Details for: FLNB

Gene ID: 2317

Symbol: FLNB

Ensembl ID: ENSG00000136068

Description: filamin B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 285.7690
    Cell Significance Index: -44.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.4615
    Cell Significance Index: -40.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 98.8408
    Cell Significance Index: -46.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.6567
    Cell Significance Index: -40.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.8542
    Cell Significance Index: -39.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.0597
    Cell Significance Index: -44.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.2517
    Cell Significance Index: -46.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.1657
    Cell Significance Index: -35.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.2776
    Cell Significance Index: -37.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2923
    Cell Significance Index: -44.5600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 9.4730
    Cell Significance Index: 152.3200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.3481
    Cell Significance Index: 39.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.8132
    Cell Significance Index: 102.1800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.3061
    Cell Significance Index: 47.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9265
    Cell Significance Index: 580.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.8673
    Cell Significance Index: 76.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.5120
    Cell Significance Index: 37.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4187
    Cell Significance Index: 33.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.2737
    Cell Significance Index: 100.5700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.2210
    Cell Significance Index: 13.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.2080
    Cell Significance Index: 83.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1281
    Cell Significance Index: 110.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0314
    Cell Significance Index: 58.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9087
    Cell Significance Index: 234.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8849
    Cell Significance Index: 676.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8556
    Cell Significance Index: 301.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8378
    Cell Significance Index: 83.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7552
    Cell Significance Index: 91.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7306
    Cell Significance Index: 132.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.7216
    Cell Significance Index: 36.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7207
    Cell Significance Index: 310.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7098
    Cell Significance Index: 15.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6344
    Cell Significance Index: 177.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5083
    Cell Significance Index: 41.0600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.4296
    Cell Significance Index: 8.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4012
    Cell Significance Index: 281.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3940
    Cell Significance Index: 34.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.2714
    Cell Significance Index: 577.0400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.2348
    Cell Significance Index: 17.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0086
    Cell Significance Index: 16.9900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9450
    Cell Significance Index: 10.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8759
    Cell Significance Index: 25.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8261
    Cell Significance Index: 55.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8243
    Cell Significance Index: 744.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7499
    Cell Significance Index: 55.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7246
    Cell Significance Index: 395.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6915
    Cell Significance Index: 32.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6902
    Cell Significance Index: 32.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6877
    Cell Significance Index: 19.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6538
    Cell Significance Index: 12.7600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5972
    Cell Significance Index: 6.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5264
    Cell Significance Index: 232.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5147
    Cell Significance Index: 355.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4639
    Cell Significance Index: 45.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4493
    Cell Significance Index: 57.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3729
    Cell Significance Index: 63.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3473
    Cell Significance Index: 640.5500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3145
    Cell Significance Index: 1.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3108
    Cell Significance Index: 6.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2527
    Cell Significance Index: 160.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2428
    Cell Significance Index: 8.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2065
    Cell Significance Index: 39.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1640
    Cell Significance Index: 252.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1562
    Cell Significance Index: 10.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1353
    Cell Significance Index: 17.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1226
    Cell Significance Index: 6.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0628
    Cell Significance Index: 8.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0619
    Cell Significance Index: 116.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0478
    Cell Significance Index: 65.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0173
    Cell Significance Index: 12.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0123
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0184
    Cell Significance Index: -13.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0187
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0282
    Cell Significance Index: -17.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0327
    Cell Significance Index: -0.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0342
    Cell Significance Index: -2.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0388
    Cell Significance Index: -29.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0606
    Cell Significance Index: -34.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0959
    Cell Significance Index: -20.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0975
    Cell Significance Index: -11.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1155
    Cell Significance Index: -13.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1180
    Cell Significance Index: -12.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1201
    Cell Significance Index: -12.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1373
    Cell Significance Index: -39.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1766
    Cell Significance Index: -25.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1817
    Cell Significance Index: -11.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2116
    Cell Significance Index: -12.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2845
    Cell Significance Index: -7.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3020
    Cell Significance Index: -35.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3394
    Cell Significance Index: -10.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3529
    Cell Significance Index: -7.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3882
    Cell Significance Index: -5.7300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.4231
    Cell Significance Index: -3.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4599
    Cell Significance Index: -10.0700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4714
    Cell Significance Index: -7.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4747
    Cell Significance Index: -23.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5242
    Cell Significance Index: -41.5200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5599
    Cell Significance Index: -4.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6049
    Cell Significance Index: -38.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6526
    Cell Significance Index: -40.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FLNB is a member of the filamin family, which are large, cytoskeletal proteins that interact with multiple partners to regulate actin dynamics and cell shape. FLNB is a tetrameric protein composed of four identical subunits, each consisting of approximately 900 amino acids. Its molecular weight is approximately 290 kDa, and it is widely expressed in various tissues, including epithelial cells, muscle cells, and the nervous system. **Pathways and Functions:** FLNB is involved in numerous cellular processes, including: 1. **Actin cytoskeleton organization**: FLNB interacts with actin-binding proteins to regulate the dynamics of the actin cytoskeleton, which is essential for cell shape, movement, and signaling. 2. **Cell adhesion**: FLNB binds to cadherins, a family of transmembrane proteins involved in cell-cell adhesion, thereby regulating cell-cell interactions and tissue morphogenesis. 3. **Signaling pathways**: FLNB interacts with various signaling molecules, including integrins, growth factors, and cytokines, to regulate cell growth, differentiation, and survival. 4. **Immune system regulation**: FLNB is expressed in immune cells, including endothelial cells, macrophages, and T cells, and plays a role in regulating immune responses, including cytokine signaling and interferon-mediated antiviral mechanisms. **Signaling Pathways and Functions:** FLNB is involved in several signaling pathways, including: 1. **Actin cytoskeleton organization**: FLNB interacts with actin-binding proteins, such as profilin and actin-associated proteins, to regulate actin dynamics. 2. **Cytokine signaling**: FLNB interacts with cytokine receptors, such as IL-1β and TNF-α, to regulate cytokine signaling and immune responses. 3. **Interferon signaling**: FLNB is involved in antiviral mechanisms mediated by interferons, including the regulation of ISG15 expression. 4. **Cell adhesion**: FLNB binds to cadherins, which are involved in cell-cell adhesion and tissue morphogenesis. **Clinical Significance:** Dysregulation of FLNB has been implicated in various diseases, including: 1. **Cancer**: FLNB mutations have been identified in several types of cancer, including breast, lung, and colon cancer, where they contribute to tumorigenesis and metastasis. 2. **Neurological disorders**: FLNB mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease and frontotemporal dementia. 3. **Immunological disorders**: FLNB is involved in regulating immune responses, and dysregulation of FLNB has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, FLNB is a multifaceted protein that plays a crucial role in various cellular processes, including actin cytoskeleton organization, cell adhesion, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of FLNB in maintaining cellular homeostasis and immune system regulation.

Genular Protein ID: 252061028

Symbol: FLNB_HUMAN

Name: Filamin-B

UniProtKB Accession Codes:

O75369 B2ZZ83 B2ZZ84 B2ZZ85 C9JKE6 C9JMC4 Q13706 Q59EC2 Q60FE7 Q6MZJ1 Q8WXS9 Q8WXT0 Q8WXT1 Q8WXT2 Q8WXT3 Q9NRB5 Q9NT26 Q9UEV9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CPTAC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 58 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9651345

Title: Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha.

PubMed ID: 9651345

DOI: 10.1074/jbc.273.28.17531

PubMed ID: 9694715

Title: A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.

PubMed ID: 9694715

PubMed ID: 11807098

Title: Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits.

PubMed ID: 11807098

DOI: 10.1083/jcb.200103037

PubMed ID: 11153914

Title: Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.

PubMed ID: 11153914

DOI: 10.1007/s004390000414

PubMed ID: 18487259

Title: Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method.

PubMed ID: 18487259

DOI: 10.1093/dnares/dsn010

PubMed ID: 16106752

Title: Vector-capping: a simple method for preparing a high-quality full-length cDNA library.

PubMed ID: 16106752

DOI: 10.1093/dnares/12.1.53

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 11739414

Title: The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

PubMed ID: 11739414

DOI: 10.1083/jcb.200104005

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 9437013

Title: Interaction of presenilins with the filamin family of actin-binding proteins.

PubMed ID: 9437013

DOI: 10.1523/jneurosci.18-03-00914.1998

PubMed ID: 8327473

Title: Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins.

PubMed ID: 8327473

DOI: 10.1073/pnas.90.13.5994

PubMed ID: 10754391

Title: Hepatitis B virus core protein interacts with the C-terminal region of actin-binding protein.

PubMed ID: 10754391

DOI: 10.1007/bf02256623

PubMed ID: 12393796

Title: Filamin A and filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.

PubMed ID: 12393796

DOI: 10.1093/hmg/11.23.2845

PubMed ID: 12496242

Title: A new member of the LIM protein family binds to filamin B and localizes at stress fibers.

PubMed ID: 12496242

DOI: 10.1074/jbc.m209339200

PubMed ID: 12525170

Title: The limits of promiscuity: isoform-specific dimerization of filamins.

PubMed ID: 12525170

DOI: 10.1021/bi026501+

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16076904

Title: The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.

PubMed ID: 16076904

DOI: 10.1242/jcs.02484

PubMed ID: 11336782

Title: Structural and functional aspects of filamins.

PubMed ID: 11336782

DOI: 10.1016/s0167-4889(01)00072-6

PubMed ID: 11252955

Title: Filamins as integrators of cell mechanics and signalling.

PubMed ID: 11252955

DOI: 10.1038/35052082

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19300455

Title: The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation.

PubMed ID: 19300455

DOI: 10.1038/cdd.2009.27

PubMed ID: 19270716

Title: ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.

PubMed ID: 19270716

DOI: 10.1038/embor.2009.23

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19505475

Title: Disease-associated substitutions in the filamin B actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin binding domains.

PubMed ID: 19505475

DOI: 10.1016/j.jmb.2009.06.009

PubMed ID: 14991055

Title: Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis.

PubMed ID: 14991055

DOI: 10.1038/ng1319

PubMed ID: 15994868

Title: Mutations in FLNB cause boomerang dysplasia.

PubMed ID: 15994868

DOI: 10.1136/jmg.2004.029967

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 16801345

Title: A molecular and clinical study of Larsen syndrome caused by mutations in FLNB.

PubMed ID: 16801345

DOI: 10.1136/jmg.2006.043687

Sequence Information:

  • Length: 2602
  • Mass: 278164
  • Checksum: 1BF5C64C86360C6A
  • Sequence:
    • MPVTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVNKRIGNL QTDLSDGLRL IALLEVLSQK 
RMYRKYHQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK AIVDGNLKLI LGLVWTLILH 
YSISMPVWED EGDDDAKKQT PKQRLLGWIQ NKIPYLPITN FNQNWQDGKA LGALVDSCAP 
GLCPDWESWD PQKPVDNARE AMQQADDWLG VPQVITPEEI IHPDVDEHSV MTYLSQFPKA 
KLKPGAPLKP KLNPKKARAY GRGIEPTGNM VKQPAKFTVD TISAGQGDVM VFVEDPEGNK 
EEAQVTPDSD KNKTYSVEYL PKVTGLHKVT VLFAGQHISK SPFEVSVDKA QGDASKVTAK 
GPGLEAVGNI ANKPTYFDIY TAGAGVGDIG VEVEDPQGKN TVELLVEDKG NQVYRCVYKP 
MQPGPHVVKI FFAGDTIPKS PFVVQVGEAC NPNACRASGR GLQPKGVRIR ETTDFKVDTK 
AAGSGELGVT MKGPKGLEEL VKQKDFLDGV YAFEYYPSTP GRYSIAITWG GHHIPKSPFE 
VQVGPEAGMQ KVRAWGPGLH GGIVGRSADF VVESIGSEVG SLGFAIEGPS QAKIEYNDQN 
DGSCDVKYWP KEPGEYAVHI MCDDEDIKDS PYMAFIHPAT GGYNPDLVRA YGPGLEKSGC 
IVNNLAEFTV DPKDAGKAPL KIFAQDGEGQ RIDIQMKNRM DGTYACSYTP VKAIKHTIAV 
VWGGVNIPHS PYRVNIGQGS HPQKVKVFGP GVERSGLKAN EPTHFTVDCT EAGEGDVSVG 
IKCDARVLSE DEEDVDFDII HNANDTFTVK YVPPAAGRYT IKVLFASQEI PASPFRVKVD 
PSHDASKVKA EGPGLSKAGV ENGKPTHFTV YTKGAGKAPL NVQFNSPLPG DAVKDLDIID 
NYDYSHTVKY TPTQQGNMQV LVTYGGDPIP KSPFTVGVAA PLDLSKIKLN GLENRVEVGK 
DQEFTVDTRG AGGQGKLDVT ILSPSRKVVP CLVTPVTGRE NSTAKFIPRE EGLYAVDVTY 
DGHPVPGSPY TVEASLPPDP SKVKAHGPGL EGGLVGKPAE FTIDTKGAGT GGLGLTVEGP 
CEAKIECSDN GDGTCSVSYL PTKPGEYFVN ILFEEVHIPG SPFKADIEMP FDPSKVVASG 
PGLEHGKVGE AGLLSVDCSE AGPGALGLEA VSDSGTKAEV SIQNNKDGTY AVTYVPLTAG 
MYTLTMKYGG ELVPHFPARV KVEPAVDTSR IKVFGPGIEG KDVFREATTD FTVDSRPLTQ 
VGGDHIKAHI ANPSGASTEC FVTDNADGTY QVEYTPFEKG LHVVEVTYDD VPIPNSPFKV 
AVTEGCQPSR VQAQGPGLKE AFTNKPNVFT VVTRGAGIGG LGITVEGPSE SKINCRDNKD 
GSCSAEYIPF APGDYDVNIT YGGAHIPGSP FRVPVKDVVD PSKVKIAGPG LGSGVRARVL 
QSFTVDSSKA GLAPLEVRVL GPRGLVEPVN VVDNGDGTHT VTYTPSQEGP YMVSVKYADE 
EIPRSPFKVK VLPTYDASKV TASGPGLSSY GVPASLPVDF AIDARDAGEG LLAVQITDQE 
GKPKRAIVHD NKDGTYAVTY IPDKTGRYMI GVTYGGDDIP LSPYRIRATQ TGDASKCLAT 
GPGIASTVKT GEEVGFVVDA KTAGKGKVTC TVLTPDGTEA EADVIENEDG TYDIFYTAAK 
PGTYVIYVRF GGVDIPNSPF TVMATDGEVT AVEEAPVNAC PPGFRPWVTE EAYVPVSDMN 
GLGFKPFDLV IPFAVRKGEI TGEVHMPSGK TATPEIVDNK DGTVTVRYAP TEVGLHEMHI 
KYMGSHIPES PLQFYVNYPN SGSVSAYGPG LVYGVANKTA TFTIVTEDAG EGGLDLAIEG 
PSKAEISCID NKDGTCTVTY LPTLPGDYSI LVKYNDKHIP GSPFTAKITD DSRRCSQVKL 
GSAADFLLDI SETDLSSLTA SIKAPSGRDE PCLLKRLPNN HIGISFIPRE VGEHLVSIKK 
NGNHVANSPV SIMVVQSEIG DARRAKVYGR GLSEGRTFEM SDFIVDTRDA GYGGISLAVE 
GPSKVDIQTE DLEDGTCKVS YFPTVPGVYI VSTKFADEHV PGSPFTVKIS GEGRVKESIT 
RTSRAPSVAT VGSICDLNLK IPEINSSDMS AHVTSPSGRV TEAEIVPMGK NSHCVRFVPQ 
EMGVHTVSVK YRGQHVTGSP FQFTVGPLGE GGAHKVRAGG PGLERGEAGV PAEFSIWTRE 
AGAGGLSIAV EGPSKAEITF DDHKNGSCGV SYIAQEPGNY EVSIKFNDEH IPESPYLVPV 
IAPSDDARRL TVMSLQESGL KVNQPASFAI RLNGAKGKID AKVHSPSGAV EECHVSELEP 
DKYAVRFIPH ENGVHTIDVK FNGSHVVGSP FKVRVGEPGQ AGNPALVSAY GTGLEGGTTG 
IQSEFFINTT RAGPGTLSVT IEGPSKVKMD CQETPEGYKV MYTPMAPGNY LISVKYGGPN 
HIVGSPFKAK VTGQRLVSPG SANETSSILV ESVTRSSTET CYSAIPKASS DASKVTSKGA 
GLSKAFVGQK SSFLVDCSKA GSNMLLIGVH GPTTPCEEVS MKHVGNQQYN VTYVVKERGD 
YVLAVKWGEE HIPGSPFHVT VP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.