Details for: ECH1

Gene ID: 1891

Symbol: ECH1

Ensembl ID: ENSG00000104823

Description: enoyl-CoA hydratase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 279.4043
    Cell Significance Index: -43.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.7448
    Cell Significance Index: -39.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 147.3974
    Cell Significance Index: -60.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 130.2628
    Cell Significance Index: -61.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 118.6270
    Cell Significance Index: -61.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.2324
    Cell Significance Index: -61.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.0600
    Cell Significance Index: -56.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.3495
    Cell Significance Index: -60.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0860
    Cell Significance Index: -34.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3203
    Cell Significance Index: -19.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7852
    Cell Significance Index: -14.8500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3936
    Cell Significance Index: 27.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6279
    Cell Significance Index: 69.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.4513
    Cell Significance Index: 114.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3916
    Cell Significance Index: 70.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2063
    Cell Significance Index: 164.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0665
    Cell Significance Index: 146.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0178
    Cell Significance Index: 121.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0019
    Cell Significance Index: 18.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9895
    Cell Significance Index: 53.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9450
    Cell Significance Index: 52.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7146
    Cell Significance Index: 110.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6436
    Cell Significance Index: 74.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5149
    Cell Significance Index: 273.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5145
    Cell Significance Index: 31.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4963
    Cell Significance Index: 22.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4668
    Cell Significance Index: 201.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4135
    Cell Significance Index: 182.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3803
    Cell Significance Index: 169.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3672
    Cell Significance Index: 71.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2861
    Cell Significance Index: 568.6200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.2357
    Cell Significance Index: 7.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1085
    Cell Significance Index: 52.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0994
    Cell Significance Index: 600.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9829
    Cell Significance Index: 126.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8436
    Cell Significance Index: 99.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8408
    Cell Significance Index: 83.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8156
    Cell Significance Index: 17.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7985
    Cell Significance Index: 21.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6917
    Cell Significance Index: 15.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6647
    Cell Significance Index: 19.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6623
    Cell Significance Index: 7.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6584
    Cell Significance Index: 7.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.5455
    Cell Significance Index: 9.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4916
    Cell Significance Index: 93.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4720
    Cell Significance Index: 80.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4318
    Cell Significance Index: 85.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4190
    Cell Significance Index: 7.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3569
    Cell Significance Index: 5.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3041
    Cell Significance Index: 49.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2910
    Cell Significance Index: 15.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2662
    Cell Significance Index: 9.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1999
    Cell Significance Index: 57.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1947
    Cell Significance Index: 39.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1777
    Cell Significance Index: 134.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0829
    Cell Significance Index: 60.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0630
    Cell Significance Index: 22.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0515
    Cell Significance Index: 1.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0454
    Cell Significance Index: 3.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0211
    Cell Significance Index: 0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0185
    Cell Significance Index: -34.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0347
    Cell Significance Index: -21.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0392
    Cell Significance Index: -72.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0469
    Cell Significance Index: -72.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0547
    Cell Significance Index: -74.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0611
    Cell Significance Index: -6.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0729
    Cell Significance Index: -46.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0737
    Cell Significance Index: -2.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0758
    Cell Significance Index: -42.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0878
    Cell Significance Index: -4.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1163
    Cell Significance Index: -13.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1249
    Cell Significance Index: -26.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1258
    Cell Significance Index: -57.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1900
    Cell Significance Index: -4.8500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2364
    Cell Significance Index: -3.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2537
    Cell Significance Index: -19.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2836
    Cell Significance Index: -22.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3516
    Cell Significance Index: -40.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3612
    Cell Significance Index: -52.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4139
    Cell Significance Index: -47.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4205
    Cell Significance Index: -17.2300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5510
    Cell Significance Index: -7.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5749
    Cell Significance Index: -59.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5842
    Cell Significance Index: -7.9700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5869
    Cell Significance Index: -4.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6485
    Cell Significance Index: -40.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6535
    Cell Significance Index: -6.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6855
    Cell Significance Index: -20.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7123
    Cell Significance Index: -17.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7288
    Cell Significance Index: -13.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7619
    Cell Significance Index: -21.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8469
    Cell Significance Index: -47.5300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.9376
    Cell Significance Index: -5.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9998
    Cell Significance Index: -61.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0193
    Cell Significance Index: -25.4800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.0495
    Cell Significance Index: -14.7100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1716
    Cell Significance Index: -7.2800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -1.2155
    Cell Significance Index: -12.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2207
    Cell Significance Index: -42.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ECH1 is a member of the enoyl-CoA hydratase family, which is involved in the regulation of fatty acid metabolism. The enzyme catalyzes the hydration of enoyl-CoA, a key step in the beta-oxidation of fatty acids. ECH1 is also implicated in protein degradation, particularly in the mitochondrial protein degradation pathway. Furthermore, ECH1 has been shown to interact with various proteins, including those involved in immune response and cellular signaling. **Pathways and Functions:** ECH1 is involved in several key metabolic pathways, including: 1. **Fatty acid beta-oxidation**: ECH1 plays a critical role in the regulation of fatty acid metabolism by catalyzing the hydration of enoyl-CoA, a key step in the beta-oxidation of fatty acids. 2. **Protein degradation**: ECH1 is implicated in the mitochondrial protein degradation pathway, where it regulates the degradation of damaged or misfolded proteins. 3. **Immune response**: ECH1 has been shown to interact with various immune-related proteins, including those involved in the regulation of immune cell function and cytokine production. 4. **Peroxisomal matrix**: ECH1 is localized to the peroxisomal matrix, where it regulates the metabolism of fatty acids and other lipids. **Clinical Significance:** The dysregulation of ECH1 has been implicated in various human diseases, including: 1. **Metabolic disorders**: Alterations in ECH1 expression have been linked to metabolic disorders, such as obesity and type 2 diabetes. 2. **Immune-related disorders**: ECH1 has been implicated in immune-related disorders, including autoimmune diseases and cancer. 3. **Neurodegenerative diseases**: ECH1 has been shown to be involved in the regulation of protein degradation in the context of neurodegenerative diseases, such as Alzheimer's disease. In conclusion, ECH1 is a multifunctional enzyme that plays a critical role in regulating fatty acid metabolism, protein degradation, and immune response. Further studies are needed to fully elucidate the mechanisms by which ECH1 regulates these processes and to explore its potential therapeutic applications in human diseases.

Genular Protein ID: 3596390669

Symbol: ECH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13011 A8K745 Q8WVX0 Q96EZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7558027

Title: Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase.

PubMed ID: 7558027

DOI: 10.1006/geno.1995.1077

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 328
  • Mass: 35816
  • Checksum: 211E0FF40379E6DA
  • Sequence:
    • MAAGIVASRR LRDLLTRRLT GSNYPGLSIS LRLTGSSAQE EASGVALGEA PDHSYESLRV 
TSAQKHVLHV QLNRPNKRNA MNKVFWREMV ECFNKISRDA DCRAVVISGA GKMFTAGIDL 
MDMASDILQP KGDDVARISW YLRDIITRYQ ETFNVIERCP KPVIAAVHGG CIGGGVDLVT 
ACDIRYCAQD AFFQVKEVDV GLAADVGTLQ RLPKVIGNQS LVNELAFTAR KMMADEALGS 
GLVSRVFPDK EVMLDAALAL AAEISSKSPV AVQSTKVNLL YSRDHSVAES LNYVASWNMS 
MLQTQDLVKS VQATTENKEL KTVTFSKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.