Details for: GPR160

Gene ID: 26996

Symbol: GPR160

Ensembl ID: ENSG00000173890

Description: G protein-coupled receptor 160

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.1971
    Cell Significance Index: -9.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.5975
    Cell Significance Index: -9.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.5002
    Cell Significance Index: -11.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 16.4302
    Cell Significance Index: -11.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3853
    Cell Significance Index: -10.8700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 8.0357
    Cell Significance Index: 60.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.9727
    Cell Significance Index: -9.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 7.7555
    Cell Significance Index: 92.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3003
    Cell Significance Index: -11.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.8077
    Cell Significance Index: 239.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0662
    Cell Significance Index: 357.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.8853
    Cell Significance Index: 26.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7419
    Cell Significance Index: 142.4400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.6745
    Cell Significance Index: 26.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5215
    Cell Significance Index: -9.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4421
    Cell Significance Index: 397.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.4243
    Cell Significance Index: 69.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.3334
    Cell Significance Index: 14.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2294
    Cell Significance Index: 33.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0673
    Cell Significance Index: 93.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0192
    Cell Significance Index: 139.6400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.5644
    Cell Significance Index: 18.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2057
    Cell Significance Index: 1088.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1940
    Cell Significance Index: 140.8100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.1883
    Cell Significance Index: 4.5500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.0716
    Cell Significance Index: 2.5000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.0659
    Cell Significance Index: 14.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9288
    Cell Significance Index: 167.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8672
    Cell Significance Index: 64.6300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.8068
    Cell Significance Index: 10.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6178
    Cell Significance Index: 61.1100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.6112
    Cell Significance Index: 5.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5955
    Cell Significance Index: 809.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5804
    Cell Significance Index: 18.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5381
    Cell Significance Index: 102.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5107
    Cell Significance Index: 23.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4289
    Cell Significance Index: 234.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4085
    Cell Significance Index: 50.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4043
    Cell Significance Index: 69.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3765
    Cell Significance Index: 8.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3675
    Cell Significance Index: 9.8300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3198
    Cell Significance Index: 3.3100
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.3155
    Cell Significance Index: 2.2000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2757
    Cell Significance Index: 1.9400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.2541
    Cell Significance Index: 1.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2497
    Cell Significance Index: 8.7800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2306
    Cell Significance Index: 3.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1710
    Cell Significance Index: 3.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1251
    Cell Significance Index: 2.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0963
    Cell Significance Index: 1.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0888
    Cell Significance Index: 17.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0873
    Cell Significance Index: 17.5200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0641
    Cell Significance Index: 0.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0370
    Cell Significance Index: 27.9900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0324
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0213
    Cell Significance Index: 2.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0107
    Cell Significance Index: 3.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0085
    Cell Significance Index: 13.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0016
    Cell Significance Index: 1.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0010
    Cell Significance Index: 1.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0060
    Cell Significance Index: -4.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0105
    Cell Significance Index: -0.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0145
    Cell Significance Index: -1.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0151
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0154
    Cell Significance Index: -3.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0169
    Cell Significance Index: -7.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0243
    Cell Significance Index: -11.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0274
    Cell Significance Index: -7.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0290
    Cell Significance Index: -3.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0345
    Cell Significance Index: -3.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0423
    Cell Significance Index: -5.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0474
    Cell Significance Index: -6.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0515
    Cell Significance Index: -7.4800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0523
    Cell Significance Index: -0.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0530
    Cell Significance Index: -1.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0630
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0636
    Cell Significance Index: -1.7300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0854
    Cell Significance Index: -0.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0917
    Cell Significance Index: -2.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0936
    Cell Significance Index: -9.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0962
    Cell Significance Index: -5.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1001
    Cell Significance Index: -6.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1002
    Cell Significance Index: -4.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1010
    Cell Significance Index: -7.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1033
    Cell Significance Index: -3.9100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1073
    Cell Significance Index: -0.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1081
    Cell Significance Index: -8.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1248
    Cell Significance Index: -8.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1259
    Cell Significance Index: -9.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1275
    Cell Significance Index: -5.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1347
    Cell Significance Index: -4.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1381
    Cell Significance Index: -1.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1484
    Cell Significance Index: -9.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1677
    Cell Significance Index: -4.3100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1751
    Cell Significance Index: -1.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1774
    Cell Significance Index: -3.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1813
    Cell Significance Index: -9.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR) Structure**: GPR160 belongs to the GPCR family, characterized by a characteristic seven-transmembrane helix structure. This structure enables the receptor to interact with G proteins, which in turn activate downstream signaling pathways. 2. **Cellular Expression**: GPR160 is expressed in a wide range of cell types, including secondary lens fibers, P/D1 enteroendocrine cells, stem cells, retinal rod cells, eye photoreceptor cells, peptic cells, enterocytes, colon epithelial cells, and mucous neck cells. 3. **Protein-Protein Interactions**: GPR160 interacts with various proteins, including G proteins, receptor kinases, and transcription factors, facilitating its role in regulating cellular responses. **Pathways and Functions:** 1. **G Protein-Coupled Receptor Signaling Pathway**: GPR160 activates the G protein-coupled receptor signaling pathway, which involves the activation of G proteins, leading to the regulation of downstream signaling pathways. 2. **Cell Signaling and Proliferation**: GPR160 regulates cellular proliferation and differentiation by interacting with growth factors and hormones, influencing cell growth and survival. 3. **Endocrine and Neuroendocrine Functions**: GPR160 plays a role in regulating endocrine and neuroendocrine functions, including the regulation of hormone secretion and the response to stress. **Clinical Significance:** 1. **Eye Diseases**: GPR160 has been implicated in the pathogenesis of eye diseases, including age-related macular degeneration and glaucoma. Alterations in GPR160 expression have been linked to disease progression. 2. **Gastrointestinal Disorders**: GPR160 has been linked to gastrointestinal disorders, including inflammatory bowel disease and irritable bowel syndrome. Abnormal expression of GPR160 has been observed in these conditions. 3. **Cancer**: GPR160 has been identified as a potential oncogene, with its expression linked to cancer progression and metastasis. Targeting GPR160 may offer a novel therapeutic strategy for cancer treatment. In conclusion, GPR160 is a multifunctional GPCR that plays a crucial role in regulating cellular responses to various stimuli. Further research is needed to fully elucidate the mechanisms underlying GPR160's functions and its clinical significance.

Genular Protein ID: 4016790818

Symbol: GP160_HUMAN

Name: Probable G-protein coupled receptor 160

UniProtKB Accession Codes:

Q9UJ42 D3DNQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 7 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11466977

Title: Mining of assembled expressed sequence tag (EST) data for protein families: application to the G protein-coupled receptor superfamily.

PubMed ID: 11466977

DOI: 10.1093/bib/1.1.93

PubMed ID: 12044878

Title: Identification of G protein-coupled receptor genes from the human genome sequence.

PubMed ID: 12044878

DOI: 10.1016/s0014-5793(02)02775-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 338
  • Mass: 39787
  • Checksum: 50B38F90E0311175
  • Sequence:
    • MTALSSENCS FQYQLRQTNQ PLDVNYLLFL IILGKILLNI LTLGMRRKNT CQNFMEYFCI 
SLAFVDLLLL VNISIILYFR DFVLLSIRFT KYHICLFTQI ISFTYGFLHY PVFLTACIDY 
CLNFSKTTKL SFKCQKLFYF FTVILIWISV LAYVLGDPAI YQSLKAQNAY SRHCPFYVSI 
QSYWLSFFMV MILFVAFITC WEEVTTLVQA IRITSYMNET ILYFPFSSHS SYTVRSKKIF 
LSKLIVCFLS TWLPFVLLQV IIVLLKVQIP AYIEMNIPWL YFVNSFLIAT VYWFNCHKLN 
LKDIGLPLDP FVNWKCCFIP LTIPNLEQIE KPISIMIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.