Details for: ERN1

Gene ID: 2081

Symbol: ERN1

Ensembl ID: ENSG00000178607

Description: endoplasmic reticulum to nucleus signaling 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.76
    Marker Score: 49047.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.74
    Marker Score: 726
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.74
    Marker Score: 1479.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.65
    Marker Score: 510
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.54
    Marker Score: 339.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.53
    Marker Score: 1360
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.52
    Marker Score: 378
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.51
    Marker Score: 378
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167533
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.4
    Marker Score: 317
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.38
    Marker Score: 3880
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.37
    Marker Score: 12927
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.31
    Marker Score: 4121
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.25
    Marker Score: 2641
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.24
    Marker Score: 746
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.21
    Marker Score: 1116
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.21
    Marker Score: 19396
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.19
    Marker Score: 7665
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.17
    Marker Score: 5049
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.16
    Marker Score: 1710
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.15
    Marker Score: 1122
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.14
    Marker Score: 368
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.13
    Marker Score: 4863
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.13
    Marker Score: 693
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.11
    Marker Score: 2618
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.11
    Marker Score: 5962
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.08
    Marker Score: 1011
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.08
    Marker Score: 36576
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.07
    Marker Score: 910
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.06
    Marker Score: 462.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.06
    Marker Score: 2411
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.05
    Marker Score: 744
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.05
    Marker Score: 925.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.04
    Marker Score: 8932.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251655
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.03
    Marker Score: 1373.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.03
    Marker Score: 712
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.02
    Marker Score: 592
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1
    Marker Score: 433
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71674.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47898
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.99
    Marker Score: 261
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30388
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.98
    Marker Score: 307
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.96
    Marker Score: 9537
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.96
    Marker Score: 1705
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14941
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.93
    Marker Score: 680
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.92
    Marker Score: 3391
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.91
    Marker Score: 985
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2701
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.89
    Marker Score: 675
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.89
    Marker Score: 746
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.88
    Marker Score: 308
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.86
    Marker Score: 299
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.85
    Marker Score: 1022
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.85
    Marker Score: 316
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.84
    Marker Score: 919
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.84
    Marker Score: 5487
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4771
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.82
    Marker Score: 420
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.81
    Marker Score: 1117
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.81
    Marker Score: 903
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 617
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.8
    Marker Score: 537
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.79
    Marker Score: 8895
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.78
    Marker Score: 616
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.78
    Marker Score: 1198
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.77
    Marker Score: 325
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.77
    Marker Score: 164
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.77
    Marker Score: 1088
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.77
    Marker Score: 40585
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.76
    Marker Score: 270.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.76
    Marker Score: 4565
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.76
    Marker Score: 3276
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.75
    Marker Score: 7767
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.75
    Marker Score: 753
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.75
    Marker Score: 5748
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.75
    Marker Score: 364
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.74
    Marker Score: 4722.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.74
    Marker Score: 397
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.74
    Marker Score: 421
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.74
    Marker Score: 862
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3070.5
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.73
    Marker Score: 645
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.73
    Marker Score: 274
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.73
    Marker Score: 895
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.72
    Marker Score: 497
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.72
    Marker Score: 295
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.72
    Marker Score: 481
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.72
    Marker Score: 1762
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.72
    Marker Score: 760

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Other Information

## Summary ERN1 is a protein that plays a critical role in the endoplasmic reticulum (ER) to nucleus (ER-to-nucleus) signaling pathway. It is involved in various cellular processes, including stress responses, cell cycle regulation, and inflammation. ## Key characteristics * ERN1 is a serine/threonine kinase that is highly expressed in various cell types. * It is a key component of the unfolded protein response (UPR), a cellular pathway that is triggered by stress conditions. * ERN1 is also involved in the regulation of cell cycle progression and apoptosis. ## Pathways and functions * ERN1 is a key regulator of the unfolded protein response (UPR). * In the UPR, ERN1 is phosphorylated by various stress signals, such as unfolded or misfolded proteins. * Phosphorylation of ERN1 leads to its translocation to the nucleus, where it exerts its effects. * ERN1 is involved in the regulation of gene expression, protein synthesis, and cell cycle progression. * It also plays a role in the regulation of inflammation and apoptosis. ## Clinical significance * Mutations in ERN1 have been linked to several human diseases, including amyotrophic lateral sclerosis, Werner syndrome, and non-alcoholic fatty liver disease. * ERN1 inhibitors are being investigated as potential therapeutic agents for these diseases. ## Additional notes * ERN1 is a highly conserved protein with a wide expression in different tissues. * It is a key regulator of cellular stress responses and cell cycle regulation. * Its dysregulation is associated with various human diseases, highlighting its importance in maintaining cellular homeostasis.

Genular Protein ID: 1410290730

Symbol: ERN1_HUMAN

Name: Serine/threonine-protein kinase

UniProtKB Accession Codes:

O75460 A1L457 A8K8N8 A8MXS7 Q59EE2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 42 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 23 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9637683

Title: A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.

PubMed ID: 9637683

DOI: 10.1101/gad.12.12.1812

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11779464

Title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

PubMed ID: 11779464

DOI: 10.1016/s0092-8674(01)00611-0

PubMed ID: 11278723

Title: Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.

PubMed ID: 11278723

DOI: 10.1074/jbc.m010677200

PubMed ID: 11175748

Title: Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.

PubMed ID: 11175748

DOI: 10.1038/35055065

PubMed ID: 12637535

Title: Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.

PubMed ID: 12637535

DOI: 10.1074/jbc.m300418200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23103912

Title: PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK-and IRE1alpha-mediated unfolded protein response.

PubMed ID: 23103912

DOI: 10.1038/ncb2593

PubMed ID: 29198525

Title: A J-Protein co-chaperone recruits bip to monomerize IRE1 and repress the unfolded protein response.

PubMed ID: 29198525

DOI: 10.1016/j.cell.2017.10.040

PubMed ID: 23378536

Title: RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1alpha)/c-Jun NH2-terminal kinase pathway.

PubMed ID: 23378536

DOI: 10.1074/jbc.m112.368829

PubMed ID: 31875558

Title: LACC1 required for NOD2-induced, ER stress-mediated innate immune outcomes in human macrophages and LACC1 risk variants modulate these outcomes.

PubMed ID: 31875558

DOI: 10.1016/j.celrep.2019.11.105

PubMed ID: 21884936

Title: Rescue of DeltaF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.

PubMed ID: 21884936

DOI: 10.1016/j.cell.2011.07.021

PubMed ID: 24508390

Title: Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association.

PubMed ID: 24508390

DOI: 10.1016/j.molcel.2014.01.004

PubMed ID: 28128204

Title: A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1alpha stability.

PubMed ID: 28128204

DOI: 10.1038/ncomms14186

PubMed ID: 28067262

Title: Sec16A is critical for both conventional and unconventional secretion of CFTR.

PubMed ID: 28067262

DOI: 10.1038/srep39887

PubMed ID: 30118681

Title: Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.

PubMed ID: 30118681

DOI: 10.1016/j.molcel.2018.06.038

PubMed ID: 32149426

Title: Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

PubMed ID: 32149426

DOI: 10.15252/embj.2019103841

PubMed ID: 16973740

Title: The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.

PubMed ID: 16973740

DOI: 10.1073/pnas.0606480103

PubMed ID: 21317875

Title: Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.

PubMed ID: 21317875

DOI: 10.1038/emboj.2011.18

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 977
  • Mass: 109735
  • Checksum: A2DF808CCE015536
  • Sequence:
    • MPARRLLLLL TLLLPGLGIF GSTSTVTLPE TLLFVSTLDG SLHAVSKRTG SIKWTLKEDP 
VLQVPTHVEE PAFLPDPNDG SLYTLGSKNN EGLTKLPFTI PELVQASPCR SSDGILYMGK 
KQDIWYVIDL LTGEKQQTLS SAFADSLCPS TSLLYLGRTE YTITMYDTKT RELRWNATYF 
DYAASLPEDD VDYKMSHFVS NGDGLVVTVD SESGDVLWIQ NYASPVVAFY VWQREGLRKV 
MHINVAVETL RYLTFMSGEV GRITKWKYPF PKETEAKSKL TPTLYVGKYS TSLYASPSMV 
HEGVAVVPRG STLPLLEGPQ TDGVTIGDKG ECVITPSTDV KFDPGLKSKN KLNYLRNYWL 
LIGHHETPLS ASTKMLERFP NNLPKHRENV IPADSEKKSF EEVINLVDQT SENAPTTVSR 
DVEEKPAHAP ARPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ 
KELEKIQLLQ QQQQQLPFHP PGDTAQDGEL LDTSGPYSES SGTSSPSTSP RASNHSLCSG 
SSASKAGSSP SLEQDDGDEE TSVVIVGKIS FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR 
ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI AIELCAATLQ EYVEQKDFAH 
LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK PHNILISMPN AHGKIKAMIS DFGLCKKLAV 
GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ 
RQANILLGAC SLDCLHPEKH EDVIARELIE KMIAMDPQKR PSAKHVLKHP FFWSLEKQLQ 
FFQDVSDRIE KESLDGPIVK QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSVRDL 
LRAMRNKKHH YRELPAEVRE TLGSLPDDFV CYFTSRFPHL LAHTYRAMEL CSHERLFQPY 
YFHEPPEPQP PVTPDAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.