Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 241.2160
Cell Significance Index: -37.5200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 148.6240
Cell Significance Index: -37.7000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 78.9308
Cell Significance Index: -37.2700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 74.3372
Cell Significance Index: -30.2000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 69.7920
Cell Significance Index: -35.9000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 31.3592
Cell Significance Index: -29.9400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 30.4309
Cell Significance Index: -37.5200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 15.9052
Cell Significance Index: -34.8100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.8678
Cell Significance Index: -37.1500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.5311
Cell Significance Index: -37.6100 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 7.3682
Cell Significance Index: 65.4100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 6.0566
Cell Significance Index: 161.7200 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 5.2904
Cell Significance Index: 32.6400 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 4.3507
Cell Significance Index: 26.7800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 4.1050
Cell Significance Index: 87.7500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 3.2735
Cell Significance Index: 63.8900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 3.2450
Cell Significance Index: 168.5700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.2233
Cell Significance Index: 90.0800 - Cell Name: peg cell (CL4033014)
Fold Change: 3.0411
Cell Significance Index: 70.2600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.9797
Cell Significance Index: 81.1100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.6647
Cell Significance Index: 480.3700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.6361
Cell Significance Index: 24.2800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.6123
Cell Significance Index: 321.2100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.3423
Cell Significance Index: 445.7500 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 2.1545
Cell Significance Index: 27.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.6038
Cell Significance Index: 123.0800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 1.5355
Cell Significance Index: 77.6000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.2377
Cell Significance Index: 56.1000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2309
Cell Significance Index: 1111.4200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2151
Cell Significance Index: 197.6200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.8519
Cell Significance Index: 1604.0500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8494
Cell Significance Index: 39.9200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6785
Cell Significance Index: 370.5700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6760
Cell Significance Index: 73.5300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.5178
Cell Significance Index: 235.0100 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.5166
Cell Significance Index: 3.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.4505
Cell Significance Index: 286.1300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4160
Cell Significance Index: 24.9800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3864
Cell Significance Index: 49.5400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3460
Cell Significance Index: 25.7900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3142
Cell Significance Index: 138.9100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.2564
Cell Significance Index: 3.6500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2242
Cell Significance Index: 22.1800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2099
Cell Significance Index: 7.3800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1815
Cell Significance Index: 24.9300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1717
Cell Significance Index: 316.6800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1495
Cell Significance Index: 17.0600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1179
Cell Significance Index: 3.3800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0910
Cell Significance Index: 18.0500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0884
Cell Significance Index: 6.2500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0874
Cell Significance Index: 11.2900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0835
Cell Significance Index: 1.8100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0388
Cell Significance Index: 2.6800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0092
Cell Significance Index: 0.2300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0076
Cell Significance Index: 0.2200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0043
Cell Significance Index: 3.0000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0025
Cell Significance Index: 3.8600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0065
Cell Significance Index: -4.9400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0103
Cell Significance Index: -7.5700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0240
Cell Significance Index: -14.9800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0251
Cell Significance Index: -18.5800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0257
Cell Significance Index: -34.9200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0352
Cell Significance Index: -3.6000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0424
Cell Significance Index: -23.9400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0506
Cell Significance Index: -0.6900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0686
Cell Significance Index: -24.6000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0777
Cell Significance Index: -11.3000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0831
Cell Significance Index: -14.1900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0919
Cell Significance Index: -9.5600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0976
Cell Significance Index: -4.5500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0997
Cell Significance Index: -28.7000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1004
Cell Significance Index: -20.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1012
Cell Significance Index: -11.5900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1042
Cell Significance Index: -12.1400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1358
Cell Significance Index: -28.6100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1705
Cell Significance Index: -1.0300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1809
Cell Significance Index: -11.0900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2402
Cell Significance Index: -12.5100 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2440
Cell Significance Index: -1.9900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2862
Cell Significance Index: -5.2900 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.2968
Cell Significance Index: -1.9700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3071
Cell Significance Index: -6.5400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3165
Cell Significance Index: -37.3200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3230
Cell Significance Index: -6.7000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3544
Cell Significance Index: -11.3500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3671
Cell Significance Index: -29.0800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5228
Cell Significance Index: -33.7300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5478
Cell Significance Index: -36.8400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6001
Cell Significance Index: -8.8600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6097
Cell Significance Index: -38.4300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6247
Cell Significance Index: -38.4000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6647
Cell Significance Index: -37.3000 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.7144
Cell Significance Index: -7.5900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7431
Cell Significance Index: -39.0200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7690
Cell Significance Index: -12.8700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8107
Cell Significance Index: -35.8600 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.8219
Cell Significance Index: -3.8000 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.8400
Cell Significance Index: -10.3900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8458
Cell Significance Index: -31.0500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8648
Cell Significance Index: -14.8200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1816079507
Symbol: MYOF_HUMAN
Name: Myoferlin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10607832
Title: Myoferlin, a candidate gene and potential modifier of muscular dystrophy.
PubMed ID: 10607832
DOI: 10.1093/hmg/9.2.217
PubMed ID: 10995573
Title: The third human FER-1-like protein is highly similar to dysferlin.
PubMed ID: 10995573
PubMed ID: 10574462
Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10574462
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11959863
Title: Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains.
PubMed ID: 11959863
PubMed ID: 17702744
Title: Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function.
PubMed ID: 17702744
PubMed ID: 18502764
Title: The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion.
PubMed ID: 18502764
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24687993
Title: Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.
PubMed ID: 24687993
DOI: 10.1096/fj.13-246470
PubMed ID: 18495154
Title: Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b.
PubMed ID: 18495154
PubMed ID: 32542751
Title: A myoferlin gain-of-function variant associates with a new type of hereditary angioedema.
PubMed ID: 32542751
DOI: 10.1111/all.14454
Sequence Information:
- Length: 2061
- Mass: 234709
- Checksum: 61D9E9447B40781C
- Sequence:
MLRVIVESAS NIPKTKFGKP DPIVSVIFKD EKKKTKKVDN ELNPVWNEIL EFDLRGIPLD FSSSLGIIVK DFETIGQNKL IGTATVALKD LTGDQSRSLP YKLISLLNEK GQDTGATIDL VIGYDPPSAP HPNDLSGPSV PGMGGDGEED EGDEDRLDNA VRGPGPKGPV GTVSEAQLAR RLTKVKNSRR MLSNKPQDFQ IRVRVIEGRQ LSGNNIRPVV KVHVCGQTHR TRIKRGNNPF FDELFFYNVN MTPSELMDEI ISIRVYNSHS LRADCLMGEF KIDVGFVYDE PGHAVMRKWL LLNDPEDTSS GSKGYMKVSM FVLGTGDEPP PERRDRDNDS DDVESNLLLP AGIALRWVTF LLKIYRAEDI PQMDDAFSQT VKEIFGGNAD KKNLVDPFVE VSFAGKKVCT NIIEKNANPE WNQVVNLQIK FPSVCEKIKL TIYDWDRLTK NDVVGTTYLH LSKIAASGGE VEDFSSSGTG AASYTVNTGE TEVGFVPTFG PCYLNLYGSP REYTGFPDPY DELNTGKGEG VAYRGRILVE LATFLEKTPP DKKLEPISND DLLVVEKYQR RRKYSLSAVF HSATMLQDVG EAIQFEVSIG NYGNKFDTTC KPLASTTQYS RAVFDGNYYY YLPWAHTKPV VTLTSYWEDI SHRLDAVNTL LAMAERLQTN IEALKSGIQG KIPANQLAEL WLKLIDEVIE DTRYTLPLTE GKANVTVLDT QIRKLRSRSL SQIHEAAVRM RSEATDVKST LAEIEDWLDK LMQLTEEPQN SMPDIIIWMI RGEKRLAYAR IPAHQVLYST SGENASGKYC GKTQTIFLKY PQEKNNGPKV PVELRVNIWL GLSAVEKKFN SFAEGTFTVF AEMYENQALM FGKWGTSGLV GRHKFSDVTG KIKLKREFFL PPKGWEWEGE WIVDPERSLL TEADAGHTEF TDEVYQNESR YPGGDWKPAE DTYTDANGDK AASPSELTCP PGWEWEDDAW SYDINRAVDE KGWEYGITIP PDHKPKSWVA AEKMYHTHRR RRLVRKRKKD LTQTASSTAR AMEELQDQEG WEYASLIGWK FHWKQRSSDT FRRRRWRRKM APSETHGAAA IFKLEGALGA DTTEDGDEKS LEKQKHSATT VFGANTPIVS CNFDRVYIYH LRCYVYQARN LLALDKDSFS DPYAHICFLH RSKTTEIIHS TLNPTWDQTI IFDEVEIYGE PQTVLQNPPK VIMELFDNDQ VGKDEFLGRS IFSPVVKLNS EMDITPKLLW HPVMNGDKAC GDVLVTAELI LRGKDGSNLP ILPPQRAPNL YMVPQGIRPV VQLTAIEILA WGLRNMKNFQ MASITSPSLV VECGGERVES VVIKNLKKTP NFPSSVLFMK VFLPKEELYM PPLVIKVIDH RQFGRKPVVG QCTIERLDRF RCDPYAGKED IVPQLKASLL SAPPCRDIVI EMEDTKPLLA SKLTEKEEEI VDWWSKFYAS SGEHEKCGQY IQKGYSKLKI YNCELENVAE FEGLTDFSDT FKLYRGKSDE NEDPSVVGEF KGSFRIYPLP DDPSVPAPPR QFRELPDSVP QECTVRIYIV RGLELQPQDN NGLCDPYIKI TLGKKVIEDR DHYIPNTLNP VFGRMYELSC YLPQEKDLKI SVYDYDTFTR DEKVGETIID LENRFLSRFG SHCGIPEEYC VSGVNTWRDQ LRPTQLLQNV ARFKGFPQPI LSEDGSRIRY GGRDYSLDEF EANKILHQHL GAPEERLALH ILRTQGLVPE HVETRTLHST FQPNISQGKL QMWVDVFPKS LGPPGPPFNI TPRKAKKYYL RVIIWNTKDV ILDEKSITGE EMSDIYVKGW IPGNEENKQK TDVHYRSLDG EGNFNWRFVF PFDYLPAEQL CIVAKKEHFW SIDQTEFRIP PRLIIQIWDN DKFSLDDYLG FLELDLRHTI IPAKSPEKCR LDMIPDLKAM NPLKAKTASL FEQKSMKGWW PCYAEKDGAR VMAGKVEMTL EILNEKEADE RPAGKGRDEP NMNPKLDLPN RPETSFLWFT NPCKTMKFIV WRRFKWVIIG LLFLLILLLF VAVLLYSLPN YLSMKIVKPN V
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.