Details for: LPAR1

Gene ID: 1902

Symbol: LPAR1

Ensembl ID: ENSG00000198121

Description: lysophosphatidic acid receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.8027
    Cell Significance Index: -22.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.5996
    Cell Significance Index: -22.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.6462
    Cell Significance Index: -22.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.8530
    Cell Significance Index: -28.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8286
    Cell Significance Index: -23.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.3198
    Cell Significance Index: 84.3100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.3429
    Cell Significance Index: 22.6500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.9280
    Cell Significance Index: 18.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.8849
    Cell Significance Index: 61.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.8485
    Cell Significance Index: 40.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 2.5783
    Cell Significance Index: 130.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.8306
    Cell Significance Index: 526.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.5897
    Cell Significance Index: 55.8600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.4932
    Cell Significance Index: 13.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3250
    Cell Significance Index: 252.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.2422
    Cell Significance Index: 18.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1554
    Cell Significance Index: 33.1200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.8720
    Cell Significance Index: 5.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8623
    Cell Significance Index: 85.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6636
    Cell Significance Index: 45.8900
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.5250
    Cell Significance Index: 3.0100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.5092
    Cell Significance Index: 5.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4861
    Cell Significance Index: 13.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4262
    Cell Significance Index: 384.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4156
    Cell Significance Index: 74.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3177
    Cell Significance Index: 6.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3034
    Cell Significance Index: 108.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2686
    Cell Significance Index: 43.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2553
    Cell Significance Index: 15.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2541
    Cell Significance Index: 27.6400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2124
    Cell Significance Index: 3.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2095
    Cell Significance Index: 25.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1664
    Cell Significance Index: 4.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1337
    Cell Significance Index: 18.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1264
    Cell Significance Index: 87.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1080
    Cell Significance Index: 2.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0882
    Cell Significance Index: 2.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0537
    Cell Significance Index: 6.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0302
    Cell Significance Index: 1.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0287
    Cell Significance Index: 13.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0237
    Cell Significance Index: 1.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0120
    Cell Significance Index: 6.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0061
    Cell Significance Index: -11.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -20.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0126
    Cell Significance Index: -5.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -19.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0156
    Cell Significance Index: -21.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0187
    Cell Significance Index: -0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0227
    Cell Significance Index: -14.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0240
    Cell Significance Index: -17.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0290
    Cell Significance Index: -21.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0321
    Cell Significance Index: -24.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0396
    Cell Significance Index: -24.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0412
    Cell Significance Index: -23.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0431
    Cell Significance Index: -8.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0434
    Cell Significance Index: -8.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0574
    Cell Significance Index: -0.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0618
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0652
    Cell Significance Index: -11.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0758
    Cell Significance Index: -4.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1037
    Cell Significance Index: -6.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1150
    Cell Significance Index: -16.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1166
    Cell Significance Index: -24.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1290
    Cell Significance Index: -15.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1620
    Cell Significance Index: -18.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1632
    Cell Significance Index: -21.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1666
    Cell Significance Index: -17.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1800
    Cell Significance Index: -13.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1901
    Cell Significance Index: -6.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2044
    Cell Significance Index: -4.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2101
    Cell Significance Index: -24.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2122
    Cell Significance Index: -22.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2623
    Cell Significance Index: -7.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2648
    Cell Significance Index: -5.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2691
    Cell Significance Index: -19.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2719
    Cell Significance Index: -12.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2759
    Cell Significance Index: -20.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2908
    Cell Significance Index: -23.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2930
    Cell Significance Index: -19.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3037
    Cell Significance Index: -14.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3156
    Cell Significance Index: -4.5200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3161
    Cell Significance Index: -5.0200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3569
    Cell Significance Index: -4.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3608
    Cell Significance Index: -7.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3651
    Cell Significance Index: -23.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3708
    Cell Significance Index: -23.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3764
    Cell Significance Index: -19.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4350
    Cell Significance Index: -22.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4687
    Cell Significance Index: -20.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4729
    Cell Significance Index: -17.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4892
    Cell Significance Index: -13.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5059
    Cell Significance Index: -17.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5227
    Cell Significance Index: -12.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5482
    Cell Significance Index: -19.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5617
    Cell Significance Index: -21.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6123
    Cell Significance Index: -26.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6240
    Cell Significance Index: -15.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6286
    Cell Significance Index: -13.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6573
    Cell Significance Index: -15.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6671
    Cell Significance Index: -21.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LPAR1 is a member of the lysophosphatidic acid receptor family, which consists of four subtypes: LPA1, LPA2, LPA3, and LPA4. These receptors are activated by lysophosphatidic acid (LPA), a bioactive phospholipid that plays a crucial role in various cellular processes. LPAR1 is characterized by its ability to bind to LPA and trigger a cascade of signaling events that regulate cellular behavior. The receptor is also known for its expression in various tissues, including the central nervous system, where it is involved in neurogenesis and neuronal development. **Pathways and Functions** LPAR1 is involved in numerous signaling pathways, including: 1. **Activation of phospholipase C activity**: LPAR1 activation leads to the activation of phospholipase C, which generates inositol trisphosphate (IP3) and diacylglycerol (DAG), signaling molecules that regulate cellular responses. 2. **Adenylate cyclase-activating G-protein coupled receptor signaling pathway**: LPAR1 activation also leads to the activation of adenylate cyclase, which increases cyclic AMP (cAMP) levels, regulating cellular responses. 3. **Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway**: In contrast, LPAR1 activation can also inhibit adenylate cyclase, leading to decreased cAMP levels and regulating cellular responses. 4. **Bleb assembly**: LPAR1 is involved in the regulation of bleb assembly, a process that regulates cellular shape and morphology. 5. **Cell chemotaxis**: LPAR1 is also involved in cell chemotaxis, the movement of cells in response to chemical gradients. **Clinical Significance** The dysregulation of LPAR1 has been implicated in various diseases, including: 1. **Neurological disorders**: LPAR1 is involved in neurogenesis and neuronal development, and its dysregulation has been implicated in neurological disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Cancer**: LPAR1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and its dysregulation has been implicated in cancer progression and metastasis. 3. **Cardiovascular disease**: LPAR1 is involved in the regulation of cardiovascular function, and its dysregulation has been implicated in cardiovascular disease, including hypertension and atherosclerosis. In conclusion, LPAR1 is a multifaceted gene that plays a crucial role in various cellular processes, including immune regulation, cellular development, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of LPAR1 and its potential as a therapeutic target.

Genular Protein ID: 453174699

Symbol: LPAR1_HUMAN

Name: Lysophosphatidic acid receptor 1

UniProtKB Accession Codes:

Q92633 B4DK36 O00656 O00722 P78351

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 29 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9070858

Title: Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid.

PubMed ID: 9070858

DOI: 10.1006/bbrc.1997.6150

PubMed ID: 9069262

Title: Lysophosphatidic acid: G-protein signalling and cellular responses.

PubMed ID: 9069262

DOI: 10.1016/s0955-0674(97)80059-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11093753

Title: Lysophosphatidic acid receptors.

PubMed ID: 11093753

DOI: 10.1124/mol.58.6.1188

PubMed ID: 18066075

Title: The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.

PubMed ID: 18066075

DOI: 10.1038/nm1685

PubMed ID: 19306925

Title: Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK.

PubMed ID: 19306925

DOI: 10.1016/j.cellsig.2009.03.011

PubMed ID: 19656035

Title: Lysophosphatidic acid signals through specific lysophosphatidic acid receptor subtypes to control key regenerative responses of human gingival and periodontal ligament fibroblasts.

PubMed ID: 19656035

DOI: 10.1902/jop.2009.080624

PubMed ID: 19733258

Title: Lysophosphatidic acid mediates migration of human mesenchymal stem cells stimulated by synovial fluid of patients with rheumatoid arthritis.

PubMed ID: 19733258

DOI: 10.1016/j.bbalip.2009.08.011

PubMed ID: 25025571

Title: Molecular regulation of lysophosphatidic acid receptor 1 trafficking to the cell surface.

PubMed ID: 25025571

DOI: 10.1016/j.cellsig.2014.07.005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25732591

Title: Comparative analyses of lysophosphatidic acid receptor-mediated signaling.

PubMed ID: 25732591

DOI: 10.1007/s00018-015-1872-8

PubMed ID: 31204173

Title: Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

PubMed ID: 31204173

DOI: 10.1016/j.devcel.2019.05.022

PubMed ID: 26091040

Title: Crystal structure of antagonist bound human lysophosphatidic acid receptor 1.

PubMed ID: 26091040

DOI: 10.1016/j.cell.2015.06.002

Sequence Information:

  • Length: 364
  • Mass: 41109
  • Checksum: 4CA6262FD00DFE74
  • Sequence:
    • MAAISTSIPV ISQPQFTAMN EPQCFYNESI AFFYNRSGKH LATEWNTVSK LVMGLGITVC 
IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST 
WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA 
IPSVGWNCIC DIENCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS 
RHSSGPRRNR DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA 
EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENPTGPTEG SDRSASSLNH TILAGVHSND 
HSVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.