Details for: FUT2

Gene ID: 2524

Symbol: FUT2

Ensembl ID: ENSG00000176920

Description: fucosyltransferase 2 (H blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.4817
    Cell Significance Index: -7.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.1498
    Cell Significance Index: -7.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 10.9683
    Cell Significance Index: -7.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.7530
    Cell Significance Index: 108.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2253
    Cell Significance Index: -8.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.9509
    Cell Significance Index: 63.9300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.6703
    Cell Significance Index: 27.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0758
    Cell Significance Index: 94.0900
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.6906
    Cell Significance Index: 9.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6015
    Cell Significance Index: 21.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6003
    Cell Significance Index: 174.0600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 1.4351
    Cell Significance Index: 17.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4324
    Cell Significance Index: 74.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3514
    Cell Significance Index: 20.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1941
    Cell Significance Index: 55.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1411
    Cell Significance Index: 185.6000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.0468
    Cell Significance Index: 10.5600
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 1.0333
    Cell Significance Index: 6.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9123
    Cell Significance Index: 63.0900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.8090
    Cell Significance Index: 11.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7827
    Cell Significance Index: 16.6700
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: 0.4752
    Cell Significance Index: 3.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3987
    Cell Significance Index: 39.4400
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.3733
    Cell Significance Index: 2.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3724
    Cell Significance Index: 13.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3421
    Cell Significance Index: 61.6700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.3251
    Cell Significance Index: 6.7800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.3206
    Cell Significance Index: 2.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3042
    Cell Significance Index: 8.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2645
    Cell Significance Index: 8.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2238
    Cell Significance Index: 5.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2048
    Cell Significance Index: 41.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1772
    Cell Significance Index: 33.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1270
    Cell Significance Index: 69.3500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1240
    Cell Significance Index: 0.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1088
    Cell Significance Index: 21.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0814
    Cell Significance Index: 3.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0787
    Cell Significance Index: 2.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0758
    Cell Significance Index: 0.7900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0664
    Cell Significance Index: 0.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0501
    Cell Significance Index: 17.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0398
    Cell Significance Index: 4.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0359
    Cell Significance Index: 6.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0178
    Cell Significance Index: 12.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0139
    Cell Significance Index: 1.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0126
    Cell Significance Index: 23.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0106
    Cell Significance Index: 16.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0081
    Cell Significance Index: 0.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0080
    Cell Significance Index: 1.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0076
    Cell Significance Index: 13.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0039
    Cell Significance Index: -1.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0070
    Cell Significance Index: -0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0107
    Cell Significance Index: -6.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0110
    Cell Significance Index: -6.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0113
    Cell Significance Index: -3.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0124
    Cell Significance Index: -5.6400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0138
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0210
    Cell Significance Index: -0.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0300
    Cell Significance Index: -2.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0301
    Cell Significance Index: -3.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0314
    Cell Significance Index: -4.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0317
    Cell Significance Index: -2.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0327
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0341
    Cell Significance Index: -7.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0347
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0358
    Cell Significance Index: -4.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0372
    Cell Significance Index: -2.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0609
    Cell Significance Index: -6.3400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0643
    Cell Significance Index: -0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0679
    Cell Significance Index: -6.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0780
    Cell Significance Index: -9.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0812
    Cell Significance Index: -5.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0850
    Cell Significance Index: -3.1200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0874
    Cell Significance Index: -0.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0880
    Cell Significance Index: -2.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0961
    Cell Significance Index: -5.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1018
    Cell Significance Index: -5.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1124
    Cell Significance Index: -6.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1146
    Cell Significance Index: -4.7000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1179
    Cell Significance Index: -1.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1190
    Cell Significance Index: -6.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1203
    Cell Significance Index: -3.8300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1214
    Cell Significance Index: -2.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1242
    Cell Significance Index: -4.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1247
    Cell Significance Index: -8.0500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1299
    Cell Significance Index: -1.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1310
    Cell Significance Index: -2.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1314
    Cell Significance Index: -1.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1359
    Cell Significance Index: -4.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1377
    Cell Significance Index: -7.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1558
    Cell Significance Index: -4.5900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.1569
    Cell Significance Index: -1.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1683
    Cell Significance Index: -4.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The FUT2 gene is a crucial enzyme involved in the transfer of fucose moieties to specific carbohydrate structures, resulting in the formation of glycosphingolipids and glycoproteins. This process is essential for the proper functioning of the immune system, as these molecules play a critical role in cell adhesion, signaling, and the regulation of immune responses. FUT2 is specifically expressed in various tissues, including the nasal mucosa, esophageal glandular cells, enterocytes, and keratinocytes. **Pathways and Functions:** The FUT2 gene is involved in several key pathways, including: 1. **Abo blood group biosynthesis:** FUT2 is responsible for the production of the ABO blood group antigens, which determine an individual's blood type. 2. **Fucosylation:** FUT2 catalyzes the transfer of fucose moieties to specific carbohydrate structures, resulting in the formation of glycosphingolipids and glycoproteins. 3. **Glycolipid metabolic process:** FUT2 plays a crucial role in the metabolism of glycosphingolipids, which are essential components of cell membranes and play a critical role in immune regulation. 4. **Glycosphingolipid biosynthesis:** FUT2 is involved in the biosynthesis of glycosphingolipids, which are essential components of cell membranes and play a critical role in immune regulation. **Clinical Significance:** The FUT2 gene has significant clinical implications, particularly in the context of immune regulation and disease pathogenesis. Some of the key clinical implications of FUT2 include: 1. **Immune system dysfunction:** Mutations in the FUT2 gene have been associated with immune system dysfunction, including increased susceptibility to infections and autoimmune diseases. 2. **Gastrointestinal disorders:** FUT2 has been implicated in the pathogenesis of gastrointestinal disorders, such as celiac disease and Crohn's disease. 3. **Cancer:** FUT2 has been associated with cancer, particularly in the context of immune regulation and tumor progression. 4. **Transplantation:** FUT2 has been implicated in the rejection of transplanted organs, particularly in the context of kidney transplantation. In conclusion, the FUT2 gene plays a critical role in immune regulation and disease pathogenesis. Further research is needed to fully understand the significance of FUT2 in the context of human health and disease.

Genular Protein ID: 1756050512

Symbol: FUT2_HUMAN

Name: Alpha(1,2)FT 2

UniProtKB Accession Codes:

Q10981 Q0VAG5 Q14338 Q5D0G2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 65 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 26 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7876235

Title: Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.

PubMed ID: 7876235

DOI: 10.1074/jbc.270.9.4640

PubMed ID: 9219535

Title: Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).

PubMed ID: 9219535

DOI: 10.1111/j.1432-1033.1997.t01-1-00750.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8621666

Title: Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals.

PubMed ID: 8621666

DOI: 10.1074/jbc.271.16.9830

PubMed ID: 8755920

Title: Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency.

PubMed ID: 8755920

PubMed ID: 8018146

Title: Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.

PubMed ID: 8018146

DOI: 10.1126/science.8018146

PubMed ID: 12692541

Title: Human susceptibility and resistance to Norwalk virus infection.

PubMed ID: 12692541

DOI: 10.1038/nm860

PubMed ID: 20506485

Title: RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation.

PubMed ID: 20506485

DOI: 10.1002/jcb.22692

PubMed ID: 21625510

Title: Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine.

PubMed ID: 21625510

DOI: 10.1371/journal.pone.0020113

PubMed ID: 22068912

Title: Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype.

PubMed ID: 22068912

DOI: 10.1073/pnas.1106408108

PubMed ID: 24733310

Title: Faecal microbiota composition in adults is associated with the FUT2 gene determining the secretor status.

PubMed ID: 24733310

DOI: 10.1371/journal.pone.0094863

PubMed ID: 9760207

Title: Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa.

PubMed ID: 9760207

DOI: 10.1007/s004390050808

PubMed ID: 18776911

Title: Common variants of FUT2 are associated with plasma vitamin B12 levels.

PubMed ID: 18776911

DOI: 10.1038/ng.210

Sequence Information:

  • Length: 343
  • Mass: 39017
  • Checksum: 12066D9CF175E13A
  • Sequence:
    • MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS TSKALGPSQL 
RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH STLAPIFRIT LPVLHSATAS 
RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY PCSWTFYHHL RQEILQEFTL HDHVREEAQK 
FLRGLQVNGS RPGTFVGVHV RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSLIFV 
VTSNGMAWCR ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG 
GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.