Details for: MS4A2

Gene ID: 2206

Symbol: MS4A2

Ensembl ID: ENSG00000149534

Description: membrane spanning 4-domains A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.0018
    Cell Significance Index: -4.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.4010
    Cell Significance Index: -4.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.4146
    Cell Significance Index: -4.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2397
    Cell Significance Index: 30.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1752
    Cell Significance Index: 72.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5103
    Cell Significance Index: 11.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4235
    Cell Significance Index: 19.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3080
    Cell Significance Index: 58.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2405
    Cell Significance Index: 5.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2195
    Cell Significance Index: 21.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1911
    Cell Significance Index: 172.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1759
    Cell Significance Index: 2.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1124
    Cell Significance Index: 2.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1090
    Cell Significance Index: 17.7200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0880
    Cell Significance Index: 1.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0758
    Cell Significance Index: 8.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0283
    Cell Significance Index: 1.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0268
    Cell Significance Index: 3.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0249
    Cell Significance Index: 0.6200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0009
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0051
    Cell Significance Index: -3.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0052
    Cell Significance Index: -0.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0052
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -8.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0060
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0091
    Cell Significance Index: -4.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0103
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0113
    Cell Significance Index: -5.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0139
    Cell Significance Index: -4.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0143
    Cell Significance Index: -2.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0159
    Cell Significance Index: -2.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0164
    Cell Significance Index: -3.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0194
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0203
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0204
    Cell Significance Index: -4.3000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0204
    Cell Significance Index: -0.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0218
    Cell Significance Index: -0.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0222
    Cell Significance Index: -0.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0229
    Cell Significance Index: -3.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0254
    Cell Significance Index: -1.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0276
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0284
    Cell Significance Index: -3.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0290
    Cell Significance Index: -0.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0305
    Cell Significance Index: -3.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0325
    Cell Significance Index: -4.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0369
    Cell Significance Index: -3.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0407
    Cell Significance Index: -4.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0434
    Cell Significance Index: -1.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0457
    Cell Significance Index: -5.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0533
    Cell Significance Index: -1.1100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0542
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0583
    Cell Significance Index: -1.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0592
    Cell Significance Index: -4.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0630
    Cell Significance Index: -4.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0641
    Cell Significance Index: -4.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0648
    Cell Significance Index: -4.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0671
    Cell Significance Index: -7.9100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0780
    Cell Significance Index: -1.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0819
    Cell Significance Index: -3.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0841
    Cell Significance Index: -0.9600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0848
    Cell Significance Index: -0.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0859
    Cell Significance Index: -4.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0900
    Cell Significance Index: -4.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0982
    Cell Significance Index: -2.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1022
    Cell Significance Index: -5.7400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1023
    Cell Significance Index: -1.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1030
    Cell Significance Index: -2.7600
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.1043
    Cell Significance Index: -1.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1051
    Cell Significance Index: -5.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1063
    Cell Significance Index: -2.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1073
    Cell Significance Index: -3.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1085
    Cell Significance Index: -1.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1095
    Cell Significance Index: -2.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1124
    Cell Significance Index: -3.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1137
    Cell Significance Index: -6.9900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1137
    Cell Significance Index: -1.2000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1143
    Cell Significance Index: -1.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1143
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.1176
    Cell Significance Index: -1.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1222
    Cell Significance Index: -2.0800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1223
    Cell Significance Index: -1.4500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1237
    Cell Significance Index: -1.2000
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1242
    Cell Significance Index: -1.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1253
    Cell Significance Index: -3.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1265
    Cell Significance Index: -4.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1342
    Cell Significance Index: -5.0800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1344
    Cell Significance Index: -1.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1377
    Cell Significance Index: -2.3200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1381
    Cell Significance Index: -1.1600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1436
    Cell Significance Index: -1.8900
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.1458
    Cell Significance Index: -1.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1460
    Cell Significance Index: -5.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MS4A2 gene exhibits several key characteristics, including: 1. **Cell surface receptor signaling pathway**: The MS4A2 gene is involved in cell surface receptor signaling, which is a critical mechanism for transmitting signals from the extracellular environment to the intracellular space. 2. **Fc-εRI complex**: The MS4A2 gene encodes a subunit of the high-affinity immunoglobulin epsilon receptor (Fc-εRI), which is a key player in regulating allergic responses and immune inflammation. 3. **Calcium mobilization**: The MS4A2 gene is implicated in calcium mobilization, a process that is essential for various cellular functions, including immune responses and signal transduction. 4. **Significant expression in multiple cell types**: The MS4A2 gene is expressed in a wide range of cell types, including basophils, goblet cells, and intestinal epithelial cells, highlighting its broad role in the immune system. **Pathways and Functions:** The MS4A2 gene is involved in several key pathways and functions, including: 1. **Fc-εRI signaling**: The MS4A2 gene encodes a subunit of the Fc-εRI complex, which is responsible for mediating IgE-dependent allergic responses and immune inflammation. 2. **Calcium mobilization**: The MS4A2 gene is implicated in calcium mobilization, a process that is essential for various cellular functions, including immune responses and signal transduction. 3. **Immune response**: The MS4A2 gene plays a critical role in regulating immune responses, including the activation of immune cells and the production of cytokines. 4. **Innate immune system**: The MS4A2 gene is also involved in the innate immune system, which provides the first line of defense against pathogens and other foreign substances. **Clinical Significance:** The MS4A2 gene has significant clinical implications, including: 1. **Allergic diseases**: The MS4A2 gene is implicated in the pathogenesis of allergic diseases, such as atopic dermatitis, asthma, and allergic rhinitis. 2. **Autoimmune diseases**: The MS4A2 gene may also play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: The MS4A2 gene has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma. 4. **Immunodeficiency disorders**: The MS4A2 gene may also be involved in immunodeficiency disorders, such as X-linked agammaglobulinemia. In conclusion, the MS4A2 gene is a critical component of the immune system, playing a pivotal role in mediating various immune responses and calcium mobilization. Its significant expression in multiple cell types and involvement in key pathways and functions highlight its broad role in the immune system. The clinical significance of the MS4A2 gene is evident in its involvement in allergic diseases, autoimmune diseases, cancer, and immunodeficiency disorders. Further research is needed to fully elucidate the functions and clinical implications of the MS4A2 gene.

Genular Protein ID: 893552682

Symbol: FCERB_HUMAN

Name: High affinity immunoglobulin epsilon receptor subunit beta

UniProtKB Accession Codes:

Q01362 Q54A81

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1535625

Title: The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.

PubMed ID: 1535625

DOI: 10.1016/s0021-9258(18)42344-7

PubMed ID: 1386024

Title: Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor.

PubMed ID: 1386024

DOI: 10.1016/0014-5793(92)80430-o

PubMed ID: 12697656

Title: Regulation of human FcepsilonRI beta chain gene expression by Oct-1.

PubMed ID: 12697656

DOI: 10.1093/intimm/dxg055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8817330

Title: A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.

PubMed ID: 8817330

DOI: 10.1093/hmg/5.7.959

PubMed ID: 8842731

Title: Association between atopic asthma and a coding variant of Fc-epsilon-RI-beta in a Japanese population.

PubMed ID: 8842731

DOI: 10.1093/hmg/5.8.1129

PubMed ID: 8968765

Title:

PubMed ID: 8968765

Sequence Information:

  • Length: 244
  • Mass: 26534
  • Checksum: CE523102D5F567AF
  • Sequence:
    • MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF 
LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY PFWGAIFFSI SGMLSIISER 
RNATYLVRGS LGANTASSIA GGTGITILII NLKKSLAYIH IHSCQKFFET KCFMASFSTE 
IVVMMLFLTI LGLGSAVSLT ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP 
PIDL

Genular Protein ID: 4271932181

Symbol: A0A0B4J2E9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J2E9

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 199
  • Mass: 21650
  • Checksum: 28E1820359BE3616
  • Sequence:
    • MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF 
LGFSISGMLS IISERRNATY LVRGSLGANT ASSIAGGTGI TILIINLKKS LAYIHIHSCQ 
KFFETKCFMA SFSTEIVVMM LFLTILGLGS AVSLTICGAG EELKGNKVPE DRVYEELNIY 
SATYSELEDP GEMSPPIDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.