Details for: E2F2

Gene ID: 1870

Symbol: E2F2

Ensembl ID: ENSG00000007968

Description: E2F transcription factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.5694
    Cell Significance Index: -4.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.8330
    Cell Significance Index: -2.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9056
    Cell Significance Index: 89.5800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.5904
    Cell Significance Index: 7.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5054
    Cell Significance Index: 8.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4999
    Cell Significance Index: 6.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4832
    Cell Significance Index: 13.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4728
    Cell Significance Index: 76.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4518
    Cell Significance Index: 49.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4457
    Cell Significance Index: 84.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4438
    Cell Significance Index: 6.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4298
    Cell Significance Index: 25.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.3061
    Cell Significance Index: -0.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3031
    Cell Significance Index: 18.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2727
    Cell Significance Index: 32.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2592
    Cell Significance Index: 11.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2430
    Cell Significance Index: 5.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2391
    Cell Significance Index: 6.8900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.2062
    Cell Significance Index: 2.5600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1996
    Cell Significance Index: 0.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1470
    Cell Significance Index: 3.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1407
    Cell Significance Index: 127.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1306
    Cell Significance Index: 2.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1302
    Cell Significance Index: 3.8300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1180
    Cell Significance Index: 1.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1162
    Cell Significance Index: 6.5200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1062
    Cell Significance Index: 1.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0938
    Cell Significance Index: 6.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0723
    Cell Significance Index: 1.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0620
    Cell Significance Index: 4.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0488
    Cell Significance Index: 1.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0437
    Cell Significance Index: 8.6800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0422
    Cell Significance Index: 0.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0414
    Cell Significance Index: 18.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0366
    Cell Significance Index: 0.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0356
    Cell Significance Index: 1.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0242
    Cell Significance Index: 0.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0137
    Cell Significance Index: 0.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0090
    Cell Significance Index: 1.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0046
    Cell Significance Index: 0.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0035
    Cell Significance Index: 1.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0038
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0050
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0103
    Cell Significance Index: -3.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0114
    Cell Significance Index: -5.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0134
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0149
    Cell Significance Index: -2.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0149
    Cell Significance Index: -0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0176
    Cell Significance Index: -3.5300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0211
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0223
    Cell Significance Index: -3.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0229
    Cell Significance Index: -2.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0235
    Cell Significance Index: -3.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0238
    Cell Significance Index: -0.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0258
    Cell Significance Index: -0.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0296
    Cell Significance Index: -2.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0329
    Cell Significance Index: -3.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0411
    Cell Significance Index: -0.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0452
    Cell Significance Index: -4.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0485
    Cell Significance Index: -6.2700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0517
    Cell Significance Index: -1.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0544
    Cell Significance Index: -1.8900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0557
    Cell Significance Index: -0.3700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0571
    Cell Significance Index: -0.5700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0600
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0645
    Cell Significance Index: -1.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0672
    Cell Significance Index: -3.4900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0682
    Cell Significance Index: -0.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0699
    Cell Significance Index: -3.6400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0721
    Cell Significance Index: -0.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0744
    Cell Significance Index: -4.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0779
    Cell Significance Index: -5.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0805
    Cell Significance Index: -0.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0814
    Cell Significance Index: -0.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0830
    Cell Significance Index: -3.8700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0847
    Cell Significance Index: -0.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0854
    Cell Significance Index: -1.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0913
    Cell Significance Index: -3.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0936
    Cell Significance Index: -4.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0943
    Cell Significance Index: -7.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0977
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0985
    Cell Significance Index: -2.6800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1069
    Cell Significance Index: -1.2100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1075
    Cell Significance Index: -1.1700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1100
    Cell Significance Index: -0.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1104
    Cell Significance Index: -4.8900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1110
    Cell Significance Index: -1.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1125
    Cell Significance Index: -1.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** E2F2 is a transcription factor that belongs to the E2F family, which is characterized by its ability to bind to specific DNA sequences and regulate gene expression. E2F2 has a unique structure, consisting of a helix-loop-helix (HLH) domain, which allows it to interact with other transcription factors and DNA. E2F2 is highly expressed in various cell types, including T-helper 17 cells, respiratory basal cells, and kidney proximal convoluted tubule epithelial cells. Its expression is also elevated in cancer cells, where it contributes to the development and progression of tumors. **Pathways and Functions:** E2F2 is involved in several key pathways, including: 1. **Cell cycle regulation:** E2F2 regulates the expression of genes involved in the G1/S transition and mitosis, ensuring proper cell cycle progression. 2. **Apoptosis regulation:** E2F2 can induce apoptosis in certain cell types, including cancer cells, by regulating the expression of pro-apoptotic genes. 3. **DNA damage response:** E2F2 regulates the expression of genes involved in DNA damage response, including those involved in nucleotide excision repair and mismatch repair. 4. **Stress response:** E2F2 can regulate the expression of genes involved in stress response, including those involved in heat shock and oxidative stress. **Clinical Significance:** E2F2 dysregulation has been implicated in various cancers, including breast, lung, and colon cancer. Overexpression of E2F2 has been observed in many cancer types, and its expression is often correlated with poor prognosis. E2F2 has also been shown to contribute to the development of cancer by regulating the expression of genes involved in cell proliferation, differentiation, and apoptosis. In addition to its role in cancer, E2F2 has also been implicated in other diseases, including: 1. **Oxidative stress-induced senescence:** E2F2 can regulate the expression of genes involved in oxidative stress-induced senescence, contributing to the development of age-related diseases. 2. **Oncogene-induced senescence:** E2F2 can regulate the expression of genes involved in oncogene-induced senescence, contributing to the development of cancer. **Conclusion:** In conclusion, E2F2 is a critical transcription factor that plays a key role in regulating the cell cycle, apoptosis, and stress response. Its dysregulation has been implicated in various cancers and other diseases, highlighting its importance as a potential therapeutic target. Further research is needed to fully understand the mechanisms by which E2F2 regulates cellular processes and to explore its potential as a therapeutic agent for cancer and other diseases.

Genular Protein ID: 3287088480

Symbol: E2F2_HUMAN

Name: Transcription factor E2F2

UniProtKB Accession Codes:

Q14209 B2R9W1 Q7Z6H1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8246995

Title: Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

PubMed ID: 8246995

DOI: 10.1128/mcb.13.12.7802-7812.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 15716352

Title: EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.

PubMed ID: 15716352

DOI: 10.1091/mbc.e04-11-0975

PubMed ID: 12502741

Title: Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.

PubMed ID: 12502741

DOI: 10.1101/gad.1046102

Sequence Information:

  • Length: 437
  • Mass: 47506
  • Checksum: 60541F4235507005
  • Sequence:
    • MLQGPRALAS AAGQTPKVVP AMSPTELWPS GLSSPQLCPA TATYYTPLYP QTAPPAAAPG 
TCLDATPHGP EGQVVRCLPA GRLPAKRKLD LEGIGRPVVP EFPTPKGKCI RVDGLPSPKT 
PKSPGEKTRY DTSLGLLTKK FIYLLSESED GVLDLNWAAE VLDVQKRRIY DITNVLEGIQ 
LIRKKAKNNI QWVGRGMFED PTRPGKQQQL GQELKELMNT EQALDQLIQS CSLSFKHLTE 
DKANKRLAYV TYQDIRAVGN FKEQTVIAVK APPQTRLEVP DRTEDNLQIY LKSTQGPIEV 
YLCPEEVQEP DSPSEEPLPS TSTLCPSPDS AQPSSSTDPS IMEPTASSVP APAPTPQQAP 
PPPSLVPLEA TDSLLELPHP LLQQTEDQFL SPTLACSSPL ISFSPSLDQD DYLWGLEAGE 
GISDLFDSYD LGDLLIN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.