Details for: ESRRA

Gene ID: 2101

Symbol: ESRRA

Ensembl ID: ENSG00000173153

Description: estrogen related receptor alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 163.6823
    Cell Significance Index: -25.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.5455
    Cell Significance Index: -26.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.3368
    Cell Significance Index: -27.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.7013
    Cell Significance Index: -26.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.4607
    Cell Significance Index: -27.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.4850
    Cell Significance Index: -26.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7206
    Cell Significance Index: -26.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8017
    Cell Significance Index: -26.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4172
    Cell Significance Index: -19.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5835
    Cell Significance Index: -12.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.6405
    Cell Significance Index: 49.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.0736
    Cell Significance Index: 184.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1623
    Cell Significance Index: 62.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7415
    Cell Significance Index: 46.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5383
    Cell Significance Index: 42.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4867
    Cell Significance Index: 67.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4279
    Cell Significance Index: 38.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3880
    Cell Significance Index: 30.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2576
    Cell Significance Index: 88.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1754
    Cell Significance Index: 61.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1063
    Cell Significance Index: 51.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0719
    Cell Significance Index: 193.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0576
    Cell Significance Index: 73.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0234
    Cell Significance Index: 166.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9194
    Cell Significance Index: 113.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9090
    Cell Significance Index: 13.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9080
    Cell Significance Index: 69.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7341
    Cell Significance Index: 6.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5503
    Cell Significance Index: 243.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5282
    Cell Significance Index: 104.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5276
    Cell Significance Index: 105.8500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5012
    Cell Significance Index: 7.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4946
    Cell Significance Index: 446.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4919
    Cell Significance Index: 23.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4771
    Cell Significance Index: 10.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4637
    Cell Significance Index: 45.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2936
    Cell Significance Index: 105.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2840
    Cell Significance Index: 155.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2694
    Cell Significance Index: 51.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2009
    Cell Significance Index: 7.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1816
    Cell Significance Index: 125.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1752
    Cell Significance Index: 11.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1551
    Cell Significance Index: 20.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1187
    Cell Significance Index: 7.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1112
    Cell Significance Index: 18.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0979
    Cell Significance Index: 13.4400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0952
    Cell Significance Index: 0.9600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0656
    Cell Significance Index: 1.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0595
    Cell Significance Index: 1.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0459
    Cell Significance Index: 2.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0344
    Cell Significance Index: 25.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0133
    Cell Significance Index: 25.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0106
    Cell Significance Index: 0.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0069
    Cell Significance Index: 5.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0012
    Cell Significance Index: 0.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0024
    Cell Significance Index: -0.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0055
    Cell Significance Index: -3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0106
    Cell Significance Index: -16.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0189
    Cell Significance Index: -25.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0288
    Cell Significance Index: -21.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0356
    Cell Significance Index: -20.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0425
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0490
    Cell Significance Index: -30.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0703
    Cell Significance Index: -20.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0767
    Cell Significance Index: -5.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0817
    Cell Significance Index: -9.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1025
    Cell Significance Index: -14.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1316
    Cell Significance Index: -15.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1367
    Cell Significance Index: -10.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1423
    Cell Significance Index: -29.9800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2023
    Cell Significance Index: -2.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2177
    Cell Significance Index: -13.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2188
    Cell Significance Index: -14.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2228
    Cell Significance Index: -5.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2274
    Cell Significance Index: -6.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2315
    Cell Significance Index: -24.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2366
    Cell Significance Index: -5.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2416
    Cell Significance Index: -1.4600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.2551
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2831
    Cell Significance Index: -8.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2968
    Cell Significance Index: -2.4200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3009
    Cell Significance Index: -1.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3049
    Cell Significance Index: -13.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3201
    Cell Significance Index: -17.9600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3288
    Cell Significance Index: -5.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3513
    Cell Significance Index: -21.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3521
    Cell Significance Index: -3.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3849
    Cell Significance Index: -14.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4170
    Cell Significance Index: -21.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4307
    Cell Significance Index: -11.0700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.4723
    Cell Significance Index: -9.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5013
    Cell Significance Index: -17.4200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5047
    Cell Significance Index: -7.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5062
    Cell Significance Index: -13.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5296
    Cell Significance Index: -26.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5298
    Cell Significance Index: -18.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5371
    Cell Significance Index: -11.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5406
    Cell Significance Index: -12.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ERRα is a transcription factor that belongs to the nuclear receptor family, which is characterized by its ability to bind to specific DNA sequences and regulate gene expression. ESRRA is specifically activated by estrogen, a key hormone involved in various physiological processes, including reproductive development and immune function. Unlike its canonical ligand, estrogen, ESRRA does not require a specific DNA response element to activate transcription. Instead, it binds to specific DNA sequences, such as the estrogen response element (ERE), and recruits coactivators to facilitate gene expression. **Pathways and Functions** ERRα is involved in various cellular processes, including: 1. **Gene expression regulation**: ESRRA regulates the expression of genes involved in cell growth, differentiation, and metabolism. It binds to specific DNA sequences and recruits coactivators to activate transcription. 2. **Metabolism**: ESRRA is involved in regulating lipid metabolism, particularly in the context of PPARα activation. It also regulates the expression of genes involved in mitochondrial biogenesis and function. 3. **Cell growth and differentiation**: ESRRA regulates the expression of genes involved in cell growth and differentiation, including those involved in the development and maintenance of immune cells. 4. **Apoptosis**: ESRRA has been shown to regulate apoptosis in various cell types, including immune cells. **Clinical Significance** ERRα has been implicated in various diseases, including: 1. **Cancer**: ESRRA has been shown to play a role in the development and progression of various cancers, including breast, prostate, and colon cancer. 2. **Immune dysfunction**: ESRRA has been implicated in immune dysfunction, including autoimmune diseases such as rheumatoid arthritis and lupus. 3. **Metabolic disorders**: ESRRA has been shown to play a role in regulating lipid metabolism and has been implicated in metabolic disorders such as obesity and type 2 diabetes. **Significantly Expressed Cells** ERRα is expressed in various cell types, including: 1. **Cardiac myocytes**: ESRRA is expressed in cardiac myocytes, particularly in the atrial and ventricular chambers. 2. **Pancreatic acinar cells**: ESRRA is expressed in pancreatic acinar cells, which are involved in the production of digestive enzymes. 3. **Enterocytes**: ESRRA is expressed in enterocytes, which are involved in the absorption of nutrients from the gut. 4. **Placental trophoblasts**: ESRRA is expressed in placental trophoblasts, which are involved in the development of the placenta. In conclusion, ESRRA is a critical regulator of various cellular processes, including gene expression, metabolism, and cell growth. Its dysregulation has been implicated in various diseases, including cancer, immune dysfunction, and metabolic disorders. Further research is needed to fully understand the role of ESRRA in human health and disease.

Genular Protein ID: 2801200439

Symbol: ERR1_HUMAN

Name: Steroid hormone receptor ERR1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3267207

Title: Identification of a new class of steroid hormone receptors.

PubMed ID: 3267207

DOI: 10.1038/331091a0

PubMed ID: 8621448

Title: Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter.

PubMed ID: 8621448

DOI: 10.1074/jbc.271.10.5795

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 8224847

Title: SV40 early-to-late switch involves titration of cellular transcriptional repressors.

PubMed ID: 8224847

DOI: 10.1101/gad.7.11.2206

PubMed ID: 9271417

Title: The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.

PubMed ID: 9271417

DOI: 10.1128/mcb.17.9.5400

PubMed ID: 12522104

Title: The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).

PubMed ID: 12522104

DOI: 10.1074/jbc.m212923200

PubMed ID: 16150865

Title: A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters.

PubMed ID: 16150865

DOI: 10.1210/me.2005-0313

PubMed ID: 17676930

Title: Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1.

PubMed ID: 17676930

DOI: 10.1021/bi700316g

PubMed ID: 18063693

Title: Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.

PubMed ID: 18063693

DOI: 10.1210/me.2007-0357

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20484414

Title: An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.

PubMed ID: 20484414

DOI: 10.1210/me.2009-0441

PubMed ID: 21190936

Title: Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor alpha (ERRalpha) cellular localization and inhibits its transcriptional activity.

PubMed ID: 21190936

DOI: 10.1074/jbc.m110.179523

PubMed ID: 23836911

Title: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.

PubMed ID: 23836911

DOI: 10.1074/jbc.m113.489674

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15337744

Title: Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.

PubMed ID: 15337744

DOI: 10.1074/jbc.m407999200

PubMed ID: 18441008

Title: Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop.

PubMed ID: 18441008

DOI: 10.1074/jbc.m801920200

Sequence Information:

  • Length: 423
  • Mass: 45510
  • Checksum: BAE62DAF0BE6BA96
  • Sequence:
  • MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH KEEEDGEGAG 
    PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE 
    CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP 
    LAVAGGPRKT AAPVNALVSH LLVVEPEKLY AMPDPAGPDG HLPAVATLCD LFDREIVVTI 
    SWAKSIPGFS SLSLSDQMSV LQSVWMEVLV LGVAQRSLPL QDELAFAEDL VLDEEGARAA 
    GLGELGAALL QLVRRLQALR LEREEYVLLK ALALANSDSV HIEDAEAVEQ LREALHEALL 
    EYEAGRAGPG GGAERRRAGR LLLTLPLLRQ TAGKVLAHFY GVKLEGKVPM HKLFLEMLEA 
    MMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.