Details for: ESRRA

Gene ID: 2101

Symbol: ESRRA

Ensembl ID: ENSG00000173153

Description: estrogen related receptor alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.14
    Marker Score: 7599.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.85
    Marker Score: 3914
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.84
    Marker Score: 8808
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.72
    Marker Score: 38414
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.65
    Marker Score: 6496
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.39
    Marker Score: 3734
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.35
    Marker Score: 3078
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.35
    Marker Score: 2073
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.34
    Marker Score: 2214
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3
    Marker Score: 1919
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.29
    Marker Score: 861
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.28
    Marker Score: 4025
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2526
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.21
    Marker Score: 1371
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.21
    Marker Score: 1278
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.2
    Marker Score: 2828
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.19
    Marker Score: 1251
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.15
    Marker Score: 1150
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.15
    Marker Score: 906.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 17941
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.14
    Marker Score: 1756.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.13
    Marker Score: 426.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.12
    Marker Score: 2658.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.11
    Marker Score: 41113
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.1
    Marker Score: 1091
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.1
    Marker Score: 1141
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.07
    Marker Score: 6835
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.04
    Marker Score: 335
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.03
    Marker Score: 3662
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.02
    Marker Score: 373
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.01
    Marker Score: 969
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71722
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47947
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.99
    Marker Score: 241
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.96
    Marker Score: 4134
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.95
    Marker Score: 467
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.93
    Marker Score: 4974
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5264
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.91
    Marker Score: 3123
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 543
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2706
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.89
    Marker Score: 5739.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.89
    Marker Score: 316
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.87
    Marker Score: 6825
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.87
    Marker Score: 7512
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.87
    Marker Score: 420
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.86
    Marker Score: 2173
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.85
    Marker Score: 212
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.85
    Marker Score: 1513
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.85
    Marker Score: 449
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.85
    Marker Score: 421
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.84
    Marker Score: 3503
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.84
    Marker Score: 1192
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.83
    Marker Score: 1337
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.82
    Marker Score: 1864
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.82
    Marker Score: 557
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.82
    Marker Score: 3327
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.81
    Marker Score: 3984
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.81
    Marker Score: 5271.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.79
    Marker Score: 16843
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.79
    Marker Score: 295
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.78
    Marker Score: 245
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.78
    Marker Score: 858
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.77
    Marker Score: 197
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.77
    Marker Score: 7945
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.77
    Marker Score: 4604
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.77
    Marker Score: 504
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.76
    Marker Score: 355
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 297
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.74
    Marker Score: 956
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.74
    Marker Score: 1805.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.73
    Marker Score: 1604.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.73
    Marker Score: 1157
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.72
    Marker Score: 303
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 345
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.72
    Marker Score: 419
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.72
    Marker Score: 207
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.71
    Marker Score: 18161
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.71
    Marker Score: 490
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7
    Marker Score: 43212
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.7
    Marker Score: 485.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.68
    Marker Score: 731
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.68
    Marker Score: 1680
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.68
    Marker Score: 382
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.68
    Marker Score: 463
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.67
    Marker Score: 193
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.67
    Marker Score: 423.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.67
    Marker Score: 550

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Other Information

**Key characteristics:** * Protein type: Nuclear receptor * Ensembl ID: ENSG00000173153 * Pathway: Dna-binding transcription factor activity, rna polymerase ii-specific * Gene expression: Transcription, regulation of lipid metabolism **Pathways and functions:** * **Regulation of mitochondrial biogenesis:** ESRRA is a key regulator of mitochondrial biogenesis, as it promotes the expression of genes involved in the formation of new mitochondria. * **Regulation of lipid metabolism:** ESRRA also regulates the expression of genes involved in lipid metabolism, including those involved in fatty acid uptake, oxidation, and storage. * **Transcriptional regulation by pparalpha:** ESRRA is a target of pparalpha, a key regulator of lipid metabolism. pparalpha promotes the expression of ESRRA, which in turn promotes mitochondrial biogenesis. * **Regulation of runx2 expression and activity:** ESRRA also regulates the expression of the runx2 gene, which is a key regulator of mitochondrial biogenesis. **Clinical significance:** Mutations in the ESRRA gene have been linked to a number of human diseases, including obesity, diabetes, and heart disease. These mutations can lead to the activation of the receptor, which can promote mitochondrial biogenesis and inflammation. This can lead to the development of these diseases. **Additional information:** * ESRRA is a orphan nuclear receptor, which means that it is not activated by any known ligands. * The protein is a member of the estrogen receptor superfamily of nuclear receptors. * ESRRA is a highly conserved protein, with similar sequences found in organisms from yeast to humans.

Genular Protein ID: 2801200439

Symbol: ERR1_HUMAN

Name: Steroid hormone receptor ERR1

UniProtKB Accession Codes:

P11474 Q14514

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 3 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PIRSF 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3267207

Title: Identification of a new class of steroid hormone receptors.

PubMed ID: 3267207

DOI: 10.1038/331091a0

PubMed ID: 8621448

Title: Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter.

PubMed ID: 8621448

DOI: 10.1074/jbc.271.10.5795

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 8224847

Title: SV40 early-to-late switch involves titration of cellular transcriptional repressors.

PubMed ID: 8224847

DOI: 10.1101/gad.7.11.2206

PubMed ID: 9271417

Title: The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.

PubMed ID: 9271417

DOI: 10.1128/mcb.17.9.5400

PubMed ID: 12522104

Title: The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).

PubMed ID: 12522104

DOI: 10.1074/jbc.m212923200

PubMed ID: 16150865

Title: A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters.

PubMed ID: 16150865

DOI: 10.1210/me.2005-0313

PubMed ID: 17676930

Title: Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1.

PubMed ID: 17676930

DOI: 10.1021/bi700316g

PubMed ID: 18063693

Title: Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.

PubMed ID: 18063693

DOI: 10.1210/me.2007-0357

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20484414

Title: An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.

PubMed ID: 20484414

DOI: 10.1210/me.2009-0441

PubMed ID: 21190936

Title: Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor alpha (ERRalpha) cellular localization and inhibits its transcriptional activity.

PubMed ID: 21190936

DOI: 10.1074/jbc.m110.179523

PubMed ID: 23836911

Title: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.

PubMed ID: 23836911

DOI: 10.1074/jbc.m113.489674

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15337744

Title: Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.

PubMed ID: 15337744

DOI: 10.1074/jbc.m407999200

PubMed ID: 18441008

Title: Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop.

PubMed ID: 18441008

DOI: 10.1074/jbc.m801920200

Sequence Information:

  • Length: 423
  • Mass: 45510
  • Checksum: BAE62DAF0BE6BA96
  • Sequence:
    • MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH KEEEDGEGAG 
PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE 
CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP 
LAVAGGPRKT AAPVNALVSH LLVVEPEKLY AMPDPAGPDG HLPAVATLCD LFDREIVVTI 
SWAKSIPGFS SLSLSDQMSV LQSVWMEVLV LGVAQRSLPL QDELAFAEDL VLDEEGARAA 
GLGELGAALL QLVRRLQALR LEREEYVLLK ALALANSDSV HIEDAEAVEQ LREALHEALL 
EYEAGRAGPG GGAERRRAGR LLLTLPLLRQ TAGKVLAHFY GVKLEGKVPM HKLFLEMLEA 
MMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.