Details for: EYA3

Gene ID: 2140

Symbol: EYA3

Ensembl ID: ENSG00000158161

Description: EYA transcriptional coactivator and phosphatase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.63
    Marker Score: 2023
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.99
    Marker Score: 2201
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.91
    Marker Score: 17921
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.87
    Marker Score: 1615
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.73
    Marker Score: 6150
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.71
    Marker Score: 105242.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.71
    Marker Score: 16253
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.7
    Marker Score: 37999
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.7
    Marker Score: 6921.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.67
    Marker Score: 56478
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.64
    Marker Score: 689
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.64
    Marker Score: 6341
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.6
    Marker Score: 59089
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.6
    Marker Score: 60578
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.58
    Marker Score: 2766
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.58
    Marker Score: 12078
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.57
    Marker Score: 3963
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.57
    Marker Score: 13467
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.55
    Marker Score: 814
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.54
    Marker Score: 30562.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.51
    Marker Score: 22643
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.51
    Marker Score: 15563.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.5
    Marker Score: 31991
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.46
    Marker Score: 2260
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.43
    Marker Score: 5921
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.33
    Marker Score: 2554
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.29
    Marker Score: 353
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.21
    Marker Score: 385
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.21
    Marker Score: 1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.2
    Marker Score: 5025.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.19
    Marker Score: 1350
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.18
    Marker Score: 2580.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.14
    Marker Score: 360
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.12
    Marker Score: 5171
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.11
    Marker Score: 1278
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.11
    Marker Score: 1487
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17222
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.1
    Marker Score: 321
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.1
    Marker Score: 396
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2198
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.07
    Marker Score: 637
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.06
    Marker Score: 526
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.03
    Marker Score: 602
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.02
    Marker Score: 1449
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.02
    Marker Score: 708
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.02
    Marker Score: 4236
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.01
    Marker Score: 588
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.01
    Marker Score: 1218
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1
    Marker Score: 2357
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1
    Marker Score: 1246
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71715
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47940
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.98
    Marker Score: 15808
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30393
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.98
    Marker Score: 545
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.97
    Marker Score: 921
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.95
    Marker Score: 306
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.94
    Marker Score: 462
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.93
    Marker Score: 826
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.93
    Marker Score: 2647
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 552
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2709
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1462
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.89
    Marker Score: 434
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.89
    Marker Score: 15856
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.89
    Marker Score: 5729
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.87
    Marker Score: 2089
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.87
    Marker Score: 448
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.87
    Marker Score: 2168
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4884
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.85
    Marker Score: 316
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.85
    Marker Score: 4574
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.85
    Marker Score: 1025
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.84
    Marker Score: 1210
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.84
    Marker Score: 847
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.83
    Marker Score: 210.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.82
    Marker Score: 332
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.82
    Marker Score: 306
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.81
    Marker Score: 855
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.8
    Marker Score: 1162
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8
    Marker Score: 2367
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.79
    Marker Score: 1307
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.79
    Marker Score: 285
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.78
    Marker Score: 3387.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.78
    Marker Score: 675
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.78
    Marker Score: 962
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.78
    Marker Score: 182
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.76
    Marker Score: 4013
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.76
    Marker Score: 816
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.76
    Marker Score: 424
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.75
    Marker Score: 408
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.75
    Marker Score: 510
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.74
    Marker Score: 213

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Other Information

## Summary EYA3 is a transcription coactivator and phosphatase that plays a crucial role in various cellular processes, including development, differentiation, and repair. It is highly expressed in specific cell types, including renal cells, neurons, and epithelial cells. ## Key characteristics * EYA3 is a protein with a conserved structure that includes an EYA domain and a PH domain. * It is a positive regulator of the DNA repair response to double-strand breaks (DSB). * EYA3 interacts with other proteins involved in DNA repair and cell cycle regulation. * It is involved in the regulation of cell migration, proliferation, and differentiation. ## Pathways and functions * **Development:** EYA3 is essential for the proper development of the kidney, eye, and other tissues. * **Differentiation:** It plays a role in the differentiation of neural cells from pluripotent stem cells. * **Repair:** EYA3 is involved in the repair of DNA damage caused by ionizing radiation and other agents. * **Regulation of cell survival:** It helps to regulate the balance between cell survival and apoptosis. * **Visual perception:** EYA3 is involved in the regulation of visual perception. ## Clinical significance * Mutations in EYA3 have been linked to several human diseases, including retinitis pigmentosa, a genetic eye disorder that affects vision. * EYA3 inhibitors are being investigated as potential treatments for cancer and other diseases that are characterized by DNA damage. ## Conclusion EYA3 is a critical regulator of various cellular processes, including development, differentiation, repair, and survival. Its clinical significance makes it a promising target for the development of novel therapeutic strategies for diseases associated with DNA damage.

Genular Protein ID: 3454023124

Symbol: EYA3_HUMAN

Name: Eyes absent homolog 3

UniProtKB Accession Codes:

Q99504 A8K190 B4DIR7 B4DNZ7 O95463 Q8IVX7 Q99813

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SABIO-RK 1 SAM 1 SFLD 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9020840

Title: A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.

PubMed ID: 9020840

DOI: 10.1038/ng0297-157

PubMed ID: 9049631

Title: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.

PubMed ID: 9049631

DOI: 10.1101/gr.7.2.128

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9887327

Title: EYA4, a novel vertebrate gene related to Drosophila eyes absent.

PubMed ID: 9887327

DOI: 10.1093/hmg/8.1.11

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19351884

Title: Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.

PubMed ID: 19351884

DOI: 10.1074/jbc.c900032200

PubMed ID: 19234442

Title: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.

PubMed ID: 19234442

DOI: 10.1038/nature07849

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 573
  • Mass: 62663
  • Checksum: 684B961B1E630371
  • Sequence:
    • MEEEQDLPEQ PVKKAKMQES GEQTISQVSN PDVSDQKPET SSLASNLPMS EEIMTCTDYI 
PRSSNDYTSQ MYSAKPYAHI LSVPVSETAY PGQTQYQTLQ QTQPYAVYPQ ATQTYGLPPF 
GALWPGMKPE SGLIQTPSPS QHSVLTCTTG LTTSQPSPAH YSYPIQASST NASLISTSST 
IANIPAAAVA SISNQDYPTY TILGQNQYQA CYPSSSFGVT GQTNSDAEST TLAATTYQSE 
KPSVMAPAPA AQRLSSGDPS TSPSLSQTTP SKDTDDQSRK NMTSKNRGKR KADATSSQDS 
ELERVFLWDL DETIIIFHSL LTGSYAQKYG KDPTVVIGSG LTMEEMIFEV ADTHLFFNDL 
EECDQVHVED VASDDNGQDL SNYSFSTDGF SGSGGSGSHG SSVGVQGGVD WMRKLAFRYR 
KVREIYDKHK SNVGGLLSPQ RKEALQRLRA EIEVLTDSWL GTALKSLLLI QSRKNCVNVL 
ITTTQLVPAL AKVLLYGLGE IFPIENIYSA TKIGKESCFE RIVSRFGKKV TYVVIGDGRD 
EEIAAKQHNM PFWRITNHGD LVSLHQALEL DFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.