Details for: EFNA2

Gene ID: 1943

Symbol: EFNA2

Ensembl ID: ENSG00000099617

Description: ephrin A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.21
    Marker Score: 2294
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2168
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15915
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.93
    Marker Score: 933.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 326
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.77
    Marker Score: 445
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 460
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.75
    Marker Score: 357
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.64
    Marker Score: 717
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.63
    Marker Score: 707
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 394
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.54
    Marker Score: 18187
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.5
    Marker Score: 202
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 204
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.44
    Marker Score: 107
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.42
    Marker Score: 512
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.41
    Marker Score: 405
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.39
    Marker Score: 803.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 622
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.36
    Marker Score: 357
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.33
    Marker Score: 459
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.32
    Marker Score: 1680
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.31
    Marker Score: 90
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3
    Marker Score: 139
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 707
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.29
    Marker Score: 196
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.29
    Marker Score: 1554
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.28
    Marker Score: 1839
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.28
    Marker Score: 927
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.27
    Marker Score: 630
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.27
    Marker Score: 2036
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.26
    Marker Score: 321
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 152
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.25
    Marker Score: 354
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.25
    Marker Score: 310
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.24
    Marker Score: 363
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.23
    Marker Score: 57
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.22
    Marker Score: 915
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.22
    Marker Score: 336
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.21
    Marker Score: 83
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.21
    Marker Score: 156
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 108
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.17
    Marker Score: 250
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.16
    Marker Score: 159
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.15
    Marker Score: 562
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.14
    Marker Score: 1344.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 123
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.14
    Marker Score: 331
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.14
    Marker Score: 105
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 151
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.13
    Marker Score: 1022
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.13
    Marker Score: 521
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 82
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.12
    Marker Score: 211
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.11
    Marker Score: 2273
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.11
    Marker Score: 458
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 124
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1
    Marker Score: 460
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 155
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.1
    Marker Score: 30

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Other Information

## Summary EFNA2 is a protein that plays a crucial role in various cellular processes, including cell-cell signaling, axon guidance, and tissue development. It is expressed in a wide range of cell types and is involved in both normal and pathological conditions. ## Key characteristics * **Function:** EFNA2 is a cell surface protein that is expressed in various cell types. * **Expression:** It is highly expressed in epithelial cells, particularly in the colon and gut. * **Interaction:** EFNA2 is known to interact with Eph receptors, which are expressed on various cell types. * **Signaling pathway:** Upon interaction with Eph receptors, EFNA2 signaling leads to the activation of downstream signaling pathways, including the PI3K/AKT pathway. ## Pathways and functions * **Cell-cell signaling:** EFNA2 is involved in cell-cell signaling pathways in the gut, where it helps to regulate epithelial cell communication and cell migration. * **Axon guidance:** EFNA2 is expressed on neurons and plays a role in axon guidance by promoting the repulsion of neurons along the developing optic nerve. * **Tissue development:** EFNA2 is also involved in tissue development, where it helps to regulate the formation of the gut and other epithelial tissues. ## Clinical significance * **Cancer:** EFNA2 mutations have been linked to several human cancers, including colon cancer and breast cancer. * **Cardiovascular disease:** Alterations in EFNA2 expression and signaling have been linked to cardiovascular disease, suggesting a potential role in regulating blood vessel formation and remodeling. * **Neurological disorders:** EFNA2 mutations have also been linked to neurological disorders such as autism and schizophrenia. ## Conclusion EFNA2 is a versatile cell surface protein that plays a critical role in various cellular processes, including cell-cell signaling, axon guidance, and tissue development. Its mutations have significant implications for human health and disease.

Genular Protein ID: 1855656246

Symbol: EFNA2_HUMAN

Name: Ephrin-A2

UniProtKB Accession Codes:

O43921 O76020

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9465306

Title: Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure.

PubMed ID: 9465306

DOI: 10.1006/geno.1997.5088

PubMed ID: 9826538

Title: Cloning, chromosomal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2.

PubMed ID: 9826538

DOI: 10.1006/bbrc.1998.9618

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19836338

Title: Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling.

PubMed ID: 19836338

DOI: 10.1016/j.str.2009.07.018

Sequence Information:

  • Length: 213
  • Mass: 23878
  • Checksum: 33C9FB1A8168B2D0
  • Sequence:
    • MAPAQRPLLP LLLLLLPLPP PPFARAEDAA RANSDRYAVY WNRSNPRFHA GAGDDGGGYT 
VEVSINDYLD IYCPHYGAPL PPAERMEHYV LYMVNGEGHA SCDHRQRGFK RWECNRPAAP 
GGPLKFSEKF QLFTPFSLGF EFRPGHEYYY ISATPPNAVD RPCLRLKVYV RPTNETLYEA 
PEPIFTSNNS CSSPGGCRLF LSTIPVLWTL LGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.