GAB1 | ENSG00000109458 | NCBI 2549

Details for: GAB1

Gene ID: 2549

Symbol: GAB1

Ensembl ID: ENSG00000109458

Description: GRB2 associated binding protein 1

Associated with

Activated ntrk2 signals through pi3k
(R-HSA-9028335)
Axon guidance
(R-HSA-422475)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-HSA-9027276)
Gab1 signalosome
(R-HSA-180292)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Met activates pi3k/akt signaling
(R-HSA-8851907)
Met activates ptpn11
(R-HSA-8865999)
Met activates rap1 and rac1
(R-HSA-8875555)
Met promotes cell motility
(R-HSA-8875878)
Met receptor recycling
(R-HSA-8875656)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Ret signaling
(R-HSA-8853659)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by met
(R-HSA-6806834)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Angiogenesis
(GO:0001525)
Cell-cell junction
(GO:0005911)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endothelial cell chemotaxis
(GO:0035767)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Insulin receptor signaling pathway
(GO:0008286)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Protein binding
(GO:0005515)
Response to hepatocyte growth factor
(GO:0035728)
Signaling adaptor activity
(GO:0035591)
Signal transduction
(GO:0007165)
Vascular endothelial growth factor signaling pathway
(GO:0038084)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 356.0379
Cell Significance Index: -55.3800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 237.4988
Cell Significance Index: -60.2400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 122.0446
Cell Significance Index: -57.6200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 106.9766
Cell Significance Index: -43.4600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 85.9286
Cell Significance Index: -57.6600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 48.1364
Cell Significance Index: -59.3500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 45.4992
Cell Significance Index: -43.4400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 19.5606
Cell Significance Index: -42.8100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.4332
Cell Significance Index: -60.9000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.9842
Cell Significance Index: 305.7400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.6911
Cell Significance Index: 151.0100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.9977
Cell Significance Index: 51.3500
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.9306
Cell Significance Index: 37.6800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8437
Cell Significance Index: 369.8400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.7104
Cell Significance Index: 45.6700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.4933
Cell Significance Index: 31.9200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3271
Cell Significance Index: 263.3700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.2365
Cell Significance Index: 30.9100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1675
Cell Significance Index: 189.8800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.1595
Cell Significance Index: 15.8200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8199
Cell Significance Index: 37.1600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5979
Cell Significance Index: 16.7100
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.5554
Cell Significance Index: 8.2000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5516
Cell Significance Index: 64.2900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5355
Cell Significance Index: 58.2500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4771
Cell Significance Index: 13.7500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3700
Cell Significance Index: 70.4200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3445
Cell Significance Index: 34.0800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3164
Cell Significance Index: 113.4800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2886
Cell Significance Index: 260.6100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2742
Cell Significance Index: 5.9400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2673
Cell Significance Index: 48.1900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2117
Cell Significance Index: 13.0100
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.2019
Cell Significance Index: 2.9000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1917
Cell Significance Index: 11.5100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1563
Cell Significance Index: 70.9500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1494
Cell Significance Index: 18.3700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1491
Cell Significance Index: 10.3100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1472
Cell Significance Index: 93.4800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1350
Cell Significance Index: 93.3600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1347
Cell Significance Index: 253.5700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1301
Cell Significance Index: 176.9400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1243
Cell Significance Index: 229.2200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0987
Cell Significance Index: 151.8700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0783
Cell Significance Index: 48.8900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0068
Cell Significance Index: -0.2400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0248
Cell Significance Index: -3.6100
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0295
Cell Significance Index: -16.1100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0363
Cell Significance Index: -16.0400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0374
Cell Significance Index: -27.7200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0447
Cell Significance Index: -0.2700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0553
Cell Significance Index: -40.5800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0725
Cell Significance Index: -54.8700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0856
Cell Significance Index: -48.2600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1122
Cell Significance Index: -5.6700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1343
Cell Significance Index: -22.9400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1747
Cell Significance Index: -50.2600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1845
Cell Significance Index: -11.9100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1997
Cell Significance Index: -20.4000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2096
Cell Significance Index: -44.1500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2289
Cell Significance Index: -31.4300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3148
Cell Significance Index: -16.4000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3496
Cell Significance Index: -18.1600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.3690
Cell Significance Index: -47.3100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3905
Cell Significance Index: -44.7400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3938
Cell Significance Index: -8.1700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.3996
Cell Significance Index: -51.6300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4219
Cell Significance Index: -7.2300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4346
Cell Significance Index: -45.2500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4405
Cell Significance Index: -20.5400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4528
Cell Significance Index: -53.4000
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.5186
Cell Significance Index: -5.5600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5237
Cell Significance Index: -59.7800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5415
Cell Significance Index: -33.2000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6000
Cell Significance Index: -47.5200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.6341
Cell Significance Index: -29.8000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.6581
Cell Significance Index: -49.0500
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.6656
Cell Significance Index: -16.2400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7072
Cell Significance Index: -47.5500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7191
Cell Significance Index: -15.3200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.8633
Cell Significance Index: -61.0600
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.9441
Cell Significance Index: -13.4400
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.9733
Cell Significance Index: -12.4800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0043
Cell Significance Index: -63.3000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.0530
Cell Significance Index: -28.2200
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -1.0976
Cell Significance Index: -16.5400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1128
Cell Significance Index: -35.6400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.1254
Cell Significance Index: -59.0900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.1429
Cell Significance Index: -27.4100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.2416
Cell Significance Index: -54.9200
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -1.2522
Cell Significance Index: -19.0500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.2705
Cell Significance Index: -11.7000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.2948
Cell Significance Index: -45.0000
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -1.3144
Cell Significance Index: -18.3800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.3660
Cell Significance Index: -16.9400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.3756
Cell Significance Index: -23.0200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.4040
Cell Significance Index: -51.5400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.4366
Cell Significance Index: -54.4000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.4546
Cell Significance Index: -31.8500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.5533
Cell Significance Index: -42.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Structure**: GAB1 is a cytoplasmic protein that consists of three SH2 domains, which are responsible for binding to phosphotyrosine-containing motifs on activated RTKs. 2. **Function**: GAB1 acts as a scaffold protein, assembling signaling complexes that contain various proteins, including RTKs, phosphatases, and kinases. 3. **Signal transduction pathways**: GAB1 is involved in signaling pathways mediated by RTKs, including the epidermal growth factor receptor (EGFR), fibroblast growth factor receptors (FGFRs), insulin-like growth factor 1 receptor (IGF-1R), and nerve growth factor receptors (NGFRs). 4. **Cellular localization**: GAB1 is primarily localized to the cytosol, where it interacts with signaling complexes. **Pathways and Functions** GAB1 is involved in various signaling pathways, including: 1. **PI3K/AKT pathway**: GAB1 interacts with activated RTKs, leading to the activation of PI3K and subsequent activation of AKT. 2. **Angiogenesis**: GAB1 promotes angiogenesis by regulating the expression of vascular endothelial growth factor (VEGF) and other angiogenic factors. 3. **Axon guidance**: GAB1 plays a role in axon guidance by regulating the expression of molecules involved in axon outgrowth and guidance. 4. **Cell-cell junction**: GAB1 is involved in the formation and maintenance of cell-cell junctions, including adherens junctions and tight junctions. 5. **Cancer**: GAB1 is often overexpressed in cancer cells, where it promotes cell growth, survival, and metastasis. **Clinical Significance** Dysregulation of GAB1 has been implicated in various diseases, including: 1. **Cancer**: GAB1 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: GAB1 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cardiovascular disease**: GAB1 has been linked to cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 4. **Diabetes**: GAB1 has been implicated in the development of type 2 diabetes, where it promotes insulin resistance and glucose metabolism dysregulation. In conclusion, GAB1 is a critical protein involved in signal transduction pathways, particularly those mediated by RTKs. Its dysregulation has been implicated in various diseases, highlighting the importance of GAB1 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the role of GAB1 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GRB2-associated-binding protein 1
Q9HA84_HUMAN

Genular Protein ID: 437945626

Symbol: GAB1_HUMAN

Name: GRB2-associated-binding protein 1

UniProtKB Accession Codes:

Q13480 A8K152 Q4W5G2 Q6P1W2

Database IDs:

Citations:

PubMed ID: 8596638

Title: A Grb2-associated docking protein in EGF- and insulin-receptor signalling.

PubMed ID: 8596638

DOI: 10.1038/379560a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 12475979

Title: Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.

PubMed ID: 12475979

DOI: 10.1074/jbc.m210656200

PubMed ID: 15010462

Title: Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.

PubMed ID: 15010462

DOI: 10.1074/jbc.m305783200

PubMed ID: 15863030

Title: Cellular signaling by fibroblast growth factor receptors.

PubMed ID: 15863030

DOI: 10.1016/j.cytogfr.2005.01.001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 29408807

Title: Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

PubMed ID: 29408807

DOI: 10.1172/jci97350

Sequence Information:

Length: 694
Mass: 76616
Checksum: E0FAC78772B6677B
Sequence:

MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII 
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEEMNKWVRC ICDICGFNPT 
EEDPVKPPGS SLQAPADLPL AINTAPPSTQ ADSSSATLPP PYQLINVPPH LETLGIQEDP 
QDYLLLINCQ SKKPEPTRTH ADSAKSTSSE TDCNDNVPSH KNPASSQSKH GMNGFFQQQM 
IYDSPPSRAP SASVDSSLYN LPRSYSHDVL PKVSPSSTEA DGELYVFNTP SGTSSVETQM 
RHVSISYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDTIPDI PPPRPPKPHP AHDRSPVETC 
SIPRTASDTD SSYCIPTAGM SPSRSNTIST VDLNKLRKDA SSQDCYDIPR AFPSDRSSSL 
EGFHNHFKVK NVLTVGSVSS EELDENYVPM NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF 
DFSSFGMQVP PPAHMGFRSS PKTPPRRPVP VADCEPPPVD RNLKPDRKVK PAPLEIKPLP 
EWEELQAPVR SPITRSFARD SSRFPMSPRP DSVHSTTSSS DSHDSEENYV PMNPNLSSED 
PNLFGSNSLD GGSSPMIKPK GDKQVEYLDL DLDSGKSTPP RKQKSSGSGS SVADERVDYV 
VVDQQKTLAL KSTREAWTDG RQSTESETPA KSVK

Genular Protein ID: 837024928

Symbol: Q9HA84_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HA84

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

Length: 275
Mass: 30334
Checksum: 3E305D407169FD1F
Sequence:

MNPNSPPRQH SSSFTEPIQE ANYVPMTPGT FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV 
PVADCEPPPV DRNLKPDRKG QSPKILRLKP HGLERTDSQT IGDFATRRKV KPAPLEIKPL 
PEWEELQAPV RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSSE 
DPNLFGSNSL DGGSSPMIKP KGDKQVEYLD LDLDSGKSTP PRKQKSSSSG SSVADERVDY 
VVVDQQKTLA LKSTREAWTD GRQSTESETP AKSVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GAB1

Associated with

Cells (max top 100)

Other Information

A Grb2-associated docking protein in EGF- and insulin-receptor signalling. PubMed ID: 8596638

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. PubMed ID: 12486104

Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. PubMed ID: 12475979

Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. PubMed ID: 15010462

Cellular signaling by fibroblast growth factor receptors. PubMed ID: 15863030

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. PubMed ID: 29408807

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Database document:

PubMed ID: 8596638

PubMed ID: 14702039

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 12486104

PubMed ID: 12475979

PubMed ID: 15010462

PubMed ID: 15863030

PubMed ID: 18669648

PubMed ID: 20068231

PubMed ID: 22223895

PubMed ID: 23186163

PubMed ID: 16959974

PubMed ID: 29408807

PubMed ID: 14702039