Details for: NR6A1

Gene ID: 2649

Symbol: NR6A1

Ensembl ID: ENSG00000148200

Description: nuclear receptor subfamily 6 group A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 304.1559
    Cell Significance Index: -47.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 181.9878
    Cell Significance Index: -46.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.5609
    Cell Significance Index: -48.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.4848
    Cell Significance Index: -47.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1729
    Cell Significance Index: -48.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6174
    Cell Significance Index: -18.8600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.3830
    Cell Significance Index: 30.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1531
    Cell Significance Index: 625.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.1248
    Cell Significance Index: 83.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.7059
    Cell Significance Index: 75.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2473
    Cell Significance Index: 450.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.1278
    Cell Significance Index: 53.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9703
    Cell Significance Index: 52.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9613
    Cell Significance Index: 150.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6408
    Cell Significance Index: 588.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5978
    Cell Significance Index: 21.8000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.5593
    Cell Significance Index: 15.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4877
    Cell Significance Index: 56.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4740
    Cell Significance Index: 65.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4559
    Cell Significance Index: 81.7000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.2902
    Cell Significance Index: 7.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2600
    Cell Significance Index: 27.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9329
    Cell Significance Index: 20.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9014
    Cell Significance Index: 623.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8084
    Cell Significance Index: 23.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7545
    Cell Significance Index: 34.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.7383
    Cell Significance Index: 1136.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7006
    Cell Significance Index: 43.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6918
    Cell Significance Index: 624.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6691
    Cell Significance Index: 44.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5394
    Cell Significance Index: 733.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4766
    Cell Significance Index: 11.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4583
    Cell Significance Index: 845.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4101
    Cell Significance Index: 66.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3764
    Cell Significance Index: 40.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3591
    Cell Significance Index: 21.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3014
    Cell Significance Index: 8.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2693
    Cell Significance Index: 507.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2644
    Cell Significance Index: 6.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2612
    Cell Significance Index: 30.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2177
    Cell Significance Index: 5.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2074
    Cell Significance Index: 25.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1982
    Cell Significance Index: 12.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1760
    Cell Significance Index: 31.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1508
    Cell Significance Index: 14.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1251
    Cell Significance Index: 79.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1249
    Cell Significance Index: 2.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1024
    Cell Significance Index: 5.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0711
    Cell Significance Index: 32.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0541
    Cell Significance Index: 29.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0206
    Cell Significance Index: -2.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0274
    Cell Significance Index: -12.1000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0449
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0512
    Cell Significance Index: -37.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0555
    Cell Significance Index: -41.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0650
    Cell Significance Index: -49.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0835
    Cell Significance Index: -47.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0889
    Cell Significance Index: -55.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0981
    Cell Significance Index: -18.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1090
    Cell Significance Index: -3.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1364
    Cell Significance Index: -39.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1430
    Cell Significance Index: -24.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2337
    Cell Significance Index: -26.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2429
    Cell Significance Index: -25.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2442
    Cell Significance Index: -16.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2503
    Cell Significance Index: -52.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2517
    Cell Significance Index: -32.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2729
    Cell Significance Index: -34.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2879
    Cell Significance Index: -39.5300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3098
    Cell Significance Index: -3.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3426
    Cell Significance Index: -25.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3678
    Cell Significance Index: -5.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3684
    Cell Significance Index: -43.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3964
    Cell Significance Index: -40.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4841
    Cell Significance Index: -8.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4956
    Cell Significance Index: -35.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5002
    Cell Significance Index: -23.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5285
    Cell Significance Index: -10.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5318
    Cell Significance Index: -42.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5549
    Cell Significance Index: -8.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5651
    Cell Significance Index: -18.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5709
    Cell Significance Index: -26.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5809
    Cell Significance Index: -19.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6201
    Cell Significance Index: -13.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6302
    Cell Significance Index: -38.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6760
    Cell Significance Index: -21.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6762
    Cell Significance Index: -14.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7203
    Cell Significance Index: -46.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7262
    Cell Significance Index: -37.8300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7395
    Cell Significance Index: -9.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7798
    Cell Significance Index: -40.9400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.7809
    Cell Significance Index: -10.9200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7942
    Cell Significance Index: -11.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8132
    Cell Significance Index: -11.6500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.8243
    Cell Significance Index: -8.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8372
    Cell Significance Index: -9.9800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.8530
    Cell Significance Index: -5.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8625
    Cell Significance Index: -22.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8943
    Cell Significance Index: -31.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9579
    Cell Significance Index: -18.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NR6A1 is a nuclear receptor that belongs to the nuclear receptor superfamily, which includes ligand-activated transcription factors that regulate gene expression in response to specific ligands. NR6A1 is specifically expressed in various tissues, including the adrenal gland, prostate, lens, retina, and cornea. Its expression is tightly regulated by transcriptional co-activators and co-repressors, which modulate its activity in response to different cellular signals. **Pathways and Functions** NR6A1 is involved in various signaling pathways that regulate cell proliferation, differentiation, and survival. Some of the key pathways and functions associated with NR6A1 include: * **Regulation of transcription by RNA polymerase II**: NR6A1 acts as a transcriptional regulator by binding to RNA polymerase II and influencing the transcriptional activity of target genes. * **Activation of pluripotent stem cell genes**: NR6A1 is involved in the regulation of genes that are essential for the maintenance of pluripotency in embryonic stem cells, such as Pou5f1, Sox2, and Nanog. * **Regulation of cell proliferation and differentiation**: NR6A1 is involved in the regulation of cell proliferation and differentiation in various tissues, including the adrenal gland, prostate, and lens. * **Involvement in gamete generation**: NR6A1 is expressed in the testes and ovaries and is involved in the regulation of gamete generation and fertility. **Clinical Significance** NR6A1 has been implicated in various diseases, including: * **Cancer**: NR6A1 is overexpressed in several types of cancer, including prostate cancer, breast cancer, and ovarian cancer. Its overexpression is associated with tumor progression and metastasis. * **Neurodegenerative diseases**: NR6A1 has been implicated in the regulation of gene expression in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * **Immune system disorders**: NR6A1 is involved in the regulation of immune system function and has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, NR6A1 is a transcription factor that plays a crucial role in regulating gene expression in various cell types, particularly those involved in development, cell differentiation, and proliferation. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and immune system disorders. Further research is needed to fully understand the mechanisms by which NR6A1 regulates gene expression and its role in human disease.

Genular Protein ID: 2240306448

Symbol: NR6A1_HUMAN

Name: Nuclear receptor subfamily 6 group A member 1

UniProtKB Accession Codes:

Q15406 O00551 O00603 Q5T6F4 Q8NHQ0 Q92898 Q99802

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8982251

Title: Characterization of the human germ cell nuclear factor gene.

PubMed ID: 8982251

DOI: 10.1016/s0167-4781(96)00157-1

PubMed ID: 9177477

Title: cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF).

PubMed ID: 9177477

DOI: 10.1016/s0167-4781(97)00043-2

PubMed ID: 9134503

Title: Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation.

PubMed ID: 9134503

DOI: 10.1677/jme.0.0180167

PubMed ID: 9537518

Title: Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF.

PubMed ID: 9537518

DOI: 10.1016/s0014-5793(98)00142-2

PubMed ID: 9493564

Title: Cloning of the human NCNF gene.

PubMed ID: 9493564

DOI: 10.3109/10799899809039161

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12080054

Title: RAP80: a novel nuclear protein that interacts with the retinoid-related testis-associated receptor.

PubMed ID: 12080054

DOI: 10.1074/jbc.m203475200

Sequence Information:

  • Length: 480
  • Mass: 54383
  • Checksum: 0D8578E192581A8E
  • Sequence:
    • MERDEPPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTISV SDDRAEQRTC 
LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK NCVMSRKQRN RCQYCRLLKC 
LQMGMNRKAI REDGMPGGRN KSIGPVQISE EEIERIMSGQ EFEEEANHWS NHGDSDHSSP 
GNRASESNQP SPGSTLSSSR SVELNGFMAF REQYMGMSVP PHYQYIPHLF SYSGHSPLLP 
QQARSLDPQS YSLIHQLLSA EDLEPLGTPM LIEDGYAVTQ AELFALLCRL ADELLFRQIA 
WIKKLPFFCE LSIKDYTCLL SSTWQELILL SSLTVYSKQI FGELADVTAK YSPSDEELHR 
FSDEGMEVIE RLIYLYHKFH QLKVSNEEYA CMKAINFLNQ DIRGLTSASQ LEQLNKRYWY 
ICQDFTEYKY THQPNRFPDL MMCLPEIRYI AGKMVNVPLE QLPLLFKVVL HSCKTSVGKE

Genular Protein ID: 1155580466

Symbol: F1DAM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1DAM1

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 2 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 5 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 476
  • Mass: 53996
  • Checksum: 6C7881E654CC9046
  • Sequence:
    • MERDEPPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTNDR AEQRTCLICG 
DRATGLHYGI ISCEGCKGFF KRSICNKRVY RCSRDKNCVM SRKQRNRCQY CRLLKCLQMG 
MNRKAIREDG MPGGRNKSIG PVQISEEEIE RIMSGQEFEE EANHWSNHGD SDHSSPGNRA 
SESNQPSPGS TLSSSRSVEL NGFMAFREQY MGMSVPPHYQ YIPHLFSYSG HSPLLPQQAR 
SLDPQSYSLI HQLLSAEDLE PLGTPMLIED GYAVTQAELF ALLCRLADEL LFRQIAWIKK 
LPFFCELSIK DYTCLLSSTW QELILLSSLT VYSKQIFGEL ADVTAKYSPS DEELHRFSDE 
GMEVIERLIY LYHKFHQLKV SNEEYACMKA INFLNQDIRG LTSASQLEQL NKRYWYICQD 
FTEYKYTHQP NRFPDLMMCL PEIRYIAGKM VNVPLEQLPL LFKVVLHSCK TSVGKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.