Details for: FUT2

Gene ID: 2524

Symbol: FUT2

Ensembl ID: ENSG00000176920

Description: fucosyltransferase 2 (H blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.14
    Marker Score: 1429
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.99
    Marker Score: 629
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.85
    Marker Score: 8870
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.77
    Marker Score: 872
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.75
    Marker Score: 816
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.63
    Marker Score: 1108
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.55
    Marker Score: 2824.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.55
    Marker Score: 9871
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.47
    Marker Score: 1230
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.34
    Marker Score: 388
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.33
    Marker Score: 3026
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.32
    Marker Score: 1174
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.31
    Marker Score: 2023
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.29
    Marker Score: 2924
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.22
    Marker Score: 3824
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.12
    Marker Score: 1309
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.04
    Marker Score: 252
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.01
    Marker Score: 7529
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1
    Marker Score: 248
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.98
    Marker Score: 603
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.93
    Marker Score: 2209
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.88
    Marker Score: 873
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.86
    Marker Score: 323
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 642.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1359
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.82
    Marker Score: 7097
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.82
    Marker Score: 789
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.8
    Marker Score: 320.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.79
    Marker Score: 202
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.78
    Marker Score: 224
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1441
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2596
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.75
    Marker Score: 1855
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 672
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.72
    Marker Score: 302
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7
    Marker Score: 1031
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.68
    Marker Score: 5883
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.66
    Marker Score: 1399
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.61
    Marker Score: 4775
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.53
    Marker Score: 183
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.52
    Marker Score: 6978
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.51
    Marker Score: 542
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.5
    Marker Score: 948
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.48
    Marker Score: 117
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.47
    Marker Score: 749
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.44
    Marker Score: 679
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.43
    Marker Score: 118
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.39
    Marker Score: 269.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.39
    Marker Score: 684
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.38
    Marker Score: 494
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.37
    Marker Score: 135
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.36
    Marker Score: 729
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.36
    Marker Score: 72
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.36
    Marker Score: 281
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.35
    Marker Score: 5415
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.35
    Marker Score: 159
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.34
    Marker Score: 98
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.34
    Marker Score: 142
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.33
    Marker Score: 171
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.33
    Marker Score: 20101
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.32
    Marker Score: 88
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 317
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.31
    Marker Score: 130
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.3
    Marker Score: 91
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.29
    Marker Score: 80
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.28
    Marker Score: 61
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.28
    Marker Score: 1162
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.27
    Marker Score: 296
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.27
    Marker Score: 2297
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.27
    Marker Score: 138
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.26
    Marker Score: 180
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.25
    Marker Score: 1532
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.25
    Marker Score: 285
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.25
    Marker Score: 180
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.25
    Marker Score: 8558
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.25
    Marker Score: 623

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Other Information

**Key characteristics:** * The FUT2 gene is located on chromosome 15p13.1. * It is a large gene with a length of approximately 10.6 kb. * It contains 13 exons and 12 introns. * The encoded protein is a transmembrane protein with a molecular weight of approximately 150 kDa. **Pathways and functions:** * FUT2 is involved in the ABO blood group biosynthesis pathway. * It is a key enzyme in the synthesis of Lewis blood group antigen. * It is also involved in the biosynthesis of other blood group antigens, such as Galactoside A and Galactoside B. * FUT2 activity is also involved in the metabolism of carbohydrates, lipids, and proteins. **Clinical significance:** * Mutations in the FUT2 gene have been linked to the ABO blood group system. * People with FUT2 mutations can have blood types that are different from their own. * This can lead to problems such as transfusion reactions, which are immune reactions between incompatible blood types. * FUT2 mutations are also associated with certain diseases, such as celiac disease and Hunter syndrome. **Additional notes:** * FUT2 is a highly conserved gene, with similar genes found in other mammals. * It is expressed in high levels in the blood, particularly in cells of the immune system. * FUT2 is a regulated gene, with its expression being controlled by various factors, including hormones and cytokines.

Genular Protein ID: 1756050512

Symbol: FUT2_HUMAN

Name: Alpha(1,2)FT 2

UniProtKB Accession Codes:

Q10981 Q0VAG5 Q14338 Q5D0G2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 65 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 26 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7876235

Title: Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.

PubMed ID: 7876235

DOI: 10.1074/jbc.270.9.4640

PubMed ID: 9219535

Title: Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).

PubMed ID: 9219535

DOI: 10.1111/j.1432-1033.1997.t01-1-00750.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8621666

Title: Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals.

PubMed ID: 8621666

DOI: 10.1074/jbc.271.16.9830

PubMed ID: 8755920

Title: Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency.

PubMed ID: 8755920

PubMed ID: 8018146

Title: Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.

PubMed ID: 8018146

DOI: 10.1126/science.8018146

PubMed ID: 12692541

Title: Human susceptibility and resistance to Norwalk virus infection.

PubMed ID: 12692541

DOI: 10.1038/nm860

PubMed ID: 20506485

Title: RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation.

PubMed ID: 20506485

DOI: 10.1002/jcb.22692

PubMed ID: 21625510

Title: Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine.

PubMed ID: 21625510

DOI: 10.1371/journal.pone.0020113

PubMed ID: 22068912

Title: Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype.

PubMed ID: 22068912

DOI: 10.1073/pnas.1106408108

PubMed ID: 24733310

Title: Faecal microbiota composition in adults is associated with the FUT2 gene determining the secretor status.

PubMed ID: 24733310

DOI: 10.1371/journal.pone.0094863

PubMed ID: 9760207

Title: Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa.

PubMed ID: 9760207

DOI: 10.1007/s004390050808

PubMed ID: 18776911

Title: Common variants of FUT2 are associated with plasma vitamin B12 levels.

PubMed ID: 18776911

DOI: 10.1038/ng.210

Sequence Information:

  • Length: 343
  • Mass: 39017
  • Checksum: 12066D9CF175E13A
  • Sequence:
    • MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS TSKALGPSQL 
RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH STLAPIFRIT LPVLHSATAS 
RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY PCSWTFYHHL RQEILQEFTL HDHVREEAQK 
FLRGLQVNGS RPGTFVGVHV RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSLIFV 
VTSNGMAWCR ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG 
GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.