Details for: GGT5

Gene ID: 2687

Symbol: GGT5

Ensembl ID: ENSG00000099998

Description: gamma-glutamyltransferase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.6214
    Cell Significance Index: -16.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.0770
    Cell Significance Index: -16.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 33.5480
    Cell Significance Index: -13.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.6700
    Cell Significance Index: -14.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.2087
    Cell Significance Index: -11.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.5852
    Cell Significance Index: -16.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9964
    Cell Significance Index: -15.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2800
    Cell Significance Index: 22.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1038
    Cell Significance Index: 12.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8548
    Cell Significance Index: 7.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7636
    Cell Significance Index: 21.8900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6288
    Cell Significance Index: 9.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3076
    Cell Significance Index: 39.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2792
    Cell Significance Index: 14.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2739
    Cell Significance Index: 12.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2728
    Cell Significance Index: 5.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2579
    Cell Significance Index: 49.0800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1733
    Cell Significance Index: 2.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1261
    Cell Significance Index: 113.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1200
    Cell Significance Index: 8.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1102
    Cell Significance Index: 2.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0709
    Cell Significance Index: 2.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0665
    Cell Significance Index: 6.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0653
    Cell Significance Index: 8.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0623
    Cell Significance Index: 2.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0323
    Cell Significance Index: 0.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0282
    Cell Significance Index: 4.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0256
    Cell Significance Index: 0.6400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0211
    Cell Significance Index: 0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0068
    Cell Significance Index: 5.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0100
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -20.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0118
    Cell Significance Index: -5.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0137
    Cell Significance Index: -21.1000
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: -0.0140
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0160
    Cell Significance Index: -21.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0183
    Cell Significance Index: -13.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0246
    Cell Significance Index: -18.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0258
    Cell Significance Index: -16.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0259
    Cell Significance Index: -14.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0275
    Cell Significance Index: -3.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0307
    Cell Significance Index: -13.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0309
    Cell Significance Index: -0.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0318
    Cell Significance Index: -5.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0324
    Cell Significance Index: -18.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0355
    Cell Significance Index: -12.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0393
    Cell Significance Index: -4.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0403
    Cell Significance Index: -8.0000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0413
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0533
    Cell Significance Index: -15.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0665
    Cell Significance Index: -13.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0685
    Cell Significance Index: -9.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0705
    Cell Significance Index: -4.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0719
    Cell Significance Index: -4.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0796
    Cell Significance Index: -9.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0868
    Cell Significance Index: -18.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0923
    Cell Significance Index: -15.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1168
    Cell Significance Index: -11.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1267
    Cell Significance Index: -14.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1298
    Cell Significance Index: -15.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1428
    Cell Significance Index: -2.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1497
    Cell Significance Index: -8.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1528
    Cell Significance Index: -17.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1562
    Cell Significance Index: -11.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1563
    Cell Significance Index: -8.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1578
    Cell Significance Index: -16.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1639
    Cell Significance Index: -12.5800
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1739
    Cell Significance Index: -2.0200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1763
    Cell Significance Index: -1.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2272
    Cell Significance Index: -14.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2391
    Cell Significance Index: -16.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2405
    Cell Significance Index: -15.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2488
    Cell Significance Index: -15.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3119
    Cell Significance Index: -17.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3121
    Cell Significance Index: -12.7900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3216
    Cell Significance Index: -2.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3294
    Cell Significance Index: -15.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3402
    Cell Significance Index: -8.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3428
    Cell Significance Index: -17.8100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3499
    Cell Significance Index: -4.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3503
    Cell Significance Index: -18.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3746
    Cell Significance Index: -5.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3812
    Cell Significance Index: -16.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3856
    Cell Significance Index: -13.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4243
    Cell Significance Index: -11.3700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4280
    Cell Significance Index: -4.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4393
    Cell Significance Index: -16.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4433
    Cell Significance Index: -12.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4487
    Cell Significance Index: -16.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4515
    Cell Significance Index: -9.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4519
    Cell Significance Index: -9.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4539
    Cell Significance Index: -15.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4742
    Cell Significance Index: -12.1900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4816
    Cell Significance Index: -9.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4861
    Cell Significance Index: -15.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5049
    Cell Significance Index: -16.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5081
    Cell Significance Index: -14.9700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5089
    Cell Significance Index: -12.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GGT5 is a gamma-glutamyltransferase enzyme that belongs to the family of gamma-glutamyltransferases, which play a crucial role in the synthesis and degradation of glutathione, a tripeptide antioxidant that protects cells from oxidative stress. Unlike other gamma-glutamyltransferases, GGT5 has been shown to have a distinct substrate specificity, preferring the conversion of glutathione to gamma-glutamylcysteine over the conventional gamma-glutamyltransferase activity. **Pathways and Functions:** GGT5 is intricately involved in various biological pathways, including: 1. **Anti-inflammatory response favoring Leishmania parasite infection**: GGT5 has been shown to modulate the anti-inflammatory response by regulating the production of glutathione, which in turn affects the proliferation and survival of Leishmania parasites. 2. **Amino acid metabolic process**: GGT5 plays a role in the regulation of amino acid metabolism, particularly in the context of glutamine and glutamate metabolism. 3. **Glutathione biosynthetic process and catabolic process**: GGT5 is involved in the synthesis and degradation of glutathione, which is essential for maintaining cellular redox balance. 4. **Leukotriene biosynthesis**: GGT5 has been implicated in the regulation of leukotriene synthesis, which is a critical process in the development of inflammatory responses. **Clinical Significance:** The clinical significance of GGT5 is multifaceted, with implications for various diseases, including: 1. **Infectious diseases**: GGT5 has been shown to play a role in the regulation of the anti-inflammatory response to Leishmania parasite infection, which has significant implications for the treatment of this disease. 2. **Cancer**: GGT5 has been implicated in the regulation of glutathione metabolism, which is a critical process in cancer development and progression. 3. **Neurological disorders**: GGT5 has been shown to play a role in the regulation of glutathione metabolism in the brain, which has implications for the treatment of neurological disorders, such as Alzheimer's disease. **Significantly Expressed Cells:** GGT5 is expressed in various cell types, including vascular leptomeningeal cells, skeletal muscle satellite stem cells, colon goblet cells, and kidney interstitial fibroblasts. This highlights the enzyme's role in maintaining tissue homeostasis and regulating immune responses. **Conclusion:** In conclusion, GGT5 is a complex enzyme that plays a critical role in regulating immune responses, metabolism, and detoxification. Further research is necessary to fully elucidate the mechanisms by which GGT5 modulates biological processes and to explore its potential therapeutic applications in the treatment of various diseases.

Genular Protein ID: 2309097162

Symbol: GGT5_HUMAN

Name: Glutathione hydrolase 5 proenzyme

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1676842

Title: Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase.

PubMed ID: 1676842

DOI: 10.1073/pnas.88.14.6303

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21447318

Title: Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.

PubMed ID: 21447318

DOI: 10.1016/j.ab.2011.03.026

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30842656

Title: S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.

PubMed ID: 30842656

DOI: 10.1038/s41586-019-1003-z

Sequence Information:

  • Length: 586
  • Mass: 62261
  • Checksum: EE37B3CE516F5788
  • Sequence:
  • MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS KVCSDIGRAI 
    LQQQGSPVDA TIAALVCTSV VNPQSMGLGG GVIFTIYNVT TGKVEVINAR ETVPASHAPS 
    LLDQCAQALP LGTGAQWIGV PGELRGYAEA HRRHGRLPWA QLFQPTIALL RGGHVVAPVL 
    SRFLHNSILR PSLQASTLRQ LFFNGTEPLR PQDPLPWPAL ATTLETVATE GVEVFYTGRL 
    GQMLVEDIAK EGSQLTLQDL AKFQPEVVDA LEVPLGDYTL YSPPPPAGGA ILSFILNVLR 
    GFNFSTESMA RPEGRVNVYH HLVETLKFAK GQRWRLGDPR SHPKLQNASR DLLGETLAQL 
    IRQQIDGRGD HQLSHYSLAE AWGHGTGTSH VSVLGEDGSA VAATSTINTP FGAMVYSPRT 
    GIILNNELLD LCERCPRGSG TTPSPVSGDR VGGAPGRCWP PVPGERSPSS MVPSILINKA 
    QGSKLVIGGA GGELIISAVA QAIMSKLWLG FDLRAAIAAP ILHVNSKGCV EYEPNFSQEV 
    QRGLQDRGQN QTQRPFFLNV VQAVSQEGAC VYAVSDLRKS GEAAGY

Genular Protein ID: 4249931475

Symbol: B4DEL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 510
  • Mass: 53813
  • Checksum: B24DD9267FD83E24
  • Sequence:
  • MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS KVCSDIGRGP 
    VDRGARGAPW LCRGPPPPWP PALGAAVPAH HRAAPRGACG GPCPQPFPAQ QHPAAFLAGV 
    NPALFFNGTE PLRPQDPLPW PALATTLETV ATEGVEVFYT GRLGQMLVED IAKEGSQLTL 
    QDLAKFQPEV VDALEVPLGD YTLYSPPPPA GGAILSFILN VLRGFNFSTE SMARPEGRVN 
    VYHHLVETLK FARGQRWRLG DPRSHPKLQN ASRDLLGETL AQLIRQQIDG RGDHQLSHYS 
    LAEAWGHGTG TSHVSVLGED GSAVAATSTI NTPFGAMVYS PRTGIILNNE LLDLCERCPR 
    GSGTTPSPAV SGDRVGGAPG RCWPPVPGER SPSSMVPSIL INKAQGSKLV IGGAGGELII 
    SAVAQAIMSK LWLGFDLRAA IAAPILHVNS KGCVEYEPNF SQEVQRGLQD RGQNQTQRPF 
    FLNVVQAVSQ EGACVYAVSD LRKSGEAAGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.