Details for: ERN1

Gene ID: 2081

Symbol: ERN1

Ensembl ID: ENSG00000178607

Description: endoplasmic reticulum to nucleus signaling 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.6326
    Cell Significance Index: -26.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.9398
    Cell Significance Index: -26.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.6820
    Cell Significance Index: -25.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.7787
    Cell Significance Index: -28.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 56.4557
    Cell Significance Index: -29.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.1696
    Cell Significance Index: -25.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3714
    Cell Significance Index: -26.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4783
    Cell Significance Index: -28.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7181
    Cell Significance Index: -26.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.6038
    Cell Significance Index: 176.9500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0330
    Cell Significance Index: -18.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6886
    Cell Significance Index: -12.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.5209
    Cell Significance Index: 59.3100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.3291
    Cell Significance Index: 53.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1842
    Cell Significance Index: 117.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0761
    Cell Significance Index: 175.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0241
    Cell Significance Index: 924.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9479
    Cell Significance Index: 25.8000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.9332
    Cell Significance Index: 2.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7386
    Cell Significance Index: 146.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6719
    Cell Significance Index: 73.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5878
    Cell Significance Index: 16.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5435
    Cell Significance Index: 25.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5323
    Cell Significance Index: 15.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5119
    Cell Significance Index: 26.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4911
    Cell Significance Index: 10.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4832
    Cell Significance Index: 21.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4669
    Cell Significance Index: 6.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3685
    Cell Significance Index: 9.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3636
    Cell Significance Index: 65.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3636
    Cell Significance Index: 17.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3505
    Cell Significance Index: 70.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3151
    Cell Significance Index: 38.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3127
    Cell Significance Index: 59.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3075
    Cell Significance Index: 4.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2559
    Cell Significance Index: 3.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2208
    Cell Significance Index: 6.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2158
    Cell Significance Index: 29.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2041
    Cell Significance Index: 111.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2018
    Cell Significance Index: 15.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1985
    Cell Significance Index: 137.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1908
    Cell Significance Index: 24.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1886
    Cell Significance Index: 24.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1591
    Cell Significance Index: 5.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1573
    Cell Significance Index: 4.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1173
    Cell Significance Index: 20.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1076
    Cell Significance Index: 8.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1075
    Cell Significance Index: 7.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0967
    Cell Significance Index: 34.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0881
    Cell Significance Index: 38.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0784
    Cell Significance Index: 4.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0136
    Cell Significance Index: 8.6600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0102
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0079
    Cell Significance Index: 14.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0071
    Cell Significance Index: 10.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0037
    Cell Significance Index: 1.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0144
    Cell Significance Index: -10.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0157
    Cell Significance Index: -21.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0258
    Cell Significance Index: -18.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0278
    Cell Significance Index: -20.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0433
    Cell Significance Index: -24.4100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0460
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0485
    Cell Significance Index: -30.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0589
    Cell Significance Index: -1.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0662
    Cell Significance Index: -0.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0699
    Cell Significance Index: -4.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0752
    Cell Significance Index: -21.6500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0861
    Cell Significance Index: -0.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0898
    Cell Significance Index: -9.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1048
    Cell Significance Index: -12.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1082
    Cell Significance Index: -15.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1145
    Cell Significance Index: -7.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1176
    Cell Significance Index: -2.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1330
    Cell Significance Index: -28.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1337
    Cell Significance Index: -7.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1509
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1588
    Cell Significance Index: -18.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1749
    Cell Significance Index: -3.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2116
    Cell Significance Index: -10.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2135
    Cell Significance Index: -25.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2393
    Cell Significance Index: -24.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2507
    Cell Significance Index: -6.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2906
    Cell Significance Index: -17.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3060
    Cell Significance Index: -19.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3066
    Cell Significance Index: -18.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3150
    Cell Significance Index: -10.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3314
    Cell Significance Index: -17.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3322
    Cell Significance Index: -8.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3472
    Cell Significance Index: -5.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3485
    Cell Significance Index: -27.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3779
    Cell Significance Index: -8.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4111
    Cell Significance Index: -18.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4127
    Cell Significance Index: -21.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4128
    Cell Significance Index: -10.8600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.4230
    Cell Significance Index: -2.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4555
    Cell Significance Index: -8.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5015
    Cell Significance Index: -18.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5150
    Cell Significance Index: -15.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERN1 is a member of the protein kinase family and exhibits kinase activity, which enables it to phosphorylate and regulate the activity of other proteins. Its unique ability to interact with various proteins, including Hsp70 and Hsp90, positions it as a key regulator of the unfolded protein response (UPR). The UPR is a complex signaling pathway that is activated in response to ER stress, which can be caused by various factors, including protein misfolding and oxidative stress. ERN1's role in the UPR is particularly noteworthy, as it can activate chaperones and promote the folding of misfolded proteins, thereby alleviating ER stress. In addition to its role in the UPR, ERN1 has been implicated in various other cellular processes, including insulin metabolic process, cellular responses to stimuli, and regulation of macroautophagy. Its ability to interact with proteins involved in these processes positions ERN1 as a key regulator of cellular homeostasis and stress response. **Pathways and Functions:** ERN1's involvement in various signaling pathways is a testament to its versatility and importance in maintaining cellular homeostasis. Some of the key pathways and functions associated with ERN1 include: 1. **Unfolded Protein Response (UPR):** ERN1 plays a critical role in the UPR, which is activated in response to ER stress. By activating chaperones and promoting the folding of misfolded proteins, ERN1 helps to alleviate ER stress and maintain cellular homeostasis. 2. **Insulin Metabolic Process:** ERN1 has been implicated in the regulation of insulin metabolic process, which is essential for maintaining glucose homeostasis. By interacting with proteins involved in this process, ERN1 helps to regulate glucose uptake and utilization. 3. **Cellular Responses to Stimuli:** ERN1's ability to interact with various proteins involved in cellular responses to stimuli positions it as a key regulator of these processes. By regulating the activity of these proteins, ERN1 helps to maintain cellular homeostasis and respond to changes in the cellular environment. 4. **Regulation of Macroautophagy:** ERN1 has been implicated in the regulation of macroautophagy, a process that is essential for maintaining cellular homeostasis. By interacting with proteins involved in macroautophagy, ERN1 helps to regulate the degradation of damaged or dysfunctional cellular components. **Clinical Significance:** ERN1's involvement in various cellular processes and signaling pathways positions it as a potential therapeutic target for various diseases. Some of the clinical applications of ERN1 include: 1. **Cancer Therapy:** ERN1's role in regulating the UPR and insulin metabolic process makes it a potential target for cancer therapy. By inhibiting ERN1, cancer cells may be forced to undergo apoptosis or undergo changes in their metabolic activity. 2. **Neurodegenerative Diseases:** ERN1's involvement in the regulation of macroautophagy and insulin metabolic process positions it as a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Diabetes:** ERN1's role in regulating insulin metabolic process makes it a potential therapeutic target for diabetes. By inhibiting ERN1, the activity of insulin-regulating proteins may be reduced, leading to improved glucose homeostasis. In conclusion, ERN1 is a multifaceted gene that plays a critical role in various cellular processes and signaling pathways. Its involvement in the UPR, insulin metabolic process, and regulation of macroautophagy positions it as a potential therapeutic target for various diseases. Further research is needed to fully elucidate the mechanisms by which ERN1 regulates cellular homeostasis and stress response, and to explore its potential therapeutic applications.

Genular Protein ID: 1410290730

Symbol: ERN1_HUMAN

Name: Serine/threonine-protein kinase

UniProtKB Accession Codes:

O75460 A1L457 A8K8N8 A8MXS7 Q59EE2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 10 Ensembl 2 EvolutionaryTrace 1 GO 42 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9637683

Title: A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.

PubMed ID: 9637683

DOI: 10.1101/gad.12.12.1812

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11779464

Title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

PubMed ID: 11779464

DOI: 10.1016/s0092-8674(01)00611-0

PubMed ID: 11278723

Title: Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.

PubMed ID: 11278723

DOI: 10.1074/jbc.m010677200

PubMed ID: 11175748

Title: Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.

PubMed ID: 11175748

DOI: 10.1038/35055065

PubMed ID: 12637535

Title: Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.

PubMed ID: 12637535

DOI: 10.1074/jbc.m300418200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23103912

Title: PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK-and IRE1alpha-mediated unfolded protein response.

PubMed ID: 23103912

DOI: 10.1038/ncb2593

PubMed ID: 29198525

Title: A J-Protein co-chaperone recruits bip to monomerize IRE1 and repress the unfolded protein response.

PubMed ID: 29198525

DOI: 10.1016/j.cell.2017.10.040

PubMed ID: 23378536

Title: RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1alpha)/c-Jun NH2-terminal kinase pathway.

PubMed ID: 23378536

DOI: 10.1074/jbc.m112.368829

PubMed ID: 31875558

Title: LACC1 required for NOD2-induced, ER stress-mediated innate immune outcomes in human macrophages and LACC1 risk variants modulate these outcomes.

PubMed ID: 31875558

DOI: 10.1016/j.celrep.2019.11.105

PubMed ID: 21884936

Title: Rescue of DeltaF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.

PubMed ID: 21884936

DOI: 10.1016/j.cell.2011.07.021

PubMed ID: 24508390

Title: Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association.

PubMed ID: 24508390

DOI: 10.1016/j.molcel.2014.01.004

PubMed ID: 28128204

Title: A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1alpha stability.

PubMed ID: 28128204

DOI: 10.1038/ncomms14186

PubMed ID: 28067262

Title: Sec16A is critical for both conventional and unconventional secretion of CFTR.

PubMed ID: 28067262

DOI: 10.1038/srep39887

PubMed ID: 30118681

Title: Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.

PubMed ID: 30118681

DOI: 10.1016/j.molcel.2018.06.038

PubMed ID: 32149426

Title: Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

PubMed ID: 32149426

DOI: 10.15252/embj.2019103841

PubMed ID: 16973740

Title: The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.

PubMed ID: 16973740

DOI: 10.1073/pnas.0606480103

PubMed ID: 21317875

Title: Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.

PubMed ID: 21317875

DOI: 10.1038/emboj.2011.18

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 977
  • Mass: 109735
  • Checksum: A2DF808CCE015536
  • Sequence:
    • MPARRLLLLL TLLLPGLGIF GSTSTVTLPE TLLFVSTLDG SLHAVSKRTG SIKWTLKEDP 
VLQVPTHVEE PAFLPDPNDG SLYTLGSKNN EGLTKLPFTI PELVQASPCR SSDGILYMGK 
KQDIWYVIDL LTGEKQQTLS SAFADSLCPS TSLLYLGRTE YTITMYDTKT RELRWNATYF 
DYAASLPEDD VDYKMSHFVS NGDGLVVTVD SESGDVLWIQ NYASPVVAFY VWQREGLRKV 
MHINVAVETL RYLTFMSGEV GRITKWKYPF PKETEAKSKL TPTLYVGKYS TSLYASPSMV 
HEGVAVVPRG STLPLLEGPQ TDGVTIGDKG ECVITPSTDV KFDPGLKSKN KLNYLRNYWL 
LIGHHETPLS ASTKMLERFP NNLPKHRENV IPADSEKKSF EEVINLVDQT SENAPTTVSR 
DVEEKPAHAP ARPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ 
KELEKIQLLQ QQQQQLPFHP PGDTAQDGEL LDTSGPYSES SGTSSPSTSP RASNHSLCSG 
SSASKAGSSP SLEQDDGDEE TSVVIVGKIS FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR 
ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI AIELCAATLQ EYVEQKDFAH 
LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK PHNILISMPN AHGKIKAMIS DFGLCKKLAV 
GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ 
RQANILLGAC SLDCLHPEKH EDVIARELIE KMIAMDPQKR PSAKHVLKHP FFWSLEKQLQ 
FFQDVSDRIE KESLDGPIVK QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSVRDL 
LRAMRNKKHH YRELPAEVRE TLGSLPDDFV CYFTSRFPHL LAHTYRAMEL CSHERLFQPY 
YFHEPPEPQP PVTPDAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.