Details for: ESRRA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 163.6823
Cell Significance Index: -25.4600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 102.5455
Cell Significance Index: -26.0100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 57.3368
Cell Significance Index: -27.0700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 50.7013
Cell Significance Index: -26.0800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 40.4607
Cell Significance Index: -27.1500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.4850
Cell Significance Index: -26.4900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.7206
Cell Significance Index: -26.0400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.8017
Cell Significance Index: -26.8400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.4172
Cell Significance Index: -19.7100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.5835
Cell Significance Index: -12.2200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.6405
Cell Significance Index: 49.6700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 3.0736
Cell Significance Index: 184.5200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.1623
Cell Significance Index: 62.3000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.7415
Cell Significance Index: 46.5000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.5383
Cell Significance Index: 42.9900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4867
Cell Significance Index: 67.3900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4279
Cell Significance Index: 38.8700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.3880
Cell Significance Index: 30.0700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.2576
Cell Significance Index: 88.9400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1754
Cell Significance Index: 61.0600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.1063
Cell Significance Index: 51.5800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0719
Cell Significance Index: 193.2300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.0576
Cell Significance Index: 73.1400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0234
Cell Significance Index: 166.4500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9194
Cell Significance Index: 113.0500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.9090
Cell Significance Index: 13.6200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9080
Cell Significance Index: 69.6800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.7341
Cell Significance Index: 6.7600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5503
Cell Significance Index: 243.3100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5282
Cell Significance Index: 104.8300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5276
Cell Significance Index: 105.8500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.5012
Cell Significance Index: 7.4000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4946
Cell Significance Index: 446.5500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4919
Cell Significance Index: 23.1200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4771
Cell Significance Index: 10.1600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4637
Cell Significance Index: 45.8800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2936
Cell Significance Index: 105.3200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2840
Cell Significance Index: 155.0800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2694
Cell Significance Index: 51.2600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2009
Cell Significance Index: 7.0600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1816
Cell Significance Index: 125.5900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1752
Cell Significance Index: 11.3100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1551
Cell Significance Index: 20.0400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1187
Cell Significance Index: 7.4800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1112
Cell Significance Index: 18.9800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0979
Cell Significance Index: 13.4400 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.0952
Cell Significance Index: 0.9600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.0656
Cell Significance Index: 1.6000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0595
Cell Significance Index: 1.6000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0459
Cell Significance Index: 2.4100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0344
Cell Significance Index: 25.2400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0133
Cell Significance Index: 25.0100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0106
Cell Significance Index: 0.3400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0069
Cell Significance Index: 5.2300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0012
Cell Significance Index: 0.5600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0019
Cell Significance Index: -3.4300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0024
Cell Significance Index: -0.2800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0030
Cell Significance Index: -0.3900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0055
Cell Significance Index: -3.4700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0106
Cell Significance Index: -16.3800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0189
Cell Significance Index: -25.7300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0288
Cell Significance Index: -21.3700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0356
Cell Significance Index: -20.1000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0425
Cell Significance Index: -4.3400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0490
Cell Significance Index: -30.6100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0703
Cell Significance Index: -20.2300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0767
Cell Significance Index: -5.7200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0817
Cell Significance Index: -9.5300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1025
Cell Significance Index: -14.9000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1316
Cell Significance Index: -15.5200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1367
Cell Significance Index: -10.8300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1423
Cell Significance Index: -29.9800 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2023
Cell Significance Index: -2.8800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2177
Cell Significance Index: -13.3800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2188
Cell Significance Index: -14.7100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2228
Cell Significance Index: -5.5700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2274
Cell Significance Index: -6.5200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2315
Cell Significance Index: -24.1100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2366
Cell Significance Index: -5.1800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2416
Cell Significance Index: -1.4600 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: -0.2551
Cell Significance Index: -0.3300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2831
Cell Significance Index: -8.0800 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2968
Cell Significance Index: -2.4200 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.3009
Cell Significance Index: -1.3100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3049
Cell Significance Index: -13.4900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3201
Cell Significance Index: -17.9600 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3288
Cell Significance Index: -5.5300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3513
Cell Significance Index: -21.5400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3521
Cell Significance Index: -3.6500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3849
Cell Significance Index: -14.5800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4170
Cell Significance Index: -21.7200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4307
Cell Significance Index: -11.0700 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.4723
Cell Significance Index: -9.8500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5013
Cell Significance Index: -17.4200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5047
Cell Significance Index: -7.4500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5062
Cell Significance Index: -13.5400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5296
Cell Significance Index: -26.7700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5298
Cell Significance Index: -18.5600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5371
Cell Significance Index: -11.4000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5406
Cell Significance Index: -12.4900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2801200439
Symbol: ERR1_HUMAN
Name: Steroid hormone receptor ERR1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3267207
Title: Identification of a new class of steroid hormone receptors.
PubMed ID: 3267207
DOI: 10.1038/331091a0
PubMed ID: 8621448
Title: Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter.
PubMed ID: 8621448
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 8224847
Title: SV40 early-to-late switch involves titration of cellular transcriptional repressors.
PubMed ID: 8224847
PubMed ID: 9271417
Title: The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.
PubMed ID: 9271417
PubMed ID: 12522104
Title: The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).
PubMed ID: 12522104
PubMed ID: 16150865
Title: A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters.
PubMed ID: 16150865
DOI: 10.1210/me.2005-0313
PubMed ID: 17676930
Title: Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1.
PubMed ID: 17676930
DOI: 10.1021/bi700316g
PubMed ID: 18063693
Title: Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.
PubMed ID: 18063693
DOI: 10.1210/me.2007-0357
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20484414
Title: An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.
PubMed ID: 20484414
DOI: 10.1210/me.2009-0441
PubMed ID: 21190936
Title: Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor alpha (ERRalpha) cellular localization and inhibits its transcriptional activity.
PubMed ID: 21190936
PubMed ID: 23836911
Title: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.
PubMed ID: 23836911
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 15337744
Title: Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.
PubMed ID: 15337744
PubMed ID: 18441008
Title: Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop.
PubMed ID: 18441008
Sequence Information:
- Length: 423
- Mass: 45510
- Checksum: BAE62DAF0BE6BA96
- Sequence:
MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH KEEEDGEGAG PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP LAVAGGPRKT AAPVNALVSH LLVVEPEKLY AMPDPAGPDG HLPAVATLCD LFDREIVVTI SWAKSIPGFS SLSLSDQMSV LQSVWMEVLV LGVAQRSLPL QDELAFAEDL VLDEEGARAA GLGELGAALL QLVRRLQALR LEREEYVLLK ALALANSDSV HIEDAEAVEQ LREALHEALL EYEAGRAGPG GGAERRRAGR LLLTLPLLRQ TAGKVLAHFY GVKLEGKVPM HKLFLEMLEA MMD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.