Details for: FOXC2

Gene ID: 2303

Symbol: FOXC2

Ensembl ID: ENSG00000176692

Description: forkhead box C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.3774
    Cell Significance Index: 19.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8837
    Cell Significance Index: 15.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7232
    Cell Significance Index: 59.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.8844
    Cell Significance Index: 26.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3071
    Cell Significance Index: 4.1900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.2300
    Cell Significance Index: 1.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2075
    Cell Significance Index: 4.4400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.1675
    Cell Significance Index: 1.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0759
    Cell Significance Index: 3.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0590
    Cell Significance Index: 7.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0037
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -3.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0047
    Cell Significance Index: -0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0110
    Cell Significance Index: -8.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0121
    Cell Significance Index: -7.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.7400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0132
    Cell Significance Index: -0.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0148
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0175
    Cell Significance Index: -2.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0180
    Cell Significance Index: -8.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0221
    Cell Significance Index: -12.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0260
    Cell Significance Index: -0.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0283
    Cell Significance Index: -8.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0286
    Cell Significance Index: -2.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0317
    Cell Significance Index: -3.9000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0318
    Cell Significance Index: -0.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0330
    Cell Significance Index: -0.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0345
    Cell Significance Index: -6.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0354
    Cell Significance Index: -1.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0478
    Cell Significance Index: -3.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0509
    Cell Significance Index: -10.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0520
    Cell Significance Index: -10.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0527
    Cell Significance Index: -7.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0550
    Cell Significance Index: -6.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0759
    Cell Significance Index: -2.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0928
    Cell Significance Index: -12.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0966
    Cell Significance Index: -4.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0968
    Cell Significance Index: -10.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1026
    Cell Significance Index: -7.6500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1070
    Cell Significance Index: -1.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1071
    Cell Significance Index: -6.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1225
    Cell Significance Index: -3.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1252
    Cell Significance Index: -2.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1333
    Cell Significance Index: -8.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1365
    Cell Significance Index: -7.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1366
    Cell Significance Index: -2.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1446
    Cell Significance Index: -9.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1593
    Cell Significance Index: -9.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1605
    Cell Significance Index: -12.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1805
    Cell Significance Index: -2.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1835
    Cell Significance Index: -5.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1896
    Cell Significance Index: -8.2400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1988
    Cell Significance Index: -2.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2026
    Cell Significance Index: -11.3700
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.2251
    Cell Significance Index: -1.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2438
    Cell Significance Index: -8.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2566
    Cell Significance Index: -13.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2579
    Cell Significance Index: -8.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2613
    Cell Significance Index: -8.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2658
    Cell Significance Index: -2.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2779
    Cell Significance Index: -7.4300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2810
    Cell Significance Index: -3.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2827
    Cell Significance Index: -7.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2873
    Cell Significance Index: -9.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2959
    Cell Significance Index: -13.0900
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2971
    Cell Significance Index: -2.2700
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.2992
    Cell Significance Index: -2.2400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3027
    Cell Significance Index: -3.8300
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.3069
    Cell Significance Index: -3.1200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3116
    Cell Significance Index: -3.0500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3130
    Cell Significance Index: -2.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3133
    Cell Significance Index: -8.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3154
    Cell Significance Index: -8.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3187
    Cell Significance Index: -10.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3198
    Cell Significance Index: -8.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3247
    Cell Significance Index: -8.1100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3252
    Cell Significance Index: -4.6700
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.3258
    Cell Significance Index: -3.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3262
    Cell Significance Index: -8.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3265
    Cell Significance Index: -8.5900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3391
    Cell Significance Index: -4.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3444
    Cell Significance Index: -13.0400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.3615
    Cell Significance Index: -2.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3621
    Cell Significance Index: -6.0600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.3695
    Cell Significance Index: -3.5400
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.3726
    Cell Significance Index: -2.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3759
    Cell Significance Index: -8.2300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3823
    Cell Significance Index: -2.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3929
    Cell Significance Index: -9.8000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3930
    Cell Significance Index: -9.5200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3931
    Cell Significance Index: -3.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3953
    Cell Significance Index: -14.5100
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.3978
    Cell Significance Index: -3.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4184
    Cell Significance Index: -9.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4195
    Cell Significance Index: -10.0600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4195
    Cell Significance Index: -5.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** FOXC2 is a transcription factor that regulates gene expression by binding to specific DNA sequences, thereby influencing the transcription of target genes. 2. **Developmental Biology:** FOXC2 is involved in various developmental processes, including embryonic development, organogenesis, and tissue patterning. 3. **Cell Differentiation:** FOXC2 regulates cell differentiation by controlling the expression of genes involved in cell fate determination. 4. **Immune Function:** FOXC2 has been implicated in immune function, with studies suggesting that it plays a role in the development and function of various immune cells, including dendritic cells and T cells. 5. **Tissue-Specific Expression:** FOXC2 is expressed in a variety of tissues, including the heart, kidneys, eyes, and immune cells. **Pathways and Functions:** 1. **Apoptotic Process Involved in Outflow Tract Morphogenesis:** FOXC2 regulates apoptosis in the outflow tract during heart development. 2. **Artery Morphogenesis:** FOXC2 is involved in the development of arteries, including the formation of blood vessels and the regulation of vascular remodeling. 3. **Blood Vessel Diameter Maintenance:** FOXC2 regulates the maintenance of blood vessel diameter, which is essential for normal vascular function. 4. **Cardiac Muscle Cell Proliferation:** FOXC2 promotes the proliferation of cardiac muscle cells, which is essential for heart development and function. 5. **Cell Differentiation:** FOXC2 regulates cell differentiation by controlling the expression of genes involved in cell fate determination. 6. **Immune Function:** FOXC2 has been implicated in immune function, with studies suggesting that it plays a role in the development and function of various immune cells. **Clinical Significance:** 1. **Congenital Heart Defects:** Mutations in the FOXC2 gene have been associated with congenital heart defects, including atrial septal defects and ventricular septal defects. 2. **Kidney Development:** FOXC2 is involved in kidney development, and mutations in the gene have been associated with kidney abnormalities, including renal agenesis and kidney cysts. 3. **Eye Development:** FOXC2 is involved in eye development, and mutations in the gene have been associated with eye abnormalities, including microphthalmia and coloboma. 4. **Immune System Disorders:** FOXC2 has been implicated in immune system disorders, including autoimmune diseases and cancer. In conclusion, the FOXC2 gene plays a critical role in various developmental processes, including embryonic development, organogenesis, and immune function. Mutations in the FOXC2 gene have been associated with congenital heart defects, kidney development abnormalities, eye abnormalities, and immune system disorders. Further research is needed to fully understand the functions of FOXC2 and its role in human disease.

Genular Protein ID: 1714269648

Symbol: FOXC2_HUMAN

Name: Forkhead box protein C2

UniProtKB Accession Codes:

Q99958 C6KMR9 Q14DA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 55 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9169153

Title: Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures.

PubMed ID: 9169153

DOI: 10.1006/geno.1997.4695

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11078474

Title: Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome.

PubMed ID: 11078474

DOI: 10.1086/316915

PubMed ID: 11371511

Title: Truncating mutations in FOXC2 cause multiple lymphedema syndromes.

PubMed ID: 11371511

DOI: 10.1093/hmg/10.11.1185

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23878394

Title: Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.

PubMed ID: 23878394

DOI: 10.1128/mcb.01387-12

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10669593

Title: Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11.

PubMed ID: 10669593

DOI: 10.1006/jmbi.1999.3476

PubMed ID: 11499682

Title: Analysis of lymphoedema-distichiasis families for FOXC2 mutations reveals small insertions and deletions throughout the gene.

PubMed ID: 11499682

DOI: 10.1007/s004390100528

Sequence Information:

  • Length: 501
  • Mass: 53719
  • Checksum: F66513878EDC3A87
  • Sequence:
    • MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYSA GMGRSYAPYH 
HHQPAAPKDL VKPPYSYIAL ITMAIQNAPE KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI 
RHNLSLNECF VKVPRDDKKP GKGSYWTLDP DSYNMFENGS FLRRRRRFKK KDVSKEKEER 
AHLKEPPPAA SKGAPATPHL ADAPKEAEKK VVIKSEAASP ALPVITKVET LSPESALQGS 
PRSAASTPAG SPDGSLPEHH AAAPNGLPGF SVENIMTLRT SPPGGELSPG AGRAGLVVPP 
LALPYAAAPP AAYGQPCAQG LEAGAAGGYQ CSMRAMSLYT GAERPAHMCV PPALDEALSD 
HPSGPTSPLS ALNLAAGQEG ALAATGHHHQ HHGHHHPQAP PPPPAPQPQP TPQPGAAAAQ 
AASWYLNHSG DLNHLPGHTF AAQQQTFPNV REMFNSHRLG IENSTLGESQ VSGNASCQLP 
YRSTPPLYRH AAPYSYDCTK Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.