Details for: VEGFD

Gene ID: 2277

Symbol: VEGFD

Ensembl ID: ENSG00000165197

Description: vascular endothelial growth factor D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 15.7571
    Cell Significance Index: 97.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.6008
    Cell Significance Index: -13.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.0545
    Cell Significance Index: 52.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2324
    Cell Significance Index: 30.0700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.8565
    Cell Significance Index: 13.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8356
    Cell Significance Index: 20.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6691
    Cell Significance Index: 19.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6278
    Cell Significance Index: 125.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5325
    Cell Significance Index: 368.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3903
    Cell Significance Index: 17.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3552
    Cell Significance Index: 27.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2990
    Cell Significance Index: 56.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2562
    Cell Significance Index: 5.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2327
    Cell Significance Index: 1.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1855
    Cell Significance Index: 66.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1795
    Cell Significance Index: 9.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1633
    Cell Significance Index: 147.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1553
    Cell Significance Index: 3.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1092
    Cell Significance Index: 10.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1085
    Cell Significance Index: 4.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0907
    Cell Significance Index: 4.0100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0651
    Cell Significance Index: 0.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0410
    Cell Significance Index: 6.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0309
    Cell Significance Index: 6.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0220
    Cell Significance Index: 1.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0091
    Cell Significance Index: 17.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0088
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0080
    Cell Significance Index: 0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0039
    Cell Significance Index: 5.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0032
    Cell Significance Index: 0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0049
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0101
    Cell Significance Index: -4.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0168
    Cell Significance Index: -7.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0211
    Cell Significance Index: -15.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0212
    Cell Significance Index: -15.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0218
    Cell Significance Index: -11.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0232
    Cell Significance Index: -0.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0251
    Cell Significance Index: -3.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0272
    Cell Significance Index: -15.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0353
    Cell Significance Index: -3.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0381
    Cell Significance Index: -10.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0505
    Cell Significance Index: -6.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0587
    Cell Significance Index: -7.2200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0724
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0732
    Cell Significance Index: -15.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0766
    Cell Significance Index: -5.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0797
    Cell Significance Index: -9.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0828
    Cell Significance Index: -11.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0859
    Cell Significance Index: -14.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0927
    Cell Significance Index: -10.9300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0949
    Cell Significance Index: -4.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1091
    Cell Significance Index: -11.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1176
    Cell Significance Index: -15.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1239
    Cell Significance Index: -1.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1253
    Cell Significance Index: -8.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1357
    Cell Significance Index: -15.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1379
    Cell Significance Index: -3.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1384
    Cell Significance Index: -6.5100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1416
    Cell Significance Index: -2.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1545
    Cell Significance Index: -15.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1667
    Cell Significance Index: -10.0100
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.1704
    Cell Significance Index: -1.7200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1747
    Cell Significance Index: -2.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1850
    Cell Significance Index: -3.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1944
    Cell Significance Index: -2.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2080
    Cell Significance Index: -15.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2142
    Cell Significance Index: -6.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2214
    Cell Significance Index: -7.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2222
    Cell Significance Index: -13.6600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2245
    Cell Significance Index: -2.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2286
    Cell Significance Index: -12.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2288
    Cell Significance Index: -11.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2417
    Cell Significance Index: -3.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2472
    Cell Significance Index: -15.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2480
    Cell Significance Index: -13.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2544
    Cell Significance Index: -11.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2623
    Cell Significance Index: -5.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2639
    Cell Significance Index: -13.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2892
    Cell Significance Index: -10.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2909
    Cell Significance Index: -8.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2984
    Cell Significance Index: -5.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3323
    Cell Significance Index: -8.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3360
    Cell Significance Index: -11.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3432
    Cell Significance Index: -6.8900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3524
    Cell Significance Index: -5.5900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3619
    Cell Significance Index: -4.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3816
    Cell Significance Index: -5.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3877
    Cell Significance Index: -8.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3891
    Cell Significance Index: -8.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3901
    Cell Significance Index: -8.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3902
    Cell Significance Index: -10.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3919
    Cell Significance Index: -7.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4100
    Cell Significance Index: -15.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4307
    Cell Significance Index: -11.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4388
    Cell Significance Index: -9.4800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.4398
    Cell Significance Index: -4.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure and expression:** VEGFD is a single-copy gene located on chromosome 3q26.3. It is highly expressed in various cell types, including those involved in tissue development and repair. 2. **Protein structure and function:** The VEGFD protein is a ligand for the VEGFR3 receptor, which is a member of the VEGF receptor family. The interaction between VEGFD and VEGFR3 triggers signaling pathways that regulate cell proliferation, differentiation, and migration. 3. **Cellular localization:** VEGFD is primarily expressed in the extracellular space, where it can interact with its receptor, VEGFR3, to regulate cellular responses. 4. **Function in development and disease:** VEGFD plays a crucial role in tissue development, including angiogenesis, which is the formation of new blood vessels from pre-existing vessels. Dysregulation of VEGFD has been implicated in various diseases, including cancer, cardiovascular disease, and inflammatory disorders. **Pathways and Functions:** 1. **Angiogenesis:** VEGFD is a key regulator of angiogenesis, which is the formation of new blood vessels from pre-existing vessels. VEGFD interacts with VEGFR3 to trigger signaling pathways that promote the migration and proliferation of endothelial cells, leading to the formation of new blood vessels. 2. **Cell proliferation and differentiation:** VEGFD is involved in the regulation of cell proliferation and differentiation in various cell types, including mesenchymal stem cells, retinal bipolar neurons, and cardiac muscle cells. 3. **Tissue repair and remodeling:** VEGFD is involved in the regulation of tissue repair and remodeling, including the formation of new blood vessels and the repair of damaged tissues. 4. **Inflammatory responses:** VEGFD is involved in the regulation of inflammatory responses, including the recruitment of immune cells to sites of inflammation. **Clinical Significance:** 1. **Cancer:** Dysregulation of VEGFD has been implicated in various types of cancer, including lung, breast, and colon cancer. VEGFD is involved in the promotion of angiogenesis and tumor growth. 2. **Cardiovascular disease:** VEGFD is involved in the regulation of angiogenesis and vascular remodeling, which is critical in the development of cardiovascular disease. 3. **Inflammatory disorders:** VEGFD is involved in the regulation of inflammatory responses, including the recruitment of immune cells to sites of inflammation. 4. **Regenerative medicine:** VEGFD is a potential target for regenerative medicine therapies aimed at promoting tissue repair and regeneration, including the use of stem cells and tissue engineering techniques. In conclusion, VEGFD is a key player in various biological processes, including angiogenesis, cell proliferation, and tissue development. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and inflammatory disorders. Further research is needed to fully understand the role of VEGFD in these processes and to explore its potential as a therapeutic target.

Genular Protein ID: 3472041714

Symbol: VEGFD_HUMAN

Name: c-Fos-induced growth factor

UniProtKB Accession Codes:

O43915 B2R7Z3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9205122

Title: Molecular cloning of a novel vascular endothelial growth factor, VEGF-D.

PubMed ID: 9205122

DOI: 10.1006/geno.1997.4774

PubMed ID: 9479493

Title: Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes.

PubMed ID: 9479493

DOI: 10.1006/geno.1997.5079

PubMed ID: 9435229

Title: Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).

PubMed ID: 9435229

DOI: 10.1073/pnas.95.2.548

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10542248

Title: Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.

PubMed ID: 10542248

DOI: 10.1074/jbc.274.45.32127

PubMed ID: 21148085

Title: Structural determinants of vascular endothelial growth factor-D - receptor binding and specificity.

PubMed ID: 21148085

DOI: 10.1182/blood-2010-08-301549

Sequence Information:

  • Length: 354
  • Mass: 40444
  • Checksum: 2048D769D735173E
  • Sequence:
    • MYREWVVVNV FMMLYVQLVQ GSSNEHGPVK RSSQSTLERS EQQIRAASSL EELLRITHSE 
DWKLWRCRLR LKSFTSMDSR SASHRSTRFA ATFYDIETLK VIDEEWQRTQ CSPRETCVEV 
ASELGKSTNT FFKPPCVNVF RCGGCCNEES LICMNTSTSY ISKQLFEISV PLTSVPELVP 
VKVANHTGCK CLPTAPRHPY SIIRRSIQIP EEDRCSHSKK LCPIDMLWDS NKCKCVLQEE 
NPLAGTEDHS HLQEPALCGP HMMFDEDRCE CVCKTPCPKD LIQHPKNCSC FECKESLETC 
CQKHKLFHPD TCSCEDRCPF HTRPCASGKT ACAKHCRFPK EKRAAQGPHS RKNP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.