Details for: GATA6

Gene ID: 2627

Symbol: GATA6

Ensembl ID: ENSG00000141448

Description: GATA binding protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 26.7502
    Cell Significance Index: -17.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4920
    Cell Significance Index: -20.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.4743
    Cell Significance Index: 146.6900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.7206
    Cell Significance Index: 20.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.5920
    Cell Significance Index: 33.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.2730
    Cell Significance Index: 174.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8924
    Cell Significance Index: 205.8400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7010
    Cell Significance Index: 17.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6419
    Cell Significance Index: 47.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4241
    Cell Significance Index: 64.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3907
    Cell Significance Index: 1255.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.3012
    Cell Significance Index: 18.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2786
    Cell Significance Index: 29.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2223
    Cell Significance Index: 26.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8814
    Cell Significance Index: 60.9500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.8451
    Cell Significance Index: 4.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8440
    Cell Significance Index: 12.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7408
    Cell Significance Index: 11.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6730
    Cell Significance Index: 13.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6175
    Cell Significance Index: 13.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6003
    Cell Significance Index: 15.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4782
    Cell Significance Index: 77.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4584
    Cell Significance Index: 90.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4418
    Cell Significance Index: 43.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4088
    Cell Significance Index: 10.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3101
    Cell Significance Index: 10.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2228
    Cell Significance Index: 38.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2069
    Cell Significance Index: 91.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1933
    Cell Significance Index: 2.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1903
    Cell Significance Index: 1.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1874
    Cell Significance Index: 35.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0883
    Cell Significance Index: 6.2500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0784
    Cell Significance Index: 0.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0617
    Cell Significance Index: 33.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0567
    Cell Significance Index: 10.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0489
    Cell Significance Index: 6.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0218
    Cell Significance Index: 2.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0213
    Cell Significance Index: 1.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0044
    Cell Significance Index: 0.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0014
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0044
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0080
    Cell Significance Index: -15.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -20.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0139
    Cell Significance Index: -0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0214
    Cell Significance Index: -2.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0227
    Cell Significance Index: -12.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0229
    Cell Significance Index: -16.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0253
    Cell Significance Index: -16.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0316
    Cell Significance Index: -4.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0321
    Cell Significance Index: -3.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0344
    Cell Significance Index: -0.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0376
    Cell Significance Index: -17.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0457
    Cell Significance Index: -9.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0492
    Cell Significance Index: -17.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0643
    Cell Significance Index: -18.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0793
    Cell Significance Index: -2.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0795
    Cell Significance Index: -10.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0898
    Cell Significance Index: -18.0100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1347
    Cell Significance Index: -0.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1657
    Cell Significance Index: -16.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1788
    Cell Significance Index: -18.6200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1807
    Cell Significance Index: -1.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2094
    Cell Significance Index: -3.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2136
    Cell Significance Index: -5.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2260
    Cell Significance Index: -16.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2332
    Cell Significance Index: -14.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2384
    Cell Significance Index: -11.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2392
    Cell Significance Index: -12.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2430
    Cell Significance Index: -6.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2444
    Cell Significance Index: -4.7700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2484
    Cell Significance Index: -3.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2501
    Cell Significance Index: -6.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2726
    Cell Significance Index: -18.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2840
    Cell Significance Index: -18.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2968
    Cell Significance Index: -18.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3211
    Cell Significance Index: -16.6800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3338
    Cell Significance Index: -5.0300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3381
    Cell Significance Index: -2.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3475
    Cell Significance Index: -19.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3666
    Cell Significance Index: -6.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3772
    Cell Significance Index: -15.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3827
    Cell Significance Index: -8.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3839
    Cell Significance Index: -16.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3867
    Cell Significance Index: -10.5300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3871
    Cell Significance Index: -2.4000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3908
    Cell Significance Index: -2.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4073
    Cell Significance Index: -14.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4357
    Cell Significance Index: -19.2700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.4753
    Cell Significance Index: -3.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4912
    Cell Significance Index: -17.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5072
    Cell Significance Index: -19.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5297
    Cell Significance Index: -18.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5477
    Cell Significance Index: -14.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5522
    Cell Significance Index: -14.7500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.5533
    Cell Significance Index: -7.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5720
    Cell Significance Index: -18.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** GATA6 is a member of the GATA family of transcription factors, which regulate the expression of target genes involved in development, differentiation, and cell growth. 2. **Cellular Expression:** GATA6 is expressed in a range of cell types, including epithelial, endothelial, and smooth muscle cells, highlighting its broad role in tissue development and maintenance. 3. **Developmental Expression:** GATA6 is dynamically expressed throughout embryonic development, including gastrulation, organogenesis, and tissue patterning. 4. **Differential Expression:** GATA6 exhibits differential expression in various tissues, suggesting its involvement in distinct developmental and cellular processes. **Pathways and Functions:** 1. **Cardiac Development:** GATA6 regulates cardiac muscle cell differentiation, proliferation, and hypertrophy, highlighting its importance in cardiac development and function. 2. **Endodermal Development:** GATA6 is essential for the formation of definitive endoderm, a critical step in embryonic development. 3. **Cell Fate Commitment:** GATA6 regulates cell fate commitment, influencing the differentiation of stem cells into specific cell types. 4. **Angiogenesis:** GATA6 promotes angiogenesis, the process of new blood vessel formation, which is crucial for tissue growth and development. 5. **Cellular Response to Stimuli:** GATA6 modulates the cellular response to various stimuli, including growth factors, hormones, and xenobiotics. **Clinical Significance:** 1. **Cardiac Disease:** Dysregulation of GATA6 has been implicated in cardiac disease, including congenital heart defects and cardiac hypertrophy. 2. **Cancer:** GATA6 has been identified as a potential oncogene in certain types of cancer, including ovarian and pancreatic cancer. 3. **Developmental Disorders:** Mutations in GATA6 have been associated with developmental disorders, such as heart defects and endodermal abnormalities. 4. **Regenerative Medicine:** GATA6 has been explored as a potential therapeutic target for regenerative medicine, particularly in the context of cardiac tissue engineering and repair. In conclusion, GATA6 is a critical regulator of developmental processes and cellular differentiation, with implications for our understanding of embryonic development, tissue homeostasis, and disease. Further research is necessary to fully elucidate the mechanisms by which GATA6 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 2026369797

Symbol: GATA6_HUMAN

Name: Transcription factor GATA-6

UniProtKB Accession Codes:

Q92908 B0YJ17 P78327

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 71 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8975704

Title: The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals.

PubMed ID: 8975704

DOI: 10.1006/geno.1996.0630

PubMed ID: 9294001

Title: Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut.

PubMed ID: 9294001

DOI: 10.1016/s0167-4781(97)00049-3

PubMed ID: 9315713

Title: GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells.

PubMed ID: 9315713

DOI: 10.1016/s0014-5793(97)01017-x

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 10608869

Title: The human and mouse GATA-6 genes utilize two promoters and two initiation codons.

PubMed ID: 10608869

DOI: 10.1074/jbc.274.53.38004

PubMed ID: 16968778

Title: A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.

PubMed ID: 16968778

DOI: 10.1073/pnas.0603424103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19666519

Title: GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.

PubMed ID: 19666519

DOI: 10.1073/pnas.0904744106

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33082341

Title: Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis.

PubMed ID: 33082341

DOI: 10.1038/s41467-020-18784-z

PubMed ID: 20631719

Title: A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect.

PubMed ID: 20631719

DOI: 10.1038/jhg.2010.84

PubMed ID: 20581743

Title: Identification of GATA6 sequence variants in patients with congenital heart defects.

PubMed ID: 20581743

DOI: 10.1203/pdr.0b013e3181ed17e4

PubMed ID: 22750565

Title: GATA6 loss-of-function mutation in atrial fibrillation.

PubMed ID: 22750565

DOI: 10.1016/j.ejmg.2012.06.007

PubMed ID: 22824924

Title: Novel GATA6 loss-of-function mutation responsible for familial atrial fibrillation.

PubMed ID: 22824924

DOI: 10.3892/ijmm.2012.1068

PubMed ID: 22158542

Title: GATA6 haploinsufficiency causes pancreatic agenesis in humans.

PubMed ID: 22158542

DOI: 10.1038/ng.1035

PubMed ID: 27756709

Title: Gain-of-function mutations in GATA6 lead to atrial fibrillation.

PubMed ID: 27756709

DOI: 10.1016/j.hrthm.2016.10.014

Sequence Information:

  • Length: 595
  • Mass: 60033
  • Checksum: C4D5410916543E0B
  • Sequence:
    • MALTDGGWCL PKRFGAAGAD ASDSRAFPAR EPSTPPSPIS SSSSSCSRGG ERGPGGASNC 
GTPQLDTEAA AGPPARSLLL SSYASHPFGA PHGPSAPGVA GPGGNLSSWE DLLLFTDLDQ 
AATASKLLWS SRGAKLSPFA PEQPEEMYQT LAALSSQGPA AYDGAPGGFV HSAAAAAAAA 
AAASSPVYVP TTRVGSMLPG LPYHLQGSGS GPANHAGGAG AHPGWPQASA DSPPYGSGGG 
AAGGGAAGPG GAGSAAAHVS ARFPYSPSPP MANGAAREPG GYAAAGSGGA GGVSGGGSSL 
AAMGGREPQY SSLSAARPLN GTYHHHHHHH HHHPSPYSPY VGAPLTPAWP AGPFETPVLH 
SLQSRAGAPL PVPRGPSADL LEDLSESREC VNCGSIQTPL WRRDGTGHYL CNACGLYSKM 
NGLSRPLIKP QKRVPSSRRL GLSCANCHTT TTTLWRRNAE GEPVCNACGL YMKLHGVPRP 
LAMKKEGIQT RKRKPKNINK SKTCSGNSNN SIPMTPTSTS SNSDDCSKNT SPTTQPTASG 
AGAPVMTGAG ESTNPENSEL KYSGQDGLYI GVSLASPAEV TSSVRPDSWC ALALA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.