Details for: EPOR
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: erythroblast (CL0000765)
Fold Change: 3.91
Marker Score: 2442 - Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169298 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.46
Marker Score: 987 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.25
Marker Score: 1929 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.08
Marker Score: 594 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.02
Marker Score: 766 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.01
Marker Score: 2557 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71779 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48003 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1
Marker Score: 915 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.94
Marker Score: 985.5 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.94
Marker Score: 1919 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 486 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 440 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2725 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.89
Marker Score: 492 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5067 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5265 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 310 - Cell Name: germ cell (CL0000586)
Fold Change: 0.85
Marker Score: 1484 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.83
Marker Score: 886.5 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.82
Marker Score: 656 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.8
Marker Score: 3348 - Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.79
Marker Score: 282 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1256 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.73
Marker Score: 11449.5 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 378 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.73
Marker Score: 554 - Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 647 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.71
Marker Score: 546 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.7
Marker Score: 226 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.7
Marker Score: 280 - Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.69
Marker Score: 343.5 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2854 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.65
Marker Score: 210 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.64
Marker Score: 11373.5 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.63
Marker Score: 669 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.62
Marker Score: 719 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.61
Marker Score: 355 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.6
Marker Score: 854 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.58
Marker Score: 181 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.57
Marker Score: 12239.5 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.56
Marker Score: 930 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.55
Marker Score: 120 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 427 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.52
Marker Score: 1222 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.51
Marker Score: 1364 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.51
Marker Score: 123 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.5
Marker Score: 3018 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.49
Marker Score: 462 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.49
Marker Score: 234 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.49
Marker Score: 242 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.49
Marker Score: 293 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.48
Marker Score: 126 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.47
Marker Score: 247 - Cell Name: osteoblast (CL0000062)
Fold Change: 0.47
Marker Score: 250 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.44
Marker Score: 1842.5 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.43
Marker Score: 413 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.43
Marker Score: 542 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.41
Marker Score: 1033 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.41
Marker Score: 121 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.41
Marker Score: 402 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.41
Marker Score: 96 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.41
Marker Score: 115 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.4
Marker Score: 440 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4
Marker Score: 288 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.4
Marker Score: 219 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.4
Marker Score: 125 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.38
Marker Score: 381 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.38
Marker Score: 259.5 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.38
Marker Score: 156 - Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.38
Marker Score: 175 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.38
Marker Score: 327 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.36
Marker Score: 147 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.36
Marker Score: 149 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.35
Marker Score: 154 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.35
Marker Score: 250 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.35
Marker Score: 5627 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.35
Marker Score: 90 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.35
Marker Score: 419 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.34
Marker Score: 227 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.34
Marker Score: 349 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.34
Marker Score: 138 - Cell Name: platelet (CL0000233)
Fold Change: 0.34
Marker Score: 153 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.34
Marker Score: 224 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.33
Marker Score: 173 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.33
Marker Score: 65 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.33
Marker Score: 219 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.33
Marker Score: 211 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.33
Marker Score: 136 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.32
Marker Score: 89 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.32
Marker Score: 113 - Cell Name: neural cell (CL0002319)
Fold Change: 0.32
Marker Score: 153 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.31
Marker Score: 66 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.31
Marker Score: 444 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.31
Marker Score: 333 - Cell Name: contractile cell (CL0000183)
Fold Change: 0.31
Marker Score: 167
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Other Information
Genular Protein ID: 1519990665
Symbol: EPOR_HUMAN
Name: Erythropoietin receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2163695
Title: The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p.
PubMed ID: 2163695
PubMed ID: 2163696
Title: Human erythropoietin receptor: cloning, expression, and biologic characterization.
PubMed ID: 2163696
PubMed ID: 1668606
Title: Cloning of the human erythropoietin receptor gene.
PubMed ID: 1668606
PubMed ID: 1654273
Title: The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1.
PubMed ID: 1654273
PubMed ID: 1324524
Title: A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells.
PubMed ID: 1324524
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1668607
Title: Cloning of the gene encoding the human erythropoietin receptor.
PubMed ID: 1668607
PubMed ID: 1664413
Title: Genomic organization of the human erythropoietin receptor gene.
PubMed ID: 1664413
PubMed ID: 1657727
Title: Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin.
PubMed ID: 1657727
PubMed ID: 11756159
Title: Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.
PubMed ID: 11756159
PubMed ID: 7534299
Title: Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways.
PubMed ID: 7534299
PubMed ID: 8662939
Title: Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family.
PubMed ID: 8662939
PubMed ID: 11722595
Title: Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia.
PubMed ID: 11722595
PubMed ID: 12027890
Title: A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
PubMed ID: 12027890
PubMed ID: 12746455
Title: Erythropoietin receptors associate with a ubiquitin ligase, p33RUL, and require its activity for erythropoietin-induced proliferation.
PubMed ID: 12746455
PubMed ID: 10374881
Title: APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.
PubMed ID: 10374881
PubMed ID: 11784712
Title: Cloning and characterization of a family of proteins associated with Mpl.
PubMed ID: 11784712
PubMed ID: 25092874
Title: RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.
PubMed ID: 25092874
DOI: 10.1084/jem.20130624
PubMed ID: 8662530
Title: Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A.
PubMed ID: 8662530
PubMed ID: 9808045
Title: An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.
PubMed ID: 9808045
DOI: 10.1038/2965
PubMed ID: 9774108
Title: Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
PubMed ID: 9774108
DOI: 10.1038/26773
PubMed ID: 10388848
Title: Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin.
PubMed ID: 10388848
PubMed ID: 9974392
Title: Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation.
PubMed ID: 9974392
PubMed ID: 8506290
Title: Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.
PubMed ID: 8506290
PubMed ID: 8174675
Title: Mutation in the negative regulatory element of the erythropoietin receptor gene in a case of sporadic primary polycythemia.
PubMed ID: 8174675
PubMed ID: 8608241
Title: Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies.
PubMed ID: 8608241
PubMed ID: 27535533
Title: Analysis of protein-coding genetic variation in 60,706 humans.
PubMed ID: 27535533
DOI: 10.1038/nature19057
Sequence Information:
- Length: 508
- Mass: 55065
- Checksum: F9F326E162E9512A
- Sequence:
MDHLGASLWP QVGSLCLLLA GAAWAPPPNL PDPKFESKAA LLAARGPEEL LCFTERLEDL VCFWEEAASA GVGPGNYSFS YQLEDEPWKL CRLHQAPTAR GAVRFWCSLP TADTSSFVPL ELRVTAASGA PRYHRVIHIN EVVLLDAPVG LVARLADESG HVVLRWLPPP ETPMTSHIRY EVDVSAGNGA GSVQRVEILE GRTECVLSNL RGRTRYTFAV RARMAEPSFG GFWSAWSEPV SLLTPSDLDP LILTLSLILV VILVLLTVLA LLSHRRALKQ KIWPGIPSPE SEFEGLFTTH KGNFQLWLYQ NDGCLWWSPC TPFTEDPPAS LEVLSERCWG TMQAVEPGTD DEGPLLEPVG SEHAQDTYLV LDKWLLPRNP PSEDLPGPGG SVDIVAMDEG SEASSCSSAL ASKPSPEGAS AASFEYTILD PSSQLLRPWT LCPELPPTPP HLKYLYLVVS DSGISTDYSS GDSQGAQGGL SDGPYSNPYE NSLIPAAEPL PPSYVACS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.