Details for: GGT5

Gene ID: 2687

Symbol: GGT5

Ensembl ID: ENSG00000099998

Description: gamma-glutamyltransferase 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.39
    Marker Score: 2754
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.75
    Marker Score: 1866.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1159
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.54
    Marker Score: 922
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.51
    Marker Score: 2913
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169025
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4
    Marker Score: 1396.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.38
    Marker Score: 576
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.34
    Marker Score: 1845
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.32
    Marker Score: 834
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.27
    Marker Score: 329
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.22
    Marker Score: 293
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.17
    Marker Score: 270
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.15
    Marker Score: 258
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.14
    Marker Score: 282
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.12
    Marker Score: 278
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.11
    Marker Score: 278
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.08
    Marker Score: 421
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 496
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.07
    Marker Score: 2141.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.06
    Marker Score: 2775
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251785.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.98
    Marker Score: 951
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.98
    Marker Score: 529
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 394
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.94
    Marker Score: 536
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.93
    Marker Score: 792
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5270
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.88
    Marker Score: 29826
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.87
    Marker Score: 3762.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.86
    Marker Score: 463
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.86
    Marker Score: 5168
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.8
    Marker Score: 344
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1616
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.77
    Marker Score: 1304.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.75
    Marker Score: 2787
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.73
    Marker Score: 347
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.72
    Marker Score: 183
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.71
    Marker Score: 268
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.71
    Marker Score: 1331
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.7
    Marker Score: 197
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10238
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.64
    Marker Score: 401
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.64
    Marker Score: 247
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.61
    Marker Score: 294
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.58
    Marker Score: 129
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.57
    Marker Score: 941
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.57
    Marker Score: 122
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.54
    Marker Score: 871
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.53
    Marker Score: 568
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 166
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.52
    Marker Score: 470
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.51
    Marker Score: 631
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.5
    Marker Score: 481
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.49
    Marker Score: 120
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.48
    Marker Score: 121
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.47
    Marker Score: 424
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.47
    Marker Score: 275
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.47
    Marker Score: 3063
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.45
    Marker Score: 294
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.45
    Marker Score: 791
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.44
    Marker Score: 2335
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 260
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.43
    Marker Score: 664
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.41
    Marker Score: 481
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.41
    Marker Score: 292
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4
    Marker Score: 198
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.4
    Marker Score: 431
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.4
    Marker Score: 97
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.39
    Marker Score: 250
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.39
    Marker Score: 1507
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.39
    Marker Score: 261
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.38
    Marker Score: 977
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.37
    Marker Score: 348
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.36
    Marker Score: 83
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 94
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.33
    Marker Score: 634
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.33
    Marker Score: 99
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.33
    Marker Score: 208
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.32
    Marker Score: 5202

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Other Information

**Key characteristics:** * GGT5 is a multifunctional enzyme that can act as a glutathione peroxidase, glutathione reductase, and glutathione S-transferase. * It is involved in the detoxification of various harmful substances, including aflatoxins, which are produced by certain fungi. * It also plays a role in the metabolism of arachidonic acid, a compound that is involved in inflammation and immune responses. * GGT5 is also involved in the regulation of inflammation and immune responses, as it can modulate the production of inflammatory cytokines. **Pathways and functions:** * GGT5 is involved in multiple pathways, including aflatoxin activation and detoxification, anti-inflammatory response, arachidonic acid metabolism, and biological oxidations. * It is involved in the regulation of inflammation and immune responses by modulating the production of inflammatory cytokines. * It also plays a role in the metabolism of lipids and fatty acids, and in the synthesis of leukotrienes and eoxins, which are involved in inflammation and cell migration. **Clinical significance:** * Mutations in the GGT5 gene have been linked to an increased risk of leishmaniasis, a parasitic infection caused by the protozoan parasite Leishmania parasite. * GGT5 is a potential target for the development of new therapies for leishmaniasis, as it is involved in the metabolism of aflatoxins, which are the main causative agents of leishmaniasis. * Inhibition of GGT5 has been shown to inhibit the growth and survival of Leishmania parasites in vitro, suggesting that it could be used as a therapeutic agent for leishmaniasis. Overall, GGT5 is a critical enzyme involved in the metabolism of various molecules, including glutathione, arachidonic acid, and aflatoxins. Its expression and activity are regulated by multiple factors, including inflammation and immune responses. Mutations in the GGT5 gene have been linked to an increased risk of leishmaniasis, suggesting that it could be a potential target for the development of new therapies for this disease.

Genular Protein ID: 2309097162

Symbol: GGT5_HUMAN

Name: Glutathione hydrolase 5 proenzyme

UniProtKB Accession Codes:

P36269 Q53XM9 Q6GMP0 Q96FC1 Q9UFM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 24 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 4 EMBL 10 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 5 RefSeq 5 Rhea 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1676842

Title: Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase.

PubMed ID: 1676842

DOI: 10.1073/pnas.88.14.6303

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21447318

Title: Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.

PubMed ID: 21447318

DOI: 10.1016/j.ab.2011.03.026

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30842656

Title: S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.

PubMed ID: 30842656

DOI: 10.1038/s41586-019-1003-z

Sequence Information:

  • Length: 586
  • Mass: 62261
  • Checksum: EE37B3CE516F5788
  • Sequence:
    • MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS KVCSDIGRAI 
LQQQGSPVDA TIAALVCTSV VNPQSMGLGG GVIFTIYNVT TGKVEVINAR ETVPASHAPS 
LLDQCAQALP LGTGAQWIGV PGELRGYAEA HRRHGRLPWA QLFQPTIALL RGGHVVAPVL 
SRFLHNSILR PSLQASTLRQ LFFNGTEPLR PQDPLPWPAL ATTLETVATE GVEVFYTGRL 
GQMLVEDIAK EGSQLTLQDL AKFQPEVVDA LEVPLGDYTL YSPPPPAGGA ILSFILNVLR 
GFNFSTESMA RPEGRVNVYH HLVETLKFAK GQRWRLGDPR SHPKLQNASR DLLGETLAQL 
IRQQIDGRGD HQLSHYSLAE AWGHGTGTSH VSVLGEDGSA VAATSTINTP FGAMVYSPRT 
GIILNNELLD LCERCPRGSG TTPSPVSGDR VGGAPGRCWP PVPGERSPSS MVPSILINKA 
QGSKLVIGGA GGELIISAVA QAIMSKLWLG FDLRAAIAAP ILHVNSKGCV EYEPNFSQEV 
QRGLQDRGQN QTQRPFFLNV VQAVSQEGAC VYAVSDLRKS GEAAGY

Genular Protein ID: 4249931475

Symbol: B4DEL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DEL3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 4 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 510
  • Mass: 53813
  • Checksum: B24DD9267FD83E24
  • Sequence:
    • MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS KVCSDIGRGP 
VDRGARGAPW LCRGPPPPWP PALGAAVPAH HRAAPRGACG GPCPQPFPAQ QHPAAFLAGV 
NPALFFNGTE PLRPQDPLPW PALATTLETV ATEGVEVFYT GRLGQMLVED IAKEGSQLTL 
QDLAKFQPEV VDALEVPLGD YTLYSPPPPA GGAILSFILN VLRGFNFSTE SMARPEGRVN 
VYHHLVETLK FARGQRWRLG DPRSHPKLQN ASRDLLGETL AQLIRQQIDG RGDHQLSHYS 
LAEAWGHGTG TSHVSVLGED GSAVAATSTI NTPFGAMVYS PRTGIILNNE LLDLCERCPR 
GSGTTPSPAV SGDRVGGAPG RCWPPVPGER SPSSMVPSIL INKAQGSKLV IGGAGGELII 
SAVAQAIMSK LWLGFDLRAA IAAPILHVNS KGCVEYEPNF SQEVQRGLQD RGQNQTQRPF 
FLNVVQAVSQ EGACVYAVSD LRKSGEAAGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.