Details for: NR6A1
Gene ID: 2649
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NR6A1
Ensembl ID: ENSG00000148200
Description: nuclear receptor subfamily 6 group A member 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 30.88rCSI 51.84%PRS 66.46
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CSI 28.14rCSI 42.9%PRS 80.33
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CSI 26.58rCSI 25.63%PRS 77.66
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CSI 23.53rCSI 37.85%PRS 67.92
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CSI 18.71rCSI 23.28%PRS 64.42
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CSI 18.1rCSI 44%PRS 64.41
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CSI 17.58rCSI 38.84%PRS 70.05
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CSI 17.3rCSI 26.1%PRS 88.22
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CSI 17.16rCSI 20.5%PRS 66.53
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CSI 17.15rCSI 53.58%PRS 68.09
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CSI 16.23rCSI 41.96%PRS 79.31
-
CSI 15.8rCSI 27.85%PRS 78.77
-
CSI 14.53rCSI 37.86%PRS 77.6
-
CSI 14.53rCSI 52.27%PRS 64.44
-
CSI 14.05rCSI 48.14%PRS 69.6
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CSI 13.65rCSI 54.05%PRS 78.09
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CSI 13.22rCSI 41.33%PRS 70.43
-
CSI 12.4rCSI 15.98%PRS 67.68
-
CSI 12.13rCSI 9.59%PRS 73.48
-
CSI 12.11rCSI 19.83%PRS 73.79
-
CSI 11.77rCSI 65.83%PRS 83.55
-
CSI 11.54rCSI 26.63%PRS 71.92
-
CSI 10.96rCSI 27.79%PRS 74.62
-
CSI 10.95rCSI 41.4%PRS 67.04
-
CSI 10.86rCSI 53.98%PRS 77.79
-
CSI 10.39rCSI 12.92%PRS 84.06
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CSI 10.12rCSI 24.73%PRS 76.03
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CSI 9.99rCSI 21.87%PRS 87.81
-
CSI 9.96rCSI 13.84%PRS 81.94
-
CSI 9.92rCSI 28.74%PRS 73.36
-
CSI 9.71rCSI 17.15%PRS 66.04
-
CSI 9.68rCSI 15.44%PRS 75.31
-
CSI 9.6rCSI 10.06%PRS 80.81
-
CSI 9.47rCSI 15.35%PRS 78.32
-
CSI 9.26rCSI 17.34%PRS 72.5
-
CSI 8.96rCSI 11.49%PRS 79.78
-
CSI 8.65rCSI 17.55%PRS 62.87
-
CSI 8.56rCSI 12.28%PRS 73.89
-
CSI 8.34rCSI 14.98%PRS 77.13
-
CSI 8.25rCSI 16.57%PRS 74.68
-
CSI 7.93rCSI 9.8%PRS 81.73
-
CSI 7.73rCSI 43.66%PRS 69.93
-
CSI 7.72rCSI 45.43%PRS 67.06
-
CSI 7.7rCSI 28.84%PRS 76.53
-
CSI 7.69rCSI 8.88%PRS 75.81
-
CSI 7.55rCSI 19.61%PRS 83.37
-
CSI 7.51rCSI 17.18%PRS 84.21
-
CSI 7.37rCSI 19.2%PRS 84.44
-
CSI 7.29rCSI 19.65%PRS 87.07
-
CSI 7.16rCSI 10.94%PRS 83.35
-
CSI 7.11rCSI 12.46%PRS 77.88
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CSI 7.06rCSI 9.07%PRS 74.06
-
CSI 6.88rCSI 11.08%PRS 74.09
-
CSI 6.6rCSI 10.86%PRS 86.8
-
CSI 6.42rCSI 14.4%PRS 67.42
-
CSI 6.4rCSI 8.21%PRS 86.16
-
CSI 6.28rCSI 11.24%PRS 82.56
-
CSI 6.26rCSI 8.56%PRS 74.97
-
CSI 6.22rCSI 45.74%PRS 71.63
-
CSI 6.11rCSI 16.28%PRS 70.83
-
CSI 6.11rCSI 26.85%PRS 77.94
-
CSI 5.92rCSI 39.28%PRS 77.95
-
CSI 5.85rCSI 8.3%PRS 80.58
-
CSI 5.79rCSI 18.52%PRS 81.27
-
CSI 5.66rCSI 8.28%PRS 87.8
-
CSI 5.54rCSI 11%PRS 79.39
-
CSI 5.52rCSI 24.53%PRS 84.22
-
CSI 5.34rCSI 3.96%PRS 77.63
-
CSI 5.33rCSI 15.16%PRS 79.23
-
CSI 5.32rCSI 4.12%PRS 86.86
-
CSI 5.18rCSI 11.81%PRS 75.41
-
CSI 5.16rCSI 7.03%PRS 75.51
-
CSI 5.06rCSI 39.22%PRS 77.25
-
CSI 4.87rCSI 24.49%PRS 80.74
-
CSI 4.86rCSI 10.54%PRS 71.01
-
CSI 4.79rCSI 34.24%PRS 80.86
-
CSI 4.79rCSI 7.43%PRS 86.44
-
CSI 4.79rCSI 9.93%PRS 80.48
-
CSI 4.78rCSI 10.52%PRS 86.76
-
CSI 4.63rCSI 7.39%PRS 86.72
-
CSI 4.52rCSI 6.04%PRS 81.53
-
CSI 4.5rCSI 4.66%PRS 86.74
-
CSI 4.4rCSI 7.99%PRS 91.64
-
CSI 4.22rCSI 4.4%PRS 82.66
-
CSI 3.95rCSI 11.73%PRS 90.84
-
CSI 3.94rCSI 6.08%PRS 82.36
-
CSI 3.92rCSI 55.6%PRS 74.82
-
CSI 3.77rCSI 14.34%PRS 74.99
-
CSI 3.71rCSI 10.22%PRS 79.02
-
CSI 3.61rCSI 5.31%PRS 76.86
-
CSI 3.4rCSI 6.18%PRS 75.37
-
CSI 3.4rCSI 3.64%PRS 85.05
-
CSI 3.28rCSI 14.41%PRS 72.08
-
CSI 3.13rCSI 8.37%PRS 76.01
-
CSI 3.03rCSI 7.22%PRS 83.15
-
CSI 3.02rCSI 25.39%PRS 71.17
-
CSI 3.01rCSI 8.43%PRS 88.93
-
CSI 2.99rCSI 20.38%PRS 75.61
-
CSI 2.89rCSI 58.82%PRS 73.51
-
CSI 2.82rCSI 57.41%PRS 74.47
-
CSI 0.1rCSI 3.4%PRS 91.6%
-
CSI 0.7rCSI 7.6%PRS 71.8%
-
CSI 0.7rCSI 5.6%PRS 78.4%
-
CSI 0.8rCSI 5.1%PRS 75.8%
-
CSI 0.8rCSI 13.1%PRS 84.8%
-
CSI 0.9rCSI 6.8%PRS 73.4%
-
CSI 1.1rCSI 5.6%PRS 84.6%
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CSI 1.2rCSI 10.2%PRS 72.2%
-
CSI 1.2rCSI 3.6%PRS 87.9%
-
CSI 1.3rCSI 8.3%PRS 78.8%
-
CSI 1.4rCSI 2.1%PRS 89.5%
-
CSI 1.4rCSI 10.4%PRS 91.1%
-
CSI 1.5rCSI 6.6%PRS 67.6%
-
CSI 1.5rCSI 15.9%PRS 79.6%
-
CSI 1.6rCSI 7.4%PRS 74.5%
-
CSI 1.7rCSI 3.7%PRS 89.5%
-
CSI 1.8rCSI 12.6%PRS 74.2%
-
CSI 1.9rCSI 10.9%PRS 79.9%
-
CSI 2.0rCSI 2.5%PRS 91.2%
-
CSI 2.1rCSI 4.1%PRS 86.3%
-
CSI 2.1rCSI 12.4%PRS 74.8%
-
CSI 2.2rCSI 5.1%PRS 70.6%
-
CSI 2.2rCSI 2.9%PRS 88.2%
-
CSI 2.2rCSI 7.2%PRS 69.7%
-
CSI 2.2rCSI 2.6%PRS 76.3%
-
CSI 2.2rCSI 1.7%PRS 86.5%
-
CSI 2.3rCSI 5.8%PRS 79.8%
-
CSI 2.3rCSI 7.6%PRS 67.7%
-
CSI 2.3rCSI 5.8%PRS 83.6%
-
CSI 2.4rCSI 4.9%PRS 70.8%
-
CSI 2.4rCSI 57.8%PRS 64.9%
-
CSI 2.4rCSI 20.9%PRS 78.0%
-
CSI 2.4rCSI 58.0%PRS 64.4%
-
CSI 2.5rCSI 21.6%PRS 71.3%
-
CSI 2.5rCSI 13.0%PRS 74.0%
-
CSI 2.5rCSI 4.3%PRS 75.7%
-
CSI 2.6rCSI 8.2%PRS 80.4%
-
CSI 2.7rCSI 2.2%PRS 85.6%
-
CSI 2.7rCSI 6.2%PRS 77.1%
-
CSI 2.8rCSI 5.3%PRS 90.2%
-
CSI 2.8rCSI 4.3%PRS 86.7%
-
CSI 2.8rCSI 57.4%PRS 74.5%
-
CSI 2.9rCSI 58.8%PRS 73.5%
-
CSI 3.0rCSI 20.4%PRS 75.6%
-
CSI 3.0rCSI 8.4%PRS 88.9%
-
CSI 3.0rCSI 25.4%PRS 71.2%
-
CSI 3.0rCSI 7.2%PRS 83.2%
-
CSI 3.1rCSI 8.4%PRS 76.0%
-
CSI 3.3rCSI 14.4%PRS 72.1%
-
CSI 3.4rCSI 3.6%PRS 85.1%
-
CSI 3.4rCSI 6.2%PRS 75.4%
-
CSI 3.6rCSI 5.3%PRS 76.9%
-
CSI 3.7rCSI 10.2%PRS 79.0%
-
CSI 3.8rCSI 14.3%PRS 75.0%
-
CSI 3.9rCSI 55.6%PRS 74.8%
-
CSI 3.9rCSI 6.1%PRS 82.4%
-
CSI 4.0rCSI 11.7%PRS 90.8%
-
CSI 4.2rCSI 4.4%PRS 82.7%
-
CSI 4.4rCSI 8.0%PRS 91.6%
-
CSI 4.5rCSI 4.7%PRS 86.7%
-
CSI 4.5rCSI 6.0%PRS 81.5%
-
CSI 4.6rCSI 7.4%PRS 86.7%
-
CSI 4.8rCSI 10.5%PRS 86.8%
-
CSI 4.8rCSI 9.9%PRS 80.5%
-
CSI 4.8rCSI 7.4%PRS 86.4%
-
CSI 4.8rCSI 34.2%PRS 80.9%
-
CSI 4.9rCSI 10.5%PRS 71.0%
-
CSI 4.9rCSI 24.5%PRS 80.7%
-
CSI 5.1rCSI 39.2%PRS 77.3%
-
CSI 5.2rCSI 7.0%PRS 75.5%
-
CSI 5.2rCSI 11.8%PRS 75.4%
-
CSI 5.3rCSI 4.1%PRS 86.9%
-
CSI 5.3rCSI 15.2%PRS 79.2%
-
CSI 5.3rCSI 4.0%PRS 77.6%
-
CSI 5.5rCSI 24.5%PRS 84.2%
-
CSI 5.5rCSI 11.0%PRS 79.4%
-
CSI 5.7rCSI 8.3%PRS 87.8%
-
CSI 5.8rCSI 18.5%PRS 81.3%
-
CSI 5.9rCSI 8.3%PRS 80.6%
-
CSI 5.9rCSI 39.3%PRS 78.0%
-
CSI 6.1rCSI 26.9%PRS 77.9%
-
CSI 6.1rCSI 16.3%PRS 70.8%
-
CSI 6.2rCSI 45.7%PRS 71.6%
-
CSI 6.3rCSI 8.6%PRS 75.0%
-
CSI 6.3rCSI 11.2%PRS 82.6%
-
CSI 6.4rCSI 8.2%PRS 86.2%
-
CSI 6.4rCSI 14.4%PRS 67.4%
-
CSI 6.6rCSI 10.9%PRS 86.8%
-
CSI 6.9rCSI 11.1%PRS 74.1%
-
CSI 7.1rCSI 9.1%PRS 74.1%
-
CSI 7.1rCSI 12.5%PRS 77.9%
-
CSI 7.2rCSI 10.9%PRS 83.4%
-
CSI 7.3rCSI 19.7%PRS 87.1%
-
CSI 7.4rCSI 19.2%PRS 84.4%
-
CSI 7.5rCSI 17.2%PRS 84.2%
-
CSI 7.6rCSI 19.6%PRS 83.4%
-
CSI 7.7rCSI 8.9%PRS 75.8%
-
CSI 7.7rCSI 28.8%PRS 76.5%
-
CSI 7.7rCSI 45.4%PRS 67.1%
-
CSI 7.7rCSI 43.7%PRS 69.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2240306448
Symbol: NR6A1_HUMAN
Name: Nuclear receptor subfamily 6 group A member 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8982251
Title: Characterization of the human germ cell nuclear factor gene.
PubMed ID: 8982251
PubMed ID: 9177477
Title: cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF).
PubMed ID: 9177477
PubMed ID: 9134503
Title: Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation.
PubMed ID: 9134503
PubMed ID: 9537518
Title: Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF.
PubMed ID: 9537518
PubMed ID: 9493564
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12080054
Title: RAP80: a novel nuclear protein that interacts with the retinoid-related testis-associated receptor.
PubMed ID: 12080054
Sequence Information:
- Length: 480
- Mass: 54383
- Checksum: 0D8578E192581A8E
- Sequence:
MERDEPPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTISV SDDRAEQRTC LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK NCVMSRKQRN RCQYCRLLKC LQMGMNRKAI REDGMPGGRN KSIGPVQISE EEIERIMSGQ EFEEEANHWS NHGDSDHSSP GNRASESNQP SPGSTLSSSR SVELNGFMAF REQYMGMSVP PHYQYIPHLF SYSGHSPLLP QQARSLDPQS YSLIHQLLSA EDLEPLGTPM LIEDGYAVTQ AELFALLCRL ADELLFRQIA WIKKLPFFCE LSIKDYTCLL SSTWQELILL SSLTVYSKQI FGELADVTAK YSPSDEELHR FSDEGMEVIE RLIYLYHKFH QLKVSNEEYA CMKAINFLNQ DIRGLTSASQ LEQLNKRYWY ICQDFTEYKY THQPNRFPDL MMCLPEIRYI AGKMVNVPLE QLPLLFKVVL HSCKTSVGKE
Genular Protein ID: 1155580466
Symbol: F1DAM1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 476
- Mass: 53996
- Checksum: 6C7881E654CC9046
- Sequence:
MERDEPPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTNDR AEQRTCLICG DRATGLHYGI ISCEGCKGFF KRSICNKRVY RCSRDKNCVM SRKQRNRCQY CRLLKCLQMG MNRKAIREDG MPGGRNKSIG PVQISEEEIE RIMSGQEFEE EANHWSNHGD SDHSSPGNRA SESNQPSPGS TLSSSRSVEL NGFMAFREQY MGMSVPPHYQ YIPHLFSYSG HSPLLPQQAR SLDPQSYSLI HQLLSAEDLE PLGTPMLIED GYAVTQAELF ALLCRLADEL LFRQIAWIKK LPFFCELSIK DYTCLLSSTW QELILLSSLT VYSKQIFGEL ADVTAKYSPS DEELHRFSDE GMEVIERLIY LYHKFHQLKV SNEEYACMKA INFLNQDIRG LTSASQLEQL NKRYWYICQD FTEYKYTHQP NRFPDLMMCL PEIRYIAGKM VNVPLEQLPL LFKVVLHSCK TSVGKE