Details for: EBF1

Gene ID: 1879

Symbol: EBF1

Ensembl ID: ENSG00000164330

Description: EBF transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 238.9659
    Cell Significance Index: -37.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 146.5838
    Cell Significance Index: -37.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.1633
    Cell Significance Index: -37.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 30.0011
    Cell Significance Index: -65.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 18.1742
    Cell Significance Index: 397.9500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 14.8387
    Cell Significance Index: 100.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 14.2226
    Cell Significance Index: 277.5900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 13.7077
    Cell Significance Index: 172.6100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 10.9947
    Cell Significance Index: 114.5300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 10.2247
    Cell Significance Index: 44.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3080
    Cell Significance Index: -36.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 8.5219
    Cell Significance Index: 146.0400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 7.9188
    Cell Significance Index: 113.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 6.3251
    Cell Significance Index: 53.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 5.0058
    Cell Significance Index: 107.0000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.9056
    Cell Significance Index: 41.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6652
    Cell Significance Index: 171.9500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.0671
    Cell Significance Index: 21.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8695
    Cell Significance Index: 70.8000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.7673
    Cell Significance Index: 8.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0538
    Cell Significance Index: 124.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9951
    Cell Significance Index: 127.5700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.9206
    Cell Significance Index: 11.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7692
    Cell Significance Index: 22.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7489
    Cell Significance Index: 102.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5758
    Cell Significance Index: 32.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5693
    Cell Significance Index: 10.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2963
    Cell Significance Index: 1.7900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.2393
    Cell Significance Index: 3.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1554
    Cell Significance Index: 8.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1292
    Cell Significance Index: 23.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0606
    Cell Significance Index: 37.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0405
    Cell Significance Index: 28.0200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0254
    Cell Significance Index: 0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0206
    Cell Significance Index: 9.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0153
    Cell Significance Index: -8.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0171
    Cell Significance Index: -32.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0207
    Cell Significance Index: -38.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0252
    Cell Significance Index: -16.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0252
    Cell Significance Index: -38.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0303
    Cell Significance Index: -41.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0349
    Cell Significance Index: -0.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0367
    Cell Significance Index: -2.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0509
    Cell Significance Index: -38.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0697
    Cell Significance Index: -38.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0739
    Cell Significance Index: -21.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0828
    Cell Significance Index: -17.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0863
    Cell Significance Index: -30.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0957
    Cell Significance Index: -19.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1139
    Cell Significance Index: -14.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1178
    Cell Significance Index: -20.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1449
    Cell Significance Index: -29.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1697
    Cell Significance Index: -24.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2334
    Cell Significance Index: -30.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2458
    Cell Significance Index: -28.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2565
    Cell Significance Index: -5.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2794
    Cell Significance Index: -28.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2913
    Cell Significance Index: -33.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3396
    Cell Significance Index: -25.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3424
    Cell Significance Index: -39.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3429
    Cell Significance Index: -5.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3547
    Cell Significance Index: -36.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3849
    Cell Significance Index: -18.0900
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.3860
    Cell Significance Index: -4.0600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4000
    Cell Significance Index: -4.6500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.4397
    Cell Significance Index: -4.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4869
    Cell Significance Index: -25.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5320
    Cell Significance Index: -35.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5322
    Cell Significance Index: -32.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5351
    Cell Significance Index: -8.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5551
    Cell Significance Index: -34.1200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.6095
    Cell Significance Index: -7.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6816
    Cell Significance Index: -17.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7236
    Cell Significance Index: -37.5900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.7520
    Cell Significance Index: -7.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7817
    Cell Significance Index: -49.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7914
    Cell Significance Index: -36.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8159
    Cell Significance Index: -11.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8323
    Cell Significance Index: -36.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8379
    Cell Significance Index: -29.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9773
    Cell Significance Index: -28.7900
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -1.0137
    Cell Significance Index: -9.3800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.0161
    Cell Significance Index: -20.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0288
    Cell Significance Index: -27.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0363
    Cell Significance Index: -38.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0413
    Cell Significance Index: -36.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0709
    Cell Significance Index: -31.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0907
    Cell Significance Index: -29.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1002
    Cell Significance Index: -36.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1515
    Cell Significance Index: -36.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.1601
    Cell Significance Index: -28.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.1762
    Cell Significance Index: -37.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.1874
    Cell Significance Index: -29.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.1933
    Cell Significance Index: -41.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.2056
    Cell Significance Index: -32.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2581
    Cell Significance Index: -32.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2727
    Cell Significance Index: -36.3200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -1.2963
    Cell Significance Index: -17.2800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -1.3076
    Cell Significance Index: -16.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor**: EBF1 belongs to the basic helix-loop-helix (bHLH) family of transcription factors, which are known for their role in regulating gene expression. 2. **Specificity**: EBF1 exhibits specificity towards RNA polymerase II (RNAP II)-specific DNA binding, indicating its involvement in the regulation of RNAP II-dependent transcriptional programs. 3. **Metal Ion Binding**: The protein's ability to bind metal ions suggests its involvement in redox-sensitive regulatory mechanisms. 4. **Cellular Expression**: EBF1 is significantly expressed in various cell types, including Purkinje cells, contractile cells, chromaffin cells, skeletal muscle fibroblasts, subcutaneous fat cells, stellate neurons, neuronal brush cells, renal interstitial pericytes, fat cells, and retinal ganglion cells. **Pathways and Functions:** 1. **Olfactory Signaling Pathway**: EBF1 is implicated in the regulation of olfactory receptor expression and olfactory signaling, highlighting its importance in the detection of odorant molecules. 2. **White Adipocyte Differentiation**: EBF1 regulates the transcriptional program of white adipocyte differentiation, influencing fat cell development and function. 3. **Sensory Perception**: The protein's role in olfactory signaling and sensory perception underscores its involvement in the detection of various stimuli, including odorants and other sensory molecules. 4. **Transcriptional Regulation**: EBF1's ability to bind RNAP II-specific DNA and regulate transcriptional programs highlights its involvement in the regulation of gene expression. **Clinical Significance:** 1. **Olfactory Disorders**: Dysregulation of EBF1 may contribute to olfactory disorders, such as anosmia or hyposmia, highlighting the protein's potential as a therapeutic target. 2. **Metabolic Disorders**: EBF1's role in white adipocyte differentiation and regulation of metabolic gene programs suggests its involvement in metabolic disorders, such as obesity and insulin resistance. 3. **Neurological Disorders**: The protein's expression in neuronal cells and its involvement in sensory perception raise the possibility of its role in neurological disorders, such as Alzheimer's disease or Parkinson's disease. 4. **Cancer**: EBF1's transcriptional regulatory functions may contribute to cancer development and progression, highlighting the need for further investigation into its role in cancer biology. In conclusion, EBF1 is a multifaceted transcription factor that plays a crucial role in regulating various cellular processes, including olfactory signaling, white adipocyte differentiation, and sensory perception. Further research into the clinical significance of EBF1 is warranted, as it may hold promise for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2664861519

Symbol: COE1_HUMAN

Name: Transcription factor COE1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10942392

Title: Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse.

PubMed ID: 10942392

PubMed ID: 14630787

Title: Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.

PubMed ID: 14630787

DOI: 10.1182/blood-2003-07-2388

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 26819314

Title: Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor.

PubMed ID: 26819314

DOI: 10.1128/jvi.03227-15

PubMed ID: 27807034

Title: Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis.

PubMed ID: 27807034

DOI: 10.1101/gad.285452.116

PubMed ID: 28968461

Title: EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.

PubMed ID: 28968461

DOI: 10.1371/journal.ppat.1006664

PubMed ID: 20592035

Title: Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif.

PubMed ID: 20592035

DOI: 10.1074/jbc.c110.150482

Sequence Information:

  • Length: 591
  • Mass: 64464
  • Checksum: E47797B6FC1E5071
  • Sequence:
  • MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA RAHFEKQPPS 
    NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN SEKTNNGIHY RLQLLYSNGI 
    RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM CRVLLTHEIM CSRCCDKKSC GNRNETPSDP 
    VIIDRFFLKF FLKCNQNCLK NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH 
    GRRARRLDPS EGTPSYLEHA TPCIKAISPS EGWTTGGATV IIIGDNFFDG LQVIFGTMLV 
    WSELITPHAI RVQTPPRHIP GVVEVTLSYK SKQFCKGTPG RFIYTALNEP TIDYGFQRLQ 
    KVIPRHPGDP ERLPKEVILK RAADLVEALY GMPHNNQEII LKRAADIAEA LYSVPRNHNQ 
    LPALANTSVH AGMMGVNSFS GQLAVNVSEA SQATNQGFTR NSSSVSPHGY VPSTTPQQTN 
    YNSVTTSMNG YGSAAMSNLG GSPTFLNGSA ANSPYAIVPS SPTMASSTSL PSNCSSSSGI 
    FSFSPANMVS AVKQKSAFAP VVRPQTSPPP TCTSTNGNSL QAISGMIVPP M

Genular Protein ID: 554347143

Symbol: B4E2U8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 578
  • Mass: 63026
  • Checksum: F617F7E252D128C5
  • Sequence:
  • MKEEPLGSGM NAVRTWMQGA GVLDANTAAQ SGVGLARAHF EKQPPSNLRK SNFFHFVLAL 
    YDRQGQPVEI ERTAFVGFVE KEKEANSEKT NNGIHYRLQL LYSNGIRTEQ DFYVRLIDSM 
    TKQAIVYEGQ DKNPEMCRVL LTHEIMCSRC CDKKSCGNRN ETPSDPVIID RFFLKFFLKC 
    NQNCLKNAGN PRDMRRFQVV VSTTVNVDGH VLAVSDNMFV HNNSKHGRRA RRLDPSEGTP 
    SYLEHAATPC IKAISPSEGW TTGGATVIII GDNFFDGLQV IFGTMLVWSE LITPHAIRVQ 
    TPPRHIPGVV EVTLSYKSKQ FCKGTPGRFI YTALNEPTID YGFQRLQKVI PRHPGDPERL 
    PKEVILKRAA DLVEALYGMP HNNQEIILKR AADIAEALYS VPRNHNQLPA LANTSVHAGM 
    MGVNSFSGQL AVNVSEASQA TNQGFTRNSS SVSPHGYVPS TTPQQTNYNS VTTSMNGYGS 
    AAMSNLGGSP TFLNGSAANS PYAIVPSSPT MASSTSLPSN CSSSSGIFSF SPANMVSAVK 
    QKSAFAPVVR PQTSPPPTCT STNGNSLQAI SGMIVPPM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.