Details for: MS4A2

Gene ID: 2206

Symbol: MS4A2

Ensembl ID: ENSG00000149534

Description: membrane spanning 4-domains A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophil (CL0000767)
    Fold Change: 3.81
    Marker Score: 1810
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.05
    Marker Score: 1995
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251817
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1714
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 473
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.42
    Marker Score: 189
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6304
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.39
    Marker Score: 116
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.37
    Marker Score: 119
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 321.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.3
    Marker Score: 179
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.18
    Marker Score: 559
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.15
    Marker Score: 72
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.13
    Marker Score: 187
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.13
    Marker Score: 82
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 57
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.11
    Marker Score: 69
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.09
    Marker Score: 62.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 77
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 111
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 80
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.07
    Marker Score: 176
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 142
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 910
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.05
    Marker Score: 3032
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 93
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.05
    Marker Score: 127
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.05
    Marker Score: 13

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Other Information

**Key characteristics:** * The MS4A2 gene is a member of the immunoglobulin superfamily. * It is a transmembrane protein with a predicted molecular weight of approximately 150 kDa. * It contains four extracellular domains, which are involved in protein-protein interactions. * It is expressed in a variety of cell types, including basophil, colon goblet cell, enterocyte of epithelium of large intestine, intestinal crypt stem cell of small intestine, transit amplifying cell of small intestine, goblet cell, enterocyte of epithelium of small intestine, transit amplifying cell of colon, and cardiac endothelial cell. **Pathways and functions:** * The MS4A2 gene is involved in cell surface receptor signaling. It is a key regulator of the Fc-epsilon receptor (fceri) signaling pathway, which is involved in inflammation and immune responses. * The MS4A2 gene is also involved in the MAPK pathway, which is involved in cell growth and differentiation. * It is involved in the regulation of inflammation and immune responses. **Clinical significance:** Mutations in the MS4A2 gene have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. These mutations can lead to the loss of function of the MS4A2 protein, which can result in the development of these diseases.

Genular Protein ID: 893552682

Symbol: FCERB_HUMAN

Name: High affinity immunoglobulin epsilon receptor subunit beta

UniProtKB Accession Codes:

Q01362 Q54A81

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1535625

Title: The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.

PubMed ID: 1535625

DOI: 10.1016/s0021-9258(18)42344-7

PubMed ID: 1386024

Title: Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor.

PubMed ID: 1386024

DOI: 10.1016/0014-5793(92)80430-o

PubMed ID: 12697656

Title: Regulation of human FcepsilonRI beta chain gene expression by Oct-1.

PubMed ID: 12697656

DOI: 10.1093/intimm/dxg055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8817330

Title: A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.

PubMed ID: 8817330

DOI: 10.1093/hmg/5.7.959

PubMed ID: 8842731

Title: Association between atopic asthma and a coding variant of Fc-epsilon-RI-beta in a Japanese population.

PubMed ID: 8842731

DOI: 10.1093/hmg/5.8.1129

PubMed ID: 8968765

Title:

PubMed ID: 8968765

Sequence Information:

  • Length: 244
  • Mass: 26534
  • Checksum: CE523102D5F567AF
  • Sequence:
    • MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF 
LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY PFWGAIFFSI SGMLSIISER 
RNATYLVRGS LGANTASSIA GGTGITILII NLKKSLAYIH IHSCQKFFET KCFMASFSTE 
IVVMMLFLTI LGLGSAVSLT ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP 
PIDL

Genular Protein ID: 4271932181

Symbol: A0A0B4J2E9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J2E9

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 199
  • Mass: 21650
  • Checksum: 28E1820359BE3616
  • Sequence:
    • MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF 
LGFSISGMLS IISERRNATY LVRGSLGANT ASSIAGGTGI TILIINLKKS LAYIHIHSCQ 
KFFETKCFMA SFSTEIVVMM LFLTILGLGS AVSLTICGAG EELKGNKVPE DRVYEELNIY 
SATYSELEDP GEMSPPIDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.