Details for: GANC

Gene ID: 2595

Symbol: GANC

Ensembl ID: ENSG00000214013

Description: glucosidase alpha, neutral C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.59
    Marker Score: 1459
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.51
    Marker Score: 2636
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.51
    Marker Score: 24214
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168544
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.39
    Marker Score: 29665.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.37
    Marker Score: 1508
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.19
    Marker Score: 43979.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1817
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.15
    Marker Score: 10786
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.11
    Marker Score: 1345
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.1
    Marker Score: 1480
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.1
    Marker Score: 4598
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.05
    Marker Score: 612
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.05
    Marker Score: 64400
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.03
    Marker Score: 4213
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.03
    Marker Score: 1165
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.02
    Marker Score: 9688
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71755
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47978
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.98
    Marker Score: 4055
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.97
    Marker Score: 6308
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.94
    Marker Score: 550
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.93
    Marker Score: 7969
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.92
    Marker Score: 2308
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.92
    Marker Score: 269
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14194
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9
    Marker Score: 5816
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.9
    Marker Score: 2122
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.9
    Marker Score: 13435
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9
    Marker Score: 3868
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.88
    Marker Score: 33247
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4988
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.87
    Marker Score: 1674
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.87
    Marker Score: 430
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.86
    Marker Score: 6628
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.86
    Marker Score: 995
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1742
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.85
    Marker Score: 3021
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.85
    Marker Score: 16873
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.85
    Marker Score: 3271
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.83
    Marker Score: 2956
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.82
    Marker Score: 1973
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.82
    Marker Score: 18362
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.82
    Marker Score: 4404
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.81
    Marker Score: 339
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8
    Marker Score: 8218
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.79
    Marker Score: 1270
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.77
    Marker Score: 577.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.76
    Marker Score: 275
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 302.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.75
    Marker Score: 650
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.74
    Marker Score: 214
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.74
    Marker Score: 41371
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.74
    Marker Score: 921
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3058.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.71
    Marker Score: 1567
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.71
    Marker Score: 195
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.67
    Marker Score: 970
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.67
    Marker Score: 192
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.66
    Marker Score: 301
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.65
    Marker Score: 701
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.65
    Marker Score: 387
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 207
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.64
    Marker Score: 357
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.64
    Marker Score: 217
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.64
    Marker Score: 509
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.63
    Marker Score: 304.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.62
    Marker Score: 346
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.61
    Marker Score: 472
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.61
    Marker Score: 162
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.6
    Marker Score: 395
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.59
    Marker Score: 744.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.59
    Marker Score: 187
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.59
    Marker Score: 409
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.58
    Marker Score: 1050
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.57
    Marker Score: 2658
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.57
    Marker Score: 343
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.57
    Marker Score: 198
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3410
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.56
    Marker Score: 211
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.56
    Marker Score: 168
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.55
    Marker Score: 205
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.55
    Marker Score: 490
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.55
    Marker Score: 811
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.54
    Marker Score: 142

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Other Information

**Key characteristics:** * GANC is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is found in a variety of cellular compartments, including the plasma membrane, endosomes, and lysosomes. * It is a glycoprotein, with a single extracellular domain and a single transmembrane domain. * It is a member of the alpha-glucosidase family of enzymes. **Pathways and functions:** GANC is involved in a variety of cellular pathways, including: * The alpha-1,4-glucosidase activity pathway, which is responsible for the processing of glycoproteins and glycolipids. * The carbohydrate binding pathway, which is responsible for the recognition and binding of carbohydrates by cells. * The maltose alpha-glucosidase activity pathway, which is responsible for the processing of maltose, a disaccharide composed of glucose and galactose. * The maltose metabolic process, which is responsible for the metabolism of maltose. * The N-glycan processing pathway, which is responsible for the processing of glycoproteins and glycolipids to form N-glycans. **Clinical significance:** GANC is a potential therapeutic target for a variety of diseases, including cancer and neurodegenerative diseases. Mutations in the GANC gene have been linked to a number of human diseases, including cancer, diabetes, and Alzheimer's disease. **Additional information:** * GANC is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a well-characterized protein, with a structure that has been determined by X-ray crystallography. * It is a relatively new protein, with only a few publications to its name.

Genular Protein ID: 3411400560

Symbol: GANC_HUMAN

Name: Neutral alpha-glucosidase C

UniProtKB Accession Codes:

Q8TET4 Q52LQ4 Q8IWZ0 Q8IZM4 Q8IZM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12370436

Title: Computer assisted cloning of human neutral alpha glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31.

PubMed ID: 12370436

DOI: 10.1073/pnas.202383599

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 914
  • Mass: 104334
  • Checksum: 7AA10E180DA7FDC2
  • Sequence:
    • MEAAVKEEIS LEDEAVDKNI FRDCNKIAFY RRQKQWLSKK STYQALLDSV TTDEDSTRFQ 
IINEASKVPL LAEIYGIEGN IFRLKINEET PLKPRFEVPD VLTSKPSTVR LISCSGDTGS 
LILADGKGDL KCHITANPFK VDLVSEEEVV ISINSLGQLY FEHLQILHKQ RAAKENEEET 
SVDTSQENQE DLGLWEEKFG KFVDIKANGP SSIGLDFSLH GFEHLYGIPQ HAESHQLKNT 
GDGDAYRLYN LDVYGYQIYD KMGIYGSVPY LLAHKLGRTI GIFWLNASET LVEINTEPAV 
EYTLTQMGPV AAKQKVRSRT HVHWMSESGI IDVFLLTGPT PSDVFKQYSH LTGTQAMPPL 
FSLGYHQCRW NYEDEQDVKA VDAGFDEHDI PYDAMWLDIE HTEGKRYFTW DKNRFPNPKR 
MQELLRSKKR KLVVISDPHI KIDPDYSVYV KAKDQGFFVK NQEGEDFEGV CWPGLSSYLD 
FTNPKVREWY SSLFAFPVYQ GSTDILFLWN DMNEPSVFRG PEQTMQKNAI HHGNWEHREL 
HNIYGFYHQM ATAEGLIKRS KGKERPFVLT RSFFAGSQKY GAVWTGDNTA EWSNLKISIP 
MLLTLSITGI SFCGADIGGF IGNPETELLV RWYQAGAYQP FFRGHATMNT KRREPWLFGE 
EHTRLIREAI RERYGLLPYW YSLFYHAHVA SQPVMRPLWV EFPDELKTFD MEDEYMLGSA 
LLVHPVTEPK ATTVDVFLPG SNEVWYDYKT FAHWEGGCTV KIPVALDTIP VFQRGGSVIP 
IKTTVGKSTG WMTESSYGLR VALSTKGSSV GELYLDDGHS FQYLHQKQFL HRKFSFCSSV 
LINSFADQRG HYPSKCVVEK ILVLGFRKEP SSVTTHSSDG KDQPVAFTYC AKTSILSLEK 
LSLNIATDWE VRII

Genular Protein ID: 2417549248

Symbol: E7EWB6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EWB6

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 282
  • Mass: 31566
  • Checksum: 192DB5DB2D04C63F
  • Sequence:
    • MEAAVKEEIS LEDEAVDKNI FRDCNKIAFY RRQKQWLSKK STYQALLDSV TTDEDSTRFQ 
IINEASKVRC QDQSPTTLDA FKGKETTVQE ETQDLSTRQH LAQKEAEEPD KQGQITWDIS 
NVAPKTENFE DLLEQTPCSA CLQGFTRDNT SSSFSEDAGI SLSTSVKLPL ASSSKPNENE 
ALPNQPPSQQ IRHNYRLLAS TVSAEMARNR QLIWELARQS EAHLDRPVVL GEQASAQREV 
ASILCRKSVL AINQLAATVE GTISVLQQFN ELLDHPLDPG RS

Genular Protein ID: 3853868492

Symbol: H3BN99_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BN99

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 357
  • Mass: 40252
  • Checksum: 233A29DD71E3677D
  • Sequence:
    • MEAAVKEEIS LEDEAVDKNI FRDCNKIAFY RRQKQWLSKK STYQALLDSV TTDEDSTRFQ 
IINEASKVPL LAEIYGIEGN IFRLKINEET PLKPRFEVPD VLTSKPSTVR LISCSGDTGS 
LILADGKGDL KCHITANPFK VDLVSEEEVV ISINSLGQLY FEHLQILHKQ RAAKENEEET 
SVDTSQENQE DLGLWEEKFG KFVDIKANGP SSIGLDFSLH GFEHLYGIPQ HAESHQLKNT 
GDGDAYRLYN LDVYGYQIYD KMGIYGSVPY LLAHKLGRTI GIFWLNASET LVEINTEPAV 
EYTLTQMGPV AAKQKVRSRT HVHWMSESGI IDVFLLTGPT PSDVFKQYSH LTDIGEK

Genular Protein ID: 2195197199

Symbol: B4DWC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DWC5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GenomeRNAi 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 282
  • Mass: 31626
  • Checksum: EE3EDDB9A401E8F5
  • Sequence:
    • MEAAVKEEIS VEDEAVDKNI FRDCNKIAFY RRQKQWLSKK STYRALLDSV TTDEDSTRFQ 
IINEASKVRC QDQSPTTLDA FKGKETTVQE ETQDLSTRQH LAQKEAEEPD KQGQITWDIS 
NVAPKTENFE DLLEQTPCSA CLQGFTRDNT SSSFSEDAGI SLSTSVKLPL ASSSKPNENE 
ALPNQPPSQQ MRHNYRLLAS TVSAEMARNR QLIWELARQS EAHLDRPVVL GEQASAQREV 
ASILCRKSVL AINQLAATVE GTISVLQRFN ELLDHPLDPG RS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.