Marker Score: 88
Cell Name: osteoclast (CL0000092)
Fold Change: 0.24
Marker Score: 118
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.24
Marker Score: 142
Cell Name: reticulocyte (CL0000558)
Fold Change: 0.23
Marker Score: 97.5
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.22
Marker Score: 282
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.22
Marker Score: 1379
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.21
Marker Score: 163
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.2
Marker Score: 110
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.2
Marker Score: 143
Cell Name: blood cell (CL0000081)
Fold Change: 0.2
Marker Score: 2269
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.19
Marker Score: 625
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.19
Marker Score: 125
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.19
Marker Score: 50
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.19
Marker Score: 64
Cell Name: Unknown (CL0000003)
Fold Change: 0.18
Marker Score: 560
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.18
Marker Score: 101
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.18
Marker Score: 178
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.17
Marker Score: 54
Cell Name: plasma cell (CL0000786)
Fold Change: 0.17
Marker Score: 192
Cell Name: mast cell (CL0000097)
Fold Change: 0.17
Marker Score: 98
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.17
Marker Score: 50
Cell Name: podocyte (CL0000653)
Fold Change: 0.17
Marker Score: 62
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.17
Marker Score: 201
Cell Name: B cell (CL0000236)
Fold Change: 0.17
Marker Score: 158
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.16
Marker Score: 59
Cell Name: myelocyte (CL0002193)
Fold Change: 0.16
Marker Score: 70
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.16
Marker Score: 152
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.16
Marker Score: 73
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.16
Marker Score: 187
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.16
Marker Score: 78.5
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.16
Marker Score: 189
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.16
Marker Score: 266
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.16
Marker Score: 107
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.15
Marker Score: 486
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.15
Marker Score: 245
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.15
Marker Score: 95
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.15
Marker Score: 85
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.15
Marker Score: 36
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.14
Marker Score: 854
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.14
Marker Score: 101
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.14
Marker Score: 53
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.14
Marker Score: 36
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.14
Marker Score: 1188
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.14
Marker Score: 540

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**Key characteristics:** - E2F2 is a large protein with a molecular weight of approximately 160 kDa. - It is a member of the E2F family of transcription factors. - E2F2 is ubiquitinated and degraded by the proteasome. - It is expressed in a wide range of cell types, including cancer cells. **Pathways and functions:** - E2F2 is involved in regulating the cell cycle through various mechanisms, including: - Promoting cell cycle entry into G1 phase - Promoting cell cycle progression from G1 to S phase - Inhibiting cell cycle entry into S phase - Promoting cell cycle arrest in G2/M phase - E2F2 also plays a role in regulating apoptosis, cell differentiation, and stem cell function. **Clinical significance:** - Aberrant expression and function of E2F2 have been linked to various human diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. - Dysregulated E2F2 signaling has been implicated in tumor growth, cell survival, and metastasis. - Targeting E2F2 has emerged as a promising therapeutic strategy for cancer and other diseases where E2F2 signaling is aberrant. **Conclusion:** E2F2 is a critical regulator of the cell cycle and is essential for maintaining genomic stability. Abnormalities in E2F2 function and expression are associated with various human diseases, highlighting its importance in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor E2F2

Genular Protein ID: 3287088480

Symbol: E2F2_HUMAN

Name: Transcription factor E2F2

UniProtKB Accession Codes:

Q14209 B2R9W1 Q7Z6H1

Database IDs:

Citations:

PubMed ID: 8246995

Title: Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

PubMed ID: 8246995

DOI: 10.1128/mcb.13.12.7802-7812.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 15716352

Title: EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.

PubMed ID: 15716352

DOI: 10.1091/mbc.e04-11-0975

PubMed ID: 12502741

Title: Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.

PubMed ID: 12502741

DOI: 10.1101/gad.1046102

Sequence Information:

Length: 437
Mass: 47506
Checksum: 60541F4235507005
Sequence:

MLQGPRALAS AAGQTPKVVP AMSPTELWPS GLSSPQLCPA TATYYTPLYP QTAPPAAAPG 
TCLDATPHGP EGQVVRCLPA GRLPAKRKLD LEGIGRPVVP EFPTPKGKCI RVDGLPSPKT 
PKSPGEKTRY DTSLGLLTKK FIYLLSESED GVLDLNWAAE VLDVQKRRIY DITNVLEGIQ 
LIRKKAKNNI QWVGRGMFED PTRPGKQQQL GQELKELMNT EQALDQLIQS CSLSFKHLTE 
DKANKRLAYV TYQDIRAVGN FKEQTVIAVK APPQTRLEVP DRTEDNLQIY LKSTQGPIEV 
YLCPEEVQEP DSPSEEPLPS TSTLCPSPDS AQPSSSTDPS IMEPTASSVP APAPTPQQAP 
PPPSLVPLEA TDSLLELPHP LLQQTEDQFL SPTLACSSPL ISFSPSLDQD DYLWGLEAGE 
GISDLFDSYD LGDLLIN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: E2F2

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. PubMed ID: 8246995

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. PubMed ID: 16360038

EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. PubMed ID: 15716352

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. PubMed ID: 12502741