Details for: DMTN

Gene ID: 2039

Symbol: DMTN

Ensembl ID: ENSG00000158856

Description: dematin actin binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.7115
    Cell Significance Index: -16.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 28.4612
    Cell Significance Index: -14.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4053
    Cell Significance Index: -14.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1155
    Cell Significance Index: -16.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7926
    Cell Significance Index: 359.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2363
    Cell Significance Index: 64.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0486
    Cell Significance Index: 103.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0319
    Cell Significance Index: 167.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9975
    Cell Significance Index: 44.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9917
    Cell Significance Index: 28.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8810
    Cell Significance Index: 33.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8110
    Cell Significance Index: 54.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7853
    Cell Significance Index: 155.8500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7714
    Cell Significance Index: 10.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7641
    Cell Significance Index: 689.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 0.7056
    Cell Significance Index: -0.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6954
    Cell Significance Index: 249.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6943
    Cell Significance Index: 41.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6563
    Cell Significance Index: 71.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5950
    Cell Significance Index: 69.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4704
    Cell Significance Index: 10.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3567
    Cell Significance Index: 18.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3123
    Cell Significance Index: 21.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2230
    Cell Significance Index: 10.1100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2193
    Cell Significance Index: 1.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2174
    Cell Significance Index: 150.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2058
    Cell Significance Index: 39.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1814
    Cell Significance Index: 3.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1778
    Cell Significance Index: 2.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1671
    Cell Significance Index: 227.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1462
    Cell Significance Index: 2.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1231
    Cell Significance Index: 67.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1094
    Cell Significance Index: 5.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1093
    Cell Significance Index: 13.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0694
    Cell Significance Index: 12.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0554
    Cell Significance Index: 4.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0354
    Cell Significance Index: 15.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0284
    Cell Significance Index: 0.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0146
    Cell Significance Index: 0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0129
    Cell Significance Index: 19.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0067
    Cell Significance Index: 4.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0050
    Cell Significance Index: 9.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0009
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0062
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0164
    Cell Significance Index: -2.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0211
    Cell Significance Index: -9.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0212
    Cell Significance Index: -11.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0218
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0281
    Cell Significance Index: -17.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0375
    Cell Significance Index: -4.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0435
    Cell Significance Index: -12.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0463
    Cell Significance Index: -4.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0479
    Cell Significance Index: -1.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0682
    Cell Significance Index: -9.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0705
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0734
    Cell Significance Index: -15.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0888
    Cell Significance Index: -6.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0901
    Cell Significance Index: -12.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0947
    Cell Significance Index: -12.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0958
    Cell Significance Index: -7.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1089
    Cell Significance Index: -2.9700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1175
    Cell Significance Index: -1.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1278
    Cell Significance Index: -2.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1334
    Cell Significance Index: -15.7300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1418
    Cell Significance Index: -3.0100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1419
    Cell Significance Index: -1.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1430
    Cell Significance Index: -6.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1441
    Cell Significance Index: -2.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1520
    Cell Significance Index: -15.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1617
    Cell Significance Index: -4.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1628
    Cell Significance Index: -9.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1661
    Cell Significance Index: -5.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1671
    Cell Significance Index: -1.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1682
    Cell Significance Index: -4.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1683
    Cell Significance Index: -5.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1767
    Cell Significance Index: -12.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1803
    Cell Significance Index: -2.4600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1852
    Cell Significance Index: -2.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1982
    Cell Significance Index: -12.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2038
    Cell Significance Index: -4.0300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2167
    Cell Significance Index: -2.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2173
    Cell Significance Index: -5.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2191
    Cell Significance Index: -11.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2314
    Cell Significance Index: -14.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2379
    Cell Significance Index: -5.1400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2388
    Cell Significance Index: -2.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2426
    Cell Significance Index: -4.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2523
    Cell Significance Index: -10.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2621
    Cell Significance Index: -14.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2772
    Cell Significance Index: -9.7100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2813
    Cell Significance Index: -3.5500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2935
    Cell Significance Index: -2.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2937
    Cell Significance Index: -7.5500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3013
    Cell Significance Index: -9.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3014
    Cell Significance Index: -5.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3145
    Cell Significance Index: -7.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Dematin is a highly conserved protein across species, with a high degree of sequence similarity between human and other organisms. The protein consists of a single domain, which is responsible for its actin-binding properties. Dematin's binding to actin filaments is thought to regulate their dynamics, influencing the formation and organization of actin filaments and their interactions with other cellular components. The protein's interaction with spectrin, a cytoskeletal protein, further supports its role in regulating the actin cytoskeleton. Dematin's expression is widespread, with significant levels found in neurons, muscle cells, and endocrine cells. The protein's expression is also detected in the lens, where it is thought to play a role in maintaining lens fiber shape and structure. **Pathways and Functions** Dematin's involvement in actin cytoskeleton organization and regulation is critical for various cellular processes, including: 1. **Actin cytoskeleton organization**: Dematin's interaction with actin filaments regulates their assembly, organization, and dynamics, influencing the formation of filopodia, lamellipodia, and actin bundles. 2. **Cell migration and shape**: Dematin's regulation of the actin cytoskeleton influences cell migration, shape, and morphology, which are essential for various cellular processes, including wound healing, cell proliferation, and tissue development. 3. **Neurological functions**: Dematin's expression in neurons suggests its involvement in neuronal function and development, including the regulation of axon growth, dendritic branching, and synaptic plasticity. 4. **Cardiovascular functions**: Dematin's expression in muscle cells and vascular smooth muscle cells suggests its role in regulating cardiovascular function, including blood pressure regulation, vascular smooth muscle contraction, and blood coagulation. **Clinical Significance** Dematin's dysregulation has been implicated in various diseases, including: 1. **Neurological disorders**: Dematin's dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cardiovascular diseases**: Dematin's dysregulation has been implicated in cardiovascular diseases, including hypertension, atherosclerosis, and cardiac arrhythmias. 3. **Muscular dystrophy**: Dematin's dysregulation has been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 4. **Cancer**: Dematin's dysregulation has been implicated in cancer, including the regulation of cell migration, invasion, and metastasis. In conclusion, dematin is a critical protein that regulates the actin cytoskeleton, influencing various cellular processes, including cell migration, shape, and morphology, as well as neurological and cardiovascular functions. Its dysregulation has been implicated in various diseases, highlighting the importance of dematin in maintaining cellular homeostasis and overall health.

Genular Protein ID: 3667044970

Symbol: DEMA_HUMAN

Name: Dematin

UniProtKB Accession Codes:

Q08495 A8K0T5 B3KP70 B3KRH3 B4DI75 E9PEJ0 Q13215 Q9BRE3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 39 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8341682

Title: Cloning of human erythroid dematin reveals another member of the villin family.

PubMed ID: 8341682

DOI: 10.1073/pnas.90.14.6651

PubMed ID: 7615546

Title: Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily.

PubMed ID: 7615546

DOI: 10.1074/jbc.270.29.17407

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10565303

Title: Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression.

PubMed ID: 10565303

DOI: 10.1016/s0165-4608(99)00081-3

PubMed ID: 11856323

Title: Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways.

PubMed ID: 11856323

DOI: 10.1046/j.0014-2956.2001.02694.x

PubMed ID: 18347014

Title: Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1.

PubMed ID: 18347014

DOI: 10.1074/jbc.m707818200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19241372

Title: Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain.

PubMed ID: 19241372

DOI: 10.1002/pro.59

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21084299

Title: Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3.

PubMed ID: 21084299

DOI: 10.1074/jbc.m110.194613

PubMed ID: 22927433

Title: Identification of a novel role for dematin in regulating red cell membrane function by modulating spectrin-actin interaction.

PubMed ID: 22927433

DOI: 10.1074/jbc.m111.305441

PubMed ID: 23060452

Title: Headpiece domain of dematin regulates calcium mobilization and signaling in platelets.

PubMed ID: 23060452

DOI: 10.1074/jbc.m112.364679

PubMed ID: 23355471

Title: The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9).

PubMed ID: 23355471

DOI: 10.1074/jbc.m112.438861

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 14660664

Title: The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site.

PubMed ID: 14660664

DOI: 10.1074/jbc.m310524200

PubMed ID: 16472756

Title: A phosphorylation-induced conformation change in dematin headpiece.

PubMed ID: 16472756

DOI: 10.1016/j.str.2005.11.007

Sequence Information:

  • Length: 405
  • Mass: 45514
  • Checksum: 77D6372E5B16EFF4
  • Sequence:
    • MERLQKQPLT SPGSVSPSRD SSVPGSPSSI VAKMDNQVLG YKDLAAIPKD KAILDIERPD 
LMIYEPHFTY SLLEHVELPR SRERSLSPKS TSPPPSPEVW ADSRSPGIIS QASAPRTTGT 
PRTSLPHFHH PETSRPDSNI YKKPPIYKQR ESVGGSPQTK HLIEDLIIES SKFPAAQPPD 
PNQPAKIETD YWPCPPSLAV VETEWRKRKA SRRGAEEEEE EEDDDSGEEM KALRERQREE 
LSKVTSNLGK MILKEEMEKS LPIRRKTRSL PDRTPFHTSL HQGTSKSSSL PAYGRTTLSR 
LQSTEFSPSG SETGSPGLQN GEGQRGRMDR GNSLPCVLEQ KIYPYEMLVV TNKGRTKLPP 
GVDRMRLERH LSAEDFSRVF AMSPEEFGKL ALWKRNELKK KASLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.