Details for: EFNB2

Gene ID: 1948

Symbol: EFNB2

Ensembl ID: ENSG00000125266

Description: ephrin B2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.09
    Marker Score: 1745
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.18
    Marker Score: 1874
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.09
    Marker Score: 7738
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.07
    Marker Score: 1788
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.02
    Marker Score: 1905
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.83
    Marker Score: 11677
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.77
    Marker Score: 567
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.67
    Marker Score: 3659.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.61
    Marker Score: 98790
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.59
    Marker Score: 498
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.59
    Marker Score: 6149
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.56
    Marker Score: 2269
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.56
    Marker Score: 6497
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.52
    Marker Score: 377
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.47
    Marker Score: 13990
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168181
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.45
    Marker Score: 4547
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.44
    Marker Score: 2222
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.43
    Marker Score: 5547
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.35
    Marker Score: 1419
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.34
    Marker Score: 3418
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.34
    Marker Score: 2245
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.29
    Marker Score: 772
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.29
    Marker Score: 2917
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.27
    Marker Score: 1138
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.25
    Marker Score: 1042
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.24
    Marker Score: 1236.5
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.21
    Marker Score: 333
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.18
    Marker Score: 1269
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.17
    Marker Score: 13199
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.15
    Marker Score: 268
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.14
    Marker Score: 8774
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.14
    Marker Score: 1685
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.14
    Marker Score: 4768
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.13
    Marker Score: 289
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.1
    Marker Score: 264
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.09
    Marker Score: 9346
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.09
    Marker Score: 599
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.08
    Marker Score: 522
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.08
    Marker Score: 971
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.07
    Marker Score: 846
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.07
    Marker Score: 36421
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16472
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.05
    Marker Score: 2095
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.04
    Marker Score: 1469
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.03
    Marker Score: 2374
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.01
    Marker Score: 21585
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71767
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47992
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1
    Marker Score: 580
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.98
    Marker Score: 4723
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.98
    Marker Score: 656
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.98
    Marker Score: 614
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.97
    Marker Score: 190
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1967
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.96
    Marker Score: 211
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.96
    Marker Score: 900
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.95
    Marker Score: 1019
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.94
    Marker Score: 249
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5311
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.91
    Marker Score: 3762
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.91
    Marker Score: 376
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.9
    Marker Score: 229
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.9
    Marker Score: 527
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.89
    Marker Score: 1514
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.88
    Marker Score: 848
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.87
    Marker Score: 250
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.87
    Marker Score: 1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.86
    Marker Score: 291
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.86
    Marker Score: 333
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.85
    Marker Score: 2025
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.85
    Marker Score: 474
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.84
    Marker Score: 391.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.82
    Marker Score: 31234
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.82
    Marker Score: 513
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.82
    Marker Score: 876
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 622
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.8
    Marker Score: 4172
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.79
    Marker Score: 15761
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.79
    Marker Score: 888
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.79
    Marker Score: 3212
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1488
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1827
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.76
    Marker Score: 178
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.76
    Marker Score: 360
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.75
    Marker Score: 217
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.75
    Marker Score: 804
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.75
    Marker Score: 280.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.74
    Marker Score: 6960
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.74
    Marker Score: 213

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Other Information

**Key characteristics:** - EFNB2 is a glycoprotein with a molecular weight of approximately 140 kDa. - It belongs to the Eph receptor family, which are involved in cell adhesion, migration, and signaling. - It is expressed in high levels in various tissues, including the cardiovascular system, central nervous system, and skin. **Pathways and functions:** - EFNB2 signaling is involved in the regulation of epithelial-mesenchymal transition (EMT), a process where epithelial cells lose their epithelial characteristics and acquire mesenchymal properties. - It plays a key role in the development and maintenance of blood vessels, including the formation of new blood vessels in embryonic and adult tissues. - In endothelial cells, EFNB2 signaling is crucial for the regulation of vascular permeability, cell migration, and angiogenesis. - It is also involved in the development and function of lymphoid organs, where it helps to regulate the differentiation of lymphoid cells. **Clinical significance:** - Mutations in the EFNB2 gene have been linked to several human diseases, including liver disease, cardiovascular disease, and cancer. - Dysregulation of EFNB2 signaling has been implicated in the pathogenesis of these diseases, suggesting that targeting EFNB2 could be a potential therapeutic strategy. **Overall,** EFNB2 is a critical cell surface protein that plays a critical role in the development, maintenance, and function of various tissues and organs in the human body. Its dysregulation has been linked to several human diseases, highlighting its importance in human health.

Genular Protein ID: 2809801407

Symbol: EFNB2_HUMAN

Name: Ephrin-B2

UniProtKB Accession Codes:

P52799 Q5JV56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8559144

Title: Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.

PubMed ID: 8559144

DOI: 10.1016/0161-5890(95)00108-5

PubMed ID: 7534404

Title: Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.

PubMed ID: 7534404

DOI: 10.1073/pnas.92.6.1866

PubMed ID: 9533549

Title: Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas.

PubMed ID: 9533549

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12734395

Title: Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells.

PubMed ID: 12734395

DOI: 10.1242/jcs.00426

PubMed ID: 16007075

Title: EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus.

PubMed ID: 16007075

DOI: 10.1038/nature03838

PubMed ID: 15998730

Title: Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus.

PubMed ID: 15998730

DOI: 10.1073/pnas.0504887102

PubMed ID: 16477309

Title: Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus.

PubMed ID: 16477309

DOI: 10.1371/journal.ppat.0020007

PubMed ID: 17376907

Title: Identification of Hendra virus G glycoprotein residues that are critical for receptor binding.

PubMed ID: 17376907

DOI: 10.1128/jvi.02022-06

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28931592

Title: Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.

PubMed ID: 28931592

DOI: 10.1091/mbc.e17-07-0450

PubMed ID: 16867992

Title: Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity.

PubMed ID: 16867992

DOI: 10.1074/jbc.m605766200

PubMed ID: 18488039

Title: Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2.

PubMed ID: 18488039

DOI: 10.1038/nsmb.1435

PubMed ID: 19836338

Title: Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling.

PubMed ID: 19836338

DOI: 10.1016/j.str.2009.07.018

PubMed ID: 19875447

Title: Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity.

PubMed ID: 19875447

DOI: 10.1074/jbc.m109.064824

Sequence Information:

  • Length: 333
  • Mass: 36923
  • Checksum: 6D9932A632626AEA
  • Sequence:
    • MAVRRDSVWK YCWGVLMVLC RTAISKSIVL EPIYWNSSNS KFLPGQGLVL YPQIGDKLDI 
ICPKVDSKTV GQYEYYKVYM VDKDQADRCT IKKENTPLLN CAKPDQDIKF TIKFQEFSPN 
LWGLEFQKNK DYYIISTSNG SLEGLDNQEG GVCQTRAMKI LMKVGQDASS AGSTRNKDPT 
RRPELEAGTN GRSSTTSPFV KPNPGSSTDG NSAGHSGNNI LGSEVALFAG IASGCIIFIV 
IIITLVVLLL KYRRRHRKHS PQHTTTLSLS TLATPKRSGN NNGSEPSDII IPLRTADSVF 
CPHYEKVSGD YGHPVYIVQE MPPQSPANIY YKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.