Details for: EVX1

Gene ID: 2128

Symbol: EVX1

Ensembl ID: ENSG00000106038

Description: even-skipped homeobox 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8271
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6837
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.51
    Marker Score: 2529
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 2.05
    Marker Score: 796
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.66
    Marker Score: 1654
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1178
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4816
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.9
    Marker Score: 501
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1403
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 516
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.58
    Marker Score: 978
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.52
    Marker Score: 994
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.49
    Marker Score: 1006
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.45
    Marker Score: 264
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6298
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.38
    Marker Score: 407
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.32
    Marker Score: 1932
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 573
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 146
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 132
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.22
    Marker Score: 326
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.21
    Marker Score: 242.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.2
    Marker Score: 106
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.17
    Marker Score: 111.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.16
    Marker Score: 33
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.16
    Marker Score: 271
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.14
    Marker Score: 167
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.14
    Marker Score: 45
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.14
    Marker Score: 365
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.13
    Marker Score: 159
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.1
    Marker Score: 72
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 72
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.08
    Marker Score: 148
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.07
    Marker Score: 115
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.07
    Marker Score: 711
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 147
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 183
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 74.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.05
    Marker Score: 92
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.04
    Marker Score: 151
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.04
    Marker Score: 29

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Other Information

**Key characteristics:** - EVX1 is a homeobox gene, which are a group of transcription factors that are involved in regulating gene expression. - It is a key regulator of oligodendrocyte development, as it is expressed in oligodendrocyte precursor cells and is required for the survival and differentiation of these cells into myelinating oligodendrocytes. - EVX1 also plays a role in the development and function of other neural cells, including microglia, blood vessel endothelial cells, and neuroendocrine cells. **Pathways and functions:** - EVX1 is a key regulator of axon guidance in the developing spinal cord. It is expressed in neurons that are migrating along the developing neural tube and is required for the guidance of these neurons to form the central nervous system. - EVX1 also plays a role in the regulation of interneuron migration. It is expressed in cells that are migrating along the developing optic nerve and is required for the formation of the optic nerve. - In addition to its roles in axon guidance and interneuron migration, EVX1 also plays a role in the regulation of neuronal cell body development and function. **Clinical significance:** Mutations in the EVX1 gene have been linked to a number of human diseases, including autism, schizophrenia, and epilepsy. These diseases are characterized by a variety of neurological symptoms, including problems with movement, learning, and behavior. EVX1 is a promising target for the treatment of these diseases, as it is a key regulator of neuronal development and function.

Genular Protein ID: 3162965194

Symbol: EVX1_HUMAN

Name: Homeobox even-skipped homolog protein 1

UniProtKB Accession Codes:

P49640 A4D199 B4DQJ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1684419

Title: Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7.

PubMed ID: 1684419

DOI: 10.1093/nar/19.23.6541

PubMed ID: 7499236

Title: Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells.

PubMed ID: 7499236

DOI: 10.1074/jbc.270.46.27695

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

Sequence Information:

  • Length: 407
  • Mass: 42440
  • Checksum: 75D696ECA1431D5A
  • Sequence:
    • MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP RAVPPATRER 
GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS VDSLSGQGQP SSSDTESDFY 
EEIEVSCTPD CATGNAEYQH SKGSGSEALV GSPNGGSETP KSNGGSGGGG SQGTLACSAS 
DQMRRYRTAF TREQIARLEK EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR 
QRLAMTWPHP ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF 
SGSLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAGGPCSCL ACHSGPANGL 
APRAAAASDF TCASTSRSDS FLTFAPSVLS KASSVALDQR EEVPLTR

Genular Protein ID: 2038959232

Symbol: B4DRC0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRC0

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 2 SAM 1

Sequence Information:

  • Length: 270
  • Mass: 27352
  • Checksum: 2F73B81D35407111
  • Sequence:
    • MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP RAVPPATRER 
GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS VDSLSGQGQP SSSDTESDFY 
EEIEVSCTPD CATGNAEYQH SKGSGSEALV GSPNGGSETP KSNSGSLRPL DTFRVLSQPY 
PRPELLCAFR HPPLYPGPAH GLGASAGGPC SCLACHSGPA NGLAPRAAAA SDFTCASTSR 
SDSFLTFAPS VLSKASSVAL DQREEVPLTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.