Details for: FOSL2

Gene ID: 2355

Symbol: FOSL2

Ensembl ID: ENSG00000075426

Description: FOS like 2, AP-1 transcription factor subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3
    Marker Score: 3207
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.55
    Marker Score: 7056
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.44
    Marker Score: 2565
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.38
    Marker Score: 5856
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.18
    Marker Score: 3212
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.14
    Marker Score: 4510
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.12
    Marker Score: 1265
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.09
    Marker Score: 37092
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.94
    Marker Score: 12355
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.92
    Marker Score: 2125
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.85
    Marker Score: 1258
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.79
    Marker Score: 2596
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.75
    Marker Score: 784
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.73
    Marker Score: 14867
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.71
    Marker Score: 4312
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.68
    Marker Score: 416
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.67
    Marker Score: 56873
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.67
    Marker Score: 647
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.65
    Marker Score: 1891
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.65
    Marker Score: 1272
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.65
    Marker Score: 820
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.64
    Marker Score: 2325
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.63
    Marker Score: 699
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.62
    Marker Score: 6985
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.61
    Marker Score: 5979
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.6
    Marker Score: 3197
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.6
    Marker Score: 911
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.6
    Marker Score: 500
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.57
    Marker Score: 3570
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.56
    Marker Score: 6495
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.56
    Marker Score: 484
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.56
    Marker Score: 2635
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.51
    Marker Score: 3644
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.49
    Marker Score: 357
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.48
    Marker Score: 2630
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.48
    Marker Score: 4650
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.47
    Marker Score: 1914
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.47
    Marker Score: 1155
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.46
    Marker Score: 371
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166624
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.45
    Marker Score: 5584
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.44
    Marker Score: 3598
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.43
    Marker Score: 835
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.43
    Marker Score: 1232
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.39
    Marker Score: 1797
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.38
    Marker Score: 444
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.37
    Marker Score: 6589
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.36
    Marker Score: 10594.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.35
    Marker Score: 456
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.34
    Marker Score: 579
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.34
    Marker Score: 1202
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.31
    Marker Score: 421
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.3
    Marker Score: 1109
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.3
    Marker Score: 472
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.3
    Marker Score: 2183
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.28
    Marker Score: 71301
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.27
    Marker Score: 1097
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.27
    Marker Score: 1369
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.27
    Marker Score: 546
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.27
    Marker Score: 1287
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.26
    Marker Score: 2374
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.26
    Marker Score: 448
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.26
    Marker Score: 1059
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.24
    Marker Score: 1038
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19433
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.23
    Marker Score: 514
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.23
    Marker Score: 619
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.21
    Marker Score: 1208
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.21
    Marker Score: 299
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.2
    Marker Score: 277
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.2
    Marker Score: 719
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.19
    Marker Score: 595
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.19
    Marker Score: 7237
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.19
    Marker Score: 240
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.19
    Marker Score: 5837
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.18
    Marker Score: 1144
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.18
    Marker Score: 1356
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.18
    Marker Score: 406
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.16
    Marker Score: 3398
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.16
    Marker Score: 668
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.16
    Marker Score: 765
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.16
    Marker Score: 2549
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.16
    Marker Score: 530
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.16
    Marker Score: 13014
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.15
    Marker Score: 1042
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.15
    Marker Score: 1351
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.15
    Marker Score: 1883
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.15
    Marker Score: 460
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.14
    Marker Score: 286
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.14
    Marker Score: 276
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.13
    Marker Score: 414
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.13
    Marker Score: 2935
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.13
    Marker Score: 1396
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.13
    Marker Score: 4718
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.13
    Marker Score: 2289
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.12
    Marker Score: 1268
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.11
    Marker Score: 2918
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.11
    Marker Score: 277
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.11
    Marker Score: 236
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.1
    Marker Score: 277

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Other Information

**Key characteristics:** * FOSL2 is a member of the FOS family of transcription factors. * It is a key regulator of cell death. * It is also involved in the regulation of inflammation, keratinocyte development, and osteoblast differentiation. * It is expressed in a variety of cell types, including skeletal muscle satellite stem cells, decidual natural killer cells, and corneal epithelial cells. **Pathways and functions:** * FOSL2 is a key regulator of cell death. It does this by binding to the Rna polymerase ii cis-regulatory region sequence-specific DNA binding (RnaPii-SR) and promoting the degradation of the FOXO1 transcription factor. * It is also involved in the regulation of inflammation. It does this by binding to the RnaPii-SR and promoting the transcription of inflammatory genes. * It is also involved in the regulation of keratinocyte development. It does this by binding to the RnaPii-SR and promoting the expression of keratin genes. * It is also involved in the regulation of osteoblast differentiation. It does this by binding to the RnaPii-SR and promoting the expression of osteoblast-specific genes. **Clinical significance:** * Mutations in the FOSL2 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * Targeting the FOSL2 gene has been investigated as a therapeutic strategy for these diseases. **Additional information:** * The FOSL2 gene is located on chromosome 17q21.1. * It is a highly conserved gene, with a similar gene found in mice. * It is expressed in high levels in many human tissues, including muscle, skin, and blood.

Genular Protein ID: 2581031366

Symbol: FOSL2_HUMAN

Name: Fos-related antigen 2

UniProtKB Accession Codes:

P15408 B2RD58 B3KP27 B4DYV4 Q6FG46

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 56 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2107490

Title: Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.

PubMed ID: 2107490

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 326
  • Mass: 35193
  • Checksum: F61738BE23C5026F
  • Sequence:
    • MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL 
QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS 
PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL 
EFMLVAHGPV CKISPEERRS PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK 
AQRSVIKPIS IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC 
SKAHRRSSSS GDQSSDSLNS PTLLAL

Genular Protein ID: 1004375905

Symbol: Q9H5M2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H5M2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 23950983

Title: Direct detection of alternative open reading frames translation products in human significantly expands the proteome.

PubMed ID: 23950983

DOI: 10.1371/journal.pone.0070698

Sequence Information:

  • Length: 122
  • Mass: 12957
  • Checksum: 701BAD1E6D421AD6
  • Sequence:
    • MSVGLDLPQM LPGSPSPSLK EAFAEDGEAG EGGGRPSLEW RLQQLLPQHP LSLSWLLTSP 
QGTGPFLPSV VICHLLDQVL SLLHSPVPTP VHSSGPGSKQ AVNSWPELSL WLVAHAPFLV 
VC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.