Details for: RNF11

Gene ID: 26994

Symbol: RNF11

Ensembl ID: ENSG00000123091

Description: ring finger protein 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 288.9192
    Cell Significance Index: -44.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 190.7008
    Cell Significance Index: -48.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 106.1300
    Cell Significance Index: -43.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.1467
    Cell Significance Index: -49.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.3299
    Cell Significance Index: -45.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.6786
    Cell Significance Index: -49.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.1885
    Cell Significance Index: -40.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4991
    Cell Significance Index: -41.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1073
    Cell Significance Index: -43.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7647
    Cell Significance Index: -50.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3661
    Cell Significance Index: -18.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.0494
    Cell Significance Index: 1165.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7828
    Cell Significance Index: 132.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7668
    Cell Significance Index: 174.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6650
    Cell Significance Index: 45.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6199
    Cell Significance Index: 324.9500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2983
    Cell Significance Index: 7.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2287
    Cell Significance Index: 64.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0907
    Cell Significance Index: 391.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0606
    Cell Significance Index: 28.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9964
    Cell Significance Index: 51.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9868
    Cell Significance Index: 107.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9605
    Cell Significance Index: 60.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9174
    Cell Significance Index: 165.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9073
    Cell Significance Index: 54.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8118
    Cell Significance Index: 23.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7959
    Cell Significance Index: 97.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7585
    Cell Significance Index: 104.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7326
    Cell Significance Index: 119.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6596
    Cell Significance Index: 14.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6519
    Cell Significance Index: 29.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6082
    Cell Significance Index: 7.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5934
    Cell Significance Index: 76.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5674
    Cell Significance Index: 5.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5639
    Cell Significance Index: 111.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5547
    Cell Significance Index: 25.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5078
    Cell Significance Index: 458.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4930
    Cell Significance Index: 14.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4885
    Cell Significance Index: 12.8500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.4630
    Cell Significance Index: 2.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4583
    Cell Significance Index: 58.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4302
    Cell Significance Index: 234.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4038
    Cell Significance Index: 178.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3524
    Cell Significance Index: 12.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3060
    Cell Significance Index: 14.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3055
    Cell Significance Index: 20.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2743
    Cell Significance Index: 16.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2514
    Cell Significance Index: 47.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1926
    Cell Significance Index: 10.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1732
    Cell Significance Index: 4.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1619
    Cell Significance Index: 10.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1587
    Cell Significance Index: 18.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1440
    Cell Significance Index: 24.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1304
    Cell Significance Index: 90.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0975
    Cell Significance Index: 2.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0959
    Cell Significance Index: 6.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0626
    Cell Significance Index: 2.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0537
    Cell Significance Index: 101.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0305
    Cell Significance Index: 2.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0098
    Cell Significance Index: 15.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0103
    Cell Significance Index: -6.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0247
    Cell Significance Index: -18.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0379
    Cell Significance Index: -0.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0481
    Cell Significance Index: -3.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0565
    Cell Significance Index: -31.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1066
    Cell Significance Index: -22.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1237
    Cell Significance Index: -3.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1789
    Cell Significance Index: -3.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1836
    Cell Significance Index: -26.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1918
    Cell Significance Index: -5.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2206
    Cell Significance Index: -3.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2207
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2284
    Cell Significance Index: -26.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2339
    Cell Significance Index: -23.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2357
    Cell Significance Index: -27.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3357
    Cell Significance Index: -8.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3429
    Cell Significance Index: -40.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3752
    Cell Significance Index: -16.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4242
    Cell Significance Index: -44.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4636
    Cell Significance Index: -36.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4920
    Cell Significance Index: -18.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6466
    Cell Significance Index: -18.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6885
    Cell Significance Index: -42.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7147
    Cell Significance Index: -15.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7291
    Cell Significance Index: -15.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8303
    Cell Significance Index: -18.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8363
    Cell Significance Index: -7.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8697
    Cell Significance Index: -16.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8908
    Cell Significance Index: -32.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9006
    Cell Significance Index: -18.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9362
    Cell Significance Index: -30.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9379
    Cell Significance Index: -29.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0073
    Cell Significance Index: -29.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0163
    Cell Significance Index: -32.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin Ligase Activity**: RNF11 possesses a RING finger domain, which enables it to bind ubiquitin and other proteins, leading to the formation of ubiquitin-ligase complexes. 2. **Protein Degradation**: RNF11 facilitates the ubiquitination and degradation of target proteins, regulating various cellular processes, including cell signaling, autophagy, and protein turnover. 3. **Cell Type-Specific Expression**: RNF11 is highly expressed in specific cell types, including GABAergic amacrine cells, progenitor cells of mammary luminal epithelium, and epithelial cells of various organs. 4. **Zinc Ion Binding**: RNF11 contains a zinc finger domain, which is essential for its enzymatic activity and protein-protein interactions. **Pathways and Functions:** 1. **Protein Autoubiquitination**: RNF11 regulates autoubiquitination of itself and other proteins, modulating cellular processes such as cell signaling and protein degradation. 2. **Early Endosome and Recycling Endosome**: RNF11 is involved in the regulation of endosomal trafficking and protein degradation, highlighting its role in maintaining cellular homeostasis. 3. **Extracellular Exosome**: RNF11 may play a role in the regulation of exosomal protein secretion and degradation, influencing cellular communication and tissue homeostasis. 4. **Nucleus and Protein Binding**: RNF11 interacts with various nuclear proteins, regulating transcriptional processes and protein-protein interactions. **Clinical Significance:** RNF11 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders**: RNF11 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its dysregulation contributes to protein accumulation and neuronal damage. 2. **Cancer**: RNF11 has been found to be overexpressed in various types of cancer, including breast, prostate, and colon cancer, where its role in protein degradation and autophagy is critical. 3. **Neurodevelopmental Disorders**: RNF11 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where its dysregulation contributes to protein misfolding and neuronal dysfunction. In conclusion, RNF11 is a multifunctional protein that plays a critical role in various cellular processes, including protein degradation, autophagy, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms and potential therapeutic applications.

Genular Protein ID: 1151745684

Symbol: RNF11_HUMAN

Name: RING finger protein 11

UniProtKB Accession Codes:

Q9Y3C5 A8KAI2 Q5T7R8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10673045

Title: Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein.

PubMed ID: 10673045

DOI: 10.1016/s0167-4781(99)00190-6

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16123141

Title: Molecular characterization of ring finger protein 11.

PubMed ID: 16123141

DOI: 10.1158/1541-7786.mcr-04-0166

PubMed ID: 14559117

Title: The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases.

PubMed ID: 14559117

DOI: 10.1016/j.bbadis.2003.07.001

PubMed ID: 14562029

Title: The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.

PubMed ID: 14562029

DOI: 10.1038/sj.bjc.6601301

PubMed ID: 14755250

Title: An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.

PubMed ID: 14755250

DOI: 10.1038/sj.onc.1207319

PubMed ID: 17917589

Title: PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain.

PubMed ID: 17917589

DOI: 10.1097/nen.0b013e3181567f17

PubMed ID: 18724389

Title: The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.

PubMed ID: 18724389

DOI: 10.1038/onc.2008.288

PubMed ID: 19131965

Title: The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.

PubMed ID: 19131965

DOI: 10.1038/emboj.2008.285

PubMed ID: 18615712

Title: Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes.

PubMed ID: 18615712

DOI: 10.1002/prot.22120

PubMed ID: 20676133

Title: Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment.

PubMed ID: 20676133

DOI: 10.1038/onc.2010.294

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 154
  • Mass: 17444
  • Checksum: C368E38148FC1D0D
  • Sequence:
    • MGNCLKSPTS DDISLLHESQ SDRASFGEGT EPDQEPPPPY QEQVPVPVYH PTPSQTRLAT 
QLTEEEQIRI AQRIGLIQHL PKGVYDPGRD GSEKKIRECV ICMMDFVYGD PIRFLPCMHI 
YHLDCIDDWL MRSFTCPSCM EPVDAALLSS YETN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.