Details for: CTTN

Gene ID: 2017

Symbol: CTTN

Ensembl ID: ENSG00000085733

Description: cortactin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 500.9154
    Cell Significance Index: -77.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 327.7042
    Cell Significance Index: -83.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 183.0087
    Cell Significance Index: -75.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 177.1150
    Cell Significance Index: -83.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 164.5017
    Cell Significance Index: -66.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 155.1755
    Cell Significance Index: -79.8200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 124.8170
    Cell Significance Index: -83.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.9036
    Cell Significance Index: -66.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 66.1419
    Cell Significance Index: -81.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.3621
    Cell Significance Index: -51.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.9982
    Cell Significance Index: -82.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1232
    Cell Significance Index: 425.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.9770
    Cell Significance Index: 55.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6369
    Cell Significance Index: 85.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5992
    Cell Significance Index: 42.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5677
    Cell Significance Index: 282.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5231
    Cell Significance Index: 209.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4877
    Cell Significance Index: 32.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4573
    Cell Significance Index: 179.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4466
    Cell Significance Index: 41.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3640
    Cell Significance Index: 71.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1254
    Cell Significance Index: 223.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1037
    Cell Significance Index: 51.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0855
    Cell Significance Index: 592.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0624
    Cell Significance Index: 79.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0000
    Cell Significance Index: 27.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9814
    Cell Significance Index: 75.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9389
    Cell Significance Index: 152.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9370
    Cell Significance Index: 121.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9231
    Cell Significance Index: 331.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8795
    Cell Significance Index: 44.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8437
    Cell Significance Index: 160.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7874
    Cell Significance Index: 22.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7741
    Cell Significance Index: 19.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7714
    Cell Significance Index: 20.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7601
    Cell Significance Index: 336.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6762
    Cell Significance Index: 610.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5981
    Cell Significance Index: 27.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5843
    Cell Significance Index: 27.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5451
    Cell Significance Index: 37.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3784
    Cell Significance Index: 3.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3668
    Cell Significance Index: 253.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3489
    Cell Significance Index: 44.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2795
    Cell Significance Index: 19.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2211
    Cell Significance Index: 416.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1721
    Cell Significance Index: 17.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1612
    Cell Significance Index: 5.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1293
    Cell Significance Index: 199.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1240
    Cell Significance Index: 21.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0887
    Cell Significance Index: 163.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0408
    Cell Significance Index: 25.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0162
    Cell Significance Index: 22.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0329
    Cell Significance Index: -14.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0371
    Cell Significance Index: -23.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0496
    Cell Significance Index: -36.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0504
    Cell Significance Index: -36.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0646
    Cell Significance Index: -1.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0894
    Cell Significance Index: -1.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1072
    Cell Significance Index: -60.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2134
    Cell Significance Index: -44.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2380
    Cell Significance Index: -68.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2461
    Cell Significance Index: -13.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2731
    Cell Significance Index: -4.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2834
    Cell Significance Index: -41.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3155
    Cell Significance Index: -5.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3281
    Cell Significance Index: -33.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3476
    Cell Significance Index: -39.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3709
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4229
    Cell Significance Index: -48.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4401
    Cell Significance Index: -19.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4436
    Cell Significance Index: -51.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4606
    Cell Significance Index: -50.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5149
    Cell Significance Index: -5.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6336
    Cell Significance Index: -74.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6393
    Cell Significance Index: -66.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6628
    Cell Significance Index: -25.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7581
    Cell Significance Index: -11.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7944
    Cell Significance Index: -20.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8170
    Cell Significance Index: -64.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8235
    Cell Significance Index: -17.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8380
    Cell Significance Index: -19.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8675
    Cell Significance Index: -22.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9191
    Cell Significance Index: -57.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9573
    Cell Significance Index: -50.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0191
    Cell Significance Index: -32.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0567
    Cell Significance Index: -36.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.2103
    Cell Significance Index: -78.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3464
    Cell Significance Index: -82.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4066
    Cell Significance Index: -44.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4719
    Cell Significance Index: -48.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5260
    Cell Significance Index: -53.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.5804
    Cell Significance Index: -64.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.6527
    Cell Significance Index: -10.7800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.6530
    Cell Significance Index: -11.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.6771
    Cell Significance Index: -35.6000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.7555
    Cell Significance Index: -24.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7892
    Cell Significance Index: -65.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7953
    Cell Significance Index: -52.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.9041
    Cell Significance Index: -46.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Cortactin is a cytoskeletal protein that belongs to the family of actin-binding proteins. It is characterized by its ability to bind to actin filaments and regulate their dynamics. Cortactin's structure consists of three domains: the N-terminal domain, the central domain, and the C-terminal domain. The central domain is responsible for binding to actin filaments, while the N-terminal domain interacts with signaling molecules and the C-terminal domain regulates the interactions with other proteins. Cortactin is expressed in various cell types, including epithelial cells, fibroblasts, and neurons, and its expression is often upregulated in response to cell migration and endocytosis. **Pathways and Functions:** Cortactin's functions are tightly linked to the regulation of actin dynamics and cellular motility. It plays a key role in: 1. **Actin filament organization**: Cortactin regulates the formation and disassembly of actin filaments, influencing cell shape and movement. 2. **Endocytosis**: Cortactin interacts with clathrin and other endocytic machinery to regulate the formation of clathrin-coated pits and vesicles. 3. **Apoptosis**: Cortactin modulates the extrinsic apoptotic signaling pathway, influencing cell survival and death. 4. **Cell migration**: Cortactin regulates the formation of focal adhesions and lamellipodia, essential for cell migration and invasion. 5. **Neurotransmission**: Cortactin plays a role in regulating the structure and function of dendritic spines and synapses. **Clinical Significance:** Cortactin's dysregulation has been implicated in various diseases, including: 1. **Cancer**: Cortactin's overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: Cortactin's dysregulation has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Cardiovascular diseases**: Cortactin's overexpression has been observed in cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 4. **Muscular dystrophy**: Cortactin's dysregulation has been implicated in muscular dystrophies, such as Duchenne muscular dystrophy. In conclusion, cortactin is a key regulator of actin dynamics and cellular motility, playing a crucial role in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of cortactin in maintaining cellular homeostasis and promoting health. Further research is needed to elucidate the mechanisms underlying cortactin's functions and to explore its potential as a therapeutic target for disease treatment.

Genular Protein ID: 1292919803

Symbol: SRC8_HUMAN

Name: Src substrate cortactin

UniProtKB Accession Codes:

Q14247 Q8N707 Q96H99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1532244

Title: Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.

PubMed ID: 1532244

PubMed ID: 8474448

Title: The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites.

PubMed ID: 8474448

DOI: 10.1128/mcb.13.5.2891-2898.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9722593

Title: Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.

PubMed ID: 9722593

DOI: 10.1074/jbc.273.36.23542

PubMed ID: 12408982

Title: Novel interaction of cortactin with endothelial cell myosin light chain kinase.

PubMed ID: 12408982

DOI: 10.1016/s0006-291x(02)02492-0

PubMed ID: 12151401

Title: Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.

PubMed ID: 12151401

DOI: 10.1074/jbc.m205005200

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15574754

Title: Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R.

PubMed ID: 15574754

DOI: 10.1158/0008-5472.can-04-2716

PubMed ID: 15561106

Title: The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.

PubMed ID: 15561106

DOI: 10.1016/j.yexcr.2004.09.005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17959782

Title: An essential role for cortactin in the modulation of the potassium channel Kv1.2.

PubMed ID: 17959782

DOI: 10.1073/pnas.0703865104

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19146815

Title: Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity.

PubMed ID: 19146815

DOI: 10.1016/j.neuron.2008.11.013

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20861316

Title: Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.

PubMed ID: 20861316

DOI: 10.1091/mbc.e09-10-0876

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21296879

Title: The immunoinhibitory adapter protein SRC homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.

PubMed ID: 21296879

DOI: 10.1074/jbc.m110.155184

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23144454

Title: Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1.

PubMed ID: 23144454

DOI: 10.1074/jbc.m112.372540

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24574519

Title: NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.

PubMed ID: 24574519

DOI: 10.1158/1541-7786.mcr-13-0654

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16636290

Title: Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.

PubMed ID: 16636290

DOI: 10.1073/pnas.0509166103

Sequence Information:

  • Length: 550
  • Mass: 61586
  • Checksum: 7799326C2B4383BB
  • Sequence:
    • MWKASAGHAV SIAQDDAGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ EHINIHKLRE 
NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV GHEYQSKLSK HCSQVDSVRG 
FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS QKDYSSGFGG KYGVQADRVD KSAVGFDYQG 
KTEKHESQRD YSKGFGGKYG IDKDKVDKSA VGFEYQGKTE KHESQKDYVK GFGGKFGVQT 
DRQDKCALGW DHQEKLQLHE SQKDYKTGFG GKFGVQSERQ DSAAVGFDYK EKLAKHESQQ 
DYSKGFGGKY GVQKDRMDKN ASTFEDVTQV SSAYQKTVPV EAVTSKTSNI RANFENLAKE 
KEQEDRRKAE AERAQRMAKE RQEQEEARRK LEEQARAKTQ TPPVSPAPQP TEERLPSSPV 
YEDAASFKAE LSYRGPVSGT EPEPVYSMEA ADYREASSQQ GLAYATEAVY ESAEAPGHYP 
AEDSTYDEYE NDLGITAVAL YDYQAAGDDE ISFDPDDIIT NIEMIDDGWW RGVCKGRYGL 
FPANYVELRQ

Genular Protein ID: 2563238223

Symbol: Q53HG7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53HG7

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 550
  • Mass: 61558
  • Checksum: 18AD5222B427B3AD
  • Sequence:
    • MWKASAGHAV SIAQDDAGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ EHINIHKLRE 
NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV GHEYQSKLSK HCSQVDSVRG 
FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS QKDYSSGFGG KYGVQADRVD KSAVGFDYQG 
KTEKHESQRD YSKGFGGKYG IDKDKVDKSA VGFEYQGKTE KHESQKDYVK GFGGKFGVQT 
DRQDKCALGW DHQEKLQLHE SQKDYKTGFG GKFGVQSERQ DSAAVGFDYK EKLAKHESQQ 
DYSKGFGGKY GVQKDRMDKN ASTFEDVTQV SSAYQKTVPV EAVTSKTSNI RANFENLAKE 
KEQEDRRKAE AERAQRMAKE RQEQEEARKK LEEQARAKTQ TPPVSPAPQP TEERLPSSPV 
YEDAASFKAE LSYRGPVSGT EPEPVYSMEA ADYREASSQQ GLAYATEAVY ESAEAPGHYP 
AEDSTYDEYE NDLGITAVAL YDYQAAGDDE ISFDPDDIIT NIEMIDDGWW RGVCKGRYGL 
FPANYVELRQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.