Details for: SEC22A

Gene ID: 26984

Symbol: SEC22A

Ensembl ID: ENSG00000121542

Description: SEC22 homolog A, vesicle trafficking protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 200.6490
    Cell Significance Index: -31.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.7421
    Cell Significance Index: -31.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 70.3488
    Cell Significance Index: -28.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.1603
    Cell Significance Index: -32.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.3435
    Cell Significance Index: -26.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.4081
    Cell Significance Index: -32.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3962
    Cell Significance Index: -27.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.9510
    Cell Significance Index: -19.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4357
    Cell Significance Index: -25.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3020
    Cell Significance Index: -32.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7090
    Cell Significance Index: 342.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3938
    Cell Significance Index: 78.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2589
    Cell Significance Index: 24.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1920
    Cell Significance Index: 26.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1504
    Cell Significance Index: 27.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1324
    Cell Significance Index: 69.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0065
    Cell Significance Index: 199.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8614
    Cell Significance Index: 23.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8205
    Cell Significance Index: 31.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7990
    Cell Significance Index: 61.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7577
    Cell Significance Index: 271.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7257
    Cell Significance Index: 655.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7183
    Cell Significance Index: 31.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7139
    Cell Significance Index: 19.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5614
    Cell Significance Index: 55.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5157
    Cell Significance Index: 12.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5018
    Cell Significance Index: 33.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4969
    Cell Significance Index: 57.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4784
    Cell Significance Index: 77.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4402
    Cell Significance Index: 47.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3441
    Cell Significance Index: 238.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3427
    Cell Significance Index: 8.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3336
    Cell Significance Index: 20.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2180
    Cell Significance Index: 6.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1850
    Cell Significance Index: 35.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1407
    Cell Significance Index: 17.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1366
    Cell Significance Index: 2.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1329
    Cell Significance Index: 23.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1315
    Cell Significance Index: 58.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1216
    Cell Significance Index: 5.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1170
    Cell Significance Index: 63.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0923
    Cell Significance Index: 2.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0844
    Cell Significance Index: 158.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0740
    Cell Significance Index: 47.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0719
    Cell Significance Index: 32.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0644
    Cell Significance Index: 8.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0629
    Cell Significance Index: 4.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0601
    Cell Significance Index: 7.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0542
    Cell Significance Index: 83.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0510
    Cell Significance Index: 94.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0337
    Cell Significance Index: 45.8500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0313
    Cell Significance Index: 0.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0268
    Cell Significance Index: 0.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0067
    Cell Significance Index: -0.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0199
    Cell Significance Index: -2.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0201
    Cell Significance Index: -2.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0304
    Cell Significance Index: -22.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0323
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0360
    Cell Significance Index: -26.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0360
    Cell Significance Index: -27.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0523
    Cell Significance Index: -29.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0565
    Cell Significance Index: -35.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0740
    Cell Significance Index: -4.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0898
    Cell Significance Index: -4.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0965
    Cell Significance Index: -27.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1423
    Cell Significance Index: -14.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1431
    Cell Significance Index: -6.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1439
    Cell Significance Index: -6.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1445
    Cell Significance Index: -17.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1558
    Cell Significance Index: -11.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1563
    Cell Significance Index: -17.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1639
    Cell Significance Index: -34.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1801
    Cell Significance Index: -2.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1917
    Cell Significance Index: -13.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2254
    Cell Significance Index: -23.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2315
    Cell Significance Index: -2.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2531
    Cell Significance Index: -6.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2994
    Cell Significance Index: -6.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2995
    Cell Significance Index: -3.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3077
    Cell Significance Index: -9.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3290
    Cell Significance Index: -20.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3374
    Cell Significance Index: -7.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3478
    Cell Significance Index: -5.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3505
    Cell Significance Index: -12.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3541
    Cell Significance Index: -28.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3546
    Cell Significance Index: -22.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3904
    Cell Significance Index: -20.5000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.4056
    Cell Significance Index: -3.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4157
    Cell Significance Index: -6.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4271
    Cell Significance Index: -9.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4380
    Cell Significance Index: -13.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4389
    Cell Significance Index: -14.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4435
    Cell Significance Index: -15.4100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4572
    Cell Significance Index: -9.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4598
    Cell Significance Index: -23.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5472
    Cell Significance Index: -10.9900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.5662
    Cell Significance Index: -7.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5760
    Cell Significance Index: -8.6800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5798
    Cell Significance Index: -7.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5856
    Cell Significance Index: -4.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SEC22A is a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor) family of proteins, which are key regulators of vesicle fusion and trafficking. SEC22A is a soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor, which interacts with the vesicle-associated membrane protein (VAMP) to facilitate the fusion of vesicles with target membranes. The SEC22A protein is characterized by its ability to bind to VAMP and other SNARE proteins, allowing it to regulate the transport of proteins between the ER and Golgi apparatus. **Pathways and Functions:** SEC22A is involved in several key cellular pathways, including: 1. **Asparagine N-linked glycosylation:** SEC22A regulates the transport of proteins to the Golgi apparatus, where they undergo asparagine N-linked glycosylation, a post-translational modification that is essential for protein function and stability. 2. **Copii-mediated vesicle transport:** SEC22A is involved in the regulation of Copii-mediated vesicle transport, a process that is essential for the transport of proteins between the ER and Golgi apparatus. 3. **Endoplasmic reticulum membrane:** SEC22A regulates the transport of proteins from the ER to the Golgi apparatus, where they are integrated into cellular membranes. 4. **Membrane fusion:** SEC22A is involved in the regulation of membrane fusion, a process that is essential for the transport of proteins between vesicles and target membranes. **Clinical Significance:** Dysregulation of SEC22A has been implicated in several neurological disorders, including: 1. **Neurodegenerative diseases:** SEC22A mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where impaired protein trafficking and synaptic function contribute to disease progression. 2. **Neurodevelopmental disorders:** SEC22A mutations have also been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where impaired protein trafficking and synaptic function contribute to cognitive and behavioral deficits. 3. **Neuromuscular disorders:** SEC22A mutations have been associated with neuromuscular disorders, such as amyotrophic lateral sclerosis (ALS) and muscular dystrophy, where impaired protein trafficking and synaptic function contribute to muscle weakness and degeneration. In conclusion, SEC22A is a critical gene involved in protein trafficking and neurotransmission. Its dysregulation has been implicated in several neurological disorders, highlighting the importance of SEC22A in maintaining proper cellular function and synaptic transmission. Further research is needed to fully understand the mechanisms by which SEC22A regulates protein trafficking and to develop therapeutic strategies for the treatment of SEC22A-related disorders.

Genular Protein ID: 1499508902

Symbol: SC22A_HUMAN

Name: Vesicle-trafficking protein SEC22a

UniProtKB Accession Codes:

Q96IW7 B2RE26 Q9Y682

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 307
  • Mass: 34948
  • Checksum: 227A7F6944EC621F
  • Sequence:
    • MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR CTLKTGHYNI 
NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM MKTNTAVRPY CFIEFDNFIQ 
RTKQRYNNPR SLSTKINLSD MQTEIKLRPP YQISMCELGS ANGVTSAFSV DCKGAGKISS 
AHQRLEPATL SGIVGFILSL LCGALNLIRG FHAIESLLQS DGDDFNYIIA FFLGTAACLY 
QCYLLVYYTG WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG 
KAPDYDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.