Details for: DAZAP1

Gene ID: 26528

Symbol: DAZAP1

Ensembl ID: ENSG00000071626

Description: DAZ associated protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 239.0944
    Cell Significance Index: -37.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.7341
    Cell Significance Index: -38.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.3931
    Cell Significance Index: -47.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.9521
    Cell Significance Index: -40.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.3603
    Cell Significance Index: -46.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.7131
    Cell Significance Index: -40.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.2381
    Cell Significance Index: -44.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.1520
    Cell Significance Index: -40.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.7231
    Cell Significance Index: -46.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8353
    Cell Significance Index: -33.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3296
    Cell Significance Index: -18.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9194
    Cell Significance Index: 51.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8411
    Cell Significance Index: 110.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6857
    Cell Significance Index: 47.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5250
    Cell Significance Index: 41.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0351
    Cell Significance Index: 66.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0051
    Cell Significance Index: 199.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9933
    Cell Significance Index: 199.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9302
    Cell Significance Index: 43.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8988
    Cell Significance Index: 811.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8904
    Cell Significance Index: 46.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8727
    Cell Significance Index: 102.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8168
    Cell Significance Index: 23.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8163
    Cell Significance Index: 132.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7304
    Cell Significance Index: 37.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7291
    Cell Significance Index: 45.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7207
    Cell Significance Index: 53.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7199
    Cell Significance Index: 32.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6894
    Cell Significance Index: 304.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6748
    Cell Significance Index: 368.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6738
    Cell Significance Index: 92.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6649
    Cell Significance Index: 81.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6412
    Cell Significance Index: 82.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6393
    Cell Significance Index: 115.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5903
    Cell Significance Index: 16.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5890
    Cell Significance Index: 40.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5821
    Cell Significance Index: 41.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5446
    Cell Significance Index: 195.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5332
    Cell Significance Index: 24.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3408
    Cell Significance Index: 235.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2907
    Cell Significance Index: 22.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2790
    Cell Significance Index: 7.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2208
    Cell Significance Index: 24.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2029
    Cell Significance Index: 7.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1447
    Cell Significance Index: 27.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1168
    Cell Significance Index: 3.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1074
    Cell Significance Index: 13.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1020
    Cell Significance Index: 10.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0916
    Cell Significance Index: 1.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0771
    Cell Significance Index: 4.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0652
    Cell Significance Index: 122.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0592
    Cell Significance Index: 10.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0502
    Cell Significance Index: 31.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0132
    Cell Significance Index: 24.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0079
    Cell Significance Index: 12.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0014
    Cell Significance Index: -1.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0139
    Cell Significance Index: -6.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0203
    Cell Significance Index: -27.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0281
    Cell Significance Index: -20.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0524
    Cell Significance Index: -38.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0790
    Cell Significance Index: -44.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0818
    Cell Significance Index: -51.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0950
    Cell Significance Index: -9.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1428
    Cell Significance Index: -41.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1461
    Cell Significance Index: -8.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1481
    Cell Significance Index: -21.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2101
    Cell Significance Index: -24.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2141
    Cell Significance Index: -5.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2147
    Cell Significance Index: -12.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2148
    Cell Significance Index: -7.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2249
    Cell Significance Index: -26.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2442
    Cell Significance Index: -10.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2486
    Cell Significance Index: -52.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2761
    Cell Significance Index: -7.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2832
    Cell Significance Index: -5.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2852
    Cell Significance Index: -19.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2961
    Cell Significance Index: -4.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3256
    Cell Significance Index: -8.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3570
    Cell Significance Index: -13.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3627
    Cell Significance Index: -6.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3893
    Cell Significance Index: -40.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4528
    Cell Significance Index: -11.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4668
    Cell Significance Index: -9.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5028
    Cell Significance Index: -39.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5772
    Cell Significance Index: -15.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6154
    Cell Significance Index: -6.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6257
    Cell Significance Index: -38.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6356
    Cell Significance Index: -32.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6823
    Cell Significance Index: -12.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7001
    Cell Significance Index: -4.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7316
    Cell Significance Index: -15.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7363
    Cell Significance Index: -17.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8325
    Cell Significance Index: -24.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8776
    Cell Significance Index: -15.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8834
    Cell Significance Index: -8.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8936
    Cell Significance Index: -13.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9010
    Cell Significance Index: -19.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9886
    Cell Significance Index: -36.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0036
    Cell Significance Index: -31.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0090
    Cell Significance Index: -10.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** DAZAP1 is predominantly found in the nucleus and cytosol, suggesting its involvement in nuclear and cytoplasmic processes. 2. **Protein interactions:** DAZAP1 interacts with various proteins, including DAZ, which is essential for spermatogenesis. 3. **RNA binding:** DAZAP1 binds to different types of RNAs, including mRNAs, poly(A) RNAs, and ribosomal RNAs. 4. **Splicing regulation:** DAZAP1 is involved in the positive regulation of mRNA splicing via the spliceosome, a complex involved in RNA processing. **Pathways and Functions:** 1. **Cell differentiation:** DAZAP1 plays a role in the differentiation of pancreatic A cells and myeloid leukocytes, indicating its involvement in the development of these cell types. 2. **Spermatogenesis:** DAZAP1 is essential for spermatogenesis, a process critical for male fertility. 3. **Fibroblast proliferation:** DAZAP1 is involved in the proliferation of fibroblasts, which are essential for tissue repair and development. 4. **RNA processing:** DAZAP1 regulates mRNA splicing, a process crucial for gene expression and cellular function. **Clinical Significance:** 1. **Cancer research:** DAZAP1 is overexpressed in various types of cancer, including pancreatic cancer. Its involvement in cell proliferation and tumor growth makes it a potential therapeutic target. 2. **Immunological disorders:** DAZAP1 is expressed in myeloid leukocytes, which are involved in the immune response. Alterations in DAZAP1 expression may contribute to immunological disorders, such as autoimmune diseases. 3. **Reproductive health:** DAZAP1 is essential for spermatogenesis, and its dysregulation may contribute to male infertility. 4. **Gene therapy:** DAZAP1's role in RNA processing and splicing regulation makes it a potential target for gene therapy approaches aimed at treating genetic disorders. In conclusion, DAZAP1 is a multifunctional gene involved in various cellular processes, including cell differentiation, spermatogenesis, and RNA processing. Its clinical significance in immunological contexts, including cancer research and immunological disorders, highlights the need for further investigation into its role in human health and disease.

Genular Protein ID: 4283261993

Symbol: DAZP1_HUMAN

Name: DAZ-associated protein 1

UniProtKB Accession Codes:

Q96EP5 Q96MJ3 Q9NRR9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10857750

Title: Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.

PubMed ID: 10857750

DOI: 10.1006/geno.2000.6169

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22001406

Title: Acetylation of Prrp K150 regulates the subcellular localization.

PubMed ID: 22001406

DOI: 10.1016/j.gene.2011.09.022

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 407
  • Mass: 43383
  • Checksum: CFEB42903F4D5AFB
  • Sequence:
    • MNNSGADEIG KLFVGGLDWS TTQETLRSYF SQYGEVVDCV IMKDKTTNQS RGFGFVKFKD 
PNCVGTVLAS RPHTLDGRNI DPKPCTPRGM QPERTRPKEG WQKGPRSDNS KSNKIFVGGI 
PHNCGETELR EYFKKFGVVT EVVMIYDAEK QRPRGFGFIT FEDEQSVDQA VNMHFHDIMG 
KKVEVKRAEP RDSKSQAPGQ PGASQWGSRV VPNAANGWAG QPPPTWQQGY GPQGMWVPAG 
QAIGGYGPPP AGRGAPPPPP PFTSYIVSTP PGGFPPPQGF PQGYGAPPQF SFGYGPPPPP 
PDQFAPPGVP PPPATPGAAP LAFPPPPSQA APDMSKPPTA QPDFPYGQYA GYGQDLSGFG 
QGFSDPSQQP PSYGGPSVPG SGGPPAGGSG FGRGQNHNVQ GFHPYRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.