Details for: EFNA2

Gene ID: 1943

Symbol: EFNA2

Ensembl ID: ENSG00000099617

Description: ephrin A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.7899
    Cell Significance Index: 26.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3801
    Cell Significance Index: 33.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2326
    Cell Significance Index: 26.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9491
    Cell Significance Index: 27.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7920
    Cell Significance Index: 47.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7588
    Cell Significance Index: 144.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7113
    Cell Significance Index: 15.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5966
    Cell Significance Index: 27.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4358
    Cell Significance Index: 22.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3122
    Cell Significance Index: 6.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2992
    Cell Significance Index: 32.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2400
    Cell Significance Index: 43.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2203
    Cell Significance Index: 12.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1599
    Cell Significance Index: 11.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1466
    Cell Significance Index: 0.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1227
    Cell Significance Index: 1.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1096
    Cell Significance Index: 3.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1002
    Cell Significance Index: 6.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0740
    Cell Significance Index: 14.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0506
    Cell Significance Index: 18.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0461
    Cell Significance Index: 41.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0428
    Cell Significance Index: 1.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0382
    Cell Significance Index: 1.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0258
    Cell Significance Index: 0.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0248
    Cell Significance Index: 3.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0160
    Cell Significance Index: 1.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0106
    Cell Significance Index: 1.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0030
    Cell Significance Index: 0.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0030
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0036
    Cell Significance Index: -0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0042
    Cell Significance Index: -0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0086
    Cell Significance Index: -13.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0114
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0127
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0157
    Cell Significance Index: -8.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0192
    Cell Significance Index: -1.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0236
    Cell Significance Index: -10.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0388
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0450
    Cell Significance Index: -9.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0564
    Cell Significance Index: -0.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0601
    Cell Significance Index: -8.7400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0615
    Cell Significance Index: -0.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0690
    Cell Significance Index: -9.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0749
    Cell Significance Index: -0.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0786
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0818
    Cell Significance Index: -13.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0890
    Cell Significance Index: -9.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0931
    Cell Significance Index: -9.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0988
    Cell Significance Index: -6.2300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1012
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1049
    Cell Significance Index: -12.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1170
    Cell Significance Index: -7.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1342
    Cell Significance Index: -2.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1406
    Cell Significance Index: -10.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1445
    Cell Significance Index: -2.4300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1508
    Cell Significance Index: -2.6000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1518
    Cell Significance Index: -2.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1518
    Cell Significance Index: -3.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1627
    Cell Significance Index: -2.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1630
    Cell Significance Index: -7.6600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1666
    Cell Significance Index: -2.3400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1741
    Cell Significance Index: -1.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1755
    Cell Significance Index: -3.6400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1899
    Cell Significance Index: -1.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1982
    Cell Significance Index: -6.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1985
    Cell Significance Index: -8.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2078
    Cell Significance Index: -6.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2159
    Cell Significance Index: -5.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2187
    Cell Significance Index: -8.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2198
    Cell Significance Index: -7.7000
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.2231
    Cell Significance Index: -2.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2257
    Cell Significance Index: -11.8500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.2412
    Cell Significance Index: -2.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2424
    Cell Significance Index: -11.3000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2425
    Cell Significance Index: -3.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2440
    Cell Significance Index: -7.7700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2561
    Cell Significance Index: -2.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2622
    Cell Significance Index: -6.5400
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.2642
    Cell Significance Index: -2.3900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2652
    Cell Significance Index: -2.9000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2698
    Cell Significance Index: -2.9800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2731
    Cell Significance Index: -5.7000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2785
    Cell Significance Index: -2.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2817
    Cell Significance Index: -8.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2827
    Cell Significance Index: -4.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2888
    Cell Significance Index: -6.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2962
    Cell Significance Index: -3.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2962
    Cell Significance Index: -3.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2963
    Cell Significance Index: -7.7900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2991
    Cell Significance Index: -4.1500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.2996
    Cell Significance Index: -2.7100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3012
    Cell Significance Index: -3.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3015
    Cell Significance Index: -8.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3020
    Cell Significance Index: -8.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EFNA2 is a member of the ephrin family, which consists of six distinct ligands (A1 to A6) and seven receptors (EphA to EphB). Ephrin-A2 is primarily expressed in various cell types, including colon goblet cells, cardiac endothelial cells, and cerebral cortex GABAergic interneurons. The protein structure of EFNA2 consists of three extracellular domains and a single transmembrane domain, allowing it to interact with Eph receptors. **Pathways and Functions:** EFNA2 plays a pivotal role in several signaling pathways, including: 1. **Eph-ephrin mediated repulsion of cells:** EFNA2 interacts with Eph receptors to mediate repulsive signals, guiding axons and regulating cell migration during development. 2. **Ephrin receptor signaling pathway:** The binding of EFNA2 to Eph receptors triggers a cascade of downstream signaling events, influencing cell growth, differentiation, and survival. 3. **Axon guidance:** EFNA2 is essential for the accurate guidance of axons during neuronal development, ensuring proper neural circuit formation. 4. **Bone remodeling:** EFNA2 is involved in the regulation of osteoclast differentiation and bone resorption, maintaining bone homeostasis. 5. **Developmental biology:** EFNA2 is crucial for the development of various tissues and organs, including the nervous system, olfactory bulb, and osteoclasts. **Clinical Significance:** Dysregulation of EFNA2 has been implicated in various diseases, including: 1. **Neurological disorders:** Mutations in EFNA2 have been associated with neurological conditions, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** Overexpression of EFNA2 has been linked to cancer progression and metastasis, suggesting its potential as a therapeutic target. 3. **Immune system dysfunction:** EFNA2 may play a role in regulating immune cell function and contributing to immune-related disorders, such as multiple sclerosis. In conclusion, EFNA2 is a critical gene involved in various cellular processes, including cell signaling, development, and bone remodeling. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the molecular mechanisms underlying EFNA2 function and its role in human disease.

Genular Protein ID: 1855656246

Symbol: EFNA2_HUMAN

Name: Ephrin-A2

UniProtKB Accession Codes:

O43921 O76020

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9465306

Title: Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure.

PubMed ID: 9465306

DOI: 10.1006/geno.1997.5088

PubMed ID: 9826538

Title: Cloning, chromosomal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2.

PubMed ID: 9826538

DOI: 10.1006/bbrc.1998.9618

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19836338

Title: Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling.

PubMed ID: 19836338

DOI: 10.1016/j.str.2009.07.018

Sequence Information:

  • Length: 213
  • Mass: 23878
  • Checksum: 33C9FB1A8168B2D0
  • Sequence:
    • MAPAQRPLLP LLLLLLPLPP PPFARAEDAA RANSDRYAVY WNRSNPRFHA GAGDDGGGYT 
VEVSINDYLD IYCPHYGAPL PPAERMEHYV LYMVNGEGHA SCDHRQRGFK RWECNRPAAP 
GGPLKFSEKF QLFTPFSLGF EFRPGHEYYY ISATPPNAVD RPCLRLKVYV RPTNETLYEA 
PEPIFTSNNS CSSPGGCRLF LSTIPVLWTL LGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.