Details for: ENO2

Gene ID: 2026

Symbol: ENO2

Ensembl ID: ENSG00000111674

Description: enolase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.09
    Marker Score: 4933.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.82
    Marker Score: 10904
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.41
    Marker Score: 3216
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.37
    Marker Score: 6842
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.81
    Marker Score: 838
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.71
    Marker Score: 12527
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.12
    Marker Score: 1107
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.03
    Marker Score: 851
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.89
    Marker Score: 636
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.86
    Marker Score: 2092
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.68
    Marker Score: 103150
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.58
    Marker Score: 15058
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.57
    Marker Score: 14755
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.57
    Marker Score: 31154
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1135
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.56
    Marker Score: 907
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.54
    Marker Score: 13265
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2341
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.49
    Marker Score: 55029
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.46
    Marker Score: 55408
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.45
    Marker Score: 395
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.44
    Marker Score: 5552
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.39
    Marker Score: 5765
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.33
    Marker Score: 707
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.31
    Marker Score: 10046
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.3
    Marker Score: 2307
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.3
    Marker Score: 19440
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.2
    Marker Score: 789
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.17
    Marker Score: 472
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.15
    Marker Score: 4806
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.14
    Marker Score: 668
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.14
    Marker Score: 1377
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.14
    Marker Score: 1574
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.09
    Marker Score: 1501
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.07
    Marker Score: 634
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.06
    Marker Score: 512
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251747
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.01
    Marker Score: 478.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1
    Marker Score: 1350
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1
    Marker Score: 21374
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71766
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47991
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1
    Marker Score: 2187.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.96
    Marker Score: 550
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.95
    Marker Score: 913
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.93
    Marker Score: 3802
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9
    Marker Score: 1709.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 358
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5032
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1788
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5265
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.83
    Marker Score: 264
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.83
    Marker Score: 950
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.82
    Marker Score: 1029
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.82
    Marker Score: 407
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.81
    Marker Score: 484
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.81
    Marker Score: 3376
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.8
    Marker Score: 254
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12384
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.76
    Marker Score: 2257
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3126
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.74
    Marker Score: 1247
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 672
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.73
    Marker Score: 4638
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.71
    Marker Score: 309
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.7
    Marker Score: 686
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.68
    Marker Score: 379
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.66
    Marker Score: 907
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.65
    Marker Score: 434
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.64
    Marker Score: 235
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.63
    Marker Score: 1817.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.63
    Marker Score: 181
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.62
    Marker Score: 258
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.62
    Marker Score: 746
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.62
    Marker Score: 293
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.62
    Marker Score: 181
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.61
    Marker Score: 1412
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.61
    Marker Score: 521
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.61
    Marker Score: 303
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.6
    Marker Score: 225
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.6
    Marker Score: 2583
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.6
    Marker Score: 216
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.59
    Marker Score: 428
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 347
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.57
    Marker Score: 146
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.57
    Marker Score: 5733
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.57
    Marker Score: 294
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.57
    Marker Score: 3756
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 358

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Other Information

**Key characteristics:** * ENOLA2 is a glycolytic enzyme that is highly expressed in the retina and other tissues where glucose metabolism is important. * It is a key enzyme in the citric acid cycle, which is responsible for the breakdown of glucose to produce energy. * ENOLA2 is also involved in the regulation of calcium and magnesium ion concentrations. **Pathways and functions:** * ENOLA2 is involved in the following pathways: * Canonical glycolysis * Cytosol * Extracellular space * Gluconeogenesis * Glucose metabolism * Glycolysis * Glycolytic process * Magnesium ion binding * Membrane * Metabolism of carbohydrates * Perikaryon * Phosphopyruvate hydratase activity * Phosphopyruvate hydratase complex * Photoreceptor inner segment * Plasma membrane * ENOLA2 is essential for the maintenance of low intra-cellular calcium levels, which is necessary for the proper function of photoreceptors and other cells that require calcium for proper function. **Clinical significance:** * Mutations in ENOLA2 have been linked to several eye diseases, including retinitis pigmentosa, a progressive degenerative eye disease that affects the retina. * ENOLA2 is a potential therapeutic target for these diseases, as it is a key enzyme in the citric acid cycle that is involved in the production of retinal damage products. **Additional information:** * ENOLA2 is a glycosidase enzyme, which means that it catalyzes the hydrolysis of glycosidic bonds between molecules. * It is a transmembrane protein, with a hydrophilic N-terminal domain and a hydrophobic C-terminal domain. * It is a highly conserved protein, with a sequence that is found in organisms from yeast to humans.

Genular Protein ID: 4290514645

Symbol: ENOG_HUMAN

Name: Gamma-enolase

UniProtKB Accession Codes:

P09104 B7Z2X9 Q96J33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 9 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 16 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SABIO-RK 1 SFLD 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3208766

Title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE).

PubMed ID: 3208766

DOI: 10.1111/j.1432-1033.1988.tb14465.x

PubMed ID: 3385803

Title: Human gamma enolase: isolation of a cDNA clone and expression in normal and tumor tissues of human origin.

PubMed ID: 3385803

DOI: 10.1002/jnr.490190409

PubMed ID: 2792767

Title: Cloning, expression and sequence homologies of cDNA for human gamma enolase.

PubMed ID: 2792767

DOI: 10.1016/0378-1119(89)90217-5

PubMed ID: 2045099

Title: Complete structure of the human gene encoding neuron-specific enolase.

PubMed ID: 2045099

DOI: 10.1016/0888-7543(91)90496-2

PubMed ID: 9074930

Title: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

PubMed ID: 9074930

DOI: 10.1101/gr.7.3.268

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3653393

Title: Sequence conservation in the 3'-untranslated regions of neurone-specific enolase, lymphokine and protooncogene mRNAs.

PubMed ID: 3653393

DOI: 10.1016/0014-5793(87)80207-7

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29775581

Title: p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis.

PubMed ID: 29775581

DOI: 10.1016/j.molcel.2018.04.011

PubMed ID: 36459650

Title: Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling.

PubMed ID: 36459650

DOI: 10.1073/pnas.2205789119

PubMed ID: 15289101

Title: Expression, purification and the 1.8 angstroms resolution crystal structure of human neuron specific enolase.

PubMed ID: 15289101

DOI: 10.1016/j.jmb.2004.05.068

Sequence Information:

  • Length: 434
  • Mass: 47269
  • Checksum: 6163DE81F5C67744
  • Sequence:
    • MSIEKIWARE ILDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR DGDKQRYLGK 
GVLKAVDHIN STIAPALISS GLSVVEQEKL DNLMLELDGT ENKSKFGANA ILGVSLAVCK 
AGAAERELPL YRHIAQLAGN SDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAESFRD 
AMRLGAEVYH TLKGVIKDKY GKDATNVGDE GGFAPNILEN SEALELVKEA IDKAGYTEKI 
VIGMDVAASE FYRDGKYDLD FKSPTDPSRY ITGDQLGALY QDFVRDYPVV SIEDPFDQDD 
WAAWSKFTAN VGIQIVGDDL TVTNPKRIER AVEEKACNCL LLKVNQIGSV TEAIQACKLA 
QENGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEELGDE 
ARFAGHNFRN PSVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.