Details for: LPAR1

Gene ID: 1902

Symbol: LPAR1

Ensembl ID: ENSG00000198121

Description: lysophosphatidic acid receptor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 5.17
    Marker Score: 6,437
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.88
    Marker Score: 747
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.48
    Marker Score: 1,382
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.48
    Marker Score: 4,774
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.44
    Marker Score: 5,849
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.29
    Marker Score: 1,504
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.15
    Marker Score: 3,019
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.1
    Marker Score: 1,044
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2
    Marker Score: 986
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.62
    Marker Score: 925
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.54
    Marker Score: 2,923
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,573
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.38
    Marker Score: 47,050
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.36
    Marker Score: 1,566
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.23
    Marker Score: 1,092
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.22
    Marker Score: 280
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.21
    Marker Score: 300
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.15
    Marker Score: 286
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.14
    Marker Score: 476
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.14
    Marker Score: 286
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.12
    Marker Score: 2,287
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.12
    Marker Score: 779
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.07
    Marker Score: 11,054
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.04
    Marker Score: 234
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.03
    Marker Score: 4,459
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.02
    Marker Score: 6,122
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.96
    Marker Score: 3,728
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.93
    Marker Score: 400
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.93
    Marker Score: 336
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.92
    Marker Score: 2,414
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9
    Marker Score: 10,112
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.89
    Marker Score: 17,678
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,045
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.87
    Marker Score: 229
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,273
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 260
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.8
    Marker Score: 279
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.79
    Marker Score: 971
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.78
    Marker Score: 10,257
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.77
    Marker Score: 373
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.76
    Marker Score: 337
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11,860
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.74
    Marker Score: 214
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.73
    Marker Score: 1,127
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.73
    Marker Score: 382
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.72
    Marker Score: 184
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.68
    Marker Score: 657
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.66
    Marker Score: 134
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.66
    Marker Score: 187
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.65
    Marker Score: 713
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.64
    Marker Score: 1,411
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.62
    Marker Score: 532
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.62
    Marker Score: 652
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.62
    Marker Score: 724
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.6
    Marker Score: 135
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.6
    Marker Score: 193
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.6
    Marker Score: 334
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.56
    Marker Score: 490
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.56
    Marker Score: 2,334
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.56
    Marker Score: 352
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.55
    Marker Score: 647
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.54
    Marker Score: 198
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.54
    Marker Score: 8,610
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.53
    Marker Score: 2,043
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 138
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 343
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 247
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.51
    Marker Score: 706
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.5
    Marker Score: 1,228
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5
    Marker Score: 564
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.49
    Marker Score: 329
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.48
    Marker Score: 238
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.47
    Marker Score: 307
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.47
    Marker Score: 1,097
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.46
    Marker Score: 778
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.45
    Marker Score: 143
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.45
    Marker Score: 1,092
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.44
    Marker Score: 2,882
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.44
    Marker Score: 805
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.44
    Marker Score: 475
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.44
    Marker Score: 311
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.44
    Marker Score: 9,300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LPAR1 is a member of the lysophosphatidic acid receptor family, which consists of four subtypes: LPA1, LPA2, LPA3, and LPA4. These receptors are activated by lysophosphatidic acid (LPA), a bioactive phospholipid that plays a crucial role in various cellular processes. LPAR1 is characterized by its ability to bind to LPA and trigger a cascade of signaling events that regulate cellular behavior. The receptor is also known for its expression in various tissues, including the central nervous system, where it is involved in neurogenesis and neuronal development. **Pathways and Functions** LPAR1 is involved in numerous signaling pathways, including: 1. **Activation of phospholipase C activity**: LPAR1 activation leads to the activation of phospholipase C, which generates inositol trisphosphate (IP3) and diacylglycerol (DAG), signaling molecules that regulate cellular responses. 2. **Adenylate cyclase-activating G-protein coupled receptor signaling pathway**: LPAR1 activation also leads to the activation of adenylate cyclase, which increases cyclic AMP (cAMP) levels, regulating cellular responses. 3. **Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway**: In contrast, LPAR1 activation can also inhibit adenylate cyclase, leading to decreased cAMP levels and regulating cellular responses. 4. **Bleb assembly**: LPAR1 is involved in the regulation of bleb assembly, a process that regulates cellular shape and morphology. 5. **Cell chemotaxis**: LPAR1 is also involved in cell chemotaxis, the movement of cells in response to chemical gradients. **Clinical Significance** The dysregulation of LPAR1 has been implicated in various diseases, including: 1. **Neurological disorders**: LPAR1 is involved in neurogenesis and neuronal development, and its dysregulation has been implicated in neurological disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Cancer**: LPAR1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and its dysregulation has been implicated in cancer progression and metastasis. 3. **Cardiovascular disease**: LPAR1 is involved in the regulation of cardiovascular function, and its dysregulation has been implicated in cardiovascular disease, including hypertension and atherosclerosis. In conclusion, LPAR1 is a multifaceted gene that plays a crucial role in various cellular processes, including immune regulation, cellular development, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of LPAR1 and its potential as a therapeutic target.

Genular Protein ID: 453174699

Symbol: LPAR1_HUMAN

Name: Lysophosphatidic acid receptor 1

UniProtKB Accession Codes:

Q92633 B4DK36 O00656 O00722 P78351

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 9 Ensembl 4 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 12 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 29 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9070858

Title: Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid.

PubMed ID: 9070858

DOI: 10.1006/bbrc.1997.6150

PubMed ID: 9069262

Title: Lysophosphatidic acid: G-protein signalling and cellular responses.

PubMed ID: 9069262

DOI: 10.1016/s0955-0674(97)80059-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11093753

Title: Lysophosphatidic acid receptors.

PubMed ID: 11093753

DOI: 10.1124/mol.58.6.1188

PubMed ID: 18066075

Title: The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.

PubMed ID: 18066075

DOI: 10.1038/nm1685

PubMed ID: 19306925

Title: Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK.

PubMed ID: 19306925

DOI: 10.1016/j.cellsig.2009.03.011

PubMed ID: 19656035

Title: Lysophosphatidic acid signals through specific lysophosphatidic acid receptor subtypes to control key regenerative responses of human gingival and periodontal ligament fibroblasts.

PubMed ID: 19656035

DOI: 10.1902/jop.2009.080624

PubMed ID: 19733258

Title: Lysophosphatidic acid mediates migration of human mesenchymal stem cells stimulated by synovial fluid of patients with rheumatoid arthritis.

PubMed ID: 19733258

DOI: 10.1016/j.bbalip.2009.08.011

PubMed ID: 25025571

Title: Molecular regulation of lysophosphatidic acid receptor 1 trafficking to the cell surface.

PubMed ID: 25025571

DOI: 10.1016/j.cellsig.2014.07.005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25732591

Title: Comparative analyses of lysophosphatidic acid receptor-mediated signaling.

PubMed ID: 25732591

DOI: 10.1007/s00018-015-1872-8

PubMed ID: 31204173

Title: Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

PubMed ID: 31204173

DOI: 10.1016/j.devcel.2019.05.022

PubMed ID: 26091040

Title: Crystal structure of antagonist bound human lysophosphatidic acid receptor 1.

PubMed ID: 26091040

DOI: 10.1016/j.cell.2015.06.002

Sequence Information:

  • Length: 364
  • Mass: 41109
  • Checksum: 4CA6262FD00DFE74
  • Sequence:
    • MAAISTSIPV ISQPQFTAMN EPQCFYNESI AFFYNRSGKH LATEWNTVSK LVMGLGITVC 
IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST 
WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA 
IPSVGWNCIC DIENCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS 
RHSSGPRRNR DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA 
EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENPTGPTEG SDRSASSLNH TILAGVHSND 
HSVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.