Details for: EVX1

Gene ID: 2128

Symbol: EVX1

Ensembl ID: ENSG00000106038

Description: even-skipped homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: club cell (CL0000158)
    Fold Change: 5.4649
    Cell Significance Index: 59.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7955
    Cell Significance Index: 93.2700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: 0.6796
    Cell Significance Index: 7.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4691
    Cell Significance Index: 16.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3017
    Cell Significance Index: 18.5000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2770
    Cell Significance Index: 3.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2444
    Cell Significance Index: 3.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0626
    Cell Significance Index: 1.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0622
    Cell Significance Index: 11.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0480
    Cell Significance Index: 43.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0470
    Cell Significance Index: 8.4700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0260
    Cell Significance Index: 0.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0071
    Cell Significance Index: 0.8700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0035
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0073
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0081
    Cell Significance Index: -0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0085
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0102
    Cell Significance Index: -1.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0195
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0349
    Cell Significance Index: -0.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0355
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0380
    Cell Significance Index: -6.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0446
    Cell Significance Index: -8.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0483
    Cell Significance Index: -4.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0493
    Cell Significance Index: -1.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0505
    Cell Significance Index: -0.6600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0516
    Cell Significance Index: -0.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0521
    Cell Significance Index: -1.6600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0628
    Cell Significance Index: -0.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0738
    Cell Significance Index: -10.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0740
    Cell Significance Index: -1.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0780
    Cell Significance Index: -8.4800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0825
    Cell Significance Index: -0.9000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0900
    Cell Significance Index: -1.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0911
    Cell Significance Index: -0.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0982
    Cell Significance Index: -11.4400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1019
    Cell Significance Index: -1.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1040
    Cell Significance Index: -13.4400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1052
    Cell Significance Index: -1.2700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1077
    Cell Significance Index: -1.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1099
    Cell Significance Index: -4.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1125
    Cell Significance Index: -11.4900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1165
    Cell Significance Index: -1.1300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1184
    Cell Significance Index: -1.4100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1224
    Cell Significance Index: -1.0900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1228
    Cell Significance Index: -1.3200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1240
    Cell Significance Index: -1.5700
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1243
    Cell Significance Index: -1.3900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1257
    Cell Significance Index: -1.4600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1289
    Cell Significance Index: -1.5300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1302
    Cell Significance Index: -1.5700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1313
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1313
    Cell Significance Index: -1.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1327
    Cell Significance Index: -9.1800
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.1369
    Cell Significance Index: -1.4400
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1425
    Cell Significance Index: -1.4700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1444
    Cell Significance Index: -1.2900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1447
    Cell Significance Index: -1.5600
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1468
    Cell Significance Index: -1.2700
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1489
    Cell Significance Index: -1.3400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1496
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1496
    Cell Significance Index: -1.4400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1503
    Cell Significance Index: -0.9300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1538
    Cell Significance Index: -1.5700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1557
    Cell Significance Index: -1.4400
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.1563
    Cell Significance Index: -1.4800
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1607
    Cell Significance Index: -1.1600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1620
    Cell Significance Index: -1.3800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1746
    Cell Significance Index: -1.5500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1755
    Cell Significance Index: -1.8200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1767
    Cell Significance Index: -1.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1777
    Cell Significance Index: -10.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1809
    Cell Significance Index: -13.4800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1826
    Cell Significance Index: -1.5700
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1834
    Cell Significance Index: -1.5200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1854
    Cell Significance Index: -1.2300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1904
    Cell Significance Index: -1.5800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1910
    Cell Significance Index: -1.4600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1931
    Cell Significance Index: -0.9200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2146
    Cell Significance Index: -1.3700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2192
    Cell Significance Index: -1.5200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2193
    Cell Significance Index: -1.4300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2260
    Cell Significance Index: -1.9100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2283
    Cell Significance Index: -1.3400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2296
    Cell Significance Index: -2.9500
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.2471
    Cell Significance Index: -1.7200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2492
    Cell Significance Index: -1.7900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2681
    Cell Significance Index: -3.1100
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: -0.2730
    Cell Significance Index: -1.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2861
    Cell Significance Index: -13.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2967
    Cell Significance Index: -7.5600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3022
    Cell Significance Index: -4.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3371
    Cell Significance Index: -5.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EVX1 is a highly conserved homeobox gene, which encodes a transcription factor that regulates gene expression by binding to specific DNA sequences. Its expression is tightly regulated during development, and its dysregulation has been implicated in various diseases. EVX1 is characterized by its ability to bind to RNA polymerase II (RNAPII)-specific DNA sequences, which are crucial for the regulation of transcription. Its expression is also influenced by chromatin modifications, highlighting the complex interplay between transcriptional regulation and epigenetic control. **Pathways and Functions** EVX1 is involved in various biological pathways, including: 1. **Neuronal development**: EVX1 plays a crucial role in regulating the expression of genes involved in neuronal development, including axon guidance and neuronal cell body formation. 2. **Immune function**: EVX1 is expressed in immune cells, including oligodendrocyte precursor cells, microglial cells, and endothelial cells, suggesting its importance in maintaining immune homeostasis. 3. **Cell proliferation**: EVX1 regulates the expression of genes involved in cell proliferation, including transit amplifying cells and intestinal crypt stem cells. 4. **Chromatin regulation**: EVX1 interacts with chromatin-modifying enzymes, influencing chromatin structure and gene expression. **Functions** EVX1 functions as a transcription factor, regulating the expression of target genes by binding to specific DNA sequences. Its binding to RNAPII-specific sequences is crucial for the regulation of transcription, and its interaction with chromatin-modifying enzymes influences chromatin structure and gene expression. EVX1 also regulates the expression of genes involved in neuronal development, immune function, and cell proliferation. **Clinical Significance** Dysregulation of EVX1 has been implicated in various immune-related disorders, including: 1. **Multiple sclerosis**: EVX1 has been shown to regulate the expression of genes involved in immune cell function, suggesting its potential role in the pathogenesis of multiple sclerosis. 2. **Autoimmune diseases**: EVX1's role in regulating immune cell function and gene expression makes it a potential target for the treatment of autoimmune diseases. 3. **Neurological disorders**: EVX1's involvement in neuronal development and immune function suggests its potential role in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, EVX1 is a critical transcription factor involved in various biological processes, including immune function, neuronal development, and cell proliferation. Its dysregulation has been implicated in various immune-related disorders, highlighting its potential as a therapeutic target. Further research is necessary to fully understand the role of EVX1 in immune function and its clinical significance in immune-related disorders.

Genular Protein ID: 3162965194

Symbol: EVX1_HUMAN

Name: Homeobox even-skipped homolog protein 1

UniProtKB Accession Codes:

P49640 A4D199 B4DQJ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1684419

Title: Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7.

PubMed ID: 1684419

DOI: 10.1093/nar/19.23.6541

PubMed ID: 7499236

Title: Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells.

PubMed ID: 7499236

DOI: 10.1074/jbc.270.46.27695

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

Sequence Information:

  • Length: 407
  • Mass: 42440
  • Checksum: 75D696ECA1431D5A
  • Sequence:
    • MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP RAVPPATRER 
GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS VDSLSGQGQP SSSDTESDFY 
EEIEVSCTPD CATGNAEYQH SKGSGSEALV GSPNGGSETP KSNGGSGGGG SQGTLACSAS 
DQMRRYRTAF TREQIARLEK EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR 
QRLAMTWPHP ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF 
SGSLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAGGPCSCL ACHSGPANGL 
APRAAAASDF TCASTSRSDS FLTFAPSVLS KASSVALDQR EEVPLTR

Genular Protein ID: 2038959232

Symbol: B4DRC0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRC0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 2 SAM 1

Sequence Information:

  • Length: 270
  • Mass: 27352
  • Checksum: 2F73B81D35407111
  • Sequence:
    • MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP RAVPPATRER 
GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS VDSLSGQGQP SSSDTESDFY 
EEIEVSCTPD CATGNAEYQH SKGSGSEALV GSPNGGSETP KSNSGSLRPL DTFRVLSQPY 
PRPELLCAFR HPPLYPGPAH GLGASAGGPC SCLACHSGPA NGLAPRAAAA SDFTCASTSR 
SDSFLTFAPS VLSKASSVAL DQREEVPLTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.