Details for: NR6A1

Gene ID: 2649

Symbol: NR6A1

Ensembl ID: ENSG00000148200

Description: nuclear receptor subfamily 6 group A member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.55
    Marker Score: 4294
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.21
    Marker Score: 4320
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.9
    Marker Score: 51563
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.89
    Marker Score: 2566
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.89
    Marker Score: 916
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.71
    Marker Score: 1584
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.63
    Marker Score: 1826
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.38
    Marker Score: 996
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.27
    Marker Score: 2506
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.19
    Marker Score: 1685
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.16
    Marker Score: 32222
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.06
    Marker Score: 78191
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.04
    Marker Score: 68942
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.99
    Marker Score: 2252
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.99
    Marker Score: 44392
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.95
    Marker Score: 4876
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.93
    Marker Score: 14757
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.88
    Marker Score: 7779
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.88
    Marker Score: 7822
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.86
    Marker Score: 68658
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.82
    Marker Score: 18827
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.82
    Marker Score: 111701
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.8
    Marker Score: 7329
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.8
    Marker Score: 1555
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.78
    Marker Score: 486
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.78
    Marker Score: 7430.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.77
    Marker Score: 15215
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.76
    Marker Score: 928
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.73
    Marker Score: 5683
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.73
    Marker Score: 6700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.71
    Marker Score: 36593
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.69
    Marker Score: 15889
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.69
    Marker Score: 5986
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.66
    Marker Score: 2087.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.64
    Marker Score: 15583
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.61
    Marker Score: 9690
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2444
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.57
    Marker Score: 25277
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.56
    Marker Score: 31066
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.51
    Marker Score: 2528
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.47
    Marker Score: 2109
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.46
    Marker Score: 421
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.45
    Marker Score: 417
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3341
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2778
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.35
    Marker Score: 1664
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19947
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.26
    Marker Score: 5852
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.23
    Marker Score: 389
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.23
    Marker Score: 7881
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.22
    Marker Score: 7223
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.22
    Marker Score: 2914
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.2
    Marker Score: 10181
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.19
    Marker Score: 590
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.18
    Marker Score: 346
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.17
    Marker Score: 5032
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.16
    Marker Score: 1001
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.15
    Marker Score: 2519
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.14
    Marker Score: 6153
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.13
    Marker Score: 798
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.13
    Marker Score: 1216
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.13
    Marker Score: 1186.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.11
    Marker Score: 358
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.1
    Marker Score: 346
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.1
    Marker Score: 4256
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.08
    Marker Score: 890
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.07
    Marker Score: 3797.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.07
    Marker Score: 530
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.04
    Marker Score: 4319
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.04
    Marker Score: 1466
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.03
    Marker Score: 535
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.03
    Marker Score: 327
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.03
    Marker Score: 1286
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.03
    Marker Score: 272
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.01
    Marker Score: 665
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.95
    Marker Score: 322
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1531
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.93
    Marker Score: 348
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.93
    Marker Score: 423
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.92
    Marker Score: 1064
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.91
    Marker Score: 1751
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.91
    Marker Score: 183
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 542
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.89
    Marker Score: 2537
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.89
    Marker Score: 280
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5030
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.87
    Marker Score: 322
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 659.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.86
    Marker Score: 502
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 332

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Other Information

**Key characteristics:** - NR6A1 is a transcription factor that regulates gene expression through the binding to specific DNA sequences. - It is a key regulator of cell proliferation, differentiation, and survival. - It is involved in the regulation of various developmental processes, including eye development and the formation of the male reproductive tract. **Pathways and functions:** - NR6A1 is a key regulator of eye development. It is expressed in lens epithelial cells, which are responsible for the development of the eye. NR6A1 binds to DNA sequences in the promoter region of the eye-specific transcription factor 1 (EGF-1) gene and promotes its expression. This leads to the development of the ciliary body, which is responsible for the function of the eye. - NR6A1 also plays a role in the development of the male reproductive tract. It is expressed in basal epithelial cells of the prostate and is required for the development of the prostate gland. NR6A1 binds to DNA sequences in the promoter region of the sox2 gene, which is responsible for the development of male reproductive tract cells. This leads to the development of the prostate gland and the seminal vesicles. **Clinical significance:** NR6A1 gene mutations have been linked to a number of human diseases, including cataracts, glaucoma, and prostate cancer. These mutations can disrupt the normal function of NR6A1, leading to the development of these diseases. **Conclusion:** NR6A1 is a key regulator of eye development and the formation of the male reproductive tract. Its mutations have been linked to a number of human diseases, highlighting its importance in human health.

Genular Protein ID: 2240306448

Symbol: NR6A1_HUMAN

Name: Nuclear receptor subfamily 6 group A member 1

UniProtKB Accession Codes:

Q15406 O00551 O00603 Q5T6F4 Q8NHQ0 Q92898 Q99802

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8982251

Title: Characterization of the human germ cell nuclear factor gene.

PubMed ID: 8982251

DOI: 10.1016/s0167-4781(96)00157-1

PubMed ID: 9177477

Title: cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF).

PubMed ID: 9177477

DOI: 10.1016/s0167-4781(97)00043-2

PubMed ID: 9134503

Title: Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation.

PubMed ID: 9134503

DOI: 10.1677/jme.0.0180167

PubMed ID: 9537518

Title: Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF.

PubMed ID: 9537518

DOI: 10.1016/s0014-5793(98)00142-2

PubMed ID: 9493564

Title: Cloning of the human NCNF gene.

PubMed ID: 9493564

DOI: 10.3109/10799899809039161

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12080054

Title: RAP80: a novel nuclear protein that interacts with the retinoid-related testis-associated receptor.

PubMed ID: 12080054

DOI: 10.1074/jbc.m203475200

Sequence Information:

  • Length: 480
  • Mass: 54383
  • Checksum: 0D8578E192581A8E
  • Sequence:
    • MERDEPPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTISV SDDRAEQRTC 
LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK NCVMSRKQRN RCQYCRLLKC 
LQMGMNRKAI REDGMPGGRN KSIGPVQISE EEIERIMSGQ EFEEEANHWS NHGDSDHSSP 
GNRASESNQP SPGSTLSSSR SVELNGFMAF REQYMGMSVP PHYQYIPHLF SYSGHSPLLP 
QQARSLDPQS YSLIHQLLSA EDLEPLGTPM LIEDGYAVTQ AELFALLCRL ADELLFRQIA 
WIKKLPFFCE LSIKDYTCLL SSTWQELILL SSLTVYSKQI FGELADVTAK YSPSDEELHR 
FSDEGMEVIE RLIYLYHKFH QLKVSNEEYA CMKAINFLNQ DIRGLTSASQ LEQLNKRYWY 
ICQDFTEYKY THQPNRFPDL MMCLPEIRYI AGKMVNVPLE QLPLLFKVVL HSCKTSVGKE

Genular Protein ID: 1155580466

Symbol: F1DAM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1DAM1

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 5 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 476
  • Mass: 53996
  • Checksum: 6C7881E654CC9046
  • Sequence:
    • MERDEPPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTNDR AEQRTCLICG 
DRATGLHYGI ISCEGCKGFF KRSICNKRVY RCSRDKNCVM SRKQRNRCQY CRLLKCLQMG 
MNRKAIREDG MPGGRNKSIG PVQISEEEIE RIMSGQEFEE EANHWSNHGD SDHSSPGNRA 
SESNQPSPGS TLSSSRSVEL NGFMAFREQY MGMSVPPHYQ YIPHLFSYSG HSPLLPQQAR 
SLDPQSYSLI HQLLSAEDLE PLGTPMLIED GYAVTQAELF ALLCRLADEL LFRQIAWIKK 
LPFFCELSIK DYTCLLSSTW QELILLSSLT VYSKQIFGEL ADVTAKYSPS DEELHRFSDE 
GMEVIERLIY LYHKFHQLKV SNEEYACMKA INFLNQDIRG LTSASQLEQL NKRYWYICQD 
FTEYKYTHQP NRFPDLMMCL PEIRYIAGKM VNVPLEQLPL LFKVVLHSCK TSVGKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.