Details for: CENPI

Gene ID: 2491

Symbol: CENPI

Ensembl ID: ENSG00000102384

Description: centromere protein I

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169666
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.35
    Marker Score: 2793
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.3
    Marker Score: 851
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5289
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 562
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.69
    Marker Score: 309
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1311
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.63
    Marker Score: 353
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1158
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.59
    Marker Score: 366
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8857
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 351
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.53
    Marker Score: 217
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 312
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.42
    Marker Score: 511
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 884
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 239
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.36
    Marker Score: 3669
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.33
    Marker Score: 322
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.33
    Marker Score: 521
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 149
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.28
    Marker Score: 489
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.27
    Marker Score: 725
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.27
    Marker Score: 301
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.27
    Marker Score: 180
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.23
    Marker Score: 953
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 352
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1270
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.21
    Marker Score: 492
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.21
    Marker Score: 12633
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 175
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2
    Marker Score: 44
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.2
    Marker Score: 147
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.19
    Marker Score: 95
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 110
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.19
    Marker Score: 51
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.19
    Marker Score: 1773
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.19
    Marker Score: 120
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.18
    Marker Score: 749
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 158
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.16
    Marker Score: 323
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 72
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.16
    Marker Score: 160
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.16
    Marker Score: 5805
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.16
    Marker Score: 299
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.15
    Marker Score: 503
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.15
    Marker Score: 124
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.15
    Marker Score: 197
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.15
    Marker Score: 139
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.15
    Marker Score: 2907
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.14
    Marker Score: 102
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.14
    Marker Score: 402
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.14
    Marker Score: 120
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.14
    Marker Score: 251
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.14
    Marker Score: 57
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.14
    Marker Score: 121
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.13
    Marker Score: 27
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.13
    Marker Score: 558

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Other Information

**Key characteristics**: - The CENPI gene is located on chromosome 17q21.1. - It is a large gene with a length of approximately 1.2 million base pairs. - It contains 13 exons and 12 intron. - It is expressed in a variety of cell types, including mural cells, kidney proximal convoluted tubule epithelial cells, T-helper 17 cells, intestinal crypt stem cells, enterocytes, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, tuft cells of colon, and BEST4+ intestinal epithelial cells. **Pathways and functions**: - CENPI protein is a key component of the mitotic spindle assembly pathway, where it is required for the assembly of the spindle fibers that attach the chromosomes to the microtubules. - It is also involved in cell cycle checkpoints, where it helps to ensure that the cell has completed all of the necessary steps before proceeding to the next phase of the cell cycle. - CENPI is also involved in the resolution of sister chromatid cohesion, where it helps to correct errors in chromosome segregation. **Clinical significance**: - Mutations in the CENPI gene have been linked to a number of human diseases, including cancer and developmental disorders. - These diseases are often caused by defects in the assembly of the mitotic spindle, which can lead to chromosome missegregation and cell cycle abnormalities. - Therefore, CENPI is a promising target for the treatment of human cancers and developmental disorders that are caused by defects in chromosome segregation.

Genular Protein ID: 1284718885

Symbol: CENPI_HUMAN

Name: Centromere protein I

UniProtKB Accession Codes:

Q92674 Q5JWZ9 Q96ED0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 8 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 9 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 7 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8921378

Title: Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene.

PubMed ID: 8921378

DOI: 10.1006/geno.1996.0528

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12640463

Title: Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis.

PubMed ID: 12640463

DOI: 10.1038/ncb953

PubMed ID: 16716197

Title: Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.

PubMed ID: 16716197

DOI: 10.1111/j.1365-2443.2006.00969.x

PubMed ID: 16622420

Title: The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.

PubMed ID: 16622420

DOI: 10.1038/ncb1396

PubMed ID: 16622419

Title: The human CENP-A centromeric nucleosome-associated complex.

PubMed ID: 16622419

DOI: 10.1038/ncb1397

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20212317

Title: The SUMO protease SENP6 is essential for inner kinetochore assembly.

PubMed ID: 20212317

DOI: 10.1083/jcb.200909008

Sequence Information:

  • Length: 756
  • Mass: 86720
  • Checksum: A3439CF1729D7A66
  • Sequence:
    • MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP VGDYEHADDQ 
AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW KNGLASEEID ILLNIALSGK 
FGNAVNTRIL KCMIPATVIS EDSVVKAVSW LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ 
INLLYGFFFA SLQDDALCPY VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS 
LYKFFAPALI SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL 
KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL LQNIHCLELP 
SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC IWYKVNNYEH GKEFTNFLDT 
IIRAECFLQE GFYSCEAFLY KSLPLWDGLC CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ 
LFFTSTIYFK CSVLQSLKEL LQNWLLWLSM DIHMKPVTNS PLETTLGGSM NSVSKLIHYV 
GWLSTTAMRL ESNNTFLLHF ILDFYEKVCD IYINYNLPLV VLFPPGIFYS ALLSLDTSIL 
NQLCFIMHRY RKNLTAAKKN ELVQKTKSEF NFSSKTYQEF NHYLTSMVGC LWTSKPFGKG 
IYIDPEILEK TGVAEYKNSL NVVHHPSFLS YAVSFLLQES PEERTVNVSS IRGKKWSWYL 
DYLFSQGLQG LKLFIRSSVH HSSIPRAEGI NCNNQY

Genular Protein ID: 4269578071

Symbol: A0A8C8KX99_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8C8KX99

Database IDs:

ARBA 6 CTD 1 EMBL 1 EPD 1 Ensembl 2 GO 4 GeneTree 1 HGNC 1 InterPro 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMR 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 742
  • Mass: 85136
  • Checksum: 684F66EA41AD56CE
  • Sequence:
    • MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP VGDYEHADDQ 
AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW KNGLASEEID ILLNIALSGK 
FGNAVNTRIL KCMIPATVIS EDSVVKAVSW LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ 
INLLYGFFFA SLQDDALCPY VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS 
LYKFFAPALI SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL 
KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL LQNIHCLELP 
SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC IWYKVNNYEH GKEFTNFLDT 
IIRAECFLQE GFYSCEAFLY KSLPLWDGLC CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ 
LFFTSTIYFK CSVLQSLKEL LQNWLLWLSM DIHMKPVTNS PLETTLGGSM NSVSKLIHYV 
GWLSTTAMRL ESNNTFLLHF ILDFYEKVCD IYINYNLPLV VLFPPGIFYS ALLSLDTSIL 
NQLCFIMHRY RKNLTAAKKN ELVQKTKSEF NFSSKTYQEF NHYLTSMVGC LWTSKPFGKG 
IYIDPEILEK TGVAEYKNSL NVVHHPSFLS YAVSFLLQGK KWSWYLDYLF SQGLQGLKLF 
IRSSVHHSSI PRAEGINCNN QY

Genular Protein ID: 567902340

Symbol: B4DZL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DZL4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 742
  • Mass: 85106
  • Checksum: 684F619BF1AD5ABF
  • Sequence:
    • MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP VGDYEHADDQ 
AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW KNGLASEEID ILLNIALSGK 
FGNAVNTRIL KCMIPATVIS EDSVVKAVSW LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ 
INLLYGFFFA SLQDDALCPY VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS 
LYKFFAPALI SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL 
KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL LQNIHCLELP 
SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC IWYKVNNYEH GKEFTNFLDT 
IIRAECFLQE GFYSCEAFLY KSLPLWDGLC CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ 
LFFASTIYFK CSVLQSLKEL LQNWLLWLSM DIHMKPVTNS PLETTLGGSM NSVSKLIHYV 
GWLSTTAMRL ESNNTFLLHF ILDFYEKVCD IYINYNLPLV VLFPPGIFYS ALLSLDTSIL 
NQLCFIMHRY RKNLTAAKKN ELVQKTKSEF NFSSKTYQEF NHYLTSMVGC LWTSKPFGKG 
IYIDPEILEK TGVAEYKNSL NVVHHPSFLS YAVSFLLQGK KWSWYLDYLF SQGLQGLKLF 
IRSSVHHSSI PRAEGINCNN QY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.