Details for: FOXO3B

Gene ID: 2310

Symbol: FOXO3B

Ensembl ID: ENSG00000240445

Description: forkhead box O3B

Associated with

  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Mitochondrial matrix
    (GO:0005759)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1996
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.03
    Marker Score: 1113
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.59
    Marker Score: 362
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.3
    Marker Score: 119.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.3
    Marker Score: 73
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.29
    Marker Score: 450
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.26
    Marker Score: 2241
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.24
    Marker Score: 911
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.23
    Marker Score: 2228
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.23
    Marker Score: 2156
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3301
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.21
    Marker Score: 12774
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.2
    Marker Score: 157
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2
    Marker Score: 402
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.19
    Marker Score: 362
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.19
    Marker Score: 6995
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.18
    Marker Score: 2617.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.17
    Marker Score: 3438
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.17
    Marker Score: 686
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.15
    Marker Score: 5803
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.15
    Marker Score: 58
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 371
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.14
    Marker Score: 1065
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.14
    Marker Score: 114.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.13
    Marker Score: 114
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.12
    Marker Score: 87
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.11
    Marker Score: 170
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1
    Marker Score: 578
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.1
    Marker Score: 110
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 172
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 110.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.09
    Marker Score: 70
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.09
    Marker Score: 94
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.09
    Marker Score: 129
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.08
    Marker Score: 142
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.08
    Marker Score: 1654
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.08
    Marker Score: 94.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.08
    Marker Score: 2585.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.07
    Marker Score: 341
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 78
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.05
    Marker Score: 42
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.04
    Marker Score: 70
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 56
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.04
    Marker Score: 244
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.04
    Marker Score: 30

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Other Information

**Key characteristics:** - The FOXO3B gene is a member of the forkhead box O (FOXO) family of transcription factors. - It is highly expressed in the enterocytes of the large intestine, colon goblet cells, intestinal crypt stem cells, transit amplifying cells of the small intestine, enterocytes of the small intestine, transit amplifying cells of the colon. - It is also expressed in central memory CD4-positive, alpha-beta T cell, tuft cell of colon, and BEST4+ intestinal epithelial cell. **Pathways and functions:** - FOXO3B is a key regulator of intestinal epithelial cell differentiation and function. - It is required for the development and maintenance of intestinal gland development and function. - It is also involved in the regulation of inflammation and mucosal barrier integrity. **Clinical significance:** - Mutations in the FOXO3B gene have been linked to several human diseases, including colorectal cancer, inflammatory bowel disease, and intestinal fibrosis. - Targeting FOXO3B has been investigated as a therapeutic strategy for these diseases. **Additional information:** - The FOXO3B gene is located on chromosome 17q21.1. - It is a highly conserved gene, with a similar gene found in humans, mice, and rats. - The FOXO3B protein is a transcriptional repressor that interacts with the DNA-binding protein FOXO1. - It is expressed in a variety of cell types, including epithelial cells, stromal cells, and immune cells.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.