Details for: PTPN18

Gene ID: 26469

Symbol: PTPN18

Ensembl ID: ENSG00000072135

Description: protein tyrosine phosphatase non-receptor type 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 170.4970
    Cell Significance Index: -26.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.1981
    Cell Significance Index: -24.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.4414
    Cell Significance Index: -29.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.5250
    Cell Significance Index: -29.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.9032
    Cell Significance Index: -29.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.6933
    Cell Significance Index: -26.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1744
    Cell Significance Index: -27.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8172
    Cell Significance Index: -23.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0349
    Cell Significance Index: -27.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5930
    Cell Significance Index: -20.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0306
    Cell Significance Index: -11.0100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.6301
    Cell Significance Index: 36.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.3897
    Cell Significance Index: 22.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3531
    Cell Significance Index: 159.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2356
    Cell Significance Index: 57.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1240
    Cell Significance Index: 130.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8365
    Cell Significance Index: 15.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7553
    Cell Significance Index: 151.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7023
    Cell Significance Index: 48.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6738
    Cell Significance Index: 30.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5617
    Cell Significance Index: 15.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5530
    Cell Significance Index: 105.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5500
    Cell Significance Index: 35.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5336
    Cell Significance Index: 96.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5223
    Cell Significance Index: 103.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5187
    Cell Significance Index: 84.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4642
    Cell Significance Index: 59.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4601
    Cell Significance Index: 13.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4389
    Cell Significance Index: 10.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4162
    Cell Significance Index: 51.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3812
    Cell Significance Index: 9.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3575
    Cell Significance Index: 16.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3287
    Cell Significance Index: 117.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2659
    Cell Significance Index: 7.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2598
    Cell Significance Index: 19.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2508
    Cell Significance Index: 136.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2390
    Cell Significance Index: 40.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2182
    Cell Significance Index: 3.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2088
    Cell Significance Index: 28.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1343
    Cell Significance Index: 4.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1237
    Cell Significance Index: 15.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0817
    Cell Significance Index: 1.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0687
    Cell Significance Index: 47.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0672
    Cell Significance Index: 6.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0594
    Cell Significance Index: 0.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0487
    Cell Significance Index: 2.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0211
    Cell Significance Index: 9.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0100
    Cell Significance Index: 1.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0061
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0093
    Cell Significance Index: -17.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0131
    Cell Significance Index: -9.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0147
    Cell Significance Index: -20.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0165
    Cell Significance Index: -10.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0170
    Cell Significance Index: -0.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0175
    Cell Significance Index: -11.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0380
    Cell Significance Index: -21.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0453
    Cell Significance Index: -20.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0729
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0743
    Cell Significance Index: -15.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0799
    Cell Significance Index: -22.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0870
    Cell Significance Index: -12.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0925
    Cell Significance Index: -6.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1183
    Cell Significance Index: -1.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1226
    Cell Significance Index: -2.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1232
    Cell Significance Index: -3.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1266
    Cell Significance Index: -8.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1736
    Cell Significance Index: -3.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1828
    Cell Significance Index: -4.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1850
    Cell Significance Index: -10.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1908
    Cell Significance Index: -12.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1919
    Cell Significance Index: -8.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2095
    Cell Significance Index: -3.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2105
    Cell Significance Index: -7.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2183
    Cell Significance Index: -11.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2392
    Cell Significance Index: -27.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2544
    Cell Significance Index: -19.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2566
    Cell Significance Index: -26.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2780
    Cell Significance Index: -2.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2890
    Cell Significance Index: -22.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2963
    Cell Significance Index: -9.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3254
    Cell Significance Index: -5.7500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3590
    Cell Significance Index: -3.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3696
    Cell Significance Index: -12.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4305
    Cell Significance Index: -11.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4385
    Cell Significance Index: -22.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4437
    Cell Significance Index: -27.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4540
    Cell Significance Index: -22.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4822
    Cell Significance Index: -7.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5305
    Cell Significance Index: -11.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5325
    Cell Significance Index: -6.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5397
    Cell Significance Index: -17.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5467
    Cell Significance Index: -10.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5563
    Cell Significance Index: -14.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5641
    Cell Significance Index: -18.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5832
    Cell Significance Index: -20.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6192
    Cell Significance Index: -14.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PTPN18 is a non-receptor protein tyrosine phosphatase (PTP) that plays a pivotal role in the regulation of immune cell signaling. This gene is highly expressed in various immune cells, including monocytes, macrophages, B cells, and natural killer cells. PTPN18 is characterized by its ability to dephosphorylate tyrosine residues on receptor tyrosine kinases (RTKs), which in turn modulates signaling pathways involved in immune responses. **Pathways and Functions:** PTPN18 is involved in several key signaling pathways, including: 1. **Cytokine signaling:** PTPN18 regulates the activity of cytokine receptors, modulating the production of pro-inflammatory and anti-inflammatory cytokines. 2. **Interleukin-1 family signaling:** PTPN18 interacts with IL-1R1 and IL-1R2, influencing the production of IL-1β and IL-1α. 3. **Interleukin-37 signaling:** PTPN18 regulates IL-37-mediated anti-inflammatory responses. 4. **Downregulation of ERBB signaling:** PTPN18 inhibits the activation of ERBB receptors, which are involved in cell proliferation and survival. PTPN18's functions in immune cell signaling are crucial for maintaining immune homeostasis and preventing excessive inflammation. By dephosphorylating RTKs, PTPN18 modulates the activity of immune cells, influencing their proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of PTPN18 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Enhanced PTPN18 activity has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Inflammatory bowel disease:** Altered PTPN18 expression has been observed in patients with inflammatory bowel disease (IBD). 3. **Cancer:** PTPN18's role in regulating cell signaling pathways makes it a potential target for cancer therapy. In conclusion, PTPN18 is a critical gene involved in the regulation of immune cell signaling and function. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into the mechanisms underlying PTPN18's functions.

Genular Protein ID: 2158702834

Symbol: PTN18_HUMAN

Name: Tyrosine-protein phosphatase non-receptor type 18

UniProtKB Accession Codes:

Q99952 B4E1E6 Q53P42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8950995

Title: Characterization of the PEST family protein tyrosine phosphatase BDP1.

PubMed ID: 8950995

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 19167335

Title: Large-scale structural analysis of the classical human protein tyrosine phosphatome.

PubMed ID: 19167335

DOI: 10.1016/j.cell.2008.11.038

Sequence Information:

  • Length: 460
  • Mass: 50482
  • Checksum: 67ED24A0504D1883
  • Sequence:
    • MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA GSRPENVRKN 
RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA YIATQGPLPH TLLDFWRLVW 
EFGVKVILMA CREIENGRKR CERYWAQEQE PLQTGLFCIT LIKEKWLNED IMLRTLKVTF 
QKESRSVYQL QYMSWPDRGV PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC 
TVDYVRQLLL TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS 
PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM ADTYAVVQKR 
GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG AHAEDARGTL PGRVPADQSP 
AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP RDPPAEWTRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.