Details for: EFNB2

Gene ID: 1948

Symbol: EFNB2

Ensembl ID: ENSG00000125266

Description: ephrin B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 267.1249
    Cell Significance Index: -41.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.0886
    Cell Significance Index: -41.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.2908
    Cell Significance Index: -34.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.9056
    Cell Significance Index: -41.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.7319
    Cell Significance Index: -41.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.8202
    Cell Significance Index: -42.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5447
    Cell Significance Index: -41.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6860
    Cell Significance Index: -19.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.0627
    Cell Significance Index: 44.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.8487
    Cell Significance Index: 129.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.4311
    Cell Significance Index: 52.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1547
    Cell Significance Index: 62.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0002
    Cell Significance Index: 141.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4280
    Cell Significance Index: 80.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2762
    Cell Significance Index: 564.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2464
    Cell Significance Index: 135.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0758
    Cell Significance Index: 215.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9527
    Cell Significance Index: 341.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9057
    Cell Significance Index: 147.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8430
    Cell Significance Index: 103.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8371
    Cell Significance Index: 19.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7085
    Cell Significance Index: 14.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6312
    Cell Significance Index: 32.7900
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.6106
    Cell Significance Index: 0.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5460
    Cell Significance Index: 98.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4431
    Cell Significance Index: 15.5700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4411
    Cell Significance Index: 6.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3966
    Cell Significance Index: 358.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3841
    Cell Significance Index: 209.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3662
    Cell Significance Index: 7.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3507
    Cell Significance Index: 18.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3432
    Cell Significance Index: 8.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3291
    Cell Significance Index: 9.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3252
    Cell Significance Index: 19.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3200
    Cell Significance Index: 22.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2826
    Cell Significance Index: 195.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2322
    Cell Significance Index: 10.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1838
    Cell Significance Index: 83.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1659
    Cell Significance Index: 31.5800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1539
    Cell Significance Index: 0.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1114
    Cell Significance Index: 22.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1091
    Cell Significance Index: 10.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1043
    Cell Significance Index: 4.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0713
    Cell Significance Index: 2.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0612
    Cell Significance Index: 7.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0565
    Cell Significance Index: 0.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0318
    Cell Significance Index: 0.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0166
    Cell Significance Index: 22.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0060
    Cell Significance Index: 9.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0092
    Cell Significance Index: -1.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0133
    Cell Significance Index: -24.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0151
    Cell Significance Index: -28.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0284
    Cell Significance Index: -3.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0303
    Cell Significance Index: -4.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0391
    Cell Significance Index: -29.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0392
    Cell Significance Index: -24.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0499
    Cell Significance Index: -31.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0545
    Cell Significance Index: -39.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0587
    Cell Significance Index: -33.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0874
    Cell Significance Index: -1.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1041
    Cell Significance Index: -2.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1139
    Cell Significance Index: -13.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1143
    Cell Significance Index: -32.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1282
    Cell Significance Index: -8.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1298
    Cell Significance Index: -4.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1303
    Cell Significance Index: -8.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1338
    Cell Significance Index: -17.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1441
    Cell Significance Index: -30.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1625
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1636
    Cell Significance Index: -27.9400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1657
    Cell Significance Index: -1.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2166
    Cell Significance Index: -10.1000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2515
    Cell Significance Index: -2.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2637
    Cell Significance Index: -38.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3055
    Cell Significance Index: -36.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3331
    Cell Significance Index: -4.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3597
    Cell Significance Index: -36.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3605
    Cell Significance Index: -26.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3660
    Cell Significance Index: -38.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3722
    Cell Significance Index: -11.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4280
    Cell Significance Index: -11.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4983
    Cell Significance Index: -30.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5035
    Cell Significance Index: -38.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5087
    Cell Significance Index: -40.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5623
    Cell Significance Index: -8.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5946
    Cell Significance Index: -14.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6946
    Cell Significance Index: -11.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7090
    Cell Significance Index: -22.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7104
    Cell Significance Index: -18.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7462
    Cell Significance Index: -47.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7536
    Cell Significance Index: -39.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7732
    Cell Significance Index: -25.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7867
    Cell Significance Index: -28.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8116
    Cell Significance Index: -9.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8161
    Cell Significance Index: -28.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8519
    Cell Significance Index: -22.4000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.8707
    Cell Significance Index: -6.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8856
    Cell Significance Index: -18.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0186
    Cell Significance Index: -10.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EFNB2 is a transmembrane protein that belongs to the ephrin family, which consists of four subfamilies: Class 1, Class 2, Class 3, and Class 4. EFNB2 is a Class 2 ephrin, characterized by the presence of a N-terminal extracellular domain and a C-terminal intracellular domain. The extracellular domain of EFNB2 contains a carbohydrate-binding site, which allows it to interact with its ligand, Ephrin-B1. The intracellular domain of EFNB2 contains a tyrosine kinase domain, which is essential for the activation of downstream signaling pathways. **Pathways and Functions:** EFNB2 is involved in several key signaling pathways, including: 1. **Eph-ephrin mediated repulsion of cells**: EFNB2 interacts with Ephrin-B1 to regulate cell-cell repulsion, which is essential for the development and organization of various tissues and organs. 2. **Eph-ephrin signaling**: EFNB2 is a key component of the Eph-ephrin signaling pathway, which regulates cell-cell interactions and influences the development and organization of various tissues and organs. 3. **Cell adhesion**: EFNB2 interacts with its ligand, Ephrin-B1, to regulate cell-cell adhesion, which is essential for the development and organization of various tissues and organs. 4. **Cell migration**: EFNB2 regulates cell migration, which is essential for the development and organization of various tissues and organs. 5. **Angiogenesis**: EFNB2 regulates angiogenesis, which is the formation of new blood vessels. **Significantly Expressed Cells:** EFNB2 is significantly expressed in various cell types, including: 1. **Endocardial cells**: EFNB2 is expressed in endocardial cells, which are essential for the development and organization of the heart. 2. **Pulmonary artery endothelial cells**: EFNB2 is expressed in pulmonary artery endothelial cells, which are essential for the development and organization of the pulmonary vasculature. 3. **Cortical thymic epithelial cells**: EFNB2 is expressed in cortical thymic epithelial cells, which are essential for the development and organization of the thymus. 4. **Taste receptor cells**: EFNB2 is expressed in taste receptor cells, which are essential for the development and organization of the taste system. 5. **Kidney capillary endothelial cells**: EFNB2 is expressed in kidney capillary endothelial cells, which are essential for the development and organization of the kidney vasculature. **Clinical Significance:** EFNB2 has been implicated in various diseases, including: 1. **Cardiovascular disease**: EFNB2 has been shown to play a role in the development and organization of the cardiovascular system, and its dysregulation has been implicated in cardiovascular disease. 2. **Cancer**: EFNB2 has been shown to play a role in the development and progression of various cancers, including breast cancer and lung cancer. 3. **Neurological disease**: EFNB2 has been shown to play a role in the development and organization of the nervous system, and its dysregulation has been implicated in neurological disease. In conclusion, EFNB2 is a critical component of the Eph-ephrin signaling pathway, which regulates cell-cell interactions and influences the development and organization of various tissues and organs. Its dysregulation has been implicated in various diseases, including cardiovascular disease, cancer, and neurological disease. Further research is needed to fully understand the role of EFNB2 in human disease and to develop novel therapeutic strategies to target this protein.

Genular Protein ID: 2809801407

Symbol: EFNB2_HUMAN

Name: Ephrin-B2

UniProtKB Accession Codes:

P52799 Q5JV56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8559144

Title: Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.

PubMed ID: 8559144

DOI: 10.1016/0161-5890(95)00108-5

PubMed ID: 7534404

Title: Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.

PubMed ID: 7534404

DOI: 10.1073/pnas.92.6.1866

PubMed ID: 9533549

Title: Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas.

PubMed ID: 9533549

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12734395

Title: Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells.

PubMed ID: 12734395

DOI: 10.1242/jcs.00426

PubMed ID: 16007075

Title: EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus.

PubMed ID: 16007075

DOI: 10.1038/nature03838

PubMed ID: 15998730

Title: Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus.

PubMed ID: 15998730

DOI: 10.1073/pnas.0504887102

PubMed ID: 16477309

Title: Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus.

PubMed ID: 16477309

DOI: 10.1371/journal.ppat.0020007

PubMed ID: 17376907

Title: Identification of Hendra virus G glycoprotein residues that are critical for receptor binding.

PubMed ID: 17376907

DOI: 10.1128/jvi.02022-06

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28931592

Title: Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.

PubMed ID: 28931592

DOI: 10.1091/mbc.e17-07-0450

PubMed ID: 16867992

Title: Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity.

PubMed ID: 16867992

DOI: 10.1074/jbc.m605766200

PubMed ID: 18488039

Title: Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2.

PubMed ID: 18488039

DOI: 10.1038/nsmb.1435

PubMed ID: 19836338

Title: Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling.

PubMed ID: 19836338

DOI: 10.1016/j.str.2009.07.018

PubMed ID: 19875447

Title: Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity.

PubMed ID: 19875447

DOI: 10.1074/jbc.m109.064824

Sequence Information:

  • Length: 333
  • Mass: 36923
  • Checksum: 6D9932A632626AEA
  • Sequence:
    • MAVRRDSVWK YCWGVLMVLC RTAISKSIVL EPIYWNSSNS KFLPGQGLVL YPQIGDKLDI 
ICPKVDSKTV GQYEYYKVYM VDKDQADRCT IKKENTPLLN CAKPDQDIKF TIKFQEFSPN 
LWGLEFQKNK DYYIISTSNG SLEGLDNQEG GVCQTRAMKI LMKVGQDASS AGSTRNKDPT 
RRPELEAGTN GRSSTTSPFV KPNPGSSTDG NSAGHSGNNI LGSEVALFAG IASGCIIFIV 
IIITLVVLLL KYRRRHRKHS PQHTTTLSLS TLATPKRSGN NNGSEPSDII IPLRTADSVF 
CPHYEKVSGD YGHPVYIVQE MPPQSPANIY YKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.