Details for: EBF1

Gene ID: 1879

Symbol: EBF1

Ensembl ID: ENSG00000164330

Description: EBF transcription factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 8
    Marker Score: 270256
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 6.97
    Marker Score: 3777
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 6.62
    Marker Score: 9311
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.13
    Marker Score: 4035
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 5.19
    Marker Score: 1896
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.49
    Marker Score: 24136
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.33
    Marker Score: 14524
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 4.2
    Marker Score: 4006
  • Cell Name: fat cell (CL0000136)
    Fold Change: 3.96
    Marker Score: 2211
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 3.76
    Marker Score: 4693
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.43
    Marker Score: 3945
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.36
    Marker Score: 1614
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.05
    Marker Score: 15982
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.01
    Marker Score: 5791
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.98
    Marker Score: 1668
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.84
    Marker Score: 1604
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.81
    Marker Score: 728
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.71
    Marker Score: 821
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.68
    Marker Score: 1204
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.6
    Marker Score: 1511
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.53
    Marker Score: 1061
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.41
    Marker Score: 6909
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.27
    Marker Score: 1357
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.15
    Marker Score: 495
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.04
    Marker Score: 20706
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.04
    Marker Score: 639
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.01
    Marker Score: 2020
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.96
    Marker Score: 2317
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.91
    Marker Score: 523
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.86
    Marker Score: 1036
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.68
    Marker Score: 3151
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.67
    Marker Score: 1189
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.65
    Marker Score: 17025
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.63
    Marker Score: 4425
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.56
    Marker Score: 765.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.54
    Marker Score: 1923
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.51
    Marker Score: 3069
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.48
    Marker Score: 366
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.48
    Marker Score: 389
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.47
    Marker Score: 859
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.46
    Marker Score: 560
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.37
    Marker Score: 5917
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.36
    Marker Score: 4046
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.32
    Marker Score: 374
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.29
    Marker Score: 775.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.27
    Marker Score: 1949
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.24
    Marker Score: 534
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.23
    Marker Score: 1331
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.22
    Marker Score: 140062
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.17
    Marker Score: 1099
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.16
    Marker Score: 39336
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.16
    Marker Score: 694
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.15
    Marker Score: 276
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.12
    Marker Score: 1107
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.12
    Marker Score: 2237
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.12
    Marker Score: 396
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.11
    Marker Score: 264
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.11
    Marker Score: 6651
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.09
    Marker Score: 1344
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.09
    Marker Score: 536
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.05
    Marker Score: 939
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.04
    Marker Score: 497
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251767
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15682
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48012
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.97
    Marker Score: 2533
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.95
    Marker Score: 645
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.94
    Marker Score: 466
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.94
    Marker Score: 1596
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.94
    Marker Score: 904
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5251
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.91
    Marker Score: 820
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9
    Marker Score: 10174
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.9
    Marker Score: 290
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.9
    Marker Score: 680
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.89
    Marker Score: 432
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.88
    Marker Score: 224
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.86
    Marker Score: 493
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.86
    Marker Score: 243
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.86
    Marker Score: 568
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.85
    Marker Score: 321
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 644
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.83
    Marker Score: 192
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.83
    Marker Score: 236
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.83
    Marker Score: 1210
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.83
    Marker Score: 379
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.82
    Marker Score: 769
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.81
    Marker Score: 1408
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.8
    Marker Score: 524
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.8
    Marker Score: 185
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.79
    Marker Score: 481
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.77
    Marker Score: 514
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.76
    Marker Score: 1583

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Other Information

**Key characteristics**: - EBF1 is a basic transcription factor that is expressed in a wide range of cell types. - It is a key regulator of the development and survival of olfactory neurons. - EBF1 is also involved in the regulation of other developmental processes, such as cell migration and differentiation. **Pathways and functions**: - EBF1 is a key regulator of the development of the olfactory system. - It is required for the specification of olfactory neuron identity and for the survival and differentiation of olfactory neurons. - EBF1 also plays a role in the regulation of other developmental processes, such as cell migration and differentiation. **Clinical significance**: - Mutations in the EBF1 gene have been linked to a number of human diseases, including Angelman syndrome and autism. - These diseases are caused by mutations in genes that are involved in the regulation of EBF1. - Understanding the role of EBF1 in human health and disease is therefore important for the development of new treatments for these disorders. **Additional Information**: - EBF1 is a highly conserved transcription factor that is found in all vertebrates. - It is a member of the EBF family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression. - EBF1 is a ubiquitin-dependent protein that is degraded by the proteasome. - It is a highly effective transcription factor that can bind to DNA and regulate gene expression in a dose-dependent manner.

Genular Protein ID: 2664861519

Symbol: COE1_HUMAN

Name: Transcription factor COE1

UniProtKB Accession Codes:

Q9UH73 Q8IW11

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10942392

Title: Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse.

PubMed ID: 10942392

PubMed ID: 14630787

Title: Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.

PubMed ID: 14630787

DOI: 10.1182/blood-2003-07-2388

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 26819314

Title: Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor.

PubMed ID: 26819314

DOI: 10.1128/jvi.03227-15

PubMed ID: 27807034

Title: Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis.

PubMed ID: 27807034

DOI: 10.1101/gad.285452.116

PubMed ID: 28968461

Title: EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.

PubMed ID: 28968461

DOI: 10.1371/journal.ppat.1006664

PubMed ID: 20592035

Title: Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif.

PubMed ID: 20592035

DOI: 10.1074/jbc.c110.150482

Sequence Information:

  • Length: 591
  • Mass: 64464
  • Checksum: E47797B6FC1E5071
  • Sequence:
    • MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA RAHFEKQPPS 
NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN SEKTNNGIHY RLQLLYSNGI 
RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM CRVLLTHEIM CSRCCDKKSC GNRNETPSDP 
VIIDRFFLKF FLKCNQNCLK NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH 
GRRARRLDPS EGTPSYLEHA TPCIKAISPS EGWTTGGATV IIIGDNFFDG LQVIFGTMLV 
WSELITPHAI RVQTPPRHIP GVVEVTLSYK SKQFCKGTPG RFIYTALNEP TIDYGFQRLQ 
KVIPRHPGDP ERLPKEVILK RAADLVEALY GMPHNNQEII LKRAADIAEA LYSVPRNHNQ 
LPALANTSVH AGMMGVNSFS GQLAVNVSEA SQATNQGFTR NSSSVSPHGY VPSTTPQQTN 
YNSVTTSMNG YGSAAMSNLG GSPTFLNGSA ANSPYAIVPS SPTMASSTSL PSNCSSSSGI 
FSFSPANMVS AVKQKSAFAP VVRPQTSPPP TCTSTNGNSL QAISGMIVPP M

Genular Protein ID: 554347143

Symbol: B4E2U8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E2U8

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 578
  • Mass: 63026
  • Checksum: F617F7E252D128C5
  • Sequence:
    • MKEEPLGSGM NAVRTWMQGA GVLDANTAAQ SGVGLARAHF EKQPPSNLRK SNFFHFVLAL 
YDRQGQPVEI ERTAFVGFVE KEKEANSEKT NNGIHYRLQL LYSNGIRTEQ DFYVRLIDSM 
TKQAIVYEGQ DKNPEMCRVL LTHEIMCSRC CDKKSCGNRN ETPSDPVIID RFFLKFFLKC 
NQNCLKNAGN PRDMRRFQVV VSTTVNVDGH VLAVSDNMFV HNNSKHGRRA RRLDPSEGTP 
SYLEHAATPC IKAISPSEGW TTGGATVIII GDNFFDGLQV IFGTMLVWSE LITPHAIRVQ 
TPPRHIPGVV EVTLSYKSKQ FCKGTPGRFI YTALNEPTID YGFQRLQKVI PRHPGDPERL 
PKEVILKRAA DLVEALYGMP HNNQEIILKR AADIAEALYS VPRNHNQLPA LANTSVHAGM 
MGVNSFSGQL AVNVSEASQA TNQGFTRNSS SVSPHGYVPS TTPQQTNYNS VTTSMNGYGS 
AAMSNLGGSP TFLNGSAANS PYAIVPSSPT MASSTSLPSN CSSSSGIFSF SPANMVSAVK 
QKSAFAPVVR PQTSPPPTCT STNGNSLQAI SGMIVPPM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.