Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 15.8490
Cell Significance Index: -4.0200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 9.4521
Cell Significance Index: -3.8400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 4.3034
Cell Significance Index: 263.8400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.8112
Cell Significance Index: 60.9100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.9289
Cell Significance Index: 61.7800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.9404
Cell Significance Index: 22.7800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8266
Cell Significance Index: 81.7700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6927
Cell Significance Index: 625.4500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.6322
Cell Significance Index: 13.4700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4531
Cell Significance Index: 49.2800 - Cell Name: myometrial cell (CL0002366)
Fold Change: 0.4428
Cell Significance Index: 5.1000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4385
Cell Significance Index: 6.2800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4376
Cell Significance Index: 71.1700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.4138
Cell Significance Index: 5.3000 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.4025
Cell Significance Index: 2.4900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3107
Cell Significance Index: 18.6500 - Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.2488
Cell Significance Index: 1.7000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2390
Cell Significance Index: 16.5300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1438
Cell Significance Index: 27.3600 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.1417
Cell Significance Index: 2.3400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1231
Cell Significance Index: 2.0600 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.1185
Cell Significance Index: 1.0000 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.1026
Cell Significance Index: 1.6300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0994
Cell Significance Index: 5.2200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0952
Cell Significance Index: 2.0900 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.0739
Cell Significance Index: 0.7800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0572
Cell Significance Index: 20.5200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0536
Cell Significance Index: 10.7500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0482
Cell Significance Index: 1.2100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0368
Cell Significance Index: 2.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0302
Cell Significance Index: 4.1500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0266
Cell Significance Index: 0.7000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0229
Cell Significance Index: 2.9300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0047
Cell Significance Index: 2.0700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0037
Cell Significance Index: 2.7100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0031
Cell Significance Index: 0.0900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0029
Cell Significance Index: 0.0500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0017
Cell Significance Index: 0.0600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0012
Cell Significance Index: 0.8100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0002
Cell Significance Index: 0.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0002
Cell Significance Index: -0.0100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0010
Cell Significance Index: -0.5500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0020
Cell Significance Index: -3.7800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0020
Cell Significance Index: -3.1300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0022
Cell Significance Index: -1.3900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0022
Cell Significance Index: -2.9900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0052
Cell Significance Index: -3.9200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0056
Cell Significance Index: -4.1300 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0066
Cell Significance Index: -3.6300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0067
Cell Significance Index: -4.1800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0079
Cell Significance Index: -1.1500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0081
Cell Significance Index: -3.6600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0082
Cell Significance Index: -2.3700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0088
Cell Significance Index: -0.1200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0129
Cell Significance Index: -2.7200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0140
Cell Significance Index: -0.3600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0143
Cell Significance Index: -2.8400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0146
Cell Significance Index: -0.2200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0176
Cell Significance Index: -3.0100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0179
Cell Significance Index: -3.2300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0185
Cell Significance Index: -2.1200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0281
Cell Significance Index: -3.4600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0289
Cell Significance Index: -0.6000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0289
Cell Significance Index: -1.8200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0319
Cell Significance Index: -4.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0329
Cell Significance Index: -0.9200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0344
Cell Significance Index: -4.0100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0348
Cell Significance Index: -4.1000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0355
Cell Significance Index: -0.4400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0360
Cell Significance Index: -3.7500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0376
Cell Significance Index: -3.8400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0405
Cell Significance Index: -2.2700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0492
Cell Significance Index: -3.3100 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0500
Cell Significance Index: -0.4300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0500
Cell Significance Index: -3.8400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0523
Cell Significance Index: -4.1400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0542
Cell Significance Index: -1.4800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0549
Cell Significance Index: -2.8500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0566
Cell Significance Index: -4.2200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0570
Cell Significance Index: -0.6200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0593
Cell Significance Index: -2.0600 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0593
Cell Significance Index: -0.7800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0631
Cell Significance Index: -1.3200 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.0648
Cell Significance Index: -0.3100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0649
Cell Significance Index: -2.8700 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0649
Cell Significance Index: -0.5000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0663
Cell Significance Index: -1.5900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0688
Cell Significance Index: -4.4400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0688
Cell Significance Index: -1.3600 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0697
Cell Significance Index: -0.9400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0712
Cell Significance Index: -3.7100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0713
Cell Significance Index: -1.5400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0729
Cell Significance Index: -2.0900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0744
Cell Significance Index: -2.3700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0751
Cell Significance Index: -2.6300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0754
Cell Significance Index: -2.4700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0768
Cell Significance Index: -2.9100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0774
Cell Significance Index: -3.6100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0794
Cell Significance Index: -3.7300 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0803
Cell Significance Index: -1.1700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1301107508
Symbol: HXK4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1354840
Title: Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism.
PubMed ID: 1354840
PubMed ID: 1871135
Title: Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs.
PubMed ID: 1871135
PubMed ID: 1511800
Title: Human pancreatic beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p13.
PubMed ID: 1511800
DOI: 10.1007/bf00429094
PubMed ID: 1612194
Title: Human islet glucokinase gene. Isolation and sequence analysis of full-length cDNA.
PubMed ID: 1612194
PubMed ID: 1502186
Title: Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.
PubMed ID: 1502186
PubMed ID: 1464666
Title: Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus.
PubMed ID: 1464666
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7742312
Title: Sugar specificity of human beta-cell glucokinase: correlation of molecular models with kinetic measurements.
PubMed ID: 7742312
DOI: 10.1021/bi00018a011
PubMed ID: 8878425
Title: Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
PubMed ID: 8878425
DOI: 10.1172/jci118974
PubMed ID: 10456334
Title: Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.
PubMed ID: 10456334
PubMed ID: 19146401
Title: Activating mutations in the human glucokinase gene revealed by genetic selection.
PubMed ID: 19146401
DOI: 10.1021/bi802142q
PubMed ID: 24187134
Title: Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.
PubMed ID: 24187134
PubMed ID: 8194664
Title: Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B.
PubMed ID: 8194664
PubMed ID: 15016359
Title: Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.
PubMed ID: 15016359
PubMed ID: 19362831
Title: Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.
PubMed ID: 19362831
PubMed ID: 22101819
Title: The active conformation of human glucokinase is not altered by allosteric activators.
PubMed ID: 22101819
PubMed ID: 23957911
Title: Structural basis for regulation of human glucokinase by glucokinase regulatory protein.
PubMed ID: 23957911
DOI: 10.1021/bi400838t
PubMed ID: 1360036
Title: Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus.
PubMed ID: 1360036
PubMed ID: 1303265
Title: Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes.
PubMed ID: 1303265
DOI: 10.1038/ng1092-153
PubMed ID: 8454109
Title: Glucokinase gene variants in the common form of NIDDM.
PubMed ID: 8454109
PubMed ID: 8495817
Title: Identification of glucokinase mutations in subjects with gestational diabetes mellitus.
PubMed ID: 8495817
PubMed ID: 8325892
Title: Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
PubMed ID: 8325892
PubMed ID: 8433729
Title: Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
PubMed ID: 8433729
PubMed ID: 8446612
Title: Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
PubMed ID: 8446612
PubMed ID: 8168652
Title: Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique.
PubMed ID: 8168652
PubMed ID: 9049484
Title: Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.
PubMed ID: 9049484
PubMed ID: 10694920
Title: Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY).
PubMed ID: 10694920
DOI: 10.1002/(sici)1098-1004(1998)12:2<136::aid-humu11>3.0.co;2-0
PubMed ID: 9662401
Title: Mutations in the glucokinase gene of the fetus result in reduced birth weight.
PubMed ID: 9662401
DOI: 10.1038/953
PubMed ID: 9435328
Title: Familial hyperinsulinism caused by an activating glucokinase mutation.
PubMed ID: 9435328
PubMed ID: 10588527
Title: Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.
PubMed ID: 10588527
PubMed ID: 11106831
Title: Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus.
PubMed ID: 11106831
PubMed ID: 11372010
Title: Neonatal diabetes mellitus due to complete glucokinase deficiency.
PubMed ID: 11372010
PubMed ID: 11916951
Title: The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
PubMed ID: 11916951
PubMed ID: 12941786
Title: Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.
PubMed ID: 12941786
PubMed ID: 15277402
Title: Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.
PubMed ID: 15277402
PubMed ID: 16965331
Title: Identification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients.
PubMed ID: 16965331
PubMed ID: 17082186
Title: Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.
PubMed ID: 17082186
PubMed ID: 17573900
Title: Mutations in GCK and HNF-1alpha explain the majority of cases with clinical diagnosis of MODY in Spain.
PubMed ID: 17573900
PubMed ID: 18322640
Title: Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.
PubMed ID: 18322640
PubMed ID: 19884385
Title: Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.
PubMed ID: 19884385
DOI: 10.1210/me.2009-0094
PubMed ID: 20375417
Title: Large islets, beta-cell proliferation, and a glucokinase mutation.
PubMed ID: 20375417
DOI: 10.1056/nejmc0909845
PubMed ID: 21604084
Title: The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY.
PubMed ID: 21604084
PubMed ID: 22611063
Title: Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis.
PubMed ID: 22611063
DOI: 10.2337/dc11-2420
PubMed ID: 25015100
Title: Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability.
PubMed ID: 25015100
DOI: 10.1093/hmg/ddu360
PubMed ID: 28247534
Title: Heterogeneity in phenotype of hyperinsulinism caused by activating glucokinase mutations: a novel mutation and its functional characterization.
PubMed ID: 28247534
DOI: 10.1111/cen.13318
Sequence Information:
- Length: 465
- Mass: 52191
- Checksum: 094D4A2F78096724
- Sequence:
MLDDRARMEA AKKEKVEQIL AEFQLQEEDL KKVMRRMQKE MDRGLRLETH EEASVKMLPT YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEEGQWS VKTKHQMYSI PEDAMTGTAE MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDID KGILLNWTKG FKASGAEGNN VVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDHQC EVGMIVGTGC NACYMEEMQN VELVEGDEGR MCVNTEWGAF GDSGELDEFL LEYDRLVDES SANPGQQLYE KLIGGKYMGE LVRLVLLRLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DTGDRKQIYN ILSTLGLRPS TTDCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK ERFHASVRRL TPSCEITFIE SEEGSGRGAA LVSAVACKKA CMLGQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.