Details for: GAB1

Gene ID: 2549

Symbol: GAB1

Ensembl ID: ENSG00000109458

Description: GRB2 associated binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.98
    Marker Score: 4963
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.46
    Marker Score: 8276
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.45
    Marker Score: 77014
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.68
    Marker Score: 2198
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.55
    Marker Score: 2933
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.4
    Marker Score: 51252
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.4
    Marker Score: 2648
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.38
    Marker Score: 1321
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.34
    Marker Score: 6717
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.27
    Marker Score: 9482.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.25
    Marker Score: 1260
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.23
    Marker Score: 11710
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.15
    Marker Score: 4142
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.11
    Marker Score: 1623
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.03
    Marker Score: 1185
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.97
    Marker Score: 1175
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.96
    Marker Score: 1144
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.79
    Marker Score: 9632
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.79
    Marker Score: 3934
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.77
    Marker Score: 2094
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.76
    Marker Score: 28214
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.76
    Marker Score: 2172
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.76
    Marker Score: 1405
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.67
    Marker Score: 2252
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.61
    Marker Score: 5714
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.59
    Marker Score: 784
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.57
    Marker Score: 853
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.54
    Marker Score: 95007.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.54
    Marker Score: 1466
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.52
    Marker Score: 30280
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.44
    Marker Score: 3401
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.41
    Marker Score: 789
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.41
    Marker Score: 979
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.4
    Marker Score: 1208
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.4
    Marker Score: 408
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.38
    Marker Score: 432
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.36
    Marker Score: 1651
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.33
    Marker Score: 1438
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.32
    Marker Score: 870
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.32
    Marker Score: 1496
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.31
    Marker Score: 48312.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20203.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.28
    Marker Score: 636
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.28
    Marker Score: 1132
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.2
    Marker Score: 453
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.2
    Marker Score: 10300
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.17
    Marker Score: 377
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.17
    Marker Score: 1014
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.17
    Marker Score: 4891
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.15
    Marker Score: 3781.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.14
    Marker Score: 411.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.07
    Marker Score: 606
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.05
    Marker Score: 332
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.04
    Marker Score: 1114
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.03
    Marker Score: 39094
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.02
    Marker Score: 205
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1
    Marker Score: 3363
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1
    Marker Score: 1824
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1
    Marker Score: 480
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71737
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1
    Marker Score: 362
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47960.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.99
    Marker Score: 1408
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.99
    Marker Score: 17603
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.99
    Marker Score: 478
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.99
    Marker Score: 285
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.98
    Marker Score: 1182
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.98
    Marker Score: 2447
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.97
    Marker Score: 248
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.97
    Marker Score: 10008.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1955
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.95
    Marker Score: 1005
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.95
    Marker Score: 357
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.95
    Marker Score: 5735
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1520
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.93
    Marker Score: 3301
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.93
    Marker Score: 1230.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.92
    Marker Score: 12196.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.91
    Marker Score: 2484
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 534
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.88
    Marker Score: 419
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.87
    Marker Score: 2137
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.87
    Marker Score: 5563
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.86
    Marker Score: 569
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.86
    Marker Score: 301
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.86
    Marker Score: 361
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.86
    Marker Score: 1030
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4868
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.84
    Marker Score: 221
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.83
    Marker Score: 803
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.83
    Marker Score: 482
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 327.5

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Other Information

**Key characteristics:** * Gene name: GAB1 * Ensembl ID: ENSG00000109458 * Protein: GAB1_HUMAN (GRB2-associated-binding protein 1) * Protein length: 131 amino acids * Expression: Highly expressed in various cell types, including cardiac neurons, oligodendrocytes, myocytes, and epithelial cells **Pathways and functions:** * The GAB1 protein is a key regulator of the PI3K/AKT signaling pathway. * The PI3K/AKT pathway is a major signaling pathway involved in a variety of cellular processes, including cell growth, differentiation, and survival. * The GAB1 protein acts as a negative regulator of the PI3K/AKT pathway. * By binding to the GRB2 protein, GAB1 prevents the activation of the PI3K/AKT pathway. * This leads to the inhibition of cell growth and proliferation. **Clinical significance:** * Mutations in the GAB1 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * In some cases, mutations in the GAB1 gene can lead to the activation of the PI3K/AKT pathway, which can result in cell growth and proliferation. * Targeting the GAB1/GRB2 signaling pathway is a promising new strategy for the treatment of cancer.

Genular Protein ID: 437945626

Symbol: GAB1_HUMAN

Name: GRB2-associated-binding protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8596638

Title: A Grb2-associated docking protein in EGF- and insulin-receptor signalling.

PubMed ID: 8596638

DOI: 10.1038/379560a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 12475979

Title: Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.

PubMed ID: 12475979

DOI: 10.1074/jbc.m210656200

PubMed ID: 15010462

Title: Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.

PubMed ID: 15010462

DOI: 10.1074/jbc.m305783200

PubMed ID: 15863030

Title: Cellular signaling by fibroblast growth factor receptors.

PubMed ID: 15863030

DOI: 10.1016/j.cytogfr.2005.01.001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 29408807

Title: Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

PubMed ID: 29408807

DOI: 10.1172/jci97350

Sequence Information:

  • Length: 694
  • Mass: 76616
  • Checksum: E0FAC78772B6677B
  • Sequence:
  • MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII 
    DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEEMNKWVRC ICDICGFNPT 
    EEDPVKPPGS SLQAPADLPL AINTAPPSTQ ADSSSATLPP PYQLINVPPH LETLGIQEDP 
    QDYLLLINCQ SKKPEPTRTH ADSAKSTSSE TDCNDNVPSH KNPASSQSKH GMNGFFQQQM 
    IYDSPPSRAP SASVDSSLYN LPRSYSHDVL PKVSPSSTEA DGELYVFNTP SGTSSVETQM 
    RHVSISYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDTIPDI PPPRPPKPHP AHDRSPVETC 
    SIPRTASDTD SSYCIPTAGM SPSRSNTIST VDLNKLRKDA SSQDCYDIPR AFPSDRSSSL 
    EGFHNHFKVK NVLTVGSVSS EELDENYVPM NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF 
    DFSSFGMQVP PPAHMGFRSS PKTPPRRPVP VADCEPPPVD RNLKPDRKVK PAPLEIKPLP 
    EWEELQAPVR SPITRSFARD SSRFPMSPRP DSVHSTTSSS DSHDSEENYV PMNPNLSSED 
    PNLFGSNSLD GGSSPMIKPK GDKQVEYLDL DLDSGKSTPP RKQKSSGSGS SVADERVDYV 
    VVDQQKTLAL KSTREAWTDG RQSTESETPA KSVK

Genular Protein ID: 837024928

Symbol: Q9HA84_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 275
  • Mass: 30334
  • Checksum: 3E305D407169FD1F
  • Sequence:
  • MNPNSPPRQH SSSFTEPIQE ANYVPMTPGT FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV 
    PVADCEPPPV DRNLKPDRKG QSPKILRLKP HGLERTDSQT IGDFATRRKV KPAPLEIKPL 
    PEWEELQAPV RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSSE 
    DPNLFGSNSL DGGSSPMIKP KGDKQVEYLD LDLDSGKSTP PRKQKSSSSG SSVADERVDY 
    VVVDQQKTLA LKSTREAWTD GRQSTESETP AKSVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.