Details for: FOXC2

Gene ID: 2303

Symbol: FOXC2

Ensembl ID: ENSG00000176692

Description: forkhead box C2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.55
    Marker Score: 1065.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7670
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251809
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 644
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.99
    Marker Score: 253
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.98
    Marker Score: 698
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.98
    Marker Score: 249
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.94
    Marker Score: 892
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8
    Marker Score: 227
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.73
    Marker Score: 4393
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.72
    Marker Score: 754.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.68
    Marker Score: 1416
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.66
    Marker Score: 764
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.66
    Marker Score: 796
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.65
    Marker Score: 349
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.63
    Marker Score: 423
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.62
    Marker Score: 658
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.6
    Marker Score: 169
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.57
    Marker Score: 966.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 260
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 334
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.49
    Marker Score: 2416
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 252
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.48
    Marker Score: 916
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.47
    Marker Score: 681
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.47
    Marker Score: 187
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.46
    Marker Score: 510
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.4
    Marker Score: 113
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.39
    Marker Score: 1460
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.39
    Marker Score: 161
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.38
    Marker Score: 238
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.38
    Marker Score: 174
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.37
    Marker Score: 200
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.36
    Marker Score: 133
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.34
    Marker Score: 201
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.33
    Marker Score: 185
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5126
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 187
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 305
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 312
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.31
    Marker Score: 111
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.3
    Marker Score: 568
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.28
    Marker Score: 69
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.28
    Marker Score: 68
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.28
    Marker Score: 64
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.27
    Marker Score: 520
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 94
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.23
    Marker Score: 68
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 59.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.23
    Marker Score: 106
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.22
    Marker Score: 615.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.21
    Marker Score: 432
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.21
    Marker Score: 187
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.2
    Marker Score: 302
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 115.5
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.19
    Marker Score: 55
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.19
    Marker Score: 79
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 102
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.19
    Marker Score: 300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.17
    Marker Score: 294
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.17
    Marker Score: 119
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.16
    Marker Score: 203
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.16
    Marker Score: 133
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 462
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 87
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.14
    Marker Score: 71
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.14
    Marker Score: 57
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 134
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.14
    Marker Score: 148
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 267.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.11
    Marker Score: 47

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Other Information

**Key characteristics** * It is a forkhead box protein, which are a large family of transcription factors that are involved in a variety of cellular processes, including development, differentiation, and proliferation. * It is a DNA-binding transcription factor, which means that it binds to DNA and regulates gene expression. * It is a key regulator of the development of the kidney. * It is also involved in the regulation of other developmental processes, such as formation of the urogenital tract and the formation of the body's blood and immune systems. **Pathways and functions** * FOXC2 is involved in the regulation of the development of the kidney. * It is expressed in a variety of cells in the kidney, including epithelial cells, endothelial cells, and mesenchymal cells. * It is required for the formation of the urogenital tract and the development of the kidney itself. * It also plays a role in the regulation of other developmental processes, such as formation of the body's blood and immune systems. **Clinical significance** FOXC2 is a promising target for the treatment of a variety of diseases, including kidney disease, cancer, and diabetes. Mutations in the FOXC2 gene have been linked to a number of human diseases, including polycystic kidney disease, which is characterized by the formation of numerous cysts in the kidneys. **Additional information** * The FOXC2 gene is located on chromosome 17q21.1. * It is a highly conserved gene, with a similar gene found in mice and zebrafish. * It is a well-studied gene, with a number of studies investigating its role in development, differentiation, and cancer.

Genular Protein ID: 1714269648

Symbol: FOXC2_HUMAN

Name: Forkhead box protein C2

UniProtKB Accession Codes:

Q99958 C6KMR9 Q14DA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 55 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9169153

Title: Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures.

PubMed ID: 9169153

DOI: 10.1006/geno.1997.4695

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11078474

Title: Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome.

PubMed ID: 11078474

DOI: 10.1086/316915

PubMed ID: 11371511

Title: Truncating mutations in FOXC2 cause multiple lymphedema syndromes.

PubMed ID: 11371511

DOI: 10.1093/hmg/10.11.1185

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23878394

Title: Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.

PubMed ID: 23878394

DOI: 10.1128/mcb.01387-12

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10669593

Title: Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11.

PubMed ID: 10669593

DOI: 10.1006/jmbi.1999.3476

PubMed ID: 11499682

Title: Analysis of lymphoedema-distichiasis families for FOXC2 mutations reveals small insertions and deletions throughout the gene.

PubMed ID: 11499682

DOI: 10.1007/s004390100528

Sequence Information:

  • Length: 501
  • Mass: 53719
  • Checksum: F66513878EDC3A87
  • Sequence:
    • MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYSA GMGRSYAPYH 
HHQPAAPKDL VKPPYSYIAL ITMAIQNAPE KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI 
RHNLSLNECF VKVPRDDKKP GKGSYWTLDP DSYNMFENGS FLRRRRRFKK KDVSKEKEER 
AHLKEPPPAA SKGAPATPHL ADAPKEAEKK VVIKSEAASP ALPVITKVET LSPESALQGS 
PRSAASTPAG SPDGSLPEHH AAAPNGLPGF SVENIMTLRT SPPGGELSPG AGRAGLVVPP 
LALPYAAAPP AAYGQPCAQG LEAGAAGGYQ CSMRAMSLYT GAERPAHMCV PPALDEALSD 
HPSGPTSPLS ALNLAAGQEG ALAATGHHHQ HHGHHHPQAP PPPPAPQPQP TPQPGAAAAQ 
AASWYLNHSG DLNHLPGHTF AAQQQTFPNV REMFNSHRLG IENSTLGESQ VSGNASCQLP 
YRSTPPLYRH AAPYSYDCTK Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.