Details for: ENO2
Gene ID: 2026
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ENO2
Ensembl ID: ENSG00000111674
Description: enolase 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 44.1rCSI 60.3%PRS 86.64
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CSI 35.19rCSI 62.01%PRS 82.04
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CSI 33.96rCSI 50.48%PRS 85.96
-
CSI 30.94rCSI 49.8%PRS 77.83
-
CSI 30.01rCSI 45.75%PRS 83.49
-
CSI 23.18rCSI 51.21%PRS 74.15
-
CSI 20.61rCSI 14.79%PRS 95.87
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CSI 19.59rCSI 28.8%PRS 80.34
-
CSI 19.45rCSI 18.76%PRS 81.41
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CSI 15.75rCSI 21.46%PRS 79.17
-
CSI 14.6rCSI 42.31%PRS 77.12
-
CSI 14.18rCSI 11.36%PRS 94.35
-
CSI 13.5rCSI 50.95%PRS 70.23
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CSI 12.96rCSI 46.65%PRS 68.99
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CSI 11.85rCSI 17.53%PRS 88.89
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CSI 11.19rCSI 38.33%PRS 73.03
-
CSI 10.81rCSI 26.26%PRS 68.83
-
CSI 10.4rCSI 24.87%PRS 74.65
-
CSI 9.72rCSI 17.47%PRS 80.84
-
CSI 9.67rCSI 20.56%PRS 80.43
-
CSI 9.43rCSI 20.46%PRS 74.84
-
CSI 9.15rCSI 12.67%PRS 82.9
-
CSI 8.51rCSI 13.08%PRS 75.03
-
CSI 8.06rCSI 9.63%PRS 71.18
-
CSI 7.85rCSI 29.65%PRS 71.37
-
CSI 7.67rCSI 29.21%PRS 78.76
-
CSI 7.62rCSI 7.49%PRS 88.27
-
CSI 7.5rCSI 15.22%PRS 67.08
-
CSI 7.48rCSI 7.83%PRS 89.02
-
CSI 7.39rCSI 5.47%PRS 81.57
-
CSI 7.37rCSI 16.32%PRS 86.39
-
CSI 7.35rCSI 8.49%PRS 79.01
-
CSI 7.12rCSI 35.39%PRS 80.84
-
CSI 6.9rCSI 14.19%PRS 73.94
-
CSI 6.87rCSI 8.81%PRS 82.87
-
CSI 6.79rCSI 5.63%PRS 87.49
-
CSI 6.79rCSI 12.72%PRS 76.66
-
CSI 6.77rCSI 76.13%PRS 90.62
-
CSI 6.72rCSI 5.11%PRS 95.82
-
CSI 6.5rCSI 9.03%PRS 84.83
-
CSI 6.4rCSI 12.86%PRS 78.89
-
CSI 6.36rCSI 10.41%PRS 77.84
-
CSI 6.33rCSI 4.27%PRS 95.8
-
CSI 6.28rCSI 14.32%PRS 79.09
-
CSI 6.16rCSI 10.66%PRS 79.76
-
CSI 6.12rCSI 14.13%PRS 75.99
-
CSI 6rCSI 47.03%PRS 89.14
-
CSI 5.82rCSI 25.59%PRS 81.16
-
CSI 5.63rCSI 34.68%PRS 88.71
-
CSI 5.6rCSI 9.81%PRS 81.77
-
CSI 5.45rCSI 18.24%PRS 71.53
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CSI 5.38rCSI 16.81%PRS 74.6
-
CSI 5.34rCSI 8.16%PRS 91.7
-
CSI 5.26rCSI 14%PRS 74.11
-
CSI 5.17rCSI 15.27%PRS 87.03
-
CSI 5.15rCSI 30.32%PRS 71.48
-
CSI 4.87rCSI 15.21%PRS 72.46
-
CSI 4.86rCSI 8.16%PRS 71.05
-
CSI 4.8rCSI 5.97%PRS 68.86
-
CSI 4.73rCSI 3.74%PRS 77.57
-
CSI 4.7rCSI 6.06%PRS 72.21
-
CSI 4.43rCSI 6.06%PRS 85.47
-
CSI 4.27rCSI 60.55%PRS 78.3
-
CSI 4.18rCSI 2.91%PRS 96.25
-
CSI 4.03rCSI 3.64%PRS 85.04
-
CSI 3.88rCSI 15.8%PRS 78.74
-
CSI 3.84rCSI 50.14%PRS 84.98
-
CSI 3.61rCSI 15.36%PRS 79.95
-
CSI 3.48rCSI 2.31%PRS 88.38
-
CSI 3.46rCSI 5.57%PRS 72.39
-
CSI 3.46rCSI 6.29%PRS 78.96
-
CSI 3.32rCSI 5.29%PRS 78.52
-
CSI 3.24rCSI 7.27%PRS 71.85
-
CSI 3.21rCSI 3.21%PRS 80.76
-
CSI 3.21rCSI 18.14%PRS 74.18
-
CSI 3.21rCSI 28.25%PRS 74.48
-
CSI 3.13rCSI 63.83%PRS 76.81
-
CSI 3.11rCSI 63.36%PRS 77.65
-
CSI 3.06rCSI 12.16%PRS 91.16
-
CSI 3rCSI 12.43%PRS 83.39
-
CSI 2.96rCSI 9.74%PRS 73.6
-
CSI 2.93rCSI 2.58%PRS 77
-
CSI 2.88rCSI 2.94%PRS 93.14
-
CSI 2.83rCSI 11.21%PRS 80.88
-
CSI 2.78rCSI 2.57%PRS 96.38
-
CSI 2.77rCSI 4.47%PRS 84.09
-
CSI 2.51rCSI 17.96%PRS 76.81
-
CSI 2.36rCSI 15.13%PRS 81.42
-
CSI 2.35rCSI 4.16%PRS 70.51
-
CSI 2.28rCSI 2.64%PRS 80.15
-
CSI 2.01rCSI 3.21%PRS 89.53
-
CSI 2rCSI 5.2%PRS 80.53
-
CSI 1.94rCSI 46.74%PRS 69.19
-
CSI 1.82rCSI 2.49%PRS 78.28
-
CSI 1.81rCSI 15.62%PRS 76.5
-
CSI 1.8rCSI 13.2%PRS 75.93
-
CSI 1.79rCSI 42.78%PRS 68.75
-
CSI 1.7rCSI 3.38%PRS 82.6
-
CSI 1.59rCSI 3.01%PRS 92.41
-
CSI 1.45rCSI 4.19%PRS 85.66
-
CSI 0.7rCSI 2.9%PRS 71.2%
-
CSI 0.8rCSI 4.8%PRS 77.7%
-
CSI 0.9rCSI 2.1%PRS 79.7%
-
CSI 1.0rCSI 3.4%PRS 86.7%
-
CSI 1.3rCSI 11.6%PRS 85.2%
-
CSI 1.3rCSI 5.9%PRS 91.3%
-
CSI 1.3rCSI 5.0%PRS 91.4%
-
CSI 1.4rCSI 4.9%PRS 97.2%
-
CSI 1.4rCSI 8.1%PRS 88.6%
-
CSI 1.5rCSI 4.2%PRS 85.7%
-
CSI 1.6rCSI 3.0%PRS 92.4%
-
CSI 1.7rCSI 3.4%PRS 82.6%
-
CSI 1.8rCSI 42.8%PRS 68.8%
-
CSI 1.8rCSI 13.2%PRS 75.9%
-
CSI 1.8rCSI 15.6%PRS 76.5%
-
CSI 1.8rCSI 2.5%PRS 78.3%
-
CSI 1.9rCSI 46.7%PRS 69.2%
-
CSI 2.0rCSI 5.2%PRS 80.5%
-
CSI 2.0rCSI 3.2%PRS 89.5%
-
CSI 2.3rCSI 2.6%PRS 80.2%
-
CSI 2.4rCSI 4.2%PRS 70.5%
-
CSI 2.4rCSI 15.1%PRS 81.4%
-
CSI 2.5rCSI 18.0%PRS 76.8%
-
CSI 2.8rCSI 4.5%PRS 84.1%
-
CSI 2.8rCSI 2.6%PRS 96.4%
-
CSI 2.8rCSI 11.2%PRS 80.9%
-
CSI 2.9rCSI 2.9%PRS 93.1%
-
CSI 2.9rCSI 2.6%PRS 77.0%
-
CSI 3.0rCSI 9.7%PRS 73.6%
-
CSI 3.0rCSI 12.4%PRS 83.4%
-
CSI 3.1rCSI 12.2%PRS 91.2%
-
CSI 3.1rCSI 63.4%PRS 77.7%
-
CSI 3.1rCSI 63.8%PRS 76.8%
-
CSI 3.2rCSI 28.3%PRS 74.5%
-
CSI 3.2rCSI 18.1%PRS 74.2%
-
CSI 3.2rCSI 3.2%PRS 80.8%
-
CSI 3.2rCSI 7.3%PRS 71.9%
-
CSI 3.3rCSI 5.3%PRS 78.5%
-
CSI 3.5rCSI 6.3%PRS 79.0%
-
CSI 3.5rCSI 5.6%PRS 72.4%
-
CSI 3.5rCSI 2.3%PRS 88.4%
-
CSI 3.6rCSI 15.4%PRS 80.0%
-
CSI 3.8rCSI 50.1%PRS 85.0%
-
CSI 3.9rCSI 15.8%PRS 78.7%
-
CSI 4.0rCSI 3.6%PRS 85.0%
-
CSI 4.2rCSI 2.9%PRS 96.3%
-
CSI 4.3rCSI 60.6%PRS 78.3%
-
CSI 4.4rCSI 6.1%PRS 85.5%
-
CSI 4.7rCSI 6.1%PRS 72.2%
-
CSI 4.7rCSI 3.7%PRS 77.6%
-
CSI 4.8rCSI 6.0%PRS 68.9%
-
CSI 4.9rCSI 8.2%PRS 71.1%
-
CSI 4.9rCSI 15.2%PRS 72.5%
-
CSI 5.2rCSI 30.3%PRS 71.5%
-
CSI 5.2rCSI 15.3%PRS 87.0%
-
CSI 5.3rCSI 14.0%PRS 74.1%
-
CSI 5.3rCSI 8.2%PRS 91.7%
-
CSI 5.4rCSI 16.8%PRS 74.6%
-
CSI 5.5rCSI 18.2%PRS 71.5%
-
CSI 5.6rCSI 9.8%PRS 81.8%
-
CSI 5.6rCSI 34.7%PRS 88.7%
-
CSI 5.8rCSI 25.6%PRS 81.2%
-
CSI 6.0rCSI 47.0%PRS 89.1%
-
CSI 6.1rCSI 14.1%PRS 76.0%
-
CSI 6.2rCSI 10.7%PRS 79.8%
-
CSI 6.3rCSI 14.3%PRS 79.1%
-
CSI 6.3rCSI 4.3%PRS 95.8%
-
CSI 6.4rCSI 10.4%PRS 77.8%
-
CSI 6.4rCSI 12.9%PRS 78.9%
-
CSI 6.5rCSI 9.0%PRS 84.8%
-
CSI 6.7rCSI 5.1%PRS 95.8%
-
CSI 6.8rCSI 76.1%PRS 90.6%
-
CSI 6.8rCSI 12.7%PRS 76.7%
-
CSI 6.8rCSI 5.6%PRS 87.5%
-
CSI 6.9rCSI 8.8%PRS 82.9%
-
CSI 6.9rCSI 14.2%PRS 73.9%
-
CSI 7.1rCSI 35.4%PRS 80.8%
-
CSI 7.4rCSI 8.5%PRS 79.0%
-
CSI 7.4rCSI 16.3%PRS 86.4%
-
CSI 7.4rCSI 5.5%PRS 81.6%
-
CSI 7.5rCSI 7.8%PRS 89.0%
-
CSI 7.5rCSI 15.2%PRS 67.1%
-
CSI 7.6rCSI 7.5%PRS 88.3%
-
CSI 7.7rCSI 29.2%PRS 78.8%
-
CSI 7.9rCSI 29.7%PRS 71.4%
-
CSI 8.1rCSI 9.6%PRS 71.2%
-
CSI 8.5rCSI 13.1%PRS 75.0%
-
CSI 9.2rCSI 12.7%PRS 82.9%
-
CSI 9.4rCSI 20.5%PRS 74.8%
-
CSI 9.7rCSI 20.6%PRS 80.4%
-
CSI 9.7rCSI 17.5%PRS 80.8%
-
CSI 10.4rCSI 24.9%PRS 74.7%
-
CSI 10.8rCSI 26.3%PRS 68.8%
-
CSI 11.2rCSI 38.3%PRS 73.0%
-
CSI 11.9rCSI 17.5%PRS 88.9%
-
CSI 13.0rCSI 46.7%PRS 69.0%
-
CSI 13.5rCSI 51.0%PRS 70.2%
-
CSI 14.2rCSI 11.4%PRS 94.4%
-
CSI 14.6rCSI 42.3%PRS 77.1%
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CSI 15.8rCSI 21.5%PRS 79.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4290514645
Symbol: ENOG_HUMAN
Name: Gamma-enolase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3208766
Title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE).
PubMed ID: 3208766
PubMed ID: 3385803
Title: Human gamma enolase: isolation of a cDNA clone and expression in normal and tumor tissues of human origin.
PubMed ID: 3385803
PubMed ID: 2792767
Title: Cloning, expression and sequence homologies of cDNA for human gamma enolase.
PubMed ID: 2792767
PubMed ID: 2045099
Title: Complete structure of the human gene encoding neuron-specific enolase.
PubMed ID: 2045099
PubMed ID: 9074930
Title: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
PubMed ID: 9074930
DOI: 10.1101/gr.7.3.268
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3653393
Title: Sequence conservation in the 3'-untranslated regions of neurone-specific enolase, lymphokine and protooncogene mRNAs.
PubMed ID: 3653393
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 29775581
Title: p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis.
PubMed ID: 29775581
PubMed ID: 36459650
Title: Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling.
PubMed ID: 36459650
PubMed ID: 15289101
Title: Expression, purification and the 1.8 angstroms resolution crystal structure of human neuron specific enolase.
PubMed ID: 15289101
Sequence Information:
- Length: 434
- Mass: 47269
- Checksum: 6163DE81F5C67744
- Sequence:
MSIEKIWARE ILDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR DGDKQRYLGK GVLKAVDHIN STIAPALISS GLSVVEQEKL DNLMLELDGT ENKSKFGANA ILGVSLAVCK AGAAERELPL YRHIAQLAGN SDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAESFRD AMRLGAEVYH TLKGVIKDKY GKDATNVGDE GGFAPNILEN SEALELVKEA IDKAGYTEKI VIGMDVAASE FYRDGKYDLD FKSPTDPSRY ITGDQLGALY QDFVRDYPVV SIEDPFDQDD WAAWSKFTAN VGIQIVGDDL TVTNPKRIER AVEEKACNCL LLKVNQIGSV TEAIQACKLA QENGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEELGDE ARFAGHNFRN PSVL