Details for: FOXO3B

Gene ID: 2310

Symbol: FOXO3B

Ensembl ID: ENSG00000240445

Description: forkhead box O3B

Associated with

  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Mitochondrial matrix
    (GO:0005759)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.9244
    Cell Significance Index: 61.6400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.5578
    Cell Significance Index: 17.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.6536
    Cell Significance Index: 40.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3700
    Cell Significance Index: 70.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3260
    Cell Significance Index: 19.5700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3161
    Cell Significance Index: 4.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2809
    Cell Significance Index: 15.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2174
    Cell Significance Index: 4.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2152
    Cell Significance Index: 1.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1852
    Cell Significance Index: 3.9500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.1799
    Cell Significance Index: 1.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1706
    Cell Significance Index: 18.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1531
    Cell Significance Index: 9.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1322
    Cell Significance Index: 3.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1027
    Cell Significance Index: 14.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0905
    Cell Significance Index: 18.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0888
    Cell Significance Index: 3.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0880
    Cell Significance Index: 8.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0867
    Cell Significance Index: 1.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0847
    Cell Significance Index: 30.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0803
    Cell Significance Index: 5.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0764
    Cell Significance Index: 68.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0639
    Cell Significance Index: 10.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0466
    Cell Significance Index: 0.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0400
    Cell Significance Index: 1.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0320
    Cell Significance Index: 3.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0207
    Cell Significance Index: 1.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0160
    Cell Significance Index: 2.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0128
    Cell Significance Index: 0.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0119
    Cell Significance Index: 1.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0097
    Cell Significance Index: 1.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0074
    Cell Significance Index: 0.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0062
    Cell Significance Index: 0.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0054
    Cell Significance Index: 0.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0051
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0075
    Cell Significance Index: -3.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0102
    Cell Significance Index: -1.7500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0137
    Cell Significance Index: -0.1900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0149
    Cell Significance Index: -0.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0197
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0226
    Cell Significance Index: -4.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0319
    Cell Significance Index: -0.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0357
    Cell Significance Index: -1.3500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0372
    Cell Significance Index: -0.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0373
    Cell Significance Index: -1.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0386
    Cell Significance Index: -1.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0397
    Cell Significance Index: -1.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0431
    Cell Significance Index: -2.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0502
    Cell Significance Index: -1.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0584
    Cell Significance Index: -1.8600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0674
    Cell Significance Index: -0.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0747
    Cell Significance Index: -1.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0759
    Cell Significance Index: -1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0760
    Cell Significance Index: -3.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0763
    Cell Significance Index: -1.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0775
    Cell Significance Index: -2.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0802
    Cell Significance Index: -2.0000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0824
    Cell Significance Index: -0.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0837
    Cell Significance Index: -1.6800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0902
    Cell Significance Index: -1.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0915
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0921
    Cell Significance Index: -2.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0964
    Cell Significance Index: -1.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0973
    Cell Significance Index: -1.9800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0976
    Cell Significance Index: -1.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0977
    Cell Significance Index: -2.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1042
    Cell Significance Index: -0.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1095
    Cell Significance Index: -2.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1127
    Cell Significance Index: -2.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1179
    Cell Significance Index: -2.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1226
    Cell Significance Index: -1.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1242
    Cell Significance Index: -2.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1307
    Cell Significance Index: -3.8500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1348
    Cell Significance Index: -0.9800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1358
    Cell Significance Index: -3.4600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1389
    Cell Significance Index: -1.9200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1405
    Cell Significance Index: -1.3900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1466
    Cell Significance Index: -2.4700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1468
    Cell Significance Index: -1.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1534
    Cell Significance Index: -3.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1542
    Cell Significance Index: -1.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1544
    Cell Significance Index: -2.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1550
    Cell Significance Index: -3.0900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1632
    Cell Significance Index: -1.9700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1654
    Cell Significance Index: -2.7300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1675
    Cell Significance Index: -1.6200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1721
    Cell Significance Index: -2.0800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1752
    Cell Significance Index: -1.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1796
    Cell Significance Index: -2.4500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1872
    Cell Significance Index: -1.9500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1886
    Cell Significance Index: -2.5900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1895
    Cell Significance Index: -2.3500
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1906
    Cell Significance Index: -1.9600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1915
    Cell Significance Index: -2.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1929
    Cell Significance Index: -2.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOXO3B exhibits several distinct characteristics that contribute to its regulatory functions. These include: 1. **DNA-binding specificity**: FOXO3B binds to specific DNA sequences, allowing it to regulate gene expression in a targeted manner. 2. **Transcriptional repression**: FOXO3B functions as a transcriptional repressor, inhibiting the expression of genes involved in cell cycle progression, apoptosis, and metabolism. 3. **Cellular localization**: FOXO3B is primarily localized to the cytosol and nucleus, where it regulates gene expression and interacts with other transcription factors. 4. **Phosphorylation-dependent activity**: FOXO3B activity is regulated by phosphorylation, which modulates its transcriptional repressive capabilities. **Pathways and Functions** FOXO3B is involved in various signaling pathways that regulate cellular homeostasis and immune function. These include: 1. **AMP-activated protein kinase (AMPK) pathway**: FOXO3B regulates AMPK activity, which is involved in glucose metabolism and energy homeostasis. 2. **PI3K/AKT pathway**: FOXO3B inhibits AKT activity, which is involved in cell survival and metabolism. 3. **Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway**: FOXO3B regulates NF-κB activity, which is involved in immune responses and inflammation. 4. **Cell cycle regulation**: FOXO3B regulates cell cycle progression by inhibiting the expression of cyclin-dependent kinases. FOXO3B plays a critical role in maintaining cellular homeostasis by regulating: 1. **Apoptosis**: FOXO3B promotes apoptosis in response to DNA damage, ensuring the elimination of damaged cells. 2. **Metabolism**: FOXO3B regulates glucose and lipid metabolism, influencing energy homeostasis. 3. **Immune responses**: FOXO3B regulates the expression of genes involved in immune responses, including cytokine production and T cell activation. **Clinical Significance** Dysregulation of FOXO3B has been implicated in various diseases, including: 1. **Cancer**: FOXO3B is often downregulated in cancer cells, leading to uncontrolled proliferation and survival. 2. **Autoimmune disorders**: FOXO3B regulates immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Metabolic disorders**: FOXO3B regulates glucose and lipid metabolism, and its dysregulation has been implicated in metabolic disorders, such as type 2 diabetes and obesity. 4. **Aging and age-related diseases**: FOXO3B is involved in the regulation of cellular homeostasis, and its dysregulation has been implicated in aging and age-related diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, FOXO3B is a critical regulator of cellular homeostasis and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its regulatory mechanisms and therapeutic potential. Further research is needed to fully elucidate the role of FOXO3B in human disease and to develop targeted therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.