Details for: GATA6

Gene ID: 2627

Symbol: GATA6

Ensembl ID: ENSG00000141448

Description: GATA binding protein 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.54
    Marker Score: 45054
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.3
    Marker Score: 51384
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.21
    Marker Score: 9225
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.74
    Marker Score: 3953
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.63
    Marker Score: 10403
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.52
    Marker Score: 487
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.51
    Marker Score: 9817.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.51
    Marker Score: 853
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168695
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.46
    Marker Score: 3973
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.44
    Marker Score: 1498
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.38
    Marker Score: 1470
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.35
    Marker Score: 4794.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20532
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.3
    Marker Score: 685
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.27
    Marker Score: 533
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.21
    Marker Score: 676
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.16
    Marker Score: 2744
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.15
    Marker Score: 11584.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.09
    Marker Score: 406
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.07
    Marker Score: 6375.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.04
    Marker Score: 1997
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251777
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.95
    Marker Score: 4567
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.95
    Marker Score: 358
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1540
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5677
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.94
    Marker Score: 805
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.93
    Marker Score: 1971
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.93
    Marker Score: 291
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.93
    Marker Score: 646
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.9
    Marker Score: 1301
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.85
    Marker Score: 342
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.83
    Marker Score: 2614
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.82
    Marker Score: 788
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.82
    Marker Score: 815
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.81
    Marker Score: 448
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.8
    Marker Score: 302.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.79
    Marker Score: 10568
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.79
    Marker Score: 1932
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.77
    Marker Score: 255
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.77
    Marker Score: 2011
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.76
    Marker Score: 650
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.76
    Marker Score: 185
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 361
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.74
    Marker Score: 234
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1497
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.74
    Marker Score: 11804
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 470
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.72
    Marker Score: 871
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 658
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.71
    Marker Score: 175
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2860
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.66
    Marker Score: 464
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.65
    Marker Score: 4215
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.64
    Marker Score: 313
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.62
    Marker Score: 322
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.62
    Marker Score: 988
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.61
    Marker Score: 274
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.6
    Marker Score: 396
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.6
    Marker Score: 225
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.6
    Marker Score: 130
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.57
    Marker Score: 345
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.57
    Marker Score: 296
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.53
    Marker Score: 137
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.5
    Marker Score: 129
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.47
    Marker Score: 460
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.47
    Marker Score: 116
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.47
    Marker Score: 421
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.46
    Marker Score: 501
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.46
    Marker Score: 571
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.46
    Marker Score: 125
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.45
    Marker Score: 564
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.45
    Marker Score: 760
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.44
    Marker Score: 877
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.44
    Marker Score: 108
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 289
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.44
    Marker Score: 181
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.42
    Marker Score: 1079

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GATA6 is a zinc finger transcription factor that belongs to the GATA family of transcription factors. * It is a key factor in the development of the cardiovascular system, including the formation of the heart, blood vessels, and heart chambers. * GATA6 is also involved in the regulation of vascular development, platelet production, and cardiac remodeling. **Pathways and functions:** * GATA6 is a key regulator of cardiac progenitor cell differentiation. * It is required for the development of the heart tube and the formation of the cardiovascular mesoderm. * GATA6 also plays a role in the regulation of cardiac remodeling and growth. * It is involved in the specification of cardiac fate in the developing embryo. **Clinical significance:** * Mutations in the GATA6 gene have been linked to several human cardiovascular disorders, including heart failure, stroke, and congenital heart defects. * These mutations can result in the loss of GATA6 function, which can lead to the development of these cardiovascular diseases. * Therefore, GATA6 is a promising target for the treatment of cardiovascular diseases. **Additional points:** * GATA6 is a highly conserved transcription factor that is found in vertebrates. * It is expressed in a variety of tissues throughout the body, including the heart, brain, liver, and kidneys. * GATA6 is a highly regulated gene, and its expression is controlled by a complex network of genetic and environmental factors.

Genular Protein ID: 2026369797

Symbol: GATA6_HUMAN

Name: Transcription factor GATA-6

UniProtKB Accession Codes:

Q92908 B0YJ17 P78327

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 GO 72 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8975704

Title: The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals.

PubMed ID: 8975704

DOI: 10.1006/geno.1996.0630

PubMed ID: 9294001

Title: Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut.

PubMed ID: 9294001

DOI: 10.1016/s0167-4781(97)00049-3

PubMed ID: 9315713

Title: GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells.

PubMed ID: 9315713

DOI: 10.1016/s0014-5793(97)01017-x

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 10608869

Title: The human and mouse GATA-6 genes utilize two promoters and two initiation codons.

PubMed ID: 10608869

DOI: 10.1074/jbc.274.53.38004

PubMed ID: 16968778

Title: A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.

PubMed ID: 16968778

DOI: 10.1073/pnas.0603424103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19666519

Title: GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.

PubMed ID: 19666519

DOI: 10.1073/pnas.0904744106

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33082341

Title: Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis.

PubMed ID: 33082341

DOI: 10.1038/s41467-020-18784-z

PubMed ID: 20631719

Title: A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect.

PubMed ID: 20631719

DOI: 10.1038/jhg.2010.84

PubMed ID: 20581743

Title: Identification of GATA6 sequence variants in patients with congenital heart defects.

PubMed ID: 20581743

DOI: 10.1203/pdr.0b013e3181ed17e4

PubMed ID: 22750565

Title: GATA6 loss-of-function mutation in atrial fibrillation.

PubMed ID: 22750565

DOI: 10.1016/j.ejmg.2012.06.007

PubMed ID: 22824924

Title: Novel GATA6 loss-of-function mutation responsible for familial atrial fibrillation.

PubMed ID: 22824924

DOI: 10.3892/ijmm.2012.1068

PubMed ID: 22158542

Title: GATA6 haploinsufficiency causes pancreatic agenesis in humans.

PubMed ID: 22158542

DOI: 10.1038/ng.1035

PubMed ID: 27756709

Title: Gain-of-function mutations in GATA6 lead to atrial fibrillation.

PubMed ID: 27756709

DOI: 10.1016/j.hrthm.2016.10.014

Sequence Information:

  • Length: 595
  • Mass: 60033
  • Checksum: C4D5410916543E0B
  • Sequence:
    • MALTDGGWCL PKRFGAAGAD ASDSRAFPAR EPSTPPSPIS SSSSSCSRGG ERGPGGASNC 
GTPQLDTEAA AGPPARSLLL SSYASHPFGA PHGPSAPGVA GPGGNLSSWE DLLLFTDLDQ 
AATASKLLWS SRGAKLSPFA PEQPEEMYQT LAALSSQGPA AYDGAPGGFV HSAAAAAAAA 
AAASSPVYVP TTRVGSMLPG LPYHLQGSGS GPANHAGGAG AHPGWPQASA DSPPYGSGGG 
AAGGGAAGPG GAGSAAAHVS ARFPYSPSPP MANGAAREPG GYAAAGSGGA GGVSGGGSSL 
AAMGGREPQY SSLSAARPLN GTYHHHHHHH HHHPSPYSPY VGAPLTPAWP AGPFETPVLH 
SLQSRAGAPL PVPRGPSADL LEDLSESREC VNCGSIQTPL WRRDGTGHYL CNACGLYSKM 
NGLSRPLIKP QKRVPSSRRL GLSCANCHTT TTTLWRRNAE GEPVCNACGL YMKLHGVPRP 
LAMKKEGIQT RKRKPKNINK SKTCSGNSNN SIPMTPTSTS SNSDDCSKNT SPTTQPTASG 
AGAPVMTGAG ESTNPENSEL KYSGQDGLYI GVSLASPAEV TSSVRPDSWC ALALA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.