Details for: CLDN17

Gene ID: 26285

Symbol: CLDN17

Ensembl ID: ENSG00000156282

Description: claudin 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 27.6263
    Cell Significance Index: 703.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 16.7480
    Cell Significance Index: 271.2600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 12.2064
    Cell Significance Index: 208.6600
  • Cell Name: mast cell (CL0000097)
    Fold Change: 8.0881
    Cell Significance Index: 106.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 8.0584
    Cell Significance Index: 201.2700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 7.8077
    Cell Significance Index: 101.0300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 7.4541
    Cell Significance Index: 102.2200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.3622
    Cell Significance Index: 14.3700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7225
    Cell Significance Index: 10.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.1541
    Cell Significance Index: 5.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1195
    Cell Significance Index: 1.6300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0673
    Cell Significance Index: 0.7700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0648
    Cell Significance Index: 0.3800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0390
    Cell Significance Index: 0.4200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0111
    Cell Significance Index: 0.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0052
    Cell Significance Index: 0.1000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0058
    Cell Significance Index: -0.1100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0094
    Cell Significance Index: -0.0500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0118
    Cell Significance Index: -0.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0143
    Cell Significance Index: -0.7400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0164
    Cell Significance Index: -0.2100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0165
    Cell Significance Index: -0.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0281
    Cell Significance Index: -0.3300
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0306
    Cell Significance Index: -0.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0308
    Cell Significance Index: -0.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0333
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0379
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0381
    Cell Significance Index: -0.3700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0392
    Cell Significance Index: -0.4700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0394
    Cell Significance Index: -0.4000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0410
    Cell Significance Index: -0.4400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0426
    Cell Significance Index: -0.5100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0429
    Cell Significance Index: -0.5200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0489
    Cell Significance Index: -0.5100
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.0514
    Cell Significance Index: -0.3800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0694
    Cell Significance Index: -0.8800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0748
    Cell Significance Index: -0.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0763
    Cell Significance Index: -0.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0813
    Cell Significance Index: -3.8200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0826
    Cell Significance Index: -0.8800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0870
    Cell Significance Index: -1.0700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0880
    Cell Significance Index: -0.5800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0904
    Cell Significance Index: -0.8400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0971
    Cell Significance Index: -1.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1021
    Cell Significance Index: -1.7300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1064
    Cell Significance Index: -0.9700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1167
    Cell Significance Index: -1.2100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1170
    Cell Significance Index: -0.9900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1171
    Cell Significance Index: -1.3900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1201
    Cell Significance Index: -1.3000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1211
    Cell Significance Index: -0.7700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1233
    Cell Significance Index: -1.3100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1300
    Cell Significance Index: -1.2400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1391
    Cell Significance Index: -1.0100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2252
    Cell Significance Index: -2.9400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2386
    Cell Significance Index: -2.0500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2774
    Cell Significance Index: -3.2800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.3381
    Cell Significance Index: -1.8100
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.3429
    Cell Significance Index: -2.9500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3502
    Cell Significance Index: -3.5800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.3520
    Cell Significance Index: -2.9100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3937
    Cell Significance Index: -4.0700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4184
    Cell Significance Index: -5.2500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.4611
    Cell Significance Index: -5.0100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4966
    Cell Significance Index: -5.4100
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.5235
    Cell Significance Index: -4.2800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.6271
    Cell Significance Index: -5.7600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -1.3829
    Cell Significance Index: -14.1100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -1.4089
    Cell Significance Index: -15.2500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -1.5185
    Cell Significance Index: -14.9800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -1.5777
    Cell Significance Index: -14.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** CLDN17 is primarily expressed on the plasma membrane, where it forms tight junctions with other claudins and occludin proteins. 2. **Structural role:** CLDN17 contributes to the formation and maintenance of tight junctions, which are essential for regulating paracellular transport, maintaining epithelial barrier function, and controlling cellular adhesion. 3. **Chloride channel activity:** CLDN17 has been shown to exhibit chloride channel activity, which is essential for regulating chloride homeostasis and maintaining cellular volume. 4. **Cell-cell communication:** CLDN17 can modulate cell-cell communication by regulating the permeability of tight junctions and influencing the distribution of signaling molecules. **Pathways and Functions:** 1. **Bicellular tight junction assembly:** CLDN17 plays a critical role in the assembly and regulation of tight junctions, which are essential for maintaining epithelial barrier function and controlling paracellular transport. 2. **Calcium-independent cell-cell adhesion:** CLDN17 mediates calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, which is crucial for maintaining tissue homeostasis and regulating cellular interactions. 3. **Cell-cell communication:** CLDN17 modulates cell-cell communication by regulating the permeability of tight junctions and influencing the distribution of signaling molecules. 4. **Chloride channel activity:** CLDN17 exhibits chloride channel activity, which is essential for regulating chloride homeostasis and maintaining cellular volume. **Clinical Significance:** Dysregulation of CLDN17 has been implicated in various diseases, including: 1. **Epithelial disorders:** Alterations in CLDN17 expression have been linked to epithelial disorders, such as inflammatory bowel disease and Barrett's esophagus. 2. **Neurological disorders:** CLDN17 has been implicated in neurological disorders, including Alzheimer's disease and multiple sclerosis, where it regulates cellular adhesion and communication. 3. **Cancer:** CLDN17 has been shown to act as a tumor suppressor, and its dysregulation has been linked to various types of cancer, including breast and lung cancer. In conclusion, CLDN17 is a critical component of cellular adhesion and communication, and its dysregulation has been implicated in various diseases. Further research is necessary to fully understand the mechanisms by which CLDN17 regulates cellular interactions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1718402263

Symbol: CLD17_HUMAN

Name: Claudin-17

UniProtKB Accession Codes:

P56750 Q3MJB5 Q6UY37

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 7 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 7 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

PubMed ID: 22402829

Title: Claudin-17 forms tight junction channels with distinct anion selectivity.

PubMed ID: 22402829

DOI: 10.1007/s00018-012-0949-x

PubMed ID: 26194246

Title: Molecular basis of claudin-17 anion selectivity.

PubMed ID: 26194246

DOI: 10.1007/s00018-015-1987-y

PubMed ID: 36008380

Title: Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.

PubMed ID: 36008380

DOI: 10.1038/s41467-022-32533-4

Sequence Information:

  • Length: 224
  • Mass: 24603
  • Checksum: 1833ED3178B7F63A
  • Sequence:
    • MAFYPLQIAG LVLGFLGMVG TLATTLLPQW RVSAFVGSNI IVFERLWEGL WMNCIRQARV 
RLQCKFYSSL LALPPALETA RALMCVAVAL SLIALLIGIC GMKQVQCTGS NERAKAYLLG 
TSGVLFILTG IFVLIPVSWT ANIIIRDFYN PAIHIGQKRE LGAALFLGWA SAAVLFIGGG 
LLCGFCCCNR KKQGYRYPVP GYRVPHTDKR RNTTMLSKTS TSYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.